TNF-α triggers rapid membrane insertion of Ca2+ permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury

Experimental Neurology

Volumn 238, Issue 2, 2012, Pages 93-102

  Yin, Hong Z ^a   Hsu, Cheng I ^a   Yu, Stephen ^a   Rao, Shyam D ^b   Sorkin, Linda S ^c   Weiss, John H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c University of California at San Diego   (United States)

Author keywords

ALS; AMPA; Amyotrophic lateral sclerosis; Ca2+ permeable AMPA receptors; Motor neuron; Phosphatidylinositol 3 kinase; Protein kinase A; Slice culture; Tumor necrosis factor alpha

Indexed keywords

1 NAPHTHYL ACETYLSPERMINE; 2,4 PYRROLIDINEDICARBOXYLIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR ANTAGONIST; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME MECHANISM; EXCITOTOXICITY; FEMALE; HISTOCHEMISTRY; MEMBRANE PERMEABILITY; MOTONEURON; MOTOR NEURON DISEASE; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPINAL CORD VENTRAL HORN; UPREGULATION;

AGE FACTORS; ANIMALS; CALCIUM; COBALT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGENTS; FEMALE; ISOQUINOLINES; KAINIC ACID; MOTOR NEURONS; NEUROFILAMENT PROTEINS; ORGAN CULTURE TECHNIQUES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SPINAL CORD; SULFONAMIDES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866495012     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.08.004     Document Type: Article

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