메뉴 건너뛰기




Volumn 274, Issue 5 37-5, 1998, Pages

Tnf-α inhibits liver collagen-α1(i) gene expression through a tissue- specific regulatory region

Author keywords

Cachexia; Cytokines; Liver fibrosis; Stellate cells; Transcription

Indexed keywords

COLLAGEN; HUMAN GROWTH HORMONE; MESSENGER RNA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

EID: 0031811115     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.274.5.g840     Document Type: Article
Times cited : (35)

References (54)
  • 1
    • 0026571471 scopus 로고
    • The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-α
    • Alcorn, J. M., J. Fierer, and M. Chojkier. The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-α. Hepatology 15: 122-129, 1992.
    • (1992) Hepatology , vol.15 , pp. 122-129
    • Alcorn, J.M.1    Fierer, J.2    Chojkier, M.3
  • 2
    • 0026721474 scopus 로고
    • Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1β, tumor necrosis factor-α, and transforming growth factor in Ito cells
    • Armendariz-Borunda, J., K. Katayama, and J. M. Seyer. Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1β, tumor necrosis factor-α, and transforming growth factor in Ito cells. J. Biol. Chem. 267: 14316-14321, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14316-14321
    • Armendariz-Borunda, J.1    Katayama, K.2    Seyer, J.M.3
  • 3
    • 0028181393 scopus 로고
    • 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury. A link to tissue fibrosis?
    • 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury. A link to tissue fibrosis? Hepatology 15: 1262-1271, 1994.
    • (1994) Hepatology , vol.15 , pp. 1262-1271
    • Bedossa, P.1    Houglum, K.2    Trautwein, C.3    Holstege, A.4    Chojkier, M.5
  • 5
    • 0025101235 scopus 로고
    • Tumor necrosis factor-α inhibits albumin gene expression in a murine model of cachexia
    • Brenner, D. A., M. Buck, S. P. Feitelberg, and M. Chojkier. Tumor necrosis factor-α inhibits albumin gene expression in a murine model of cachexia. J. Clin. Invest. 85: 248-255, 1990.
    • (1990) J. Clin. Invest. , vol.85 , pp. 248-255
    • Brenner, D.A.1    Buck, M.2    Feitelberg, S.P.3    Chojkier, M.4
  • 6
    • 0024503589 scopus 로고
    • Prolonged activation of jun and collagenase genes by tumor necrosis factor-α
    • Brenner, D. A., M. O'Hara, P. Angel, M. Chojkier, and M. Karin. Prolonged activation of jun and collagenase genes by tumor necrosis factor-α. Nature 337: 661-663, 1989.
    • (1989) Nature , vol.337 , pp. 661-663
    • Brenner, D.A.1    O'Hara, M.2    Angel, P.3    Chojkier, M.4    Karin, M.5
  • 7
    • 0029921173 scopus 로고    scopus 로고
    • Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants
    • Buck, M., and M. Chojkier. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J. 15: 1753-1765, 1996.
    • (1996) EMBO J. , vol.15 , pp. 1753-1765
    • Buck, M.1    Chojkier, M.2
  • 8
    • 0030011283 scopus 로고    scopus 로고
    • 1(I) gene expression and wound healing in a murine model of cachexia
    • 1(I) gene expression and wound healing in a murine model of cachexia. Am. J. Pathol. 149: 195-204, 1996.
    • (1996) Am. J. Pathol. , vol.149 , pp. 195-204
    • Buck, M.1    Houglum, K.2    Chojkier, M.3
  • 9
    • 0028013216 scopus 로고
    • LAP (NF-IL6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation
    • Buck, M., H. Turler, and M. Chojkier. LAP (NF-IL6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation. EMBO J. 13: 851-860, 1994.
    • (1994) EMBO J. , vol.13 , pp. 851-860
    • Buck, M.1    Turler, H.2    Chojkier, M.3
  • 10
    • 0022446673 scopus 로고
    • Hepatocyte collagen production in vivo in normal rats
    • Chojkier, M. Hepatocyte collagen production in vivo in normal rats. J. Clin. Invest. 78: 333-339, 1986.
    • (1986) J. Clin. Invest. , vol.78 , pp. 333-339
    • Chojkier, M.1
  • 11
    • 0028793417 scopus 로고
    • Regulation of liver-specific gene expression
    • edited by J. Boyer and R. Ockner. Orlando, FL: Saunders
    • Chojkier, M. Regulation of liver-specific gene expression. In: Progress in Liver Diseases, edited by J. Boyer and R. Ockner. Orlando, FL: Saunders, 1995, p. 37-61.
    • (1995) Progress in Liver Diseases , pp. 37-61
    • Chojkier, M.1
  • 13
    • 0021087552 scopus 로고
    • Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss
    • Chojkier, M., R. Spanheimer, and B. Peterkofsky. Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. J. Clin. Invest. 72: 826-835, 1983.
    • (1983) J. Clin. Invest. , vol.72 , pp. 826-835
    • Chojkier, M.1    Spanheimer, R.2    Peterkofsky, B.3
  • 14
    • 0030006484 scopus 로고    scopus 로고
    • TNF-α inactivation of collagen receptors
    • Chou, D. H., W. Lee, and C. A. G. McCulloch. TNF-α inactivation of collagen receptors. J. Immunol. 156: 4354-4362, 1996.
    • (1996) J. Immunol. , vol.156 , pp. 4354-4362
    • Chou, D.H.1    Lee, W.2    McCulloch, C.A.G.3
  • 15
    • 0021989344 scopus 로고
    • Fine structural analysis of the human pro-α1(I) collagen gene
    • Chu, M.-L., W. deWet, M. Bernard, and F. Ramirez. Fine structural analysis of the human pro-α1(I) collagen gene. J. Biol. Chem. 260: 2315-2320, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 2315-2320
    • Chu, M.-L.1    DeWet, W.2    Bernard, M.3    Ramirez, F.4
  • 16
    • 0023234619 scopus 로고
    • Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels
    • Davis, B. H., B. M. Pratt, and J. A. Madri. Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels. J. Biol. Chem. 262: 10280-10286, 1987.
    • (1987) J. Biol. Chem. , vol.262 , pp. 10280-10286
    • Davis, B.H.1    Pratt, B.M.2    Madri, J.A.3
  • 17
    • 0022296893 scopus 로고
    • 2 production by human synovial cells and dermal fibroblasts
    • 2 production by human synovial cells and dermal fibroblasts. J. Exp. Med. 162: 2163-2168, 1985.
    • (1985) J. Exp. Med. , vol.162 , pp. 2163-2168
    • Dayer, J.M.1    Beutler, B.2    Cerami, A.3
  • 18
    • 0025062982 scopus 로고
    • LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein
    • Descombes, P., M. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4: 1541-1551, 1990.
    • (1990) Genes Dev. , vol.4 , pp. 1541-1551
    • Descombes, P.1    Chojkier, M.2    Lichtsteiner, S.3    Falvey, E.4    Schibler, U.5
  • 19
    • 0025806153 scopus 로고
    • How are the regulators regulated?
    • Falvey, E., and U. Schibler. How are the regulators regulated? FASEB J. 5: 309-314, 1991.
    • (1991) FASEB J. , vol.5 , pp. 309-314
    • Falvey, E.1    Schibler, U.2
  • 20
    • 0024314801 scopus 로고
    • Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
    • Friedman, S. L., F. J. Roll, J. Boyles, D. M. Arenson, and D. M. Bissell. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J. Biol. Chem. 264: 10756-10762, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 10756-10762
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Arenson, D.M.4    Bissell, D.M.5
  • 21
    • 0001572310 scopus 로고
    • Fat-storing (Ito) cell biology
    • edited by I. M. Arias, T. Boyer, N. Fausto, W. Jakoby, D. Schachter, and D. A. Shafritz. New York: Raven
    • Geerts, A., P. De Bleser, M. L. Hautekeete, T. Niki, and E. Wisse. Fat-storing (Ito) cell biology. In: The Liver: Biology and Pathobiology, edited by I. M. Arias, T. Boyer, N. Fausto, W. Jakoby, D. Schachter, and D. A. Shafritz. New York: Raven, 1994, p. 819-838.
    • (1994) The Liver: Biology and Pathobiology , pp. 819-838
    • Geerts, A.1    De Bleser, P.2    Hautekeete, M.L.3    Niki, T.4    Wisse, E.5
  • 23
    • 0028795386 scopus 로고
    • Induction of an acute phase response in rats stimulates the expression of α1(1) procollagen messenger ribonucleic acid in their livers
    • Greenwel, P., M. J. Iraburu, M. Reyes-Romero, N. Merza-Cruz, E. Casado, J. A. Solis-Herruzo, and M. Rojkind. Induction of an acute phase response in rats stimulates the expression of α1(1) procollagen messenger ribonucleic acid in their livers. Lab. Invest. 72: 83-91, 1995.
    • (1995) Lab. Invest. , vol.72 , pp. 83-91
    • Greenwel, P.1    Iraburu, M.J.2    Reyes-Romero, M.3    Merza-Cruz, N.4    Casado, E.5    Solis-Herruzo, J.A.6    Rojkind, M.7
  • 24
    • 0028876152 scopus 로고
    • Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells
    • Gressner, A. M., B. Lahme, and A. Brenzel. Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells. Hepatology 22: 1507-1518, 1995.
    • (1995) Hepatology , vol.22 , pp. 1507-1518
    • Gressner, A.M.1    Lahme, B.2    Brenzel, A.3
  • 27
    • 0030934866 scopus 로고    scopus 로고
    • Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on Serine 133
    • Houglum, K., K. S. Lee, and M. Chojkier. Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on Serine 133. J. Clin. Invest. 99: 1322-1389, 1997.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1322-1389
    • Houglum, K.1    Lee, K.S.2    Chojkier, M.3
  • 28
    • 0028176086 scopus 로고
    • Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site
    • Inagaki, Y., S. Truter, and F. Ramirez. Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J. Biol. Chem. 269: 14828-14834, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14828-14834
    • Inagaki, Y.1    Truter, S.2    Ramirez, F.3
  • 29
    • 0028850885 scopus 로고
    • Overlapping pathways mediate the opposing actions of tumor necrosis factor-α and transforming growth factor-β on α2(I) collagen gene transcription
    • Inagaki, Y., S. Truter, S. Tanaka, M. DiLiberto, and F. Ramirez. Overlapping pathways mediate the opposing actions of tumor necrosis factor-α and transforming growth factor-β on α2(I) collagen gene transcription. J. Biol. Chem. 270: 3353-3358, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3353-3358
    • Inagaki, Y.1    Truter, S.2    Tanaka, S.3    DiLiberto, M.4    Ramirez, F.5
  • 30
    • 0010111937 scopus 로고
    • Extracellular matrix and the development of tissue architecture: A mechanochemical perspective
    • edited by M. Zern and L. Reid. New York: Dekker
    • Ingber, D. E. Extracellular matrix and the development of tissue architecture: a mechanochemical perspective. In: Extracellular Matrix, edited by M. Zern and L. Reid. New York: Dekker, 1993, p. 403-428.
    • (1993) Extracellular Matrix , pp. 403-428
    • Ingber, D.E.1
  • 31
    • 0023696096 scopus 로고
    • Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome
    • Lahdevirta, J., C. P. Maury, A. Teppo, and H. Repo. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am. J. Med. 85: 289-291, 1988.
    • (1988) Am. J. Med. , vol.85 , pp. 289-291
    • Lahdevirta, J.1    Maury, C.P.2    Teppo, A.3    Repo, H.4
  • 32
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGF-α and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee, K. S., M. Buck, K. Houglum, and M. Chojkier. Activation of hepatic stellate cells by TGF-α and collagen type I is mediated by oxidative stress through c-myb expression. J. Clin. Invest. 96: 2461-2468, 1995.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 33
    • 0025756330 scopus 로고
    • Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
    • Lewis, M., L. A. Tartaglia, A. Lee, G. L. Bennett, G. C. Rice, G. H. W. Wong, E. Y. Chen, and D. V. Goeddel. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA 88: 2830-2834, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2830-2834
    • Lewis, M.1    Tartaglia, L.A.2    Lee, A.3    Bennett, G.L.4    Rice, G.C.5    Wong, G.H.W.6    Chen, E.Y.7    Goeddel, D.V.8
  • 34
    • 0028174348 scopus 로고
    • Cell-specific expression of α1(I) collagen-hGH minigenes in transgenic mice
    • Liska, D. J., M. J. Reed, E. H. Sage, and P. Bornstein. Cell-specific expression of α1(I) collagen-hGH minigenes in transgenic mice. J. Cell Biol. 125: 695-704, 1994.
    • (1994) J. Cell Biol. , vol.125 , pp. 695-704
    • Liska, D.J.1    Reed, M.J.2    Sage, E.H.3    Bornstein, P.4
  • 35
    • 0025429160 scopus 로고
    • A highly conserved intronic sequence is involved in transcriptional regulation of the α1(I) collagen gene
    • Liska, D. J., J. L. Slack, and P. Bornstein. A highly conserved intronic sequence is involved in transcriptional regulation of the α1(I) collagen gene. Cell Regul. 1: 487-498, 1990.
    • (1990) Cell Regul. , vol.1 , pp. 487-498
    • Liska, D.J.1    Slack, J.L.2    Bornstein, P.3
  • 37
    • 0027316151 scopus 로고
    • Deficiencies in collagen phagocytosis by human fibroblasts in vitro: A mechanism for fibrosis?
    • McCulloch, C. A. G., and G. C. Knowles. Deficiencies in collagen phagocytosis by human fibroblasts in vitro: a mechanism for fibrosis? J. Cell. Physiol. 155: 461-471, 1993.
    • (1993) J. Cell. Physiol. , vol.155 , pp. 461-471
    • McCulloch, C.A.G.1    Knowles, G.C.2
  • 38
    • 0029114675 scopus 로고
    • Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis
    • Miyazaki, Y., K. Araki, C. Vesin, I. Garcia, Y. Kapanci, J. A. Whitsett, P. F. Piguet, and P. Vassalli. Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J. Clin. Invest. 96: 250-259, 1995.
    • (1995) J. Clin. Invest. , vol.96 , pp. 250-259
    • Miyazaki, Y.1    Araki, K.2    Vesin, C.3    Garcia, I.4    Kapanci, Y.5    Whitsett, J.A.6    Piguet, P.F.7    Vassalli, P.8
  • 39
    • 0020318439 scopus 로고
    • Structure of wild-type and mutant mouse β2-microglobulin genes
    • Parnes, J. R., and J. G. Seidman. Structure of wild-type and mutant mouse β2-microglobulin genes. Cell 29: 661-669, 1982.
    • (1982) Cell , vol.29 , pp. 661-669
    • Parnes, J.R.1    Seidman, J.G.2
  • 40
    • 0342501533 scopus 로고
    • Coordinate regulation of cartilage collagen and proteoglycan synthesis in scorbutic guinea pig
    • edited by A. Sen and T. Phornhill. New York: Liss
    • Peterkofsky, B., R. G. Spanheimer, and T. A. Bird. Coordinate regulation of cartilage collagen and proteoglycan synthesis in scorbutic guinea pig. In: Development and Diseases of Cartilage and Bone Matrix, edited by A. Sen and T. Phornhill. New York: Liss, 1987, p. 33-43.
    • (1987) Development and Diseases of Cartilage and Bone Matrix , pp. 33-43
    • Peterkofsky, B.1    Spanheimer, R.G.2    Bird, T.A.3
  • 41
    • 0024414604 scopus 로고
    • Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis
    • Piguet, P. F., M. A. Collart, G. E. Grau, Y. Kapanci, and P. Vassalli. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170: 655-663, 1989.
    • (1989) J. Exp. Med. , vol.170 , pp. 655-663
    • Piguet, P.F.1    Collart, M.A.2    Grau, G.E.3    Kapanci, Y.4    Vassalli, P.5
  • 42
    • 0025211892 scopus 로고
    • Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis
    • Piguet, P. F., M. A. Collart, G. E. Grau, A. P. Sappino, and P. Vassalli. Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis. Nature 344: 245-247, 1990.
    • (1990) Nature , vol.344 , pp. 245-247
    • Piguet, P.F.1    Collart, M.A.2    Grau, G.E.3    Sappino, A.P.4    Vassalli, P.5
  • 43
    • 0025779161 scopus 로고
    • A fibroblast-specific factor binds to an upstream negative control element in the promoter of the mouse α1(I) collagen gene
    • Ravazzolo, R., G. Karsenty, and B. de Crombrugghe. A fibroblast-specific factor binds to an upstream negative control element in the promoter of the mouse α1(I) collagen gene. J. Biol. Chem. 266: 7382-7387, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7382-7387
    • Ravazzolo, R.1    Karsenty, G.2    De Crombrugghe, B.3
  • 44
    • 0029097265 scopus 로고
    • Sp1 binding activity increases in activated Ito cells
    • Rippe, R. A., G. Almounajed, and D. Brenner. Sp1 binding activity increases in activated Ito cells. Hepatology 22: 241-251, 1995.
    • (1995) Hepatology , vol.22 , pp. 241-251
    • Rippe, R.A.1    Almounajed, G.2    Brenner, D.3
  • 45
    • 0026076135 scopus 로고
    • Transforming-growth-factor-β activation elements in the distal promoter regions of the rat α1-type I collagen gene
    • Ritzenthaler, J. D., R. H. Goldstein, A. Fine, A. Lichtler, D. W. Rowe, and B. D. Smith. Transforming-growth-factor-β activation elements in the distal promoter regions of the rat α1-type I collagen gene. Biochem. J. 280: 157-162, 1991.
    • (1991) Biochem. J. , vol.280 , pp. 157-162
    • Ritzenthaler, J.D.1    Goldstein, R.H.2    Fine, A.3    Lichtler, A.4    Rowe, D.W.5    Smith, B.D.6
  • 46
    • 0027378273 scopus 로고
    • Regulation of the α1(I) collagen promoter via a transforming growth factor-β activation element
    • Ritzenthaler, J. D., R. H. Goldstein, A. Fine, and B. D. Smith. Regulation of the α1(I) collagen promoter via a transforming growth factor-β activation element. J. Biol. Chem. 268: 13625-13631, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13625-13631
    • Ritzenthaler, J.D.1    Goldstein, R.H.2    Fine, A.3    Smith, B.D.4
  • 47
    • 0023856558 scopus 로고
    • A nuclear factor I binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β
    • Rossi, P., G. Karsenty, A. B. Roberts, N. S. Roche, M. B. Sporn, and B. de Crombrugghe. A nuclear factor I binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β. Cell 52: 405-414, 1988.
    • (1988) Cell , vol.52 , pp. 405-414
    • Rossi, P.1    Karsenty, G.2    Roberts, A.B.3    Roche, N.S.4    Sporn, M.B.5    De Crombrugghe, B.6
  • 50
    • 0023931034 scopus 로고
    • Tumor necrosis factor-α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts
    • Solis-Herruzo, J. A., D. A. Brenner, and M. Chojkier. Tumor necrosis factor-α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J. Biol. Chem. 263: 5841-5845, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5841-5845
    • Solis-Herruzo, J.A.1    Brenner, D.A.2    Chojkier, M.3
  • 51
    • 0021964893 scopus 로고
    • A specific decrease in collagen synthesis in acutely fasted, vitamin C-supplemented, guinea pigs
    • Spanheimer, R. G., and B. Peterkofsky. A specific decrease in collagen synthesis in acutely fasted, vitamin C-supplemented, guinea pigs. J. Biol. Chem. 260: 3955-3962, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3955-3962
    • Spanheimer, R.G.1    Peterkofsky, B.2
  • 53
    • 0027333425 scopus 로고
    • Tumor necrosis factor, other cytokines and disease
    • Tracey, K. J., and A. Cerami. Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol. 9: 317-343, 1993.
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 317-343
    • Tracey, K.J.1    Cerami, A.2
  • 54
    • 0023094408 scopus 로고
    • Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease
    • Waage, A., A. Halstensen, and T. Espevik. Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1: 355-357, 1987.
    • (1987) Lancet , vol.1 , pp. 355-357
    • Waage, A.1    Halstensen, A.2    Espevik, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.