메뉴 건너뛰기




Volumn 114, Issue 3, 2015, Pages 498-518

Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD

Author keywords

Antiplatelet agents; Atherosclerosis; Cytokines; Inflammation; Platelet physiology

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ATOPAXAR; C REACTIVE PROTEIN; CANGRELOR; CELL ADHESION MOLECULE; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; CLOPIDOGREL; CYCLOOXYGENASE 1; CYCLOPHILLIN A; INTEGRIN; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; RANTES; THROMBOCYTE FACTOR 4; TICAGRELOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VORAPAXAR; ANTIINFLAMMATORY AGENT; AUTACOID;

EID: 84940641465     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-11-0947     Document Type: Article
Times cited : (63)

References (192)
  • 1
    • 5444230139 scopus 로고    scopus 로고
    • Platelets: Signaling cells in the immune continuum
    • Weyrich AS, Zimmerman GA. Platelets: signaling cells in the immune continuum. Trends Immunol 2004; 25: 489–495.
    • (2004) Trends Immunol , vol.25 , pp. 489-495
    • Weyrich, A.S.1    Zimmerman, G.A.2
  • 2
    • 2342641311 scopus 로고    scopus 로고
    • The evolving role of platelets in inflammation
    • Weyrich AS, et al. The evolving role of platelets in inflammation. J Thromb Haemost 2003; 1: 1897–1905.
    • (2003) J Thromb Haemost , vol.1 , pp. 1897-1905
    • Weyrich, A.S.1
  • 3
    • 33745962709 scopus 로고    scopus 로고
    • Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype
    • de Boer HC, et al. Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype. Arterioscl Thromb Vasc Biol 2006; 26: 1653–1659.
    • (2006) Arterioscl Thromb Vasc Biol , vol.26 , pp. 1653-1659
    • De Boer, H.C.1
  • 4
    • 1142273373 scopus 로고    scopus 로고
    • Role of platelets in coronary thrombosis and reperfusion of ischaemic myocardium
    • Gawaz M. Role of platelets in coronary thrombosis and reperfusion of ischaemic myocardium. Cardiovasc Res 2004; 61: 498–511.
    • (2004) Cardiovasc Res , vol.61 , pp. 498-511
    • Gawaz, M.1
  • 5
    • 0033990516 scopus 로고    scopus 로고
    • Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis
    • Gawaz M, et al. Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis. Atherosclerosis 2000; 148: 75–85.
    • (2000) Atherosclerosis , vol.148 , pp. 75-85
    • Gawaz, M.1
  • 6
    • 0022272798 scopus 로고
    • Platelets, macrophages, endothelium, and growth factors. Their effects upon cells and their possible roles in atherogenesis
    • Ross R, et al. Platelets, macrophages, endothelium, and growth factors. Their effects upon cells and their possible roles in atherogenesis. Ann NY Acad Sci 1985; 454: 254–260.
    • (1985) Ann NY Acad Sci , vol.454 , pp. 254-260
    • Ross, R.1
  • 7
    • 0025939394 scopus 로고
    • Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production
    • Hawrylowicz CM, et al. Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 1991; 174: 785–790.
    • (1991) J Exp Med , vol.174 , pp. 785-790
    • Hawrylowicz, C.M.1
  • 8
    • 16444364523 scopus 로고    scopus 로고
    • Platelets and chemokines in atherosclerosis: Partners in crime
    • Weber C. Platelets and chemokines in atherosclerosis: partners in crime. Circ Res 2005; 96: 612–616.
    • (2005) Circ Res , vol.96 , pp. 612-616
    • Weber, C.1
  • 9
    • 0035799376 scopus 로고    scopus 로고
    • RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium
    • von Hundelshausen P, et al. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 2001; 103: 1772–1777.
    • (2001) Circulation , vol.103 , pp. 1772-1777
    • Von Hundelshausen, P.1
  • 10
    • 0037126048 scopus 로고    scopus 로고
    • Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    • Schober A, et al. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation 2002; 106: 1523–1529.
    • (2002) Circulation , vol.106 , pp. 1523-1529
    • Schober, A.1
  • 11
    • 0034651633 scopus 로고    scopus 로고
    • The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages
    • Scheuerer B, et al. The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 2000; 95: 1158–1166.
    • (2000) Blood , vol.95 , pp. 1158-1166
    • Scheuerer, B.1
  • 12
    • 0037093278 scopus 로고    scopus 로고
    • Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface
    • Sachais BS, et al. Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. Blood 2002; 99: 3613–3622.
    • (2002) Blood , vol.99 , pp. 3613-3622
    • Sachais, B.S.1
  • 13
    • 0347043610 scopus 로고    scopus 로고
    • Platelet factor 4 localization in carotid atherosclerotic plaques: Correlation with clinical parameters
    • Pitsilos S, et al. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thromb Haemost 2003; 906: 1112–1120.
    • (2003) Thromb Haemost , vol.906 , pp. 1112-1120
    • Pitsilos, S.1
  • 14
    • 0037458650 scopus 로고    scopus 로고
    • Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells
    • Nassar T, et al. Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells. J Biol Chem 2003; 278: 6187–6193.
    • (2003) J Biol Chem , vol.278 , pp. 6187-6193
    • Nassar, T.1
  • 15
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn V, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591–594.
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1
  • 16
    • 31044436262 scopus 로고    scopus 로고
    • Platelets in inflammation and atherogenesis
    • Gawaz M, et al. Platelets in inflammation and atherogenesis. J Clin Invest 2005; 115: 3378–3384.
    • (2005) J Clin Invest , vol.115 , pp. 3378-3384
    • Gawaz, M.1
  • 17
    • 0032744218 scopus 로고    scopus 로고
    • Differential regulation of platelet aggregation by matrix metalloproteinases-9 and –2
    • Fernandez-Patron C, et al. Differential regulation of platelet aggregation by matrix metalloproteinases-9 and –2. Thromb Haemost 1999; 82: 1730–1735.
    • (1999) Thromb Haemost , vol.82 , pp. 1730-1735
    • Fernandez-Patron, C.1
  • 18
    • 0037109144 scopus 로고    scopus 로고
    • Engagement of glycoprotein IIb/IIIa (Alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells
    • May AE, et al. Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation 2002; 106: 2111–2117.
    • (2002) Circulation , vol.106 , pp. 2111-2117
    • May, A.E.1
  • 19
    • 0037418164 scopus 로고    scopus 로고
    • Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation
    • Nannizzi-Alaimo L, et al. Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation. Circulation 2003; 107: 1123–1128.
    • (2003) Circulation , vol.107 , pp. 1123-1128
    • Nannizzi-Alaimo, L.1
  • 20
    • 0036136424 scopus 로고    scopus 로고
    • Leukocyte adhesion deficiency syndromes: Adhesion and tethering defects involving beta 2 integrins and selectin ligands
    • Bunting M, et al. Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr Opin Hematol 2002; 9: 30–35.
    • (2002) Curr Opin Hematol , vol.9 , pp. 30-35
    • Bunting, M.1
  • 21
    • 34248196591 scopus 로고    scopus 로고
    • Immune regulation by microvascular endothelial cells: Directing innate and adaptive immunity, coagulation, and inflammation
    • Danese S, et al. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 2007; 178: 6017–6022.
    • (2007) J Immunol , vol.178 , pp. 6017-6022
    • Danese, S.1
  • 22
    • 34748914299 scopus 로고    scopus 로고
    • Evolving functions of endothelial cells in inflammation
    • Pober JS, Sessa WC. Evolving functions of endothelial cells in inflammation. Nature Rev Immunol 2007; 7: 803–815.
    • (2007) Nature Rev Immunol , vol.7 , pp. 803-815
    • Pober, J.S.1    Sessa, W.C.2
  • 23
    • 79953826916 scopus 로고    scopus 로고
    • Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli
    • Chatterjee M, et al. Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood 2011; 117: 3907–3911.
    • (2011) Blood , vol.117 , pp. 3907-3911
    • Chatterjee, M.1
  • 24
    • 38049113170 scopus 로고    scopus 로고
    • Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    • Stellos K, et al. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation 2008; 117: 206–215.
    • (2008) Circulation , vol.117 , pp. 206-215
    • Stellos, K.1
  • 25
    • 33646680285 scopus 로고    scopus 로고
    • Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo
    • Massberg S, et al. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med 2006; 203: 1221–1233.
    • (2006) J Exp Med , vol.203 , pp. 1221-1233
    • Massberg, S.1
  • 26
    • 77951562613 scopus 로고    scopus 로고
    • Platelet aggregates-induced human CD34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro
    • Stellos K, et al. Platelet aggregates-induced human CD34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro. Semin Thromb Hemost 2010; 36: 139–145.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 139-145
    • Stellos, K.1
  • 27
    • 47249149222 scopus 로고    scopus 로고
    • CXCR7, CXCR4 and CXCL12: An eccentric trio?
    • Thelen M, Thelen S. CXCR7, CXCR4 and CXCL12: an eccentric trio? J Neuroimmunol 2008; 198: 9–13.
    • (2008) J Neuroimmunol , vol.198 , pp. 9-13
    • Thelen, M.1    Thelen, S.2
  • 28
    • 78651328424 scopus 로고    scopus 로고
    • PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)
    • Kraemer BF, et al. PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1). J Mol Med 2010; 88: 1277–1288.
    • (2010) J Mol Med , vol.88 , pp. 1277-1288
    • Kraemer, B.F.1
  • 29
    • 80051531008 scopus 로고    scopus 로고
    • High shear flow induces migration of adherent human platelets
    • Kraemer BF, et al. High shear flow induces migration of adherent human platelets. Platelets 2011; 22: 415–421.
    • (2011) Platelets , vol.22 , pp. 415-421
    • Kraemer, B.F.1
  • 30
    • 84894254008 scopus 로고    scopus 로고
    • Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery
    • Rath D, et al. Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery. Eur Heart J 2014; 35: 386–394.
    • (2014) Eur Heart J , vol.35 , pp. 386-394
    • Rath, D.1
  • 31
    • 84903740197 scopus 로고    scopus 로고
    • SDF-1alpha induces differential trafficking of CXCR4-CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival
    • Chatterjee M, et al. SDF-1alpha induces differential trafficking of CXCR4-CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival. FASEB J 2014; 28: 2864–2878.
    • (2014) FASEB J , vol.28 , pp. 2864-2878
    • Chatterjee, M.1
  • 32
    • 84920195692 scopus 로고    scopus 로고
    • Macrophage Migration Inhibitory Factor Limits Activation- Induced Apoptosis of Platelets via CXCR7-Dependent Akt Signaling
    • Chatterjee M, et al. Macrophage Migration Inhibitory Factor Limits Activation- Induced Apoptosis of Platelets via CXCR7-Dependent Akt Signaling. Circ Res 2014; 115: 939–949.
    • (2014) Circ Res , vol.115 , pp. 939-949
    • Chatterjee, M.1
  • 33
    • 41149093871 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor in cardiovascular disease
    • Zernecke A, et al. Macrophage migration inhibitory factor in cardiovascular disease. Circulation 2008; 117: 1594–1602.
    • (2008) Circulation , vol.117 , pp. 1594-1602
    • Zernecke, A.1
  • 34
    • 84886997623 scopus 로고    scopus 로고
    • Platelets are a previously unrecognised source of MIF
    • Strussmann T, et al. Platelets are a previously unrecognised source of MIF. Thromb Haemost 2013; 110: 1004–1013.
    • (2013) Thromb Haemost , vol.110 , pp. 1004-1013
    • Strussmann, T.1
  • 35
    • 84872754527 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response
    • Muller II, et al. Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response. PloS one 2012; 7: e38376.
    • (2012) Plos One , vol.7
    • Muller, I.I.1
  • 36
    • 84896935584 scopus 로고    scopus 로고
    • Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases
    • Seizer P, et al. Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases. Cardiovasc Res 2014; 102: 17–23.
    • (2014) Cardiovasc Res , vol.102 , pp. 17-23
    • Seizer, P.1
  • 37
    • 84899755570 scopus 로고    scopus 로고
    • Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling
    • Wang L, et al. Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling. Thromb Haemost 2014; 111: 873–882.
    • (2014) Thromb Haemost , vol.111 , pp. 873-882
    • Wang, L.1
  • 38
    • 84865199630 scopus 로고    scopus 로고
    • Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation
    • Elvers M, et al. Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation. Blood 2012; 120: 1317–1326.
    • (2012) Blood , vol.120 , pp. 1317-1326
    • Elvers, M.1
  • 39
    • 12144291702 scopus 로고    scopus 로고
    • Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions
    • Coppinger JA, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 2004; 103: 2096–2104.
    • (2004) Blood , vol.103 , pp. 2096-2104
    • Coppinger, J.A.1
  • 40
    • 68049112204 scopus 로고    scopus 로고
    • Dissociation of pentameric to monomeric C-reactive protein on activated platelets localises inflammation to atherosclerotic plaques
    • Eisenhardt SU, et al. Dissociation of pentameric to monomeric C-reactive protein on activated platelets localises inflammation to atherosclerotic plaques. Circ Res 2009; 105: 128–137.
    • (2009) Circ Res , vol.105 , pp. 128-137
    • Eisenhardt, S.U.1
  • 41
    • 17144369225 scopus 로고    scopus 로고
    • Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: Potential for paracrine/ autocrine effects
    • Venugopal SK, et al. Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: potential for paracrine/ autocrine effects. Am J Pathol 2005; 166: 1265–1271.
    • (2005) Am J Pathol , vol.166 , pp. 1265-1271
    • Venugopal, S.K.1
  • 42
    • 33646041638 scopus 로고    scopus 로고
    • C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients
    • Tsimikas S, et al. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 2006; 47 (8 Suppl): C19–31.
    • (2006) J am Coll Cardiol , vol.47
    • Tsimikas, S.1
  • 43
    • 0032923669 scopus 로고    scopus 로고
    • C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992
    • Koenig W, et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999; 99: 237–242.
    • (1999) Circulation , vol.99 , pp. 237-242
    • Koenig, W.1
  • 44
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker PM, et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342: 836–843.
    • (2000) N Engl J Med , vol.342 , pp. 836-843
    • Ridker, P.M.1
  • 45
    • 0037469179 scopus 로고    scopus 로고
    • Coming of age of C-reactive protein: Using inflammation markers in cardiology
    • Yeh ET, Willerson JT. Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation 2003; 107: 370–371.
    • (2003) Circulation , vol.107 , pp. 370-371
    • Yeh, E.T.1    Willerson, J.T.2
  • 46
    • 3042677716 scopus 로고    scopus 로고
    • C-reactive protein: Risk marker or mediator in atherothrombosis?
    • Jialal I, et al. C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension 2004; 44: 6–11.
    • (2004) Hypertension , vol.44 , pp. 6-11
    • Jialal, I.1
  • 47
    • 0042744797 scopus 로고    scopus 로고
    • C-reactive protein: A critical update
    • Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003; 111: 1805–1812.
    • (2003) J Clin Invest , vol.111 , pp. 1805-1812
    • Pepys, M.B.1    Hirschfield, G.M.2
  • 48
    • 33748417874 scopus 로고    scopus 로고
    • CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions
    • Devaraj S, et al. CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions. Am J Physiol Heart Circ Physiol 2006; 291: H1170–1176.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Devaraj, S.1
  • 49
    • 22044446512 scopus 로고    scopus 로고
    • Local release of C-reactive protein from vulnerable plaque or coronary arterial wall injured by stenting
    • Inoue T, et al. Local release of C-reactive protein from vulnerable plaque or coronary arterial wall injured by stenting. J Am Coll Cardiol 2005; 46: 239–245.
    • (2005) J am Coll Cardiol , vol.46 , pp. 239-245
    • Inoue, T.1
  • 50
    • 32544448716 scopus 로고    scopus 로고
    • Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction
    • Meuwissen M, et al. Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction. J Clin Pathol 2006; 59: 196–201.
    • (2006) J Clin Pathol , vol.59 , pp. 196-201
    • Meuwissen, M.1
  • 51
    • 0035099170 scopus 로고    scopus 로고
    • Generation of C-reactive protein and complement components in atherosclerotic plaques
    • Yasojima K, et al. Generation of C-reactive protein and complement components in atherosclerotic plaques. AmJ Pathol 2001; 158: 1039–1051.
    • (2001) Amj Pathol , vol.158 , pp. 1039-1051
    • Yasojima, K.1
  • 52
    • 33846001313 scopus 로고    scopus 로고
    • Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: MCRP(m)
    • Ji SR, et al. Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m). FASEB J 2007; 21: 284–294.
    • (2007) FASEB J , vol.21 , pp. 284-294
    • Ji, S.R.1
  • 53
    • 2142751587 scopus 로고    scopus 로고
    • Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells
    • Khreiss T, et al. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 2004; 109: 2016–2022.
    • (2004) Circulation , vol.109 , pp. 2016-2022
    • Khreiss, T.1
  • 54
    • 77958466789 scopus 로고    scopus 로고
    • Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease
    • Muller K, et al. Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease. Atherosclerosis 2010; 213: 256–262.
    • (2010) Atherosclerosis , vol.213 , pp. 256-262
    • Muller, K.1
  • 55
    • 33644775853 scopus 로고    scopus 로고
    • Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease
    • Angiolillo DJ, et al. Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease. Diabetes 2006; 55: 780–784.
    • (2006) Diabetes , vol.55 , pp. 780-784
    • Angiolillo, D.J.1
  • 56
    • 26244441368 scopus 로고    scopus 로고
    • Loss of pentameric symmetry in C-reactive protein induces interleukin- 8 secretion through peroxynitrite signaling in human neutrophils
    • Khreiss T, et al. Loss of pentameric symmetry in C-reactive protein induces interleukin- 8 secretion through peroxynitrite signaling in human neutrophils. Circ Res 2005; 97: 690–697.
    • (2005) Circ Res , vol.97 , pp. 690-697
    • Khreiss, T.1
  • 57
    • 0035500615 scopus 로고    scopus 로고
    • Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil-endothelial cell adhesion
    • Zouki C, et al. Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil-endothelial cell adhesion. J Immunol 2001; 167: 5355–5361.
    • (2001) J Immunol , vol.167 , pp. 5355-5361
    • Zouki, C.1
  • 58
    • 33750201265 scopus 로고    scopus 로고
    • C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production
    • Singh U, et al. C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production. Arterioscl Thromb Vasc Biol 2006; 26: 2469–2475.
    • (2006) Arterioscl Thromb Vasc Biol , vol.26 , pp. 2469-2475
    • Singh, U.1
  • 59
    • 7544244583 scopus 로고    scopus 로고
    • Opposing effects of C-reactive protein isoforms on shear-induced neutrophil-platelet adhesion and neutrophil aggregation in whole blood
    • Khreiss T, et al. Opposing effects of C-reactive protein isoforms on shear-induced neutrophil-platelet adhesion and neutrophil aggregation in whole blood. Circulation 2004; 110: 2713–2720.
    • (2004) Circulation , vol.110 , pp. 2713-2720
    • Khreiss, T.1
  • 60
    • 79953190431 scopus 로고    scopus 로고
    • No reduction of atherosclerosis in C-reactive protein (CRP)- deficient mice
    • Teupser D, et al. No reduction of atherosclerosis in C-reactive protein (CRP)- deficient mice. J Biol Chem 2011; 286: 6272–6279.
    • (2011) J Biol Chem , vol.286 , pp. 6272-6279
    • Teupser, D.1
  • 61
    • 84899085982 scopus 로고    scopus 로고
    • Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
    • Simon LM, et al. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood 2014; 123: e37–45.
    • (2014) Blood , vol.123
    • Simon, L.M.1
  • 62
    • 84867264069 scopus 로고    scopus 로고
    • MicroRNAs in platelet biogenesis and function
    • Dangwal S, Thum T. MicroRNAs in platelet biogenesis and function. Thromb Haemost 2012; 108: 599–604.
    • (2012) Thromb Haemost , vol.108 , pp. 599-604
    • Dangwal, S.1    Thum, T.2
  • 63
    • 84884490899 scopus 로고    scopus 로고
    • Activated platelets can deliver mRNA regulatory Ago2*microRNA complexes to endothelial cells via microparticles
    • Laffont B, et al. Activated platelets can deliver mRNA regulatory Ago2*microRNA complexes to endothelial cells via microparticles. Blood 2013; 122: 253–261.
    • (2013) Blood , vol.122 , pp. 253-261
    • Laffont, B.1
  • 64
    • 84864562476 scopus 로고    scopus 로고
    • MicroRNAs in platelet biogenesis and function: Implications in vascular homeostasis and inflammation
    • Gatsiou A, et al. MicroRNAs in platelet biogenesis and function: implications in vascular homeostasis and inflammation. Curr Vasc Pharmacol 2012; 10: 524–531.
    • (2012) Curr Vasc Pharmacol , vol.10 , pp. 524-531
    • Gatsiou, A.1
  • 65
    • 84885946027 scopus 로고    scopus 로고
    • Platelet microRNAs: From platelet biology to possible disease biomarkers and therapeutic targets
    • Stakos DA, et al. Platelet microRNAs: From platelet biology to possible disease biomarkers and therapeutic targets. Platelets 2013; 24: 579–589.
    • (2013) Platelets , vol.24 , pp. 579-589
    • Stakos, D.A.1
  • 66
    • 74749096058 scopus 로고    scopus 로고
    • VAMP8/endobrevin is overexpressed in hyperreactive human platelets: Suggested role for platelet microRNA
    • Kondkar AA, et al. VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA. J Thromb Haemost 2010; 8: 369–378.
    • (2010) J Thromb Haemost , vol.8 , pp. 369-378
    • Kondkar, A.A.1
  • 67
    • 80051523967 scopus 로고    scopus 로고
    • Characterization of human platelet microRNA by quantitative PCR coupled with an annotation network for predicted target genes
    • Osman A, Falker K. Characterization of human platelet microRNA by quantitative PCR coupled with an annotation network for predicted target genes. Platelets 2011; 22: 433–441.
    • (2011) Platelets , vol.22 , pp. 433-441
    • Osman, A.1    Falker, K.2
  • 68
    • 80054085814 scopus 로고    scopus 로고
    • Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*
    • Sondermeijer BM, et al. Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*. PloS one 2011; 6: e25946.
    • (2011) Plos One , vol.6
    • Sondermeijer, B.M.1
  • 69
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482–2494.
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 70
    • 33744999455 scopus 로고    scopus 로고
    • Biology and pharmacology of the platelet P2Y12 receptor
    • Storey RF. Biology and pharmacology of the platelet P2Y12 receptor. Curr- Pharm Design 2006; 12: 1255–1259.
    • (2006) Curr- Pharm Design , vol.12 , pp. 1255-1259
    • Storey, R.F.1
  • 71
    • 82955187885 scopus 로고    scopus 로고
    • Antiplatelet agents for the treatment and prevention of atherothrombosis
    • Patrono C, Andreotti F, Arnesen H, et al. Antiplatelet agents for the treatment and prevention of atherothrombosis. Eur Heart J 2011; 32: 2922–2932.
    • (2011) Eur Heart J , vol.32 , pp. 2922-2932
    • Patrono, C.1    Reotti, F.2    Arnesen, H.3
  • 72
    • 34249991214 scopus 로고    scopus 로고
    • Human platelets synthesize and express functional tissue factor
    • Panes O, et al. Human platelets synthesize and express functional tissue factor. Blood 2007; 109: 5242–5250.
    • (2007) Blood , vol.109 , pp. 5242-5250
    • Panes, O.1
  • 73
    • 10244249152 scopus 로고    scopus 로고
    • Platelets synthesize large amounts of active plasminogen activator inhibitor 1
    • Brogren H, et al. Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood 2004; 104: 3943–3948.
    • (2004) Blood , vol.104 , pp. 3943-3948
    • Brogren, H.1
  • 74
    • 0026068368 scopus 로고
    • Dynamics of leukocyte-platelet adhesion in whole blood
    • Rinder HM, et al. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991; 78: 1730–1737.
    • (1991) Blood , vol.78 , pp. 1730-1737
    • Rinder, H.M.1
  • 75
    • 43749116203 scopus 로고    scopus 로고
    • Tissue factor and IL8 production by P-selectin-dependent platelet-monocyte aggregates in whole blood involves phosphorylation of Lyn and is inhibited by IL10
    • Christersson C, et al. Tissue factor and IL8 production by P-selectin-dependent platelet-monocyte aggregates in whole blood involves phosphorylation of Lyn and is inhibited by IL10. J Thromb Haemost 2008; 6: 986–994.
    • (2008) J Thromb Haemost , vol.6 , pp. 986-994
    • Christersson, C.1
  • 76
    • 0029093883 scopus 로고
    • P-selectin regulates platelet-activating factor synthesis and phagocytosis by monocytes
    • Elstad MR, et al. P-selectin regulates platelet-activating factor synthesis and phagocytosis by monocytes. J Immunol 1995; 155: 2109–2122.
    • (1995) J Immunol , vol.155 , pp. 2109-2122
    • Elstad, M.R.1
  • 77
    • 59049104632 scopus 로고    scopus 로고
    • Protein synthesis by platelets: Historical and new perspectives
    • Weyrich AS, et al. Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost 2009; 7: 241–246.
    • (2009) J Thromb Haemost , vol.7 , pp. 241-246
    • Weyrich, A.S.1
  • 78
    • 75749139265 scopus 로고    scopus 로고
    • Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    • Boilard E, et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 2010; 327: 580–583.
    • (2010) Science , vol.327 , pp. 580-583
    • Boilard, E.1
  • 79
    • 84893915758 scopus 로고    scopus 로고
    • Effect of platelet reactivity, endothelial function, and inflammatory status on outcomes in patients with stable angina pectoris on clopidogrel therapy
    • Woo JS, et al. Effect of platelet reactivity, endothelial function, and inflammatory status on outcomes in patients with stable angina pectoris on clopidogrel therapy. Am J Cardiol 2014; 113: 786–792.
    • (2014) Am J Cardiol , vol.113 , pp. 786-792
    • Woo, J.S.1
  • 80
    • 65649099288 scopus 로고    scopus 로고
    • Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting
    • Antonino MJ, et al. Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting. Am J Cardiol 2009; 103: 1546–1550.
    • (2009) Am J Cardiol , vol.103 , pp. 1546-1550
    • Antonino, M.J.1
  • 81
    • 0028951498 scopus 로고
    • Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells
    • Weber C, et al. Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 1995; 91: 1914–1917.
    • (1995) Circulation , vol.91 , pp. 1914-1917
    • Weber, C.1
  • 82
    • 84896738120 scopus 로고    scopus 로고
    • Antiplatelet therapy: Targeting the TxA2 pathway
    • Fontana P, et al. Antiplatelet therapy: targeting the TxA2 pathway. J Cardiovasc Transl Res 2014; 7: 29–38.
    • (2014) J Cardiovasc Transl Res , vol.7 , pp. 29-38
    • Fontana, P.1
  • 83
    • 84880852776 scopus 로고    scopus 로고
    • Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock
    • Otto GP, et al. Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock. Platelets 2013; 24: 480–485.
    • (2013) Platelets , vol.24 , pp. 480-485
    • Otto, G.P.1
  • 84
    • 33846528967 scopus 로고    scopus 로고
    • Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart
    • Birnbaum Y, et al. Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart. Prostagland Other Lipid Med 2007; 83: 89–98.
    • (2007) Prostagland Other Lipid Med , vol.83 , pp. 89-98
    • Birnbaum, Y.1
  • 85
    • 33748363508 scopus 로고    scopus 로고
    • Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat
    • Birnbaum Y, et al. Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat. Circulation 2006; 114: 929–935.
    • (2006) Circulation , vol.114 , pp. 929-935
    • Birnbaum, Y.1
  • 86
    • 80053989952 scopus 로고    scopus 로고
    • Monocyte-platelet interaction induces a pro-inflammatory phenotype in circulating monocytes
    • Passacquale G, et al. Monocyte-platelet interaction induces a pro-inflammatory phenotype in circulating monocytes. PloS one 2011; 6: e25595.
    • (2011) Plos One , vol.6
    • Passacquale, G.1
  • 87
    • 43549114554 scopus 로고    scopus 로고
    • Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6
    • Machado FS, et al. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med 2008; 205: 1077–1086.
    • (2008) J Exp Med , vol.205 , pp. 1077-1086
    • Machado, F.S.1
  • 88
    • 79955941385 scopus 로고    scopus 로고
    • Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice
    • Javeed A, et al. Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice. Inflam Res 2011; 60: 389–398.
    • (2011) Inflam Res , vol.60 , pp. 389-398
    • Javeed, A.1
  • 89
    • 0030956673 scopus 로고    scopus 로고
    • Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
    • Ridker PM, et al. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973–979.
    • (1997) N Engl J Med , vol.336 , pp. 973-979
    • Ridker, P.M.1
  • 90
    • 0024406369 scopus 로고
    • Steering Committee of the Physicians’ Health Study Research Group
    • Final report on the aspirin component of the ongoing Physicians’ Health Study
    • Final report on the aspirin component of the ongoing Physicians’ Health Study. Steering Committee of the Physicians’ Health Study Research Group. N Engl J Med 1989; 321: 129–135.
    • (1989) N Engl J Med , vol.321 , pp. 129-135
  • 91
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
    • Antithrombotic Trialists C, Baigent C, Blackwell L, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009; 373: 1849–1860.
    • (2009) Lancet , vol.373 , pp. 1849-1860
    • Antithrombotic Trialists, C.1    Baigent, C.2    Blackwell, L.3
  • 92
    • 79957954493 scopus 로고    scopus 로고
    • Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin
    • Bartolucci AA, et al. Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin. Am J Cardiol 2011; 107: 1796–1801.
    • (2011) Am J Cardiol , vol.107 , pp. 1796-1801
    • Bartolucci, A.A.1
  • 93
    • 84867179822 scopus 로고    scopus 로고
    • Primary prevention of ischaemic cardiovascular disorders with antiplatelet agents
    • Meade T. Primary prevention of ischaemic cardiovascular disorders with antiplatelet agents. Handb Exp Pharmacol 2012; 210: 565–605.
    • (2012) Handb Exp Pharmacol , vol.210 , pp. 565-605
    • Meade, T.1
  • 94
    • 84922599826 scopus 로고    scopus 로고
    • The role of the cardiologist in the primary prevention of cardiovascular disease with aspirin
    • Verheugt FW. The role of the cardiologist in the primary prevention of cardiovascular disease with aspirin. J Am Coll Cardiol 2015; 65: 122–124.
    • (2015) J am Coll Cardiol , vol.65 , pp. 122-124
    • Verheugt, F.W.1
  • 95
    • 84940686022 scopus 로고    scopus 로고
    • A Systematic Review of Aspirin in Primary Prevention: Is It Time for a New Approach?
    • Epub ahead of print
    • Brotons C, et al. A Systematic Review of Aspirin in Primary Prevention: Is It Time for a New Approach? Am J Cardiovasc Drugs 2014; Epub ahead of print.
    • (2014) Am J Cardiovasc Drugs
    • Brotons, C.1
  • 96
    • 84904193620 scopus 로고    scopus 로고
    • Prevention and treatment of cancer with aspirin: Where do we stand?
    • Pasche B, et al. Prevention and treatment of cancer with aspirin: where do we stand? Semin Oncol 2014; 41: 397–401.
    • (2014) Semin Oncol , vol.41 , pp. 397-401
    • Pasche, B.1
  • 97
    • 0033600543 scopus 로고    scopus 로고
    • Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin
    • Ikonomidis I, et al. Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation 1999; 100: 793–798.
    • (1999) Circulation , vol.100 , pp. 793-798
    • Ikonomidis, I.1
  • 98
    • 33644983315 scopus 로고    scopus 로고
    • Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome
    • Chen YG, et al. Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome. Chin Med J 2006; 119: 32–36.
    • (2006) Chin Med J , vol.119 , pp. 32-36
    • Chen, Y.G.1
  • 99
    • 0141682387 scopus 로고    scopus 로고
    • Influence of aspirin on inflammatory markers in patients after acute myocardial infarction
    • Solheim S, et al. Influence of aspirin on inflammatory markers in patients after acute myocardial infarction. Am J Cardiol 2003; 92: 843–845.
    • (2003) Am J Cardiol , vol.92 , pp. 843-845
    • Solheim, S.1
  • 100
    • 33751224446 scopus 로고    scopus 로고
    • No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease
    • Solheim S, et al. No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease. Thromb Haemost 2006; 96: 660–664.
    • (2006) Thromb Haemost , vol.96 , pp. 660-664
    • Solheim, S.1
  • 101
    • 0348110562 scopus 로고    scopus 로고
    • Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry
    • Li N, et al. Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry. Thromb Res 2003; 111: 165–170.
    • (2003) Thromb Res , vol.111 , pp. 165-170
    • Li, N.1
  • 102
    • 64749106872 scopus 로고    scopus 로고
    • Beyond platelet inhibition: Potential pleiotropic effects of ADP-receptor antagonists
    • Iyengar S, Rabbani LE. Beyond platelet inhibition: potential pleiotropic effects of ADP-receptor antagonists. J Thromb Thrombol 2009; 27: 300–306.
    • (2009) J Thromb Thrombol , vol.27 , pp. 300-306
    • Iyengar, S.1    Rabbani, L.E.2
  • 103
    • 0026495238 scopus 로고
    • Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
    • Palabrica T, et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 1992; 359: 848–851.
    • (1992) Nature , vol.359 , pp. 848-851
    • Palabrica, T.1
  • 104
    • 0037374428 scopus 로고    scopus 로고
    • Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease
    • Klinkhardt U, et al. Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease. Clin Pharmacol Therap 2003; 73: 232–241.
    • (2003) Clin Pharmacol Therap , vol.73 , pp. 232-241
    • Klinkhardt, U.1
  • 105
    • 0036220890 scopus 로고    scopus 로고
    • Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model
    • Klinkhardt U, et al. Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model. Clin Pharmacol Therap 2002; 71: 176–185.
    • (2002) Clin Pharmacol Therap , vol.71 , pp. 176-185
    • Klinkhardt, U.1
  • 106
    • 2542488125 scopus 로고    scopus 로고
    • Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome
    • Xiao Z, Theroux P. Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 2004; 43: 1982–1988.
    • (2004) J am Coll Cardiol , vol.43 , pp. 1982-1988
    • Xiao, Z.1    Theroux, P.2
  • 107
    • 31344437038 scopus 로고    scopus 로고
    • Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease
    • Azar RR, et al. Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease. Am Heart J 2006; 151: 521 e1–e4.
    • (2006) Am Heart J , vol.151 , Issue.521
    • Azar, R.R.1
  • 108
    • 33746154921 scopus 로고    scopus 로고
    • Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels
    • Vavuranakis M, et al. Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels. Clin Therap 2006; 28: 860–871.
    • (2006) Clin Therap , vol.28 , pp. 860-871
    • Vavuranakis, M.1
  • 109
    • 1542722301 scopus 로고    scopus 로고
    • Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention
    • Quinn MJ, et al. Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention. Am J Cardiol 2004; 93: 679–684.
    • (2004) Am J Cardiol , vol.93 , pp. 679-684
    • Quinn, M.J.1
  • 110
    • 33748081769 scopus 로고    scopus 로고
    • Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus
    • Harding SA, et al. Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus. Heart 2006; 92: 1335–1337.
    • (2006) Heart , vol.92 , pp. 1335-1337
    • Harding, S.A.1
  • 111
    • 20144373281 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation
    • Sabatine MS, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005; 352: 1179–1189.
    • (2005) N Engl J Med , vol.352 , pp. 1179-1189
    • Sabatine, M.S.1
  • 112
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006; 354: 1706–1717.
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1
  • 113
    • 84871313410 scopus 로고    scopus 로고
    • Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis
    • Bellemain-Appaix A, et al. Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. J Am Med Assoc 2012; 308: 2507–2516.
    • (2012) J am Med Assoc , vol.308 , pp. 2507-2516
    • Bellemain-Appaix, A.1
  • 114
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Mehta SR, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001; 358: 527–533.
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1
  • 115
    • 0038771932 scopus 로고    scopus 로고
    • Association between C-reactive protein levels and subsequent cardiac events among patients with stable angina treated with coronary artery stenting
    • Dibra A, et al. Association between C-reactive protein levels and subsequent cardiac events among patients with stable angina treated with coronary artery stenting. Am J Med 2003; 114: 715–722.
    • (2003) Am J Med , vol.114 , pp. 715-722
    • Dibra, A.1
  • 116
    • 4644326910 scopus 로고    scopus 로고
    • Inflammation and restenosis after percutaneous coronary interventions
    • Toutouzas K, et al. Inflammation and restenosis after percutaneous coronary interventions. Eur Heart J 2004; 25: 1679–1687.
    • (2004) Eur Heart J , vol.25 , pp. 1679-1687
    • Toutouzas, K.1
  • 117
    • 33646561025 scopus 로고    scopus 로고
    • Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: Results from the CLEAR PLATELETS 1b study
    • Gurbel PA, et al. Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study. J Am Coll Cardiol 2006; 48: 2186–2191.
    • (2006) J am Coll Cardiol , vol.48 , pp. 2186-2191
    • Gurbel, P.A.1
  • 118
    • 0035885045 scopus 로고    scopus 로고
    • Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with C-reactive protein
    • Chew DP, et al. Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with C-reactive protein. Am J Cardiol 2001; 88: 672–674.
    • (2001) Am J Cardiol , vol.88 , pp. 672-674
    • Chew, D.P.1
  • 119
    • 0037106972 scopus 로고    scopus 로고
    • Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus
    • Bhatt DL, et al. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus. Am J Cardiol 2002; 90: 625–628.
    • (2002) Am J Cardiol , vol.90 , pp. 625-628
    • Bhatt, D.L.1
  • 120
    • 33847793850 scopus 로고    scopus 로고
    • Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors
    • Meune C, et al. Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors. Eur J Heart Fail 2007; 9: 197–201.
    • (2007) Eur J Heart Fail , vol.9 , pp. 197-201
    • Meune, C.1
  • 121
    • 76149125479 scopus 로고    scopus 로고
    • PROCLAIM: Pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin
    • Willerson JT, et al. PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin. Texas Heart Inst J 2009; 36: 530–539.
    • (2009) Texas Heart Inst J , vol.36 , pp. 530-539
    • Willerson, J.T.1
  • 122
    • 26444450583 scopus 로고    scopus 로고
    • P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells
    • Wang L, et al. P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells. BMC Immunol 2004; 5: 16.
    • (2004) BMC Immunol , vol.5
    • Wang, L.1
  • 123
    • 5344257562 scopus 로고    scopus 로고
    • ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels
    • Wihlborg AK, et al. ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscl Thromb Vasc Biol 2004; 24: 1810–1815.
    • (2004) Arterioscl Thromb Vasc Biol , vol.24 , pp. 1810-1815
    • Wihlborg, A.K.1
  • 124
    • 78650675653 scopus 로고    scopus 로고
    • Role of the P2Y12 receptor in the modulation of murine dendritic cell function by ADP
    • Ben Addi A, et al. Role of the P2Y12 receptor in the modulation of murine dendritic cell function by ADP. J Immunol 2010; 185: 5900–5906.
    • (2010) J Immunol , vol.185 , pp. 5900-5906
    • Ben Addi, A.1
  • 125
    • 84897022751 scopus 로고    scopus 로고
    • LPS-induced systemic inflammation is more severe in P2Y12 null mice
    • Liverani E, et al. LPS-induced systemic inflammation is more severe in P2Y12 null mice. J Leukocyte Biol 2014; 95: 313–323.
    • (2014) J Leukocyte Biol , vol.95 , pp. 313-323
    • Liverani, E.1
  • 126
    • 84912021475 scopus 로고    scopus 로고
    • Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared to clopidogrel in the PLATO study
    • Storey RF, et al. Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared to clopidogrel in the PLATO study. Platelets 2014; 25: 517–525.
    • (2014) Platelets , vol.25 , pp. 517-525
    • Storey, R.F.1
  • 127
    • 77950848980 scopus 로고    scopus 로고
    • Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel
    • Husted S, et al. Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel. Clin Cardiol 2010; 33: 206–212.
    • (2010) Clin Cardiol , vol.33 , pp. 206-212
    • Husted, S.1
  • 128
    • 84895522368 scopus 로고    scopus 로고
    • Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome
    • Bonello L, et al. Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome. J Am Coll Cardiol 2014; 63: 872–877.
    • (2014) J am Coll Cardiol , vol.63 , pp. 872-877
    • Bonello, L.1
  • 129
    • 84894420031 scopus 로고    scopus 로고
    • Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1
    • Armstrong D, et al. Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1. J Cardiovasc Pharmacol Ther 2014; 19: 209–219.
    • (2014) J Cardiovasc Pharmacol Ther , vol.19 , pp. 209-219
    • Armstrong, D.1
  • 130
    • 43349085701 scopus 로고    scopus 로고
    • A2A receptors in inflammation and injury: Lessons learned from transgenic animals
    • Hasko G, Pacher P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukocyte Biol 2008; 83: 447–455.
    • (2008) J Leukocyte Biol , vol.83 , pp. 447-455
    • Hasko, G.1    Pacher, P.2
  • 131
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • Hasko G, et al. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nature Rev Drug Discov 2008; 7: 759–770.
    • (2008) Nature Rev Drug Discov , vol.7 , pp. 759-770
    • Hasko, G.1
  • 132
    • 0348222661 scopus 로고    scopus 로고
    • Adenosine: An endogenous regulator of innate immunity
    • Hasko G, Cronstein BN. Adenosine: an endogenous regulator of innate immunity. Trends Immunol 2004; 25: 33–39.
    • (2004) Trends Immunol , vol.25 , pp. 33-39
    • Hasko, G.1    Cronstein, B.N.2
  • 133
    • 84899943554 scopus 로고    scopus 로고
    • Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis
    • Rahman M, et al. Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis. Platelets 2014; 25: 257–263.
    • (2014) Platelets , vol.25 , pp. 257-263
    • Rahman, M.1
  • 134
    • 84861830383 scopus 로고    scopus 로고
    • Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: A placebo-controlled study in rats
    • Grzesk G, et al. Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: a placebo-controlled study in rats. Thromb Res 2012; 130: 65–69.
    • (2012) Thromb Res , vol.130 , pp. 65-69
    • Grzesk, G.1
  • 135
    • 84879376704 scopus 로고    scopus 로고
    • High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells
    • Grzesk G, et al. High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells. BioMed Res Intern 2013; 2013: 928271.
    • (2013) Biomed Res Intern , vol.2013
    • Grzesk, G.1
  • 136
    • 84931281970 scopus 로고    scopus 로고
    • Differential effects of platelets and platelet inhibition by ticagrelor on TLR2– and TLR4-mediated inflammatory responses
    • Tunjungputri RN, et al. Differential effects of platelets and platelet inhibition by ticagrelor on TLR2– and TLR4-mediated inflammatory responses. Thromb Haemost 2015; 113: 1035–1045.
    • (2015) Thromb Haemost , vol.113 , pp. 1035-1045
    • Tunjungputri, R.N.1
  • 137
    • 38349140973 scopus 로고    scopus 로고
    • The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities
    • Frelinger AL, 3rd, et al. The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities. J Thromb Haemost 2008; 6: 359–365.
    • (2008) J Thromb Haemost , vol.6 , pp. 359-365
    • Frelinger, A.L.1
  • 138
    • 84861719794 scopus 로고    scopus 로고
    • Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse
    • Totani L, et al. Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse. Thromb Haemost 2012; 107: 1130–1140.
    • (2012) Thromb Haemost , vol.107 , pp. 1130-1140
    • Totani, L.1
  • 139
    • 34447521877 scopus 로고    scopus 로고
    • The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin
    • Frelinger AL, 3rd, et al. The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin. Thromb Haemost 2007; 98: 192–200.
    • (2007) Thromb Haemost , vol.98 , pp. 192-200
    • Frelinger, A.L.1
  • 140
    • 39749148867 scopus 로고    scopus 로고
    • The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses
    • Judge HM, et al. The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses. Platelets 2008; 19: 125–133.
    • (2008) Platelets , vol.19 , pp. 125-133
    • Judge, H.M.1
  • 141
    • 33745337868 scopus 로고    scopus 로고
    • Platelet inhibition with prasugrel (CS-747) compared with clopidogrel in patients undergoing coronary stenting: The subset from the JUMBO study
    • Serebruany VL, et al. Platelet inhibition with prasugrel (CS-747) compared with clopidogrel in patients undergoing coronary stenting: the subset from the JUMBO study. Postgrad Med J 2006; 82: 404–410.
    • (2006) Postgrad Med J , vol.82 , pp. 404-410
    • Serebruany, V.L.1
  • 142
    • 54949112440 scopus 로고    scopus 로고
    • Greater reduction of platelet activation markers and plateletmonocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease
    • Braun OO, et al. Greater reduction of platelet activation markers and plateletmonocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease. Thromb Haemost 2008; 100: 626–633.
    • (2008) Thromb Haemost , vol.100 , pp. 626-633
    • Braun, O.O.1
  • 143
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001–2015.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1
  • 144
    • 84871698742 scopus 로고    scopus 로고
    • Prasugrel metabolites inhibit neutrophil functions
    • Liverani E, et al. Prasugrel metabolites inhibit neutrophil functions. J Pharmacol Exp Therap 2013; 344: 231–243.
    • (2013) J Pharmacol Exp Therap , vol.344 , pp. 231-243
    • Liverani, E.1
  • 145
    • 78650949523 scopus 로고    scopus 로고
    • Clopidogrel discontinuation and platelet reactivity following coronary stenting
    • Mylotte D, et al. Clopidogrel discontinuation and platelet reactivity following coronary stenting. J Thromb Haemost 2011; 9: 24–32.
    • (2011) J Thromb Haemost , vol.9 , pp. 24-32
    • Mylotte, D.1
  • 146
    • 38949209538 scopus 로고    scopus 로고
    • Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome
    • Ho PM, et al. Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. J Am Med Assoc 2008; 299: 532–539.
    • (2008) J am Med Assoc , vol.299 , pp. 532-539
    • Ho, P.M.1
  • 147
    • 70350550067 scopus 로고    scopus 로고
    • Effect of clopidogrel discontinuation at 1 year after drug eluting stent placement on soluble CD40L, P-selectin and C-reactive protein levels: DECADES (Discontinuation Effect of Clopidogrel After Drug Eluting Stent): A multicenter, open-label study
    • Wykrzykowska JJ, et al. Effect of clopidogrel discontinuation at 1 year after drug eluting stent placement on soluble CD40L, P-selectin and C-reactive protein levels: DECADES (Discontinuation Effect of Clopidogrel After Drug Eluting Stent): a multicenter, open-label study. J Thromb Thrombol 2009; 28: 410–417.
    • (2009) J Thromb Thrombol , vol.28 , pp. 410-417
    • Wykrzykowska, J.J.1
  • 148
    • 84925345310 scopus 로고    scopus 로고
    • Men with Lower HDL Cholesterol Levels have Significant Increment of Soluble CD40 Ligand and High-sensitivity CRP Levels Following the Cessation of Long-term Clopidogrel Therapy
    • Epub ahead of print
    • Obradovic S, et al. Men with Lower HDL Cholesterol Levels have Significant Increment of Soluble CD40 Ligand and High-sensitivity CRP Levels Following the Cessation of Long-term Clopidogrel Therapy. J Atheroscl Thromb 2014; Epub ahead of print.
    • (2014) J Atheroscl Thromb
    • Obradovic, S.1
  • 149
    • 79851500881 scopus 로고    scopus 로고
    • Clopidogrel withdrawal: Is there a „rebound“ phenomenon?
    • Sambu N, et al. Clopidogrel withdrawal: is there a „rebound“ phenomenon? Thromb Haemost 2011; 105: 211–220.
    • (2011) Thromb Haemost , vol.105 , pp. 211-220
    • Sambu, N.1
  • 150
    • 77952229611 scopus 로고    scopus 로고
    • Effects of clopidogrel on „aspirin specific“ pathways of platelet inhibition
    • Hobson AR, et al. Effects of clopidogrel on „aspirin specific“ pathways of platelet inhibition. Platelets 2009; 20: 386–390.
    • (2009) Platelets , vol.20 , pp. 386-390
    • Hobson, A.R.1
  • 151
    • 77949308981 scopus 로고    scopus 로고
    • Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy
    • Armstrong PC, et al. Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy. J Thromb Haemost 2010; 8: 613–615.
    • (2010) J Thromb Haemost , vol.8 , pp. 613-615
    • Armstrong, P.C.1
  • 152
    • 33645993590 scopus 로고    scopus 로고
    • P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation
    • Shankar H, et al. P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. J Thromb Haemost 2006; 4: 638–647.
    • (2006) J Thromb Haemost , vol.4 , pp. 638-647
    • Shankar, H.1
  • 153
    • 33747088257 scopus 로고    scopus 로고
    • Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1– and cyclooxygenase- 2-independent pathway: A 700-patient study of aspirin resistance
    • Frelinger AL, 3rd, et al. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1– and cyclooxygenase- 2-independent pathway: a 700-patient study of aspirin resistance. Circulation 2006; 113: 2888–2896.
    • (2006) Circulation , vol.113 , pp. 2888-2896
    • Frelinger, A.L.1
  • 154
    • 75249104914 scopus 로고    scopus 로고
    • A double-blind, randomized study on prevention and existence of a rebound phenomenon of platelets after cessation of clopidogrel treatment
    • Sibbing D, et al. A double-blind, randomized study on prevention and existence of a rebound phenomenon of platelets after cessation of clopidogrel treatment. J Am Coll Cardiol 2010; 55: 558–565.
    • (2010) J am Coll Cardiol , vol.55 , pp. 558-565
    • Sibbing, D.1
  • 155
    • 85044698530 scopus 로고    scopus 로고
    • Randomised, double-blind trial on the value of tapered discontinuation of clopidogrel maintenance therapy after drug-eluting stent implantation. Intracoronary Stenting and Antithrombotic Regimen: CAUTION in Discontinuing Clopidogrel Therapy--ISAR-CAUTION
    • Fiedler KA, et al. Randomised, double-blind trial on the value of tapered discontinuation of clopidogrel maintenance therapy after drug-eluting stent implantation. Intracoronary Stenting and Antithrombotic Regimen: CAUTION in Discontinuing Clopidogrel Therapy--ISAR-CAUTION. Thromb Haemost 2014; 111: 1041–1049.
    • (2014) Thromb Haemost , vol.111 , pp. 1041-1049
    • Fiedler, K.A.1
  • 156
    • 84923285247 scopus 로고    scopus 로고
    • Prasugrel plus aspirin beyond 12 months is associated with improved outcomes after TAXUS Liberte paclitaxel-eluting coronary stent placement
    • Garratt KN, et al. Prasugrel plus aspirin beyond 12 months is associated with improved outcomes after TAXUS Liberte paclitaxel-eluting coronary stent placement. Circulation 2015; 131: 62–73.
    • (2015) Circulation , vol.131 , pp. 62-73
    • Garratt, K.N.1
  • 157
    • 0344665785 scopus 로고    scopus 로고
    • Comparative pharmacology of GP IIb/IIIa antagonists
    • Schror K, Weber AA. Comparative pharmacology of GP IIb/IIIa antagonists. J Thromb Thrombol 2003; 15: 71–80.
    • (2003) J Thromb Thrombol , vol.15 , pp. 71-80
    • Schror, K.1    Weber, A.A.2
  • 158
    • 0032485876 scopus 로고    scopus 로고
    • Pharmacodynamic profile of short-term abciximab treatment demonstrates prolonged platelet inhibition with gradual recovery from GP IIb/IIIa receptor blockade
    • Mascelli MA, et al. Pharmacodynamic profile of short-term abciximab treatment demonstrates prolonged platelet inhibition with gradual recovery from GP IIb/IIIa receptor blockade. Circulation 1998; 97: 1680–1688.
    • (1998) Circulation , vol.97 , pp. 1680-1688
    • Mascelli, M.A.1
  • 159
    • 33846498466 scopus 로고    scopus 로고
    • Effects of GP IIb/IIIa inhibitors on vascular inflammation, coronary microcirculation, and platelet function
    • Kereiakes DJ. Effects of GP IIb/IIIa inhibitors on vascular inflammation, coronary microcirculation, and platelet function. Rev Cardiovasc Med 2006; 7 (Suppl 4): S3–11.
    • (2006) Rev Cardiovasc Med , vol.7
    • Kereiakes, D.J.1
  • 160
    • 0037132843 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A meta-analysis of all major randomised clinical trials
    • Boersma E, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet 2002; 359: 189–198.
    • (2002) Lancet , vol.359 , pp. 189-198
    • Boersma, E.1
  • 161
    • 0035838353 scopus 로고    scopus 로고
    • Abciximab suppresses the rise in levels of circulating inflammatory markers after percutaneous coronary revascularization
    • Lincoff AM, et al. Abciximab suppresses the rise in levels of circulating inflammatory markers after percutaneous coronary revascularization. Circulation 2001; 104: 163–167.
    • (2001) Circulation , vol.104 , pp. 163-167
    • Lincoff, A.M.1
  • 162
    • 0842304379 scopus 로고    scopus 로고
    • Activation of the inflammation, coagulation, and fibrinolysis systems, without influence of abciximab infusion in patients with non-ST-elevation acute coronary syndromes treated with dalteparin: A GUSTO IV substudy
    • James SK, et al. Activation of the inflammation, coagulation, and fibrinolysis systems, without influence of abciximab infusion in patients with non-ST-elevation acute coronary syndromes treated with dalteparin: a GUSTO IV substudy. Am Heart J 2004; 147: 267–274.
    • (2004) Am Heart J , vol.147 , pp. 267-274
    • James, S.K.1
  • 163
    • 34347204130 scopus 로고    scopus 로고
    • Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease
    • Steinhubl SR, et al. Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease. Vasc Med 2007; 12: 113–122.
    • (2007) Vasc Med , vol.12 , pp. 113-122
    • Steinhubl, S.R.1
  • 164
    • 4344583343 scopus 로고    scopus 로고
    • Decreased soluble cell adhesion molecules after tirofiban infusion in patients with unstable angina pectoris
    • Ercan E, et al. Decreased soluble cell adhesion molecules after tirofiban infusion in patients with unstable angina pectoris. Thromb J 2004; 2: 4.
    • (2004) Thromb J , vol.2
    • Ercan, E.1
  • 165
    • 10044270840 scopus 로고    scopus 로고
    • Effects of tirofiban on acute systemic inflammatory response in elective percutaneous coronary interventions
    • Akbulut M, et al. Effects of tirofiban on acute systemic inflammatory response in elective percutaneous coronary interventions. Curr Med Res Opin 2004; 20: 1759–1767.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1759-1767
    • Akbulut, M.1
  • 166
    • 71849119604 scopus 로고    scopus 로고
    • Intravenous platelet blockade with cangrelor during PCI
    • Bhatt DL, et al. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med 2009; 361: 2330–2341.
    • (2009) N Engl J Med , vol.361 , pp. 2330-2341
    • Bhatt, D.L.1
  • 167
    • 77955226780 scopus 로고    scopus 로고
    • Update on the clinical development of cangrelor
    • Ueno M, et al. Update on the clinical development of cangrelor. Exp Rev Cardiovasc Ther 2010; 8: 1069–1077.
    • (2010) Exp Rev Cardiovasc Ther , vol.8 , pp. 1069-1077
    • Ueno, M.1
  • 168
    • 27644562205 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa and P2Y12 receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses
    • Judge HM, et al. Glycoprotein IIb/IIIa and P2Y12 receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses. Platelets 2005; 16: 398–407.
    • (2005) Platelets , vol.16 , pp. 398-407
    • Judge, H.M.1
  • 169
    • 84922218802 scopus 로고    scopus 로고
    • Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: Insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER)
    • Jones WS, et al. Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER). Am Heart J 2014; 168: 588–596.
    • (2014) Am Heart J , vol.168 , pp. 588-596
    • Jones, W.S.1
  • 170
    • 84867336413 scopus 로고    scopus 로고
    • Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: A prespecified subgroup analysis of the TRA 2 degrees P-TIMI 50 trial
    • Scirica BM, et al. Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2 degrees P-TIMI 50 trial. Lancet 2012; 380: 1317–1324.
    • (2012) Lancet , vol.380 , pp. 1317-1324
    • Scirica, B.M.1
  • 171
    • 84897999257 scopus 로고    scopus 로고
    • Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy
    • Storey RF, et al. Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy. Thromb Haemost 2014; 111: 883–891.
    • (2014) Thromb Haemost , vol.111 , pp. 883-891
    • Storey, R.F.1
  • 172
    • 84862764516 scopus 로고    scopus 로고
    • Atopaxar and its effects on markers of platelet activation and inflammation: Results from the LANCELOT CAD program
    • O’Donoghue ML, et al. Atopaxar and its effects on markers of platelet activation and inflammation: results from the LANCELOT CAD program. J Thromb Thrombol 2012; 34: 36–43.
    • (2012) J Thromb Thrombol , vol.34 , pp. 36-43
    • O’Donoghue, M.L.1
  • 173
    • 33845369431 scopus 로고    scopus 로고
    • Effect of antiplatelet agents clopidogrel, aspirin, and cilostazol on circulating tissue factor procoagulant activity in patients with peripheral arterial disease
    • Rao AK, et al. Effect of antiplatelet agents clopidogrel, aspirin, and cilostazol on circulating tissue factor procoagulant activity in patients with peripheral arterial disease. Thromb Haemost 2006; 96: 738–743.
    • (2006) Thromb Haemost , vol.96 , pp. 738-743
    • Rao, A.K.1
  • 174
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, et al. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J 2006; 27: 1038–1047.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1
  • 175
    • 61349148702 scopus 로고    scopus 로고
    • Long-term clopidogrel administration following severe coronary injury reduces proliferation and inflammation via inhibition of nuclear factorkappaB and activator protein 1 activation in pigs
    • Pels K, et al. Long-term clopidogrel administration following severe coronary injury reduces proliferation and inflammation via inhibition of nuclear factorkappaB and activator protein 1 activation in pigs. Eur J Clin Invest 2009; 39: 174–182.
    • (2009) Eur J Clin Invest , vol.39 , pp. 174-182
    • Pels, K.1
  • 176
    • 34948902899 scopus 로고    scopus 로고
    • Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/ IIIa) receptors cooperate in NF-kappaB activation of human neutrophils
    • Salanova B, et al. Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/ IIIa) receptors cooperate in NF-kappaB activation of human neutrophils. J Biol Chem 2007; 282: 27960–27969.
    • (2007) J Biol Chem , vol.282 , pp. 27960-27969
    • Salanova, B.1
  • 177
    • 27144559270 scopus 로고    scopus 로고
    • Effect of clopidogrel on the expression of inflammatory markers in rabbit ischaemic coronary artery
    • Molero L, et al. Effect of clopidogrel on the expression of inflammatory markers in rabbit ischaemic coronary artery. Br J Pharmacol 2005; 146: 419–424.
    • (2005) Br J Pharmacol , vol.146 , pp. 419-424
    • Molero, L.1
  • 178
    • 34247869852 scopus 로고    scopus 로고
    • Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial
    • Bhatt DL, et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol 2007; 49: 1982–1988.
    • (2007) J am Coll Cardiol , vol.49 , pp. 1982-1988
    • Bhatt, D.L.1
  • 179
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Ridker PM, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359: 2195–2207.
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1
  • 180
    • 69849105377 scopus 로고    scopus 로고
    • Inhibition of platelet-rich arterial thrombus in vivo: Acute antithrombotic effect of intravenous HMG-CoA reductase therapy
    • Obi C, et al. Inhibition of platelet-rich arterial thrombus in vivo: acute antithrombotic effect of intravenous HMG-CoA reductase therapy. Arterioscl Thromb Vasc Biol 2009; 29: 1271–1276.
    • (2009) Arterioscl Thromb Vasc Biol , vol.29 , pp. 1271-1276
    • Obi, C.1
  • 181
    • 34249727787 scopus 로고    scopus 로고
    • Moderation of the platelet releasate response by aspirin
    • Coppinger JA, et al. Moderation of the platelet releasate response by aspirin. Blood 2007; 109: 4786–4792.
    • (2007) Blood , vol.109 , pp. 4786-4792
    • Coppinger, J.A.1
  • 182
    • 84884564336 scopus 로고    scopus 로고
    • Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events
    • Voora D, et al. Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. J Am Coll Cardiol 2013; 62: 1267–1276.
    • (2013) J am Coll Cardiol , vol.62 , pp. 1267-1276
    • Voora, D.1
  • 183
    • 3242693541 scopus 로고    scopus 로고
    • Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary intervention
    • Vivekananthan DP, et al. Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary intervention. Am J Cardiol 2004; 94: 358–360.
    • (2004) Am J Cardiol , vol.94 , pp. 358-360
    • Vivekananthan, D.P.1
  • 184
    • 33747874088 scopus 로고    scopus 로고
    • A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: The ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial
    • Montalescot G, et al. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial. J Am Coll Cardiol 2006; 48: 931–938.
    • (2006) J am Coll Cardiol , vol.48 , pp. 931-938
    • Montalescot, G.1
  • 185
    • 33745960097 scopus 로고    scopus 로고
    • Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: Evidence for antioxidant and antiinflammatory effects
    • Heitzer T, et al. Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects. Arterioscl Thromb Vasc Biol 2006; 26: 1648–1652.
    • (2006) Arterioscl Thromb Vasc Biol , vol.26 , pp. 1648-1652
    • Heitzer, T.1
  • 186
    • 7944228717 scopus 로고    scopus 로고
    • Platelet aggregation inhibition blocks C-reactive protein and interleukin-6 (IL-6) elevation after the coronary angioplasty: Effect of the –174 G/C IL-6 gene polymorphism
    • Merino A, et al. Platelet aggregation inhibition blocks C-reactive protein and interleukin-6 (IL-6) elevation after the coronary angioplasty: effect of the –174 G/C IL-6 gene polymorphism. Am J Cardiol 2004; 94: 1300–1303.
    • (2004) Am J Cardiol , vol.94 , pp. 1300-1303
    • Merino, A.1
  • 187
    • 0742305175 scopus 로고    scopus 로고
    • GP IIb/IIIa inhibition with eptifibatide lowers levels of soluble CD40L and RANTES after percutaneous coronary intervention
    • Welt FG, et al. GP IIb/IIIa inhibition with eptifibatide lowers levels of soluble CD40L and RANTES after percutaneous coronary intervention. Catheter Cardiovasc Intervent 2004; 61: 185–189.
    • (2004) Catheter Cardiovasc Intervent , vol.61 , pp. 185-189
    • Welt, F.G.1
  • 188
    • 84866113069 scopus 로고    scopus 로고
    • Platelets: Active players in the pathogenesis of arthritis and SLE
    • Boilard E, et al. Platelets: active players in the pathogenesis of arthritis and SLE. Nat Rev Rheumatol 2012; 8: 534–542.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 534-542
    • Boilard, E.1
  • 189
    • 84862776514 scopus 로고    scopus 로고
    • Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis
    • Langer HF, et al. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res 2012; 110: 1202–1210.
    • (2012) Circ Res , vol.110 , pp. 1202-1210
    • Langer, H.F.1
  • 190
    • 84886996926 scopus 로고    scopus 로고
    • Crosstalk between platelets and the complement system in immune protection and disease
    • Verschoor A, Langer HF. Crosstalk between platelets and the complement system in immune protection and disease. Thromb Haemost 2013; 110: 910–919.
    • (2013) Thromb Haemost , vol.110 , pp. 910-919
    • Verschoor, A.1    Langer, H.F.2
  • 191
    • 84928944621 scopus 로고    scopus 로고
    • PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction
    • Bonaca MP, et al.; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med 2015; 372: 1791–1800.
    • (2015) N Engl J Med , vol.372 , pp. 1791-1800
    • Bonaca, M.P.1
  • 192
    • 84918772240 scopus 로고    scopus 로고
    • DAPT Study Investigators.Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents
    • Mauri L, et al.; DAPT Study Investigators.Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med 2014; 371: 2155–2166.
    • (2014) N Engl J Med , vol.371 , pp. 2155-2166
    • Mauri, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.