Resveratrol suppresses the inflammatory responses of human gingival epithelial cells in a SIRT1 independent manner

Journal of Periodontal Research

Volumn 50, Issue 5, 2015, Pages 586-593

  Minagawa, T ^a   Okui, T ^a   Takahashi, N ^a   Nakajima, T ^b   Tabeta, K ^a   Murakami, S ^c   Yamazaki, K ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Anti inflammatory effect; Human gingival epithelial cell; Resveratrol; SIRT1

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1;

EPITHELIUM CELL; GINGIVA; HUMAN;

CHEMOKINE CCL2; EPITHELIAL CELLS; GINGIVA; HUMANS; INTERLEUKIN-8; NF-KAPPA B;

EID: 84940901227     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/jre.12238     Document Type: Article

References (37)

1. Okui T, Aoki-Nonaka Y, Nakajima T, Yamazaki K. The role of distinct T cell subsets in periodontitis - studies from humans and rodent models. Curr Oral Health Rep 2014;1:114-123.
2. Takahashi N, Honda T, Domon H, Nakajima T, Tabeta K, Yamazaki K. Interleukin-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. J Periodontal Res 2010;45:512-519.
3. Chung JH, Manganiello V, Dyck JR. Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol 2012;22:546-554.
4. Baur JA, Pearson KJ, Price NL et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342.
5. Pearson KJ, Baur JA, Lewis KN et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 2008;8:157-168.
6. Vang O. What is new for resveratrol? Is a new set of recommendations necessary? Ann N Y Acad Sci 2013;1290:1-11.
7. Donnelly LE, Newton R, Kennedy GE et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 2004;287:L774-L783.
8. Rizzo A, Bevilacqua N, Guida L, Annunziata M, Romano Carratelli C, Paolillo R. Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells. Cytokine 2012;60:197-204.
9. Timmers S, Konings E, Bilet L et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011;14:612-622.
10. Militaru C, Donoiu I, Craciun A, Scorei ID, Bulearca AM, Scorei RI. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life. Nutrition 2013;29:178-183.
11. Yoshino J, Conte C, Fontana L et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 2012;16:658-664.
12. Poulsen MM, Vestergaard PF, Clasen BF et al. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 2013;62:1186-1195.
13. Kong S, McBurney MW, Fang D. Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol 2012;90:6-13.
14. Um JH, Park SJ, Kang H et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010;59:554-563.
15. Spanier G, Xu H, Xia N et al. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol, 2009;60(suppl 4):111-116.
16. Csiszar A. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci 2011;1215:117-122.
17. Murakami S, Yoshimura N, Koide H et al. Activation of adenosine-receptor-enhanced iNOS mRNA expression by gingival epithelial cells. J Dent Res 2002;81:236-240.
18. Takahashi N, Okui T, Tabeta K, Yamazaki K. Effect of interleukin-17 on the expression of chemokines in gingival epithelial cells. Eur J Oral Sci 2011;119:339-344.
19. Miyazawa H, Tabeta K, Miyauchi S et al. Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice. Lipids Health Dis 2012;11:121.
20. Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity 2013;39:1003-1018.
21. Yucel-Lindberg T, Bage T. Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med 2013;15:e7.
22. Price NL, Gomes AP, Ling AJ et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 2012;15:675-690.
23. Hubbard BP, Gomes AP, Dai H et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 2013;339:1216-1219.
24. Yeung F, Hoberg JE, Ramsey CS et al. Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004;23:2369-2380.
25. Valcarcel-Ares MN, Riveiro-Naveira RR, Vaamonde-Garcia C et al. Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes. Rheumatology (Oxford) 2014;53:1332-1343.
26. Zaidi SF, Ahmed K, Yamamoto T et al. Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells. Biol Pharm Bull 2009;32:1931-1935.
27. Zong Y, Sun L, Liu B et al. Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. PLoS ONE 2012;7:e44107.
28. Park GJ, Kim YS, Kang KL et al. Effects of sirtuin 1 activation on nicotine and lipopolysaccharide-induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts. J Periodontal Res 2013;48:483-492.
29. Zhong LM, Zong Y, Sun L et al. Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PLoS ONE 2012;7:e32195.
30. Park HJ, Jeong SK, Kim SR et al. Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-κB activation. Arch Pharm Res 2009;32:583-591.
31. Casati MZ, Algayer C, Cardoso da Cruz G et al. Resveratrol decreases periodontal breakdown and modulates local levels of cytokines during periodontitis in rats. J Periodontol 2013;84:e58-e64.
32. Tseng PC, Hou SM, Chen RJ et al. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res 2011;26:2552-2563.
33. Shakibaei M, Buhrmann C, Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand (RANKL) activation of NF-κB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011;286:11492-11505.
34. He X, Andersson G, Lindgren U, Li Y. Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production. Biochem Biophys Res Commun 2010;401:356-362.
35. Liu ZP, Li WX, Yu B et al. Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model. J Med Food 2005;8:14-19.
36. Xuzhu G, Komai-Koma M, Leung BP et al. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis 2012;71:129-135.
37. Durbin SM, Jackson JR, Ryan MJ, Gigliotti JC, Alway SE, Tou JC. Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats. J Bone Miner Metab 2014;32:38-47.