Defining the functional states of Th17 cells

F1000Research

Volumn 4, Issue , 2015, Pages

  Lee, Youjin ^a   Kuchroo, Vijay ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 23;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL HETEROGENEITY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; NONHUMAN; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE SUBPOPULATION; TH17 CELL;

EID: 84940976589     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.6116.1     Document Type: Review

References (74)

1. Khader SA Gopal R: IL-17 in protective immunity to intracellular pathogens. Virulence. 2010;1(5):423-427. 21178483 10.4161/viru.1.5.12862 2953849
2. Khader SA Guglani L Rangel-Moreno J: IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. J Immunol. 2011;187(10):5402-5407. 22003199 10.4049/jimmunol.1101377 3208087
3. Mosmann TR Coffman RL: TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145-173. 2523712 10.1146/annurev.iy.07.040189.001045
4. King C Tangye SG Mackay CR: T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol. 2008;26:741-766. 18173374 10.1146/annurev.immunol.26.021607.090344
5. Zhu J Paul WE: Heterogeneity and plasticity of T helper cells. Cell Res. 2010;20(1):4-12. 20010916 10.1038/cr.2009.138 3494736
6. Zhu J Yamane H Paul WE: Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol. 2010;28:445-489. 20192806 10.1146/annurev-immunol-030409-101212 3502616
7. Cox CA Shi G Yin H: Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J Immunol. 2008;180(11):7141-22. 18490741 10.4049/jimmunol.180.11.7414 2753359
8. Zamvil SS Steinman L: The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol. 1990;8:579-621. 2188675 10.1146/annurev.iy.08.040190.003051
9. Panitch HS Hirsch RL Haley AS: Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1987;1(8538):893-895. 2882294 10.1016/S0140-6736(87)92863-7
10. Wolf SF Temple PA Kobayashi M: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol. 1991;146(9):3074-3081. 1673147
11. Stern AS Magram J Presky DH: Interleukin-12 an integral cytokine in the immune response. Life Sci. 1996;58(8):639-654. 8594314 10.1016/S0024-3205(96)80003-8
12. Chua AO Chizzonite R Desai BB: Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol. 1994;153(1):128-136. 7911493
13. Presky DH Yang H Minetti LJ: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A. 1996;26(24):14002-7. 8943050 10.1073/pnas.93.24.14002 19484
14. Gately MK Renzetti LM Magram J: The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol. 1998;16:495-521. 9597139 10.1146/annurev.immunol.16.1.495
15. Szabo SJ Kim ST Costa GL: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100(6):655-669. 10761931 10.1016/S0092-8674(00)80702-3
16. Brok Herbert PM van Meurs M Blezer E: Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody. J Immunol. 2002;169(11):6554-6563. 12444167 10.4049/jimmunol.169.11.6554
17. Langrish CL Chen Y Blumenschein WM: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005;201(2):233-240. 15657292 10.1084/jem.20041257 2212798 F1000 Recommendation
18. Gran B Zhang G Yu S: IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol. 2002;169(12):7104-7110. 12471147 10.4049/jimmunol.169.12.7104
19. Becher B Durell BG Noelle RJ: Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest. 2002;110(4):493-497. 12189243 10.1172/JCI15751 150420 F1000 Recommendation
20. Zhang G Gran B Yu S: Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol. 2003;170(4):2153-2160. 12574388 10.4049/jimmunol.170.4.2153
21. Willenborg DO Fordham S Bernard CC: IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol. 1996;157(8):3223-3227. 8871615 F1000 Recommendation
22. Ferber IA Brocke S Taylor-Edwards C: Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol. 1996;156(1):5-7. 8598493 F1000 Recommendation
23. Oppmann B Lesley R Blom B: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13(5):715-725. 11114383 10.1016/S1074-7613(00)00070-4
24. Langrish CL McKenzie BS Wilson NJ: IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev. 2004;202(1):96-105. 15546388 10.1111/j.0105-2896.2004.00214.x
25. Cua DJ Sherlock J Chen Y: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421(6924):744-748. 12610626 10.1038/nature01355 F1000 Recommendation
26. Croxford AL Mair F Becher B: IL-23: one cytokine in control of autoimmunity. Eur J Immunol. 2012;42(9):2263-2273. 22949325 10.1002/eji.201242598
27. Aggarwal S Ghilardi N Xie M: Interleukin-23 promotes a distinct CD 4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278(3):1910-1914. 12417590 10.1074/jbc.M207577200
28. Diveu C McGeachy MJ Cua DJ: Cytokines that regulate autoimmunity. Curr Opin Immunol. 2008;20(6):663-668. 18834938 10.1016/j.coi.2008.09.003
29. Murphy CA Langrish CL Chen Y: Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med. 2003;198(12):1951-7. 14662908 10.1084/jem.20030896 2194162 F1000 Recommendation
30. Uhlig HH McKenzie BS Hue S: Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity. 2006;25(2):309-318. 16919486 10.1016/j.immuni.2006.05.017 F1000 Recommendation
31. Bettelli E Carrier Y Gao W: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235-238. 16648838 10.1038/nature04753 F1000 Recommendation
32. Mangan PR Harrington LE O'Quinn DB: Transforming growth factor-beta induces development of the TH17 lineage. Nature. 2006;441(7090):231-234. 16648837 10.1038/nature04754 F1000 Recommendation
33. Veldhoen M Hocking RJ Atkins CJ: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179-189. 16473830 10.1016/j.immuni.2006.01.001 F1000 Recommendation
34. Cargill M Schrodi SJ Chang M: A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80(2):273-90. 17236132 10.1086/511051 1785338 F1000 Recommendation
35. Rahman P Inman RD Gladman DD: Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 2008;58(4):1020-1025. 18383363 10.1002/art.23389
36. Rahman P Inman RD Maksymowych WP: Association of interleukin 23 receptor variants with psoriatic arthritis. J Rheumatol. 2009;36(1):137-140. 19040306 10.3899/jrheum.080458
37. Huber AK Jacobson EM Jazdzewski K: Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity. J Clin Endocrinol Metab. 2008;93(3):1077-1081. 18073300 10.1210/jc.2007-2190 2266952 F1000 Recommendation
38. Ali S Srivastava AK Chopra R: IL12B SNPs and copy number variation in IL23R gene associated with susceptibility to leprosy. J Med Genet. 2013;50(1):34-42. 23240095 10.1136/jmedgenet-2012-101214
39. Núñez C Dema B Cénit MC: IL23R: a susceptibility locus for celiac disease and multiple sclerosis? Genes Immun. 2008;9(4):289-293. 18368064 10.1038/gene.2008.16
40. Eirís N González-Lara L Santos-Juanes J: Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus. J Dermatol Sci. 2014;75(3):167-172. 24957500 10.1016/j.jdermsci.2014.05.010
41. Hofstetter HH Ibrahim SM Koczan D: Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol. 2005;237(2):123-130. 16386239 10.1016/j.cellimm.2005.11.002 F1000 Recommendation
42. Luger D Silver PB Tang J: Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205(4):799-810. 18391061 10.1084/jem.20071258 2292220 F1000 Recommendation
43. Genovese MC Van den Bosch F Roberson SA: LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 2010;62(4):929-939. 20131262 10.1002/art.27334 F1000 Recommendation
44. Huh JR Leung MW Huang P: Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature. 2011;472(7344):486-490. 21441909 10.1038/nature09978 3172133 F1000 Recommendation
45. Xiao S Yosef N Yang J: Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014;40(4):477-489. 24745332 10.1016/j.immuni.2014.04.004 4066874
46. Maddur MS Miossec P Kaveri SV: Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol. 2012;181(1):8-18. 22640807 10.1016/j.ajpath.2012.03.044
47. Hueber W Sands BE Lewitzky S: Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut. 2012;61(12):1693-1700. 22595313 10.1136/gutjnl-2011-301668 F1000 Recommendation
48. Kamada N Seo S Chen GY: Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13(5):321-335. 23618829 10.1038/nri3430
49. Atarashi K Nishimura J Shima T: ATP drives lamina propria TH17 cell differentiation. Nature. 2008;455(7214):808-812. 18716618 10.1038/nature07240 F1000 Recommendation
50. Ivanov II Frutos Rde L Manel N: Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008;4(4):337-349. 18854238 10.1016/j.chom.2008.09.009 2597589 F1000 Recommendation
51. O'Connor W Jr Kamanaka M Booth CJ: A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol. 2009;10(6):603-609. 19448631 10.1038/ni.1736 2709990 F1000 Recommendation
52. O'Connor W Jr Zenewicz LA Flavell RA: The dual nature of TH17 cells: shifting the focus to function. Nat Immunol. 2010;11(6):471-476. 20485275 10.1038/ni.1882
53. Lee Y Awasthi A Yosef N: Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012;13(10):991-999. 22961052 10.1038/ni.2416 3459594 F1000 Recommendation
54. Ghoreschi K Laurence A Yang X: Generation of pathogenic TH17 cells in the absence of TGF-β signalling. Nature. 2010;467(7318):967-971. 20962846 10.1038/nature09447 3108066 F1000 Recommendation
55. McGeachy MJ Bak-Jensen KS Chen Y: TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology. Nat Immunol. 2007;8(12):1390-1397. 17994024 10.1038/ni1539 F1000 Recommendation
56. McGeachy MJ Cua DJ: Th17 cell differentiation: the long and winding road. Immunity. 2008;28(4):445-453. 18400187 10.1016/j.immuni.2008.03.001
57. Korn T Bettelli E Oukka M: IL-17 and Th17 Cells. Annu Rev Immunol. 2009;27:485-517. 19132915 10.1146/annurev.immunol.021908.132710
58. Jäger A Dardalhon V Sobel RA: Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009;183(11):7169-7177. 19890056 10.4049/jimmunol.0901906 2921715
59. Codarri L Gyülvészi G Tosevski V: RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol. 2011;12(6):560-567. 21516112 10.1038/ni.2027 F1000 Recommendation
60. Duvallet E Semerano L Assier E: Interleukin-23: a key cytokine in inflammatory diseases. Ann Med. 2011;43(7):503-511. 21585245 10.3109/07853890.2011.577093
61. El-Behi M Ciric B Dai H: The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF. Nat Immunol. 2011;12(6):568-575. 21516111 10.1038/ni.2031 3116521 F1000 Recommendation
62. Chung Y Chang SH Martinez GJ: Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009;30(4):576-587. 19362022 10.1016/j.immuni.2009.02.007 2705871 F1000 Recommendation
63. Zielinski CE Mele F Aschenbrenner D: Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. Nature. 2012;484(7395):514-518. 22466287 10.1038/nature10957 F1000 Recommendation
64. Ma CS Chew GY Simpson N: Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med. 2008;205(7):1551-1557. 18591410 10.1084/jem.20080218 2442632 F1000 Recommendation
65. Yosef N Shalek AK Gaublomme JT: Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013;496(7446):461-468. 23467089 10.1038/nature11981 3637864 F1000 Recommendation
66. Kalisky T Blainey P Quake SR: Genomic analysis at the single-cell level. Annu Rev Genet. 2011;45:431-445. 21942365 10.1146/annurev-genet-102209-163607 3878048
67. Blainey PC Quake SR: Dissecting genomic diversity, one cell at a time. Nat Methods. 2014;11(1):19-21. 24524132 10.1038/nmeth.2783 3947563
68. Trombetta JJ Gennert D Lu D: Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing. Curr Protoc Mol Biol. 2014;107:4.22.1-4.22.17. 24984854 10.1002/0471142727.mb0422s107 4338574 F1000 Recommendation
69. Shalek AK Satija R Adiconis X: Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature. 2013;498(7453):236-240. 23685454 10.1038/nature12172 3683364 F1000 Recommendation
70. Yosef N Zalckvar E Rubinstein AD: ANAT: a tool for constructing and analyzing functional protein networks. Sci Signal. 2011;4(196):pl1. 22028466 10.1126/scisignal.2001935
71. Dardalhon V Herpers B Noraz N: Lentivirus-mediated gene transfer in primary T cells is enhanced by a central DNA flap. Gene Ther. 2001;8(3):190-198. 11313790 10.1038/sj.gt.3301378
72. McManus MT Haines BB Dillon CP: Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol. 2002;169(10):5754-5760. 12421955 10.4049/jimmunol.169.10.5754
73. Shalek AK Robinson JT Karp ES: Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci U S A. 2010;107(5):1870-1875. 20080678 10.1073/pnas.0909350107 2836617 F1000 Recommendation
74. Shalek AK Gaublomme JT Wang L: Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano lett. 2012;12(12):6498-6504. 23190424 10.1021/nl3042917 3573729 F1000 Recommendation