Soluble tumor necrosis factor alpha promotes retinal ganglion cell death in glaucoma via calcium-permeable ampa receptor activation

Journal of Neuroscience

Volumn 35, Issue 35, 2015, Pages 12088-12102

  Cueva Vargas, Jorge L ^a   Osswald, Ingrid K ^b   Unsain, Nicolas ^c,d   Aurousseau, Mark R ^b   Barker, Philip A ^c   Bowie, Derek ^b   Di Polo, Adriana ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d INSTITUTO DE INVESTIGACIÓN MÉDICA MERCEDES Y MARTÍN FERREYRA   (Argentina)

Author keywords

AMPA receptor; Calcium; Glaucoma; Neuroinflammation; Retinal ganglion cell; Tumor necrosis factor

Indexed keywords

AMPA RECEPTOR; CALCIUM PERMEABLE AMPA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CALCIUM; CARRIER PROTEIN; CHOLINE ACETYLTRANSFERASE; COBALT; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; SODIUM CHLORIDE; TNFRSF1A PROTEIN, RAT; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; XENP 1595;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; GLAUCOMA; IMMUNOHISTOCHEMISTRY; INTRAOCULAR HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; MACROGLIA; METABOLISM; MICROGLIA; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CALCIUM; CARRIER PROTEINS; CELL DEATH; CHOLINE O-ACETYLTRANSFERASE; COBALT; DISEASE MODELS, ANIMAL; EPENDYMOGLIAL CELLS; GLAUCOMA; MALE; MICROGLIA; RATS; RECEPTORS, AMPA; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; RETINAL GANGLION CELLS; SALINE SOLUTION, HYPERTONIC; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84940935326     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1273-15.2015     Document Type: Article

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