Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors

Annals of Neurology

Volumn 65, Issue 2, 2009, Pages 160-166

  Ouardouz, Mohamed ^a   Coderre, Elaine ^a   Zamponi, Gerald W ^b   Hameed, Shameed ^b   Yin, Xinghua ^c   Trapp, Bruce D ^c   Stys, Peter K ^b,d  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c LERNER RESEARCH INSTITUTE   (United States)

^d HRIC 1AA22 ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CALCIUM; CALCIUM CHANNEL; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 5; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; KAINIC ACID RECEPTOR AGONIST; NEURONAL NITRIC OXIDE SYNTHASE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; RYANODINE RECEPTOR; SCAVENGER;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CENTRAL NERVOUS SYSTEM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEREGULATION; GRAY MATTER; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MOLECULAR MECHANICS; NERVE FIBER; NONHUMAN; PATHOPHYSIOLOGY; PERTUSSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPINAL CORD; SPINE; WHITE MATTER;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; AXONS; CALCIUM; CALCIUM CHANNEL BLOCKERS; EGTAZIC ACID; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICROSCOPY, IMMUNOELECTRON; NERVE FIBERS, MYELINATED; NITRIC OXIDE SYNTHASE TYPE I; PERTUSSIS TOXIN; RATS; RATS, LONG-EVANS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; SPINAL CORD;

EID: 62549113032     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21539     Document Type: Article

References (37)

1. Ouardouz M, Coderre E, Basak A, et al. Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors. Ann Neurol 2009;65:151-159.
2. Agrawal SK, Fehlings MG. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 1997;17:1055-1063.
3. Gallo V, Ghiani CA. Glutamate receptors in glia: new cells, new inputs and new functions. Trends Pharmacol Sci 2000;21: 252-258.
4. Li S, Stys PK. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter. J Neurosci 2000;20:1190-1198.
5. Park E, Liu Y, Fehlings MG. Changes in glial cell white matter AMPA receptor expression after spinal cord injury and relationship to apoptotic cell death. Exp Neurol 2003; 182:35-48.
6. Steinhauser C, Gallo V. News on glutamate receptors in glial cells. Trends Neurosci 1996;19:339-345.
7. Verkhratsky A, Steinhauser C. Ion channels in glial cells. Brain Res Brain Res Rev 2000;32:380-412.
8. Yoshioka A, Bacskai B, Pleasure D. Pathophysiology of oligo-dendroglial excitotoxicity. J Neurosci Res 1996;46:427-437.
9. Matute C, Alberdi E, Domercq M, et al. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci 2001;24:224-230.
10. Matute C, Sanchez-Gomez MV, Martinez-Millan L, et al. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc Natl Acad Sci U S A 1997;94:8830-8835.
11. McDonald JW, Althomsous SP, Hyrc KL, et al. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med 1998;4:291-297.
12. Tekkok SB, Goldberg MP. AMPA/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter. J Neurosci 2001;21:4237-4248.
13. McCracken E, Fowler JH, Dewar D, et al. Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502. J Cereb Blood Flow Metab 2002;22:1090-1097.
14. Pitt D, Werner P, Raine CS. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 2000;6:67-70.
15. Rosenberg LJ, Teng YD, Wrathall JR. 2,3-dihydroxy-6-tiitro-7-sidfamoyl- benzo( f)quinoxaline reduces glial loss and acute wdiite matter pathology after experimental spinal cord contusion. J Neurosci 1999;19:464-475.
16. Smith T, Groom A, Zhu B et al. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat Med 2000;6: 62- 66.
17. Wrathall JR, Choiniere D, Teng YD. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J Neurosci 1994;14:6598-6607.
18. Wrathall JR, Teng YD, Marriott R. Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma. Exp Neurol 1997;145: 565-573.
19. Micu I, Coderre E, Jiang Q, et al. NMDA receptors mediate Ca accumulation in central nervous system myelin during chemical ischemia. Nature 2006:439:988-992.
20. Clarke VR, Ballyk BA, Hoo KH, et al. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 1997;389:599-603.
21. Mayer ML, Ghosal A, Dolman NP, et al. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J Neurosci 2006;26: 2852-2861.
22. Ouardouz M, Nikolaeva M, Coderre E, et al. Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron 2003;40:53-63.
23. Lerma J. Kainate receptor physiology. Curr Opin Pharmacol 2006;6:89-97.
24. Rozas JL, Paternain AV, Lerma J. Noncanonical signaling by ionotropic kainate receptors. Neuron 2003;39:543-553.
25. Berridge MJ. Cardiac calcium signalling. Biochem Soc Trans 2003;31:930-933.
26. Foskett JK, White C, Cheung KH, et al. Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev 2007;87:593-658.
27. Flogel U, Merx MW, Godecke A, et al. Myoglobin: a scavenger of bioactive NO. Proc Natl Acad Sci U S A 2001;98:735-740.
28. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43: 109-142.
29. Xu X, Star RA, Tortorici G, et al. Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx. J Biol Chem 1994;269: 12645-12653.
30. Oka A, Belliveau MJ, Rosenberg PA, et al. Vulnerability of ol-igodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci 1993; 13:1441-1453.
31. Baltan S, Besancou EF, Mbow B, et al. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci 2008;28:1479-1489.
32. Emptage N, Bliss TV, Fine A. Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. Neuron 1999;22: 115-124.
33. Philipson KD, Nicoll DA. Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol 2000;62:111-133.
34. Vicente S, Figueroa S, Perez-Rodriguez R, et al. Nitric oxide donors induce calcium-mobilisation from internal stores but do not stimulate catecholamine secretion by bovine chromaffin cells in resting conditions. Cell Calcium 2005;37:163-172.
35. Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338: 278-285.
36. Sattler R, Charlton MP, Hafner M, et al. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. J Neurochern 1998:71:2349-2364.
37. Satder R, Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med 2000;78:3-13.