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Volumn 26, Issue 9, 2015, Pages 2081-2095

The future of polycystic kidney disease research-as seen by the 12 kaplan awardees

(13)  Antignac, Corinne a,b   Calvet, James P c   Germino, Gregory G d   Grantham, Jared J c   Guay Woodford, Lisa M e   Harris, Peter C f   Hildebrandt, Friedhelm g   Peters, Dorien J M h   Somlo, Stefan i   Torres, Vicente E f   Walz, Gerd j   Zhou, Jing g   Yu, Alan S L c  


Author keywords

[No Author keywords available]

Indexed keywords

POLYCYSTIN; IFT139 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN; MULTIPROTEIN COMPLEX; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIC KIDNEY DISEASE 2 PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84940734635     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2014121192     Document Type: Conference Paper
Times cited : (35)

References (111)
  • 2
    • 78649875479 scopus 로고    scopus 로고
    • MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein
    • Islam MR, Jimenez T, Pelham C, Rodova M, Puri S, Magenheimer BS, Maser RL, Widmann C, Calvet JP:MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem 285: 38818-38831, 2010
    • (2010) J Biol Chem , vol.285 , pp. 38818-38831
    • Islam, M.R.1    Jimenez, T.2    Pelham, C.3    Rodova, M.4    Puri, S.5    Magenheimer, B.S.6    Maser, R.L.7    Widmann, C.8    Calvet, J.P.9
  • 6
    • 0027279639 scopus 로고
    • Childhood onset autosomal dominant polycystic kidney disease in sibs: Clinical picture and recurrence risk. German Working Group on Paediatric Nephrology (Arbeitsgemeinschaft für Pdiatrische Nephrologie
    • Zerres K, Rudnik-Schöneborn S, Deget F: Childhood onset autosomal dominant polycystic kidney disease in sibs: clinical picture and recurrence risk. German Working Group on Paediatric Nephrology (Arbeitsgemeinschaft für Pdiatrische Nephrologie. J Med Genet 30: 583-588, 1993
    • (1993) J Med Genet , vol.30 , pp. 583-588
    • Zerres, K.1    Rudnik-Schöneborn, S.2    Deget, F.3
  • 9
    • 84878703370 scopus 로고    scopus 로고
    • The mutation, a key determinant of phenotype in ADPKD
    • Harris PC, Hopp K: The mutation, a key determinant of phenotype in ADPKD. J Am Soc Nephrol 24: 868-870, 2013
    • (2013) J Am Soc Nephrol , vol.24 , pp. 868-870
    • Harris, P.C.1    Hopp, K.2
  • 10
    • 37549071892 scopus 로고    scopus 로고
    • Mosaicism in autosomal dominant polycystic kidney disease revealed by genetic testing to enable living related renal transplantation
    • Connor A, Lunt PW, Dolling C, Patel Y, Meredith AL, Gardner A, Hamilton NK, Dudley CR: Mosaicism in autosomal dominant polycystic kidney disease revealed by genetic testing to enable living related renal transplantation.AmJ Transplant 8: 232-237, 2008
    • (2008) Am J Transplant , vol.8 , pp. 232-237
    • Connor, A.1    Lunt, P.W.2    Dolling, C.3    Patel, Y.4    Meredith, A.L.5    Gardner, A.6    Hamilton, N.K.7    Dudley, C.R.8
  • 16
    • 84885183918 scopus 로고    scopus 로고
    • Modifying disease in cystic fibrosis: Current and future therapies on the horizon
    • Ong T, Ramsey BW: Modifying disease in cystic fibrosis: current and future therapies on the horizon. Curr Opin Pulm Med 19: 645-651, 2013
    • (2013) Curr Opin Pulm Med , vol.19 , pp. 645-651
    • Ong, T.1    Ramsey, B.W.2
  • 17
    • 0030582668 scopus 로고    scopus 로고
    • The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type i
    • Qian F, Watnick TJ, Onuchic LF, Germino GG: The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell 87: 979-987, 1996
    • (1996) Cell , vol.87 , pp. 979-987
    • Qian, F.1    Watnick, T.J.2    Onuchic, L.F.3    Germino, G.G.4
  • 18
    • 0032132758 scopus 로고    scopus 로고
    • Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease
    • Watnick TJ, Torres VE, Gandolph MA, Qian F, Onuchic LF, Klinger KW, Landes G, Germino GG: Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease. Mol Cell 2: 247-251, 1998
    • (1998) Mol Cell , vol.2 , pp. 247-251
    • Watnick, T.J.1    Torres, V.E.2    Gandolph, M.A.3    Qian, F.4    Onuchic, L.F.5    Klinger, K.W.6    Landes, G.7    Germino, G.G.8
  • 19
    • 0033033706 scopus 로고    scopus 로고
    • Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease
    • Pei Y, Watnick T, He N, Wang K, Liang Y, Parfrey P, Germino G, St George-Hyslop P: Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease. J AmSoc Nephrol 10: 1524-1529, 1999
    • (1999) J AmSoc Nephrol , vol.10 , pp. 1524-1529
    • Pei, Y.1    Watnick, T.2    He, N.3    Wang, K.4    Liang, Y.5    Parfrey, P.6    Germino, G.7    St George-Hyslop, P.8
  • 23
    • 36849037019 scopus 로고    scopus 로고
    • A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1
    • Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG: A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13: 1490-1495, 2007
    • (2007) Nat Med , vol.13 , pp. 1490-1495
    • Piontek, K.1    Menezes, L.F.2    Garcia-Gonzalez, M.A.3    Huso, D.L.4    Germino, G.G.5
  • 24
    • 33845265926 scopus 로고    scopus 로고
    • Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na+,K+,2Cl- Co-transporter-dependent cystic dilation
    • Magenheimer BS, St John PL, Isom KS, Abrahamson DR, De Lisle RC, Wallace DP, Maser RL, Grantham JJ, Calvet JP: Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na+,K+,2Cl- Co-transporter-dependent cystic dilation. J Am Soc Nephrol 17: 3424-3437, 2006
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3424-3437
    • Magenheimer, B.S.1    St John, P.L.2    Isom, K.S.3    Abrahamson, D.R.4    De Lisle, R.C.5    Wallace, D.P.6    Maser, R.L.7    Grantham, J.J.8    Calvet, J.P.9
  • 25
    • 84870707829 scopus 로고    scopus 로고
    • Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4a as a disease modifier
    • Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG: Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4a as a disease modifier. PLoS Genet 8: e1003053, 2012
    • (2012) PLoS Genet , vol.8 , pp. e1003053
    • Menezes, L.F.1    Zhou, F.2    Patterson, A.D.3    Piontek, K.B.4    Krausz, K.W.5    Gonzalez, F.J.6    Germino, G.G.7
  • 27
    • 36249030528 scopus 로고    scopus 로고
    • Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice
    • Lantinga-van Leeuwen IS, Leonhard WN, van der Wal A, Breuning MH, de Heer E, Peters DJ: Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet 16: 3188-3196, 2007
    • (2007) Hum Mol Genet , vol.16 , pp. 3188-3196
    • Lantinga-van Leeuwen, I.S.1    Leonhard, W.N.2    Van Der Wal, A.3    Breuning, M.H.4    De Heer, E.5    Peters, D.J.6
  • 29
    • 44349116202 scopus 로고    scopus 로고
    • Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia
    • Patel V, Li L, Cobo-Stark P, Shao X, Somlo S, Lin F, Igarashi P: Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17: 1578-1590, 2008
    • (2008) Hum Mol Genet , vol.17 , pp. 1578-1590
    • Patel, V.1    Li, L.2    Cobo-Stark, P.3    Shao, X.4    Somlo, S.5    Lin, F.6    Igarashi, P.7
  • 30
    • 67649884993 scopus 로고    scopus 로고
    • Toxic tubular injury in kidneys fromPkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways
    • Happé H, LeonhardWN, van derWal A, van de Water B, Lantinga-van Leeuwen IS, Breuning MH, de Heer E, Peters DJ: Toxic tubular injury in kidneys fromPkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Hum Mol Genet 18: 2532-2542, 2009
    • (2009) Hum Mol Genet , vol.18 , pp. 2532-2542
    • Happé, H.1    Leonhard, W.N.2    Van Der Wal, A.3    Van De Water, B.4    Lantinga-van Leeuwen, I.S.5    Breuning, M.H.6    De Heer, E.7    Peters, D.J.8
  • 32
    • 0027221060 scopus 로고
    • Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease
    • Wilson PD, Du J, Norman JT: Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease. Eur J Cell Biol 61: 131-138, 1993
    • (1993) Eur J Cell Biol , vol.61 , pp. 131-138
    • Wilson, P.D.1    Du, J.2    Norman, J.T.3
  • 33
  • 35
    • 34248180073 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease
    • Rossetti S, Harris PC: Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease. J Am Soc Nephrol 18: 1374-1380, 2007
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1374-1380
    • Rossetti, S.1    Harris, P.C.2
  • 38
    • 84926662001 scopus 로고    scopus 로고
    • Clinical and genetic characterization of a founder PKHD1 mutation in Afrikaners with ARPKD
    • Lambie L, Amin R, Essop F, Krause A, Cnaan A, Guay-Woodford L: Clinical and genetic characterization of a founder PKHD1 mutation in Afrikaners with ARPKD. Pediatr Nephrol 30: 273-279, 2015
    • (2015) Pediatr Nephrol , vol.30 , pp. 273-279
    • Lambie, L.1    Amin, R.2    Essop, F.3    Krause, A.4    Cnaan, A.5    Guay-Woodford, L.6
  • 40
    • 84902188257 scopus 로고    scopus 로고
    • Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
    • Harris PC, Torres VE: Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease. JClin Invest 124: 2315-2324, 2014
    • (2014) JClin Invest , vol.124 , pp. 2315-2324
    • Harris, P.C.1    Torres, V.E.2
  • 41
    • 84891818486 scopus 로고    scopus 로고
    • Strategies targeting cAMP signaling in the treatment of polycystic kidney disease
    • Torres VE, Harris PC: Strategies targeting cAMP signaling in the treatment of polycystic kidney disease.JAmSocNephrol 25: 18-32, 2014
    • (2014) J Am SocNephrol , vol.25 , pp. 18-32
    • Torres, V.E.1    Harris, P.C.2
  • 44
    • 69249209682 scopus 로고    scopus 로고
    • Prevalence of renal cell carcinoma in patients with autosomal dominant polycystic kidney disease and chronic renal failure
    • Hajj P, Ferlicot S, Massoud W, Awad A, Hammoudi Y, Charpentier B, Durrbach A, Droupy S, Benot G: Prevalence of renal cell carcinoma in patients with autosomal dominant polycystic kidney disease and chronic renal failure. Urology 74: 631-634, 2009
    • (2009) Urology , vol.74 , pp. 631-634
    • Hajj, P.1    Ferlicot, S.2    Massoud, W.3    Awad, A.4    Hammoudi, Y.5    Charpentier, B.6    Durrbach, A.7    Droupy, S.8    Benot, G.9
  • 49
    • 4644367485 scopus 로고    scopus 로고
    • Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
    • Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP: Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J Biol Chem 279: 40419-40430, 2004
    • (2004) J Biol Chem , vol.279 , pp. 40419-40430
    • Yamaguchi, T.1    Wallace, D.P.2    Magenheimer, B.S.3    Hempson, S.J.4    Grantham, J.J.5    Calvet, J.P.6
  • 50
    • 84861592850 scopus 로고    scopus 로고
    • MYC suppresses cancer metastasis by direct transcriptional silencing of av and b3 integrin subunits
    • LiuH, Radisky DC, YangD, Xu R, Radisky ES, Bissell MJ, Bishop JM: MYC suppresses cancer metastasis by direct transcriptional silencing of av and b3 integrin subunits. Nat Cell Biol 14: 567-574, 2012
    • (2012) Nat Cell Biol , vol.14 , pp. 567-574
    • Liu, H.1    Radisky, D.C.2    Yang, D.3    Xu, R.4    Radisky, E.S.5    Bissell, M.J.6    Bishop, J.M.7
  • 52
    • 77249103612 scopus 로고    scopus 로고
    • Molecular advances in autosomal dominant polycystic kidney disease
    • Gallagher AR, Germino GG, Somlo S: Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis 17: 118-130, 2010
    • (2010) Adv Chronic Kidney Dis , vol.17 , pp. 118-130
    • Gallagher, A.R.1    Germino, G.G.2    Somlo, S.3
  • 54
    • 0037019017 scopus 로고    scopus 로고
    • Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpkmice with polycystic kidney disease
    • Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB: Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpkmice with polycystic kidney disease. Curr Biol 12: R378-R380, 2002
    • (2002) Curr Biol , vol.12 , pp. R378-R380
    • Pazour, G.J.1    San Agustin, J.T.2    Follit, J.A.3    Rosenbaum, J.L.4    Witman, G.B.5
  • 55
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • Yoder BK, Hou X, Guay-Woodford LM: The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia.JAmSocNephrol 13: 2508-2516, 2002
    • (2002) J Am SocNephrol , vol.13 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3
  • 56
    • 0037884961 scopus 로고    scopus 로고
    • Kidneyspecific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
    • Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein LS, Somlo S, Igarashi P: Kidneyspecific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A 100: 5286-5291, 2003
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5286-5291
    • Lin, F.1    Hiesberger, T.2    Cordes, K.3    Sinclair, A.M.4    Goldstein, L.S.5    Somlo, S.6    Igarashi, P.7
  • 58
    • 84883455352 scopus 로고    scopus 로고
    • Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease
    • Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S: Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet 45: 1004-1012, 2013
    • (2013) Nat Genet , vol.45 , pp. 1004-1012
    • Ma, M.1    Tian, X.2    Igarashi, P.3    Pazour, G.J.4    Somlo, S.5
  • 59
    • 67649844614 scopus 로고    scopus 로고
    • Polycystins and primary cilia: Primers for cell cycle progression
    • Zhou J: Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol 71: 83-113, 2009
    • (2009) Annu Rev Physiol , vol.71 , pp. 83-113
    • Zhou, J.1
  • 64
    • 34147215806 scopus 로고    scopus 로고
    • Fibrocystin/ polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia
    • Wang S, Zhang J,Nauli SM, Li X, Starremans PG, Luo Y, Roberts KA, Zhou J: Fibrocystin/ polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.Mol Cell Biol 27: 3241-3252, 2007
    • (2007) Mol Cell Biol , vol.27 , pp. 3241-3252
    • Wang, S.1    Zhang, J.2    Nauli, S.M.3    Li, X.4    Starremans, P.G.5    Luo, Y.6    Roberts, K.A.7    Zhou, J.8
  • 65
    • 40449121293 scopus 로고    scopus 로고
    • Nek8 regulates the expression and localization of polycystin-1 and polycystin-2
    • Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J: Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol 19: 469-476, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 469-476
    • Sohara, E.1    Luo, Y.2    Zhang, J.3    Manning, D.K.4    Beier, D.R.5    Zhou, J.6
  • 66
    • 84964315230 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein
    • Su X, Driscoll K, Yao G, Raed A, Wu M, Beales PL, Zhou J: Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum Mol Genet 23: 5441-5451, 2014
    • (2014) Hum Mol Genet , vol.23 , pp. 5441-5451
    • Su, X.1    Driscoll, K.2    Yao, G.3    Raed, A.4    Wu, M.5    Beales, P.L.6    Zhou, J.7
  • 67
    • 84898815152 scopus 로고    scopus 로고
    • Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex
    • Yao G, Su X, Nguyen V, Roberts K, Li X, Takakura A, Plomann M, Zhou J: Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. Hum Mol Genet 23: 2769-2779, 2014
    • (2014) Hum Mol Genet , vol.23 , pp. 2769-2779
    • Yao, G.1    Su, X.2    Nguyen, V.3    Roberts, K.4    Li, X.5    Takakura, A.6    Plomann, M.7    Zhou, J.8
  • 70
    • 40349087260 scopus 로고    scopus 로고
    • Cep164 is a mediator protein required for the maintenance of genomic stability through modulation ofMDC1, RPA, and CHK1
    • SivasubramaniamS, Sun X, Pan YR,Wang S, Lee EY: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation ofMDC1, RPA, and CHK1. Genes Dev 22: 587-600, 2008
    • (2008) Genes Dev , vol.22 , pp. 587-600
    • Sivasubramaniam, S.1    Sun, X.2    Pan, Y.R.3    Wang, S.4    Lee, E.Y.5
  • 74
    • 77954382620 scopus 로고    scopus 로고
    • Primary cilia disappear in rat podocytes during glomerular development
    • Ichimura K, Kurihara H, Sakai T: Primary cilia disappear in rat podocytes during glomerular development. Cell Tissue Res 341: 197-209, 2010
    • (2010) Cell Tissue Res , vol.341 , pp. 197-209
    • Ichimura, K.1    Kurihara, H.2    Sakai, T.3
  • 77
    • 84455169599 scopus 로고    scopus 로고
    • The podocyte cytoskeleton-key to a functioning glomerulus in health and disease
    • Welsh GI, Saleem MA: The podocyte cytoskeleton-key to a functioning glomerulus in health and disease. Nat Rev Nephrol 8: 14-21, 2012
    • (2012) Nat Rev Nephrol , vol.8 , pp. 14-21
    • Welsh, G.I.1    Saleem, M.A.2
  • 79
    • 84899750733 scopus 로고    scopus 로고
    • Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells
    • Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K: Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int 85: 1058-1067, 2014
    • (2014) Kidney Int , vol.85 , pp. 1058-1067
    • Buchholz, B.1    Faria, D.2    Schley, G.3    Schreiber, R.4    Eckardt, K.U.5    Kunzelmann, K.6
  • 80
    • 84906840833 scopus 로고    scopus 로고
    • An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2
    • Ravichandran K, Zafar I, He Z, Doctor RB, Moldovan R, Mullick AE, Edelstein CL: An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. Hum Mol Genet 23: 4919-4931, 2014
    • (2014) Hum Mol Genet , vol.23 , pp. 4919-4931
    • Ravichandran, K.1    Zafar, I.2    He, Z.3    Doctor, R.B.4    Moldovan, R.5    Mullick, A.E.6    Edelstein, C.L.7
  • 84
    • 84879637271 scopus 로고    scopus 로고
    • Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease
    • Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X: Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. JClin Invest 123: 3084-3098, 2013
    • (2013) JClin Invest , vol.123 , pp. 3084-3098
    • Zhou, X.1    Fan, L.X.2    Sweeney, W.E.3    Denu, J.M.4    Avner, E.D.5    Li, X.6
  • 87
    • 77954510897 scopus 로고    scopus 로고
    • Emerging evidence of a link between the polycystins and the mTOR pathways
    • Boletta A: Emerging evidence of a link between the polycystins and the mTOR pathways. Pathogenetics 2: 6, 2009
    • (2009) Pathogenetics , vol.2 , pp. 6
    • Boletta, A.1
  • 91
    • 77949528561 scopus 로고    scopus 로고
    • Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR
    • Dere R,Wilson PD, Sandford RN,Walker CL: Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. PLoS ONE 5: e9239, 2010
    • (2010) PLoS ONE , vol.5 , pp. e9239
    • Dere, R.1    Wilson, P.D.2    Sandford, R.N.3    Walker, C.L.4
  • 92
    • 65449176538 scopus 로고    scopus 로고
    • Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1
    • Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB,GerminoGG, Pandolfi PP, Boletta A: Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol 29: 2359-2371, 2009
    • (2009) Mol Cell Biol , vol.29 , pp. 2359-2371
    • Distefano, G.1    Boca, M.2    Rowe, I.3    Wodarczyk, C.4    Ma, L.5    Piontek, K.B.6    Germino, G.G.7    Pandolfi, P.P.8    Boletta, A.9
  • 93
    • 77957847881 scopus 로고    scopus 로고
    • Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
    • Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA: Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest 120: 3617-3628, 2010
    • (2010) J Clin Invest , vol.120 , pp. 3617-3628
    • Qin, S.1    Taglienti, M.2    Nauli, S.M.3    Contrino, L.4    Takakura, A.5    Zhou, J.6    Kreidberg, J.A.7
  • 94
    • 18744380752 scopus 로고    scopus 로고
    • Rapamycinmarkedly slows disease progression in a rat model of polycystic kidney disease
    • Tao Y, Kim J, Schrier RW, Edelstein CL: Rapamycinmarkedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol 16: 46-51, 2005
    • (2005) J Am Soc Nephrol , vol.16 , pp. 46-51
    • Tao, Y.1    Kim, J.2    Schrier, R.W.3    Edelstein, C.L.4
  • 95
    • 33644859253 scopus 로고    scopus 로고
    • Inhibition of mTOR with sirolimus slows disease progression in Han: SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)
    • Wahl PR, Serra AL, Le Hir M, Molle KD, Hall MN, Wüthrich RP: Inhibition of mTOR with sirolimus slows disease progression in Han: SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant 21: 598-604, 2006
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 598-604
    • Wahl, P.R.1    Serra, A.L.2    Le Hir, M.3    Molle, K.D.4    Hall, M.N.5    Wüthrich, R.P.6
  • 96
    • 77949887674 scopus 로고    scopus 로고
    • Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
    • Shillingford JM, Piontek KB, Germino GG, Weimbs T: Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J AmSocNephrol 21: 489-497, 2010
    • (2010) J AmSocNephrol , vol.21 , pp. 489-497
    • Shillingford, J.M.1    Piontek, K.B.2    Germino, G.G.3    Weimbs, T.4
  • 97
    • 77957595691 scopus 로고    scopus 로고
    • Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease
    • Zafar I, Ravichandran K, Belibi FA, Doctor RB, Edelstein CL: Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease. Kidney Int 78: 754-761, 2010
    • (2010) Kidney Int , vol.78 , pp. 754-761
    • Zafar, I.1    Ravichandran, K.2    Belibi, F.A.3    Doctor, R.B.4    Edelstein, C.L.5
  • 98
    • 84867010095 scopus 로고    scopus 로고
    • Folate-conjugated rapamycin slows progression of polycystic kidney disease
    • Shillingford JM, Leamon CP, Vlahov IR, Weimbs T: Folate-conjugated rapamycin slows progression of polycystic kidney disease. J Am Soc Nephrol 23: 1674-1681, 2012
    • (2012) J Am Soc Nephrol , vol.23 , pp. 1674-1681
    • Shillingford, J.M.1    Leamon, C.P.2    Vlahov, I.R.3    Weimbs, T.4
  • 99
    • 84868119743 scopus 로고    scopus 로고
    • Rapamycinmediated suppression of renal cyst expansion in del34 Pkd1-/-mutantmouse embryos: An investigation of the feasibility of renal cyst prevention in the foetus
    • Stayner C, Shields J, Slobbe L, Shillingford JM, Weimbs T, Eccles MR: Rapamycinmediated suppression of renal cyst expansion in del34 Pkd1-/-mutantmouse embryos: an investigation of the feasibility of renal cyst prevention in the foetus. Nephrology (Carlton) 17: 739-747, 2012
    • (2012) Nephrology (Carlton) , vol.17 , pp. 739-747
    • Stayner, C.1    Shields, J.2    Slobbe, L.3    Shillingford, J.M.4    Weimbs, T.5    Eccles, M.R.6
  • 101
    • 84870174500 scopus 로고    scopus 로고
    • Sirolimus produced S-shaped effect on adult polycystic kidneys after 2-year treatment
    • Soliman A, Zamil S, Lotfy A, Ismail E: Sirolimus produced S-shaped effect on adult polycystic kidneys after 2-year treatment. Transplant Proc 44: 2936-2939, 2012
    • (2012) Transplant Proc , vol.44 , pp. 2936-2939
    • Soliman, A.1    Zamil, S.2    Lotfy, A.3    Ismail, E.4
  • 102
    • 84874516609 scopus 로고    scopus 로고
    • MTOR inhibition in autosomal-dominant polycystic kidney disease (ADPKD): The question remains open
    • Jardine MJ, Liyanage T, Buxton E, Perkovic V: mTOR inhibition in autosomal-dominant polycystic kidney disease (ADPKD): the question remains open. Nephrol Dial Transplant 28: 242-244, 2013
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 242-244
    • Jardine, M.J.1    Liyanage, T.2    Buxton, E.3    Perkovic, V.4
  • 103
    • 84906966672 scopus 로고    scopus 로고
    • Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: An open-label randomized controlled pilot study
    • Braun WE, Schold JD, Stephany BR, Spirko RA, Herts BR: Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study. Clin J AmSoc Nephrol 9: 881-888, 2014
    • (2014) Clin J AmSoc Nephrol , vol.9 , pp. 881-888
    • Braun, W.E.1    Schold, J.D.2    Stephany, B.R.3    Spirko, R.A.4    Herts, B.R.5
  • 104
    • 0025380629 scopus 로고
    • Polycystic kidney disease: Neoplasia in disguise
    • Grantham JJ: Polycystic kidney disease: neoplasia in disguise. Am J Kidney Dis 15: 110-116, 1990
    • (1990) Am J Kidney Dis , vol.15 , pp. 110-116
    • Grantham, J.J.1
  • 105
    • 0023204539 scopus 로고
    • Cyst formation and growth in autosomal dominant polycystic kidney disease
    • Grantham JJ, Geiser JL, Evan AP: Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney Int 31: 1145-1152, 1987
    • (1987) Kidney Int , vol.31 , pp. 1145-1152
    • Grantham, J.J.1    Geiser, J.L.2    Evan, A.P.3
  • 106
    • 84860420284 scopus 로고    scopus 로고
    • Why kidneys fail in autosomal dominant polycystic kidney disease
    • Grantham JJ, Mulamalla S, Swenson-Fields KI: Why kidneys fail in autosomal dominant polycystic kidney disease. Nat Rev Nephrol 7: 556-566, 2011
    • (2011) Nat Rev Nephrol , vol.7 , pp. 556-566
    • Grantham, J.J.1    Mulamalla, S.2    Swenson-Fields, K.I.3
  • 107
    • 39049085896 scopus 로고    scopus 로고
    • Generation and evolution of atubular glomeruli in the progression of renal disorders
    • Chevalier RL, Forbes MS: Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 19: 197-206, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 197-206
    • Chevalier, R.L.1    Forbes, M.S.2
  • 108
    • 79960047826 scopus 로고    scopus 로고
    • Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: A new look at an old model
    • Forbes MS, Thornhill BA, Chevalier RL: Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model. Am J Physiol Renal Physiol 301: F110-F117, 2011
    • (2011) Am J Physiol Renal Physiol , vol.301 , pp. F110-F117
    • Forbes, M.S.1    Thornhill, B.A.2    Chevalier, R.L.3
  • 109
    • 84903192830 scopus 로고    scopus 로고
    • Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease
    • Galarreta CI, Grantham JJ, Forbes MS, Maser RL, Wallace DP, Chevalier RL: Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease. Am J Pathol 184: 1957-1966, 2014
    • (2014) Am J Pathol , vol.184 , pp. 1957-1966
    • Galarreta, C.I.1    Grantham, J.J.2    Forbes, M.S.3    Maser, R.L.4    Wallace, D.P.5    Chevalier, R.L.6
  • 111
    • 38149005366 scopus 로고    scopus 로고
    • Vasopressin directly regulates cyst growth in polycystic kidney disease
    • WangX,WuY,Ward CJ,Harris PC, TorresVE: Vasopressin directly regulates cyst growth in polycystic kidney disease. J AmSoc Nephrol 19: 102-108, 2008
    • (2008) J AmSoc Nephrol , vol.19 , pp. 102-108
    • Wang, X.1    Wu, Y.2    Ward, C.J.3    Harris, P.C.4    Torres, V.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.