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Volumn 33, Issue 9, 2015, Pages 2798-2810

CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells

Author keywords

Alpha6 Integrin; Mammalian target of rapamycin; Mesenchymal Stem Cells; Tissue transglutaminase; TNFalpha

Indexed keywords

ALPHA6 INTEGRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMININ; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84940467275     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2063     Document Type: Article
Times cited : (36)

References (61)
  • 1
    • 84881425870 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A new trend for cell therapy
    • Wei X, Yang X, Han ZP, et al., Mesenchymal stem cells: A new trend for cell therapy. Acta Pharmacol Sin 2013; 34: 747-754.
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 747-754
    • Wei, X.1    Yang, X.2    Han, Z.P.3
  • 3
    • 84862281756 scopus 로고    scopus 로고
    • Markers for characterization of bone marrow multipotential stromal cells
    • Boxall SA, Jones E,. Markers for characterization of bone marrow multipotential stromal cells. Stem Cells Int 2012; 2012: 975871.
    • (2012) Stem Cells Int , vol.2012 , pp. 975871
    • Boxall, S.A.1    Jones, E.2
  • 4
    • 84901477349 scopus 로고    scopus 로고
    • Concise review: The surface markers and identity of human mesenchymal stem cells
    • Lv FJ, Tuan RS, Cheung KM, et al., Concise review: The surface markers and identity of human mesenchymal stem cells. Stem Cells 2014; 32: 1408-1419.
    • (2014) Stem Cells , vol.32 , pp. 1408-1419
    • Lv, F.J.1    Tuan, R.S.2    Cheung, K.M.3
  • 5
    • 59649122044 scopus 로고    scopus 로고
    • The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice
    • Lee RH, Seo MJ, Pulin AA, et al., The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood 2009; 113: 816-826.
    • (2009) Blood , vol.113 , pp. 816-826
    • Lee, R.H.1    Seo, M.J.2    Pulin, A.A.3
  • 6
    • 84860542424 scopus 로고    scopus 로고
    • CD49f enhances multipotency and maintains stemness through the direct regulation of OCT4 and SOX2
    • Yu KR, Yang SR, Jung JW, et al., CD49f enhances multipotency and maintains stemness through the direct regulation of OCT4 and SOX2. Stem Cells 2012; 30: 876-887.
    • (2012) Stem Cells , vol.30 , pp. 876-887
    • Yu, K.R.1    Yang, S.R.2    Jung, J.W.3
  • 7
    • 84893315703 scopus 로고    scopus 로고
    • Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment
    • Rodin S, Antonsson L, Niaudet C, et al., Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun 2014; 5: 3195.
    • (2014) Nat Commun , vol.5 , pp. 3195
    • Rodin, S.1    Antonsson, L.2    Niaudet, C.3
  • 8
    • 77953274486 scopus 로고    scopus 로고
    • Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
    • Rodin S, Domogatskaya A, Strom S, et al., Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol 2010; 28: 611-615.
    • (2010) Nat Biotechnol , vol.28 , pp. 611-615
    • Rodin, S.1    Domogatskaya, A.2    Strom, S.3
  • 9
    • 50849142558 scopus 로고    scopus 로고
    • Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions
    • Shen Q, Wang Y, Kokovay E, et al., Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions. Cell Stem Cell 2008; 3: 289-300.
    • (2008) Cell Stem Cell , vol.3 , pp. 289-300
    • Shen, Q.1    Wang, Y.2    Kokovay, E.3
  • 10
    • 79960106880 scopus 로고    scopus 로고
    • Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
    • Notta F, Doulatov S, Laurenti E, et al., Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011; 333: 218-221.
    • (2011) Science , vol.333 , pp. 218-221
    • Notta, F.1    Doulatov, S.2    Laurenti, E.3
  • 11
    • 84871603152 scopus 로고    scopus 로고
    • Adhesion in the stem cell niche: Biological roles and regulation
    • Chen S, Lewallen M, Xie T,. Adhesion in the stem cell niche: Biological roles and regulation. Development 2013; 140: 255-265.
    • (2013) Development , vol.140 , pp. 255-265
    • Chen, S.1    Lewallen, M.2    Xie, T.3
  • 13
    • 33845222777 scopus 로고    scopus 로고
    • Innate immunity and inflammation in ageing: A key for understanding age-related diseases
    • Licastro F, Candore G, Lio D, et al., Innate immunity and inflammation in ageing: A key for understanding age-related diseases. Immun Ageing 2005; 2: 8.
    • (2005) Immun Ageing , vol.2 , pp. 8
    • Licastro, F.1    Candore, G.2    Lio, D.3
  • 14
    • 84866152284 scopus 로고    scopus 로고
    • Inflammation and oxidative stress in obesity-related glomerulopathy
    • Tang J, Yan H, Zhuang S,. Inflammation and oxidative stress in obesity-related glomerulopathy. Int J Nephrol 2012; 2012: 608397.
    • (2012) Int J Nephrol , vol.2012 , pp. 608397
    • Tang, J.1    Yan, H.2    Zhuang, S.3
  • 15
    • 0027333425 scopus 로고
    • Tumor necrosis factor, other cytokines and disease
    • Tracey KJ, Cerami A,. Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 1993; 9: 317-343.
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 317-343
    • Tracey, K.J.1    Cerami, A.2
  • 16
    • 0033708837 scopus 로고    scopus 로고
    • Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
    • Cenci S, Weitzmann MN, Roggia C, et al., Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest 2000; 106: 1229-1237.
    • (2000) J Clin Invest , vol.106 , pp. 1229-1237
    • Cenci, S.1    Weitzmann, M.N.2    Roggia, C.3
  • 17
    • 62449127652 scopus 로고    scopus 로고
    • Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing
    • Fu X, Han B, Cai S, et al., Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing. Wound Repair Regen 2009; 17: 185-191.
    • (2009) Wound Repair Regen , vol.17 , pp. 185-191
    • Fu, X.1    Han, B.2    Cai, S.3
  • 18
    • 77951889580 scopus 로고    scopus 로고
    • Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    • Ren G, Zhao X, Zhang L, et al., Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 2010; 184: 2321-2328.
    • (2010) J Immunol , vol.184 , pp. 2321-2328
    • Ren, G.1    Zhao, X.2    Zhang, L.3
  • 19
    • 84858702725 scopus 로고    scopus 로고
    • TNF-alpha increases bone marrow mesenchymal stem cell migration to ischemic tissues
    • Xiao Q, Wang SK, Tian H, et al., TNF-alpha increases bone marrow mesenchymal stem cell migration to ischemic tissues. Cell Biochem Biophys 2012; 62: 409-414.
    • (2012) Cell Biochem Biophys , vol.62 , pp. 409-414
    • Xiao, Q.1    Wang, S.K.2    Tian, H.3
  • 20
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern S, Eichler H, Stoeve J, et al., Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006; 24: 1294-1301.
    • (2006) Stem Cells , vol.24 , pp. 1294-1301
    • Kern, S.1    Eichler, H.2    Stoeve, J.3
  • 21
    • 80052243951 scopus 로고    scopus 로고
    • Establishment of clinically compliant human embryonic stem cells in an autologous feeder-free system
    • Fu X, Toh WS, Liu H, et al., Establishment of clinically compliant human embryonic stem cells in an autologous feeder-free system. Tissue Eng Part C Methods 2011; 17: 927-937.
    • (2011) Tissue Eng Part C Methods , vol.17 , pp. 927-937
    • Fu, X.1    Toh, W.S.2    Liu, H.3
  • 22
  • 23
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • Baksh D, Yao R, Tuan RS,. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2007; 25: 1384-1392.
    • (2007) Stem Cells , vol.25 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 24
    • 77952347589 scopus 로고    scopus 로고
    • Marthiens V, Kazanis I, Moss L et al. Adhesion molecules in the stem cell niche - More than just staying in shape?
    • Marthiens V, Kazanis I, Moss L et al. Adhesion molecules in the stem cell niche-More than just staying in shape? J Cell Sci 2010; 123: 1613-1622.
    • (2010) J Cell Sci , vol.123 , pp. 1613-1622
  • 25
    • 37049021330 scopus 로고    scopus 로고
    • Patterns of laminins and integrins in the embryonic ventricular zone of the CNS
    • Lathia JD, Patton B, Eckley DM, et al., Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol 2007; 505: 630-643.
    • (2007) J Comp Neurol , vol.505 , pp. 630-643
    • Lathia, J.D.1    Patton, B.2    Eckley, D.M.3
  • 26
    • 77951637056 scopus 로고    scopus 로고
    • Characterization of integrin engagement during defined human embryonic stem cell culture
    • Meng Y, Eshghi S, Li YJ, et al., Characterization of integrin engagement during defined human embryonic stem cell culture. FASEB J 2010; 24: 1056-1065.
    • (2010) FASEB J , vol.24 , pp. 1056-1065
    • Meng, Y.1    Eshghi, S.2    Li, Y.J.3
  • 27
    • 33646392969 scopus 로고    scopus 로고
    • Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins
    • Qian H, Tryggvason K, Jacobsen SE, et al., Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins. Blood 2006; 107: 3503-3510.
    • (2006) Blood , vol.107 , pp. 3503-3510
    • Qian, H.1    Tryggvason, K.2    Jacobsen, S.E.3
  • 28
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl J, Eirew P, Ricketson I, et al., Purification and unique properties of mammary epithelial stem cells. Nature 2006; 439: 993-997.
    • (2006) Nature , vol.439 , pp. 993-997
    • Stingl, J.1    Eirew, P.2    Ricketson, I.3
  • 29
    • 0026061509 scopus 로고
    • The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin
    • Cooper HM, Tamura RN, Quaranta V,. The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. J Cell Biol 1991; 115: 843-850.
    • (1991) J Cell Biol , vol.115 , pp. 843-850
    • Cooper, H.M.1    Tamura, R.N.2    Quaranta, V.3
  • 30
    • 0025720737 scopus 로고
    • Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains
    • Tamura RN, Cooper HM, Collo G, et al., Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci USA 1991; 88: 10183-10187.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10183-10187
    • Tamura, R.N.1    Cooper, H.M.2    Collo, G.3
  • 31
    • 0028828282 scopus 로고
    • Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development
    • Thorsteinsdottir S, Roelen BA, Freund E, et al., Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development. Dev Dyn 1995; 204: 240-258.
    • (1995) Dev Dyn , vol.204 , pp. 240-258
    • Thorsteinsdottir, S.1    Roelen, B.A.2    Freund, E.3
  • 32
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal BB., Signalling pathways of the TNF superfamily: A double-edged sword. Nat Rev Immunol 2003; 3: 745-756.
    • (2003) Nat Rev Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 33
    • 84874397559 scopus 로고    scopus 로고
    • TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins
    • Tigges U, Boroujerdi A, Welser-Alves JV, et al., TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins. J Neuroinflammation 2013; 10: 33.
    • (2013) J Neuroinflammation , vol.10 , pp. 33
    • Tigges, U.1    Boroujerdi, A.2    Welser-Alves, J.V.3
  • 34
    • 0036784154 scopus 로고    scopus 로고
    • Role of alpha(v)beta(3)-integrin in TNF-alpha-induced endothelial cell migration
    • Gao B, Saba TM, Tsan MF,. Role of alpha(v)beta(3)-integrin in TNF-alpha-induced endothelial cell migration. Am J Physiol Cell Physiol 2002; 283: C1196-1205.
    • (2002) Am J Physiol Cell Physiol , vol.283 , pp. C1196-C1205
    • Gao, B.1    Saba, T.M.2    Tsan, M.F.3
  • 35
    • 78650966081 scopus 로고    scopus 로고
    • Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging
    • Halfon S, Abramov N, Grinblat B, et al., Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. Stem Cells Dev 2011; 20: 53-66.
    • (2011) Stem Cells Dev , vol.20 , pp. 53-66
    • Halfon, S.1    Abramov, N.2    Grinblat, B.3
  • 36
    • 84874919298 scopus 로고    scopus 로고
    • CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties
    • Yang ZX, Han ZB, Ji YR, et al., CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One 2013; 8: e59354.
    • (2013) PLoS One , vol.8 , pp. e59354
    • Yang, Z.X.1    Han, Z.B.2    Ji, Y.R.3
  • 37
    • 0033846816 scopus 로고    scopus 로고
    • Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis
    • Bruunsgaard H, Skinhoj P, Pedersen AN, et al., Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis. Clin Exp Immunol 2000; 121: 255-260.
    • (2000) Clin Exp Immunol , vol.121 , pp. 255-260
    • Bruunsgaard, H.1    Skinhoj, P.2    Pedersen, A.N.3
  • 38
    • 0031695408 scopus 로고    scopus 로고
    • Loss of laminin and of the laminin receptor integrin subunit alpha 6 in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis
    • Rinaldi N, Barth TF, Weis D, et al., Loss of laminin and of the laminin receptor integrin subunit alpha 6 in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis. Ann Rheum Dis 1998; 57: 559-565.
    • (1998) Ann Rheum Dis , vol.57 , pp. 559-565
    • Rinaldi, N.1    Barth, T.F.2    Weis, D.3
  • 39
    • 0034672148 scopus 로고    scopus 로고
    • Characterization and functional analysis of laminin isoforms in human bone marrow
    • Siler U, Seiffert M, Puch S, et al., Characterization and functional analysis of laminin isoforms in human bone marrow. Blood 2000; 96: 4194-4203.
    • (2000) Blood , vol.96 , pp. 4194-4203
    • Siler, U.1    Seiffert, M.2    Puch, S.3
  • 40
    • 79961138056 scopus 로고    scopus 로고
    • Tumor necrosis factor restricts hematopoietic stem cell activity in mice: Involvement of two distinct receptors
    • Pronk CJ, Veiby OP, Bryder D, et al., Tumor necrosis factor restricts hematopoietic stem cell activity in mice: Involvement of two distinct receptors. J Exp Med 2011; 208: 1563-1570.
    • (2011) J Exp Med , vol.208 , pp. 1563-1570
    • Pronk, C.J.1    Veiby, O.P.2    Bryder, D.3
  • 41
    • 3042616096 scopus 로고    scopus 로고
    • Excessive production of tumor necrosis factor-alpha by bone marrow T lymphocytes is essential in causing bone marrow failure in patients with aplastic anemia
    • Hara T, Ando K, Tsurumi H, et al., Excessive production of tumor necrosis factor-alpha by bone marrow T lymphocytes is essential in causing bone marrow failure in patients with aplastic anemia. Eur J Haematol 2004; 73: 10-16.
    • (2004) Eur J Haematol , vol.73 , pp. 10-16
    • Hara, T.1    Ando, K.2    Tsurumi, H.3
  • 42
    • 34548790066 scopus 로고    scopus 로고
    • Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: Role in homing efficiency in NOD/SCID mice
    • Shi M, Li J, Liao L, et al., Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: Role in homing efficiency in NOD/SCID mice. Haematologica 2007; 92: 897-904.
    • (2007) Haematologica , vol.92 , pp. 897-904
    • Shi, M.1    Li, J.2    Liao, L.3
  • 43
    • 84899462416 scopus 로고    scopus 로고
    • Involvement of TNF-alpha in differential gene expression pattern of CXCR4 on human marrow-derived mesenchymal stem cells
    • Ziaei R, Ayatollahi M, Yaghobi R, et al., Involvement of TNF-alpha in differential gene expression pattern of CXCR4 on human marrow-derived mesenchymal stem cells. Mol Biol Rep 2014; 41: 1059-1066.
    • (2014) Mol Biol Rep , vol.41 , pp. 1059-1066
    • Ziaei, R.1    Ayatollahi, M.2    Yaghobi, R.3
  • 44
    • 0037317032 scopus 로고    scopus 로고
    • Transglutaminases: Crosslinking enzymes with pleiotropic functions
    • Lorand L, Graham RM,. Transglutaminases: Crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 2003; 4: 140-156.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 140-156
    • Lorand, L.1    Graham, R.M.2
  • 45
    • 67650928193 scopus 로고    scopus 로고
    • Tissue transglutaminase promotes or suppresses tumors depending on cell context
    • Chhabra A, Verma A, Mehta K,. Tissue transglutaminase promotes or suppresses tumors depending on cell context. Anticancer Res 2009; 29: 1909-1919.
    • (2009) Anticancer Res , vol.29 , pp. 1909-1919
    • Chhabra, A.1    Verma, A.2    Mehta, K.3
  • 46
    • 78049427740 scopus 로고    scopus 로고
    • Transglutaminase 2: A multi-tasking protein in the complex circuitry of inflammation and cancer
    • Mehta K, Kumar A, Kim HI,. Transglutaminase 2: A multi-tasking protein in the complex circuitry of inflammation and cancer. Biochem Pharmacol 2010; 80: 1921-1929.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1921-1929
    • Mehta, K.1    Kumar, A.2    Kim, H.I.3
  • 47
    • 84899973791 scopus 로고    scopus 로고
    • Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: Role in cancer cell migration
    • Kumar A, Hu J, LaVoie HA, et al., Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: Role in cancer cell migration. BMC Cancer 2014; 14: 256.
    • (2014) BMC Cancer , vol.14 , pp. 256
    • Kumar, A.1    Hu, J.2    LaVoie, H.A.3
  • 48
    • 0035469864 scopus 로고    scopus 로고
    • Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin
    • Akimov SS, Belkin AM,. Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood 2001; 98: 1567-1576.
    • (2001) Blood , vol.98 , pp. 1567-1576
    • Akimov, S.S.1    Belkin, A.M.2
  • 49
    • 0031811115 scopus 로고    scopus 로고
    • TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region
    • Houglum K, Buck M, Kim DJ, et al., TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region. Am J Physiol 1998; 274: G840-847.
    • (1998) Am J Physiol , vol.274 , pp. G840-G847
    • Houglum, K.1    Buck, M.2    Kim, D.J.3
  • 50
    • 0035403504 scopus 로고    scopus 로고
    • Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa
    • Johnson K, Hashimoto S, Lotz M, et al., Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa. Am J Pathol 2001; 159: 149-163.
    • (2001) Am J Pathol , vol.159 , pp. 149-163
    • Johnson, K.1    Hashimoto, S.2    Lotz, M.3
  • 51
    • 0027405028 scopus 로고
    • Expression induced by interleukin-6 of tissue-type transglutaminase in human hepatoblastoma HepG2 cells
    • Suto N, Ikura K, Sasaki R,. Expression induced by interleukin-6 of tissue-type transglutaminase in human hepatoblastoma HepG2 cells. J Biol Chem 1993; 268: 7469-7473.
    • (1993) J Biol Chem , vol.268 , pp. 7469-7473
    • Suto, N.1    Ikura, K.2    Sasaki, R.3
  • 52
    • 84865564723 scopus 로고    scopus 로고
    • IL1beta induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-kappaB
    • Carrero R, Cerrada I, Lledo E, et al., IL1beta induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-kappaB. Stem Cell Rev 2012; 8: 905-916.
    • (2012) Stem Cell Rev , vol.8 , pp. 905-916
    • Carrero, R.1    Cerrada, I.2    Lledo, E.3
  • 53
    • 84879911724 scopus 로고    scopus 로고
    • IFN-gamma and TNF-alpha synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFkappaB signaling
    • Wang L, Zhao Y, Liu Y, et al., IFN-gamma and TNF-alpha synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFkappaB signaling. Stem Cells 2013; 31: 1383-1395.
    • (2013) Stem Cells , vol.31 , pp. 1383-1395
    • Wang, L.1    Zhao, Y.2    Liu, Y.3
  • 54
    • 69249206717 scopus 로고    scopus 로고
    • MTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
    • Castilho RM, Squarize CH, Chodosh LA, et al., mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009; 5: 279-289.
    • (2009) Cell Stem Cell , vol.5 , pp. 279-289
    • Castilho, R.M.1    Squarize, C.H.2    Chodosh, L.A.3
  • 55
    • 84867676626 scopus 로고    scopus 로고
    • The aged niche disrupts muscle stem cell quiescence
    • Chakkalakal JV, Jones KM, Basson MA, et al., The aged niche disrupts muscle stem cell quiescence. Nature 2012; 490: 355-360.
    • (2012) Nature , vol.490 , pp. 355-360
    • Chakkalakal, J.V.1    Jones, K.M.2    Basson, M.A.3
  • 56
    • 65949104286 scopus 로고    scopus 로고
    • MTORC1 signaling governs hematopoietic stem cell quiescence
    • Gan B, DePinho RA,. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 2009; 8: 1003-1006.
    • (2009) Cell Cycle , vol.8 , pp. 1003-1006
    • Gan, B.1    DePinho, R.A.2
  • 57
    • 84904409445 scopus 로고    scopus 로고
    • Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells
    • Gharibi B, Farzadi S, Ghuman M, et al., Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells. Stem Cells 2014; 32: 2256-2266.
    • (2014) Stem Cells , vol.32 , pp. 2256-2266
    • Gharibi, B.1    Farzadi, S.2    Ghuman, M.3
  • 58
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE, DePinho RA,. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007; 8: 703-713.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 59
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • Johnson SC, Rabinovitch PS, Kaeberlein M,. mTOR is a key modulator of ageing and age-related disease. Nature 2013; 493: 338-345.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 60
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Liu Y, et al., mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009; 2: ra75.
    • (2009) Sci Signal , vol.2 , pp. ra75
    • Chen, C.1    Liu, Y.2    Liu, Y.3
  • 61
    • 84862994618 scopus 로고    scopus 로고
    • MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
    • Yilmaz OH, Katajisto P, Lamming DW, et al., mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 2012; 486: 490-495.
    • (2012) Nature , vol.486 , pp. 490-495
    • Yilmaz, O.H.1    Katajisto, P.2    Lamming, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.