The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses

Platelets

Volumn 19, Issue 2, 2008, Pages 125-133

  Judge, Heather M ^a   Buckland, Robert J ^a   Sugidachi, Atsuhiro ^b   Jakubowski, Joseph A ^c   Storey, Robert F ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b DAIICHI SANKYO CO   (Japan)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Clopidogrel; P2Y12; Platelet; Prasugrel; Receptor inhibition

Indexed keywords

AR C66931MX; CANGRELOR; CD40 LIGAND; CLOPIDOGREL; LIPOCORTIN 5; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; R 138727; RADIOLIGAND; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ADULT; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKOCYTE AGGREGATION; LIGAND BINDING; LOADING DRUG DOSE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RECEPTOR BLOCKING; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

ADENOSINE MONOPHOSPHATE; ADULT; ANNEXIN A5; BLOOD PLATELETS; CELL ADHESION MOLECULES; CYTOPLASMIC GRANULES; HUMANS; MICROFILAMENT PROTEINS; MIDDLE AGED; PHOSPHOPROTEINS; PHOSPHORYLATION; PIPERAZINES; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECEPTORS, PURINERGIC P2; THIOPHENES; TICLOPIDINE;

EID: 39749148867     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100701694144     Document Type: Article

References (37)