P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 3, 2006, Pages 638-647

  Shankar, H ^a   Garcia, A ^a   Prabhakar, J ^a   Kim, S ^a   Kunapuli, Satya P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ERK1 2; P2Y12; PAR; Platelet; Src; Thrombin; TXA2

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 4 [4 [4 (AMINOIMINOMETHYL)PHENYL] 1 PIPERAZINYL] 1 PIPERIDINEACETIC ACID; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; AR C 69931MX; ARACHIDONIC ACID; CANGRELOR; CLOPIDOGREL; FIBRINOGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEOSIDE DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPID DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; PURINE P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; THROMBIN; THROMBOXANE A2; THROMBOXANE B2; 1,3 BUTADIENE DERIVATIVE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ADENOSINE PHOSPHATE; ANTITHROMBOCYTIC AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRILE; P2RY12 PROTEIN, HUMAN; PHOSPHOLIPASE A; PROTEASE-ACTIVATED RECEPTOR 4; PROTEIN TYROSINE KINASE; PURINE P2 RECEPTOR; PYRIMIDINE DERIVATIVE; THROMBIN RECEPTOR; TICLOPIDINE;

ANIMAL CELL; ANTICOAGULATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; THROMBOCYTE;

ADENOSINE MONOPHOSPHATE; ANIMALS; BLOOD PLATELETS; BUTADIENES; ENZYME INHIBITORS; HUMANS; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; NITRILES; PHOSPHOLIPASES A; PLATELET AGGREGATION INHIBITORS; PYRIMIDINES; RECEPTOR, PAR-1; RECEPTORS, PURINERGIC P2; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; THROMBIN; THROMBOXANE A2; TICLOPIDINE;

EID: 33645993590     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.01789.x     Document Type: Article

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