Differential effects of platelets and platelet inhibition by ticagrelor on TLR2- and TLR4-mediated inflammatory responses

Thrombosis and Haemostasis

Volumn 113, Issue 5, 2015, Pages 1035-1045

  Tunjungputri, Rahajeng N ^a,b   van der Ven, Andre J ^a   Riksen, Niels ^a   Rongen, Gerard ^a   Tacke, Sabine ^a   van den Berg, T N A Daniëlle ^a   Fijnheer, Rob ^c   Gomes, Marc E ^d   Dinarello, Charles A ^a,e   van de Veerdonk, Frank L ^a   Gasem, M Hussein ^b   Netea, Mihai G ^a   Joosten, Leo A B ^a   de Groot, Philip G ^c   de Mast, Quirijn ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b DIPONEGORO UNIVERSITY   (Indonesia)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d CANISIUS WILHELMINA HOSPITAL   (Netherlands)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Platelet monocyte complex; Platelets; Ticagrelor; Toll like receptor

Indexed keywords

BETA3 INTEGRIN; CD14 ANTIGEN; CYTOCHALASIN B; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PADGEM PROTEIN; PLACEBO; PURINERGIC P2 RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR ANTAGONIST; TICAGRELOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CYTOKINE; LIGAND; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; INFLAMMATION; MALE; MONOCYTE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; PLASMA PROTEIN BINDING; PLATELET FIBRINOGEN BINDING; PLATELET MONOCYTE COMPLEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; THROMBOCYTE FUNCTION; YOUNG ADULT; ANALOGS AND DERIVATIVES; BLOOD CLOTTING PARAMETERS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; THROMBOCYTE; THROMBOCYTE ACTIVATION;

ADENOSINE; ADENOSINE DIPHOSPHATE; ADULT; BLOOD PLATELETS; CROSS-OVER STUDIES; CYTOKINES; DOUBLE-BLIND METHOD; HUMANS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; LIGANDS; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; PHAGOCYTOSIS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; YOUNG ADULT;

EID: 84931281970     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-07-0579     Document Type: Article

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