Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery

European Heart Journal

Volumn 35, Issue 6, 2014, Pages 386-394

  Rath, Dominik ^a   Chatterjee, Madhumita ^a   Borst, Oliver ^a   Müller, Karin ^a   Stellos, Konstantinos ^b   MacK, Andreas F ^a   Bongartz, Angela ^a   Bigalke, Boris ^a   Langer, Harald ^a   Schwab, Matthias ^c,d   Gawaz, Meinrad ^a   Geisler, Tobias ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

Author keywords

Acute coronary syndrome; CXCR4; CXCR7; SDF 1

Indexed keywords

ACUTE CORONARY SYNDROME; CXCR4; CXCR7; SDF-1;

ACUTE CORONARY SYNDROME; AGED; BLOOD PLATELETS; CHEMOKINE CXCL12; CORONARY ARTERY DISEASE; FEMALE; HUMANS; MALE; PILOT PROJECTS; PROSPECTIVE STUDIES; RECEPTORS, CXCR; RECEPTORS, CXCR4; RECOVERY OF FUNCTION; STROKE VOLUME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84894254008     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/eht448     Document Type: Article

References (52)

1. Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, Bosch-Marce M, Masuda H, LosordoDW, Isner JM, Asahara T. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 2003;107:1322-1328.
2. Schmidt-Lucke C, Rö ssig L, Fichtlscherer S, Vasa M, Britten M, Kämper U, Dimmeler S, Zeiher AM. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005;111:2981-2987.
3. Zernecke A, Schober A, Bot I, von Hundelshausen P, Liehn EA, Möpps B, Mericskay M, Gierschik P, Biessen EA,Weber C. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment ofsmooth muscle progenitor cells. Circ Res 2005;96:784-791.
4. Massberg S, Konrad I, Schürzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M. Platelets secrete stromal cellderived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med 2006;203:1221-1233.
5. Stellos K, Bigalke B, Langer H, Geisler T, Schad A, Kö gel A, Pfaff F, Stakos D, Seizer P, Müller I, Htun P, Lindemann S, GawazM. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J 2009;30: 584-593.
6. Stellos K, Ruf M, Sopova K, Kilias A, Rahmann A, Stamatelopoulos K, Jorbenadze R, Geisler T, Gawaz M, Bigalke B. Plasma levels of stromal cell-derived factor-1 in patients with coronary artery disease: Effect of clinical presentation and cardiovascular risk factors. Atherosclerosis 2011;219:913-916.
7. Geisler T, Fekecs L, Wurster T, Chiribiri A, Schuster A, Nagel E, Miller S, Gawaz M, Stellos K, Bigalke B. Association of platelet-SDF-1 with hemodynamic function and infarct size using cardiac MR in patients with AMI. Eur J Radiol 2012;81:e486-e490.
8. Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, GeislerT, Schlosshauer B, Lunov O, Engelhardt S, Simmet T,GawazM. The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation 2012;125:685-696.
9. Hu X, Dai S, Wu WJ, TanW, Zhu X, Mu J, Guo Y, Bolli R, Rokosh G. Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation 2007;116:654-663.
10. Zhang D, Fan GC, zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M,Wang Y. Overexpression ofCXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol 2008;44:281-292.
11. Wegner SA, Ehrenberg PK, Chang G, Dayhoff DE, Sleeker AL, MichaelNL.Genomic organization and functional characterization of the chemokine receptor cxcr4, a major entry coreceptor for human immunodeficiency virus type 1. J Biol Chem 1998;273:4754-4760.
12. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor cxcr4 in haematopoiesis and in cerebellar development. Nature 1998; 393:595-599.
13. Feil C, Augustin HG. Endothelial cells differentially express functional cxc-chemokine receptor-4 (cxcr-4/fusin) under the control of autocrine activity and exogenous cytokines. Biochem Biophys Res Commun 1998;247:38-45.
14. Lazarini F, Casanova P, Tham TN, De Clercq E, Arenzana-Seisdedos F, Baleux F, Dubois-Dalcq M. Differential signalling of the chemokine receptor cxcr4 by stromal cell-derived factor 1 and the hiv glycoprotein in rat neurons and astrocytes. Eur J Neurosci 2000;12:117-125.
15. Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, Schall TJ. A novel chemokine receptor for sdf-1 and i-tac involved in cell survival, cell adhesion, and tumor development. J Exp Med 2006;203:2201-2213.
16. Tripathi V, Verma R, Dinda A, Malhotra N, Kaur J, Luthra K. Differential expression of rdc1/cxcr7 in the human placenta. J Clin Immunol 2009;29:379-386.
17. Miao Z, Luker KE, Summers BC, Berahovich R, Bhojani MS, Rehemtulla A, Kleer CG, Essner JJ, Nasevicius A, Luker GD, Howard MC, Schall TJ. Cxcr7 (rdc1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci USA 2007;104:15735-15740.
18. Wang J, Shiozawa Y,Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R, Taichman RS. The role of cxcr7/rdc1 as a chemokine receptor for cxcl12/sdf-1 in prostate cancer. J Biol Chem 2008;283:4283-4294.
19. Gerrits H, van Ingen Schenau DS, Bakker NE, van Disseldorp AJ, Strik A, Hermens LS, Koenen TB, Krajnc-Franken MA, Gossen JA. Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis 2008;46:235-245.
20. Sierro F, Biben C, Mart?́nez-Muñoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA 2007;104:14759-14764.
21. Martinez A, Kapas S, Miller MJ,Ward Y, Cuttitta F. Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells. Endocrinology 2000;141:406-411.
22. Liu H, XueW, Ge G, Luo X, Li Y, Xiang H, Ding X, Tian P, Tian X. Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1alpha in MSCs. Biochem Biophys Res Commun 2010;401:509-515.
23. Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 2005;280:35760-35766.
24. Third universal definition of myocardial infarction. Eur Heart J 2012;33:2551-2567.
25. World Medical Association Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 1997;35:2-3.
26. ICH Harmonised Tripartite Guideline. Guideline for Good Clinical Practice. J Postgrad Med 2001;47:45-50:121-130, 199-203.
27. Directive 2001/20/EC of the European Parliament and of the Council of 4th April 2001 on the approximation of the laws, regulations and administrative provisions of the member states relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use. Med Etika Bioet 2002;9:12-19.
28. Chatterjee M, Huang Z, ZhangW, Jiang L, Hultenby K, Zhu L, Hu H, NilssonGP, Li N. Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood 2011;117:3907-3911.
29. Canals M, Scholten DJ, Munnik S, Han MK, Smit MJ, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE 2012;7:e34192.
30. Lapham CK, Romantseva T, Petricoin E, King LR, Manischewitz J, Zaitseva MB, Golding H. CXCR4 heterogeneity in primary cells: possible role of ubiquitination. J Leukoc Biol 2002;72:1206-1214.
31. Schiller NB, Shah PN, Crawford M. Recommendations. for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 1989;2: 258-267.
32. Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: pro-and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008;111:1227-1233.
33. Stellos K, Langer H, Daub K, Schoenberger T, Gauss A, Geisler T, Bigalke B, Mueller I, Schumm M, Schaefer I, Seizer P, Kraemer BF, Siegel-Axel D, May AE, Lindemann S, Gawaz M. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34 + cells to endothelial progenitor cells. Circulation 2008;117:206-215.
34. Stellos K, Gawaz M. Platelets and stromal cell-derived factor-1 in progenitor cell recruitment. Semin Thromb Hemost 2007;33:159-164.
35. Langer H, May AE, Daub K, Heinzmann U, Lang P, Schumm M, Vestweber D, Massberg S, Schönberger T, Pfisterer I, Hatzopoulos AK, Gawaz M. Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro. Circ Res 2006;98:e2-10.
36. Kraemer BF, Borst O, Gehring EM, Schoenberger T, Urban B, Ninci E, Seizer P, Schmidt C, Bigalke B, Koch M, Martinovic I, Daub K, Merz T, Schwanitz L, Stellos K, Fiesel F, Schaller M, Lang F, Gawaz M, Lindemann S. PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1). J Mol Med (Berl) 2010;88:1277-1288.
37. Kraemer BF, Schmidt C, Urban B, Bigalke B, Schwanitz L, Koch M, Seizer P, Schaller M, Gawaz M, Lindemann S. High shear flow induces migration of adherent human platelets. Platelets 2011;22:415-421.
38. Thelen M, Thelen S. CXCR7, CXCR4 and CXCL12: an eccentric trio? J Neuroimmunol 2008;198:9-13.
39. Levoye A, Balabanian K, Baleux F, Bachelerie F, Lagane B. CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signalling. Blood 2009; 113:6085-6093.
40. Mazzinghi B, Ronconi E, Lazzeri E, Sagrinati C, Ballerini L, Angelotti ML, Parente E, Mancina R, Netti GS, Becherucci F, Gacci M, Carini M, Gesualdo L, Rotondi M, Maggi E, Lasagni L, Serio M, Romagnani S, Romagnani P. Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J Exp Med 2008;205:479-490.
41. Boldajipour B, Mahabaleshwar H, Kardash E, Reichman-Fried M, Blaser H, Minina S. Control of chemokine-guided cell migration by ligand sequestration. Cell 2008;132: 463-473.
42. Dambly-Chaudiere C, Cubedo N, Ghysen A. Control of cell migration in the development of the posterior lateral line: Antagonistic interactions between the chemokine receptors cxcr4 and cxcr7/rdc1. BMC Dev Biol 2007;7:23.
43. Roland J, Murphy BJ, Ahr B, Robert-Hebmann V, Delauzun V, Nye KE, Devaux C, Biard-Piechaczyk M. Role of the intracellular domains ofCXCR4 in SDF-1-mediated signaling. Blood 2003;101:399-406.
44. Liu H, Liu S, Li Y, Wang X, Xue W, Ge G, Luo X. The role of SDF-1-CX CR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS One 2012;7: e34608.
45. Liehn EA, Tuchscheerer N, Kanzler I, Drechsler M, Fraemohs L, Schuh A, Koenen RR, Zander S, Soehnlein O, Hristov M, Grigorescu G, Urs AO, Leabu M, Bucur I, Merx MW, Zernecke A, Ehling J, Gremse F, Lammers T, Kiessling F, Bernhagen J, Schober A, Weber C. Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction. J Am Coll Cardiol 2011;58:2415-2423.
46. Yan X, Cai S, XiongX, SunW, Dai X,Chen S, YeQ, SongZ, Jiang Q,XuZ. Chemokine receptor CXCR7 mediates human endothelial progenitor cells survival, angiogenesis, but not proliferation. J Cell Biochem 2012;113:1437-1446.
47. Gomes AL, Carvalho T, Serpa J, Torre C, Dias S. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis. Blood 2010; 115:3886-3894.
48. Wang JD, Ou TT, Wang CJ, Chang TK, Lee HJ. Platelet apoptosis resistance and increased CXCR4 expression in pediatric patients with chronic immune thrombocytopenic purpura. Thromb Res 2010;126:311-318.
49. Stellos K, Rahmann A, Kilias A, Ruf M, Sopova K, Stamatelopoulos K, Jorbenadze R, Weretka S, Geisler T, Gawaz M, Weig HJ, Bigalke B. Expression of platelet-bound stromal cell-derived factor-1 in patients with non-valvular atrial fibrillation and ischemic heart disease. J Thromb Haemost 2012;10:49-55.
50. Salim JP, Goette NP, Lev PR, Chazarreta CD, Heller PG, Alvarez C, Molinas FC, Marta RF. Dysregulation of stromal derived factor 1/CXCR4 axis in the megakaryocytic lineage in essential thrombocythemia. Br J Haematol 2009;144: 69-77.
51. De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis DA, Yarchoan R, Zhang HH, Fales HM, Tosato G. Differential processing of stromal-derived factor-1{alpha} and stromal-derived factor-1(beta) explains functional diversity. Blood 2004;103:2452-2459.
52. Davis DA, Singer KE, De La Luz Sierra M, Narazaki M, Yang F, Fales HM, Yarchoan R, Tosato G. Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1a in the circulation. Blood 2005;105:4561-4568.