-
1
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
Hideshima, T., et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci USA 102, 8567-8572, doi: 10.1073/pnas.0503221102 (2005
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8567-8572
-
-
Hideshima, T.1
-
2
-
-
33751172982
-
Aggresome induction by proteasome inhibitor bortezomib and alpha-Tubulin hyperacetylation by tubulin deacetylase (tdac) inhibitor lbh589 are synergistic in myeloma cells
-
Catley, L., et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-Tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 108, 3441-3449, doi: 10.1182/blood-2006-04-016055 (2006
-
(2006)
Blood
, vol.108
, pp. 3441-3449
-
-
Catley, L.1
-
3
-
-
77953937449
-
The pan-hdac inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human dlbcl cells in vitro and in vivo
-
Dasmahapatra, G., et al. The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood 115, 4478-4487, doi: 10.1182/blood-2009-12-257261 (2010
-
(2010)
Blood
, vol.115
, pp. 4478-4487
-
-
Dasmahapatra, G.1
-
4
-
-
84876053292
-
Mcl-1 and fbw7 control a dominant survival pathway underlying hdac and bcl-2 inhibitor synergy in squamous cell carcinoma
-
He, L., et al. Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma. Cancer Discov 3, 324-337, doi: 10.1158/2159-8290.cd-12-0417 (2013
-
(2013)
Cancer Discov
, vol.3
, pp. 324-337
-
-
He, L.1
-
5
-
-
84871822817
-
Vorinostat, an hdac inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mtor signaling pathway in a human xenograft murine model
-
Kurundkar, D., et al. Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicol Appl Pharmacol 266, 233-244, doi: 10.1016/j. taap.2012.11.002 (2013
-
(2013)
Toxicol Appl Pharmacol
, vol.266
, pp. 233-244
-
-
Kurundkar, D.1
-
6
-
-
84871433034
-
Positive and negative regulation of podoplanin expression by tgf-beta and histone deacetylase inhibitors in oral and pharyngeal squamous cell carcinoma cell lines
-
Ohta, M., et al. Positive and negative regulation of podoplanin expression by TGF-beta and histone deacetylase inhibitors in oral and pharyngeal squamous cell carcinoma cell lines. Oral Oncol 49, 20-26, doi: 10.1016/j.oraloncology.2012.06.017 (2013
-
(2013)
Oral Oncol
, vol.49
, pp. 20-26
-
-
Ohta, M.1
-
7
-
-
40849135481
-
The sirtuin family: Therapeutic targets to treat diseases of aging
-
Milne, J. C. & Denu, J. M. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12, 11-17, doi: 10.1016/j.cbpa.2008.01.019 (2008
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 11-17
-
-
Milne, J.C.1
Denu, J.M.2
-
8
-
-
62149085241
-
Pharmaceutical strategies for activating sirtuins
-
Sauve, A. A. Pharmaceutical strategies for activating sirtuins. Curr Pharm Des 15, 45-56 (2009
-
(2009)
Curr Pharm des
, vol.15
, pp. 45-56
-
-
Sauve, A.A.1
-
9
-
-
77958488312
-
Sirt1 activation by small molecules: Kinetic and biophysical evidence for direct interaction of enzyme and activator
-
Dai, H., et al. SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem 285, 32695-32703, doi: 10.1074/jbc.M110.133892 (2010
-
(2010)
J Biol Chem
, vol.285
, pp. 32695-32703
-
-
Dai, H.1
-
10
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
Haigis, M. C. & Sinclair, D. A. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5, 253-295, doi: 10.1146/annurev.pathol.4.110807.092250 (2010
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
11
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating sirt1 and pgc-1 alpha
-
Lagouge, M., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha. Cell 127, 1109-1122, doi: 10.1016/j.cell.2006.11.013 (2006
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
-
12
-
-
0034677535
-
Transcriptional silencing and longevity protein sir2 is an naddependent histone deacetylase
-
Imai, S., Armstrong, C. M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NADdependent histone deacetylase. Nature 403, 795-800, doi: 10.1038/35001622 (2000
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
13
-
-
0037066738
-
Conserved enzymatic production and biological effect of o-Acetyl-Adp-ribose by silent information regulator 2-like nad+-dependent deacetylases
-
Borra, M. T., et al. Conserved enzymatic production and biological effect of O-Acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem 277, 12632-12641, doi: 10.1074/jbc.M111830200 (2002
-
(2002)
J Biol Chem
, vol.277
, pp. 12632-12641
-
-
Borra, M.T.1
-
14
-
-
0037166269
-
Structural identification of 2?-And 3?-o-Acetyl-Adp-ribose as novel metabolites derived from the sir2 family of beta-nad+-dependent histone/protein deacetylases
-
Jackson, M. D. & Denu, J. M. Structural identification of 2?-And 3?-O-Acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta-NAD+-dependent histone/protein deacetylases. J Biol Chem 277, 18535-18544, doi: 10.1074/jbc.M200671200 (2002
-
(2002)
J Biol Chem
, vol.277
, pp. 18535-18544
-
-
Jackson, M.D.1
Denu, J.M.2
-
15
-
-
3242719545
-
Modulation of nf-kappab-dependent transcription and cell survival by the sirt1 deacetylase
-
Yeung, F., et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23, 2369-2380, doi: 10.1038/sj.emboj.7600244 (2004
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
-
16
-
-
27244435939
-
Mammalian sirt1 limits replicative life span in response to chronic genotoxic stress
-
Chua, K. F., et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2, 67-76, doi: 10.1016/j.cmet.2005.06.007 (2005
-
(2005)
Cell Metab
, vol.2
, pp. 67-76
-
-
Chua, K.F.1
-
17
-
-
44849096876
-
The sirt1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein, R., et al. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3, e2020, doi: 10.1371/journal.pone.0002020 (2008
-
(2008)
PLoS One
, vol.3
, pp. e2020
-
-
Firestein, R.1
-
18
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in sirt1 mutant mice
-
Wang, R. H., et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14, 312-323, doi: 10.1016/j.ccr.2008.09.001 (2008
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
-
19
-
-
28544444366
-
Cancer-specific functions of sirt1 enable human epithelial cancer cell growth and survival
-
Ford, J., Jiang, M. & Milner, J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 65, 10457-10463, doi: 10.1158/0008-5472.can-05-1923 (2005
-
(2005)
Cancer Res
, vol.65
, pp. 10457-10463
-
-
Ford, J.1
Jiang, M.2
Milner, J.3
-
20
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg, B., et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66, 4368-4377, doi: 10.1158/0008-5472.can-05-3617 (2006
-
(2006)
Cancer Res
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
-
21
-
-
30544445468
-
Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated ras-mapk signaling in human cancer cells
-
Ota, H., et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25, 176-185, doi: 10.1038/sj.onc.1209049 (2006
-
(2006)
Oncogene
, vol.25
, pp. 176-185
-
-
Ota, H.1
-
22
-
-
84894768842
-
A critical re-Assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma
-
Do, H., et al. A critical re-Assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. Scientific reports 4, 4186, doi: 10.1038/srep04186 (2014
-
(2014)
Scientific Reports
, vol.4
, Issue.4186
-
-
Do, H.1
-
23
-
-
84862852344
-
Sirt1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (pauf), a novel oncogene, by suppression of beta-catenin
-
Cho, I. R., et al. SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of beta-catenin. Biochem Biophys Res Commun 423, 270-275, doi: 10.1016/j.bbrc.2012.05.107 (2012
-
(2012)
Biochem Biophys Res Commun
, vol.423
, pp. 270-275
-
-
Cho, I.R.1
-
24
-
-
84926370059
-
Novel role of mitochondrial manganese superoxide dismutase in stat3 dependent pluripotency of mouse embryonic stem cells
-
Sheshadri, P., et al. Novel Role of Mitochondrial Manganese Superoxide Dismutase in STAT3 Dependent Pluripotency of Mouse Embryonic Stem Cells. Scientific reports 5, 9516, doi: 10.1038/srep09516 (2015
-
(2015)
Scientific Reports
, vol.5
, Issue.9516
-
-
Sheshadri, P.1
-
25
-
-
84934321954
-
Oral intake of curcumin markedly activated CYP 3a4: In vivo and ex-vivo studies
-
Hsieh, Y. W., et al. Oral intake of curcumin markedly activated CYP 3A4: in vivo and ex-vivo studies. Scientific reports 4, 6587, doi: 10.1038/srep06587 (2014
-
(2014)
Scientific Reports
, vol.4
, pp. 6587
-
-
Hsieh, Y.W.1
-
26
-
-
85043218169
-
Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of jak-2/stat-3 signaling pathway
-
Hu, A., et al. Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling pathway. American journal of cancer research 5, 278-288 (2015
-
(2015)
American Journal of Cancer Research
, vol.5
, pp. 278-288
-
-
Hu, A.1
-
27
-
-
81155148158
-
Preclinical evaluation of a novel sirt1 modulator srt1720 in multiple myeloma cells
-
Chauhan, D., et al. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. British journal of haematology 155, 588-598, doi: 10.1111/j.1365-2141.2011.08888.x (2011
-
(2011)
British Journal of Haematology
, vol.155
, pp. 588-598
-
-
Chauhan, D.1
-
28
-
-
33748899449
-
Transcoronary transplantation of progenitor cells after myocardial infarction
-
Assmus, B., et al. Transcoronary transplantation of progenitor cells after myocardial infarction. The New England journal of medicine 355, 1222-1232, doi: 10.1056/NEJMoa051779 (2006
-
(2006)
The New England Journal of Medicine
, vol.355
, pp. 1222-1232
-
-
Assmus, B.1
-
29
-
-
84940192849
-
Angptl2 increases bone metastasis of breast cancer cells through enhancing cxcr4 signaling
-
Masuda, T., et al. ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling. Scientific reports 5, 9170, doi: 10.1038/srep09170 (2015
-
(2015)
Scientific Reports
, vol.5
, Issue.9170
-
-
Masuda, T.1
-
30
-
-
84912079125
-
Angiogenesis effect of therapeutic ultrasound on ischemic hind limb in mice
-
Huang, J. J., et al. Angiogenesis effect of therapeutic ultrasound on ischemic hind limb in mice. American journal of translational research 6, 703-713 (2014
-
(2014)
American Journal of Translational Research
, vol.6
, pp. 703-713
-
-
Huang, J.J.1
-
31
-
-
77958055646
-
Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of ikk beta protein of the nf kappa b pathway
-
Duarte, V. M., et al. Curcumin Enhances the Effect of Cisplatin in Suppression of Head and Neck Squamous Cell Carcinoma via Inhibition of IKK beta Protein of the NF kappa B Pathway. Molecular Cancer Therapeutics 9, 2665-2675 (2010
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, pp. 2665-2675
-
-
Duarte, V.M.1
-
32
-
-
83055172870
-
Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma scc-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways
-
Ip, S. W., et al. Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways. Cell Biochemistry\s & \sfunction 29, 641-650 (2011
-
(2011)
Cell Biochemistry\s & \Sfunction
, vol.29
, pp. 641-650
-
-
Ip, S.W.1
-
33
-
-
33747470228
-
Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane
-
Chakravarti, N. Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). International Journal of Cancer 119, 1268-1275 (2006
-
(2006)
International Journal of Cancer
, vol.119
, pp. 1268-1275
-
-
Chakravarti, N.1
-
34
-
-
77949736603
-
Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells
-
Chakravarti, N., et al. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prevention Research 3, 331-338 (2010
-
(2010)
Cancer Prevention Research
, vol.3
, pp. 331-338
-
-
Chakravarti, N.1
-
35
-
-
84860315306
-
Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis
-
Masuelli, L., et al. Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis. Front Biosci 17, 498-508 (2012
-
(2012)
Front Biosci
, vol.17
, pp. 498-508
-
-
Masuelli, L.1
-
36
-
-
84916938355
-
Resveratrol potentiates the in vitro and in vivo anti-Tumoral effects of curcumin in head and neck carcinomas
-
Masuelli, L., et al. Resveratrol potentiates the in vitro and in vivo anti-Tumoral effects of curcumin in head and neck carcinomas. Oncotarget 5, 10745-10762 (2014
-
(2014)
Oncotarget
, vol.5
, pp. 10745-10762
-
-
Masuelli, L.1
-
37
-
-
84861852370
-
Are sirtuins viable targets for improving healthspan and lifespan? Nature reviews
-
Baur, J. A., Ungvari, Z., Minor, R. K., Le Couteur, D. G. & de Cabo, R. Are sirtuins viable targets for improving healthspan and lifespan? Nature reviews. Drug discovery 11, 443-461, doi: 10.1038/nrd3738 (2012
-
(2012)
Drug Discovery
, vol.11
, pp. 443-461
-
-
Baur, J.A.1
Ungvari, Z.2
Minor, R.K.3
Le Couteur, D.G.4
De Cabo, R.5
-
38
-
-
0037236792
-
Anticancer potential of curcumin: Preclinical and clinical studies
-
Aggarwal, B. B., Kumar, A. & Bharti, A. C. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer research 23, 363-398 (2003
-
(2003)
Anticancer Research
, vol.23
, pp. 363-398
-
-
Aggarwal, B.B.1
Kumar, A.2
Bharti, A.C.3
-
39
-
-
79952554406
-
Inhibitory effect of curcumin on oral carcinoma cal27 cells via suppression of notch1 and nf? B signaling pathways
-
Liao, S., et al. Inhibitory effect of curcumin on oral carcinoma CAL27 cells via suppression of Notch1 and NF? B signaling pathways. Journal of Cellular Biochemistry 112, 1055-1065 (2011
-
(2011)
Journal of Cellular Biochemistry
, vol.112
, pp. 1055-1065
-
-
Liao, S.1
-
40
-
-
33646028804
-
Molecular targets of dietary agents for prevention and therapy of cancer
-
Aggarwal, B. B. & Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical Pharmacology 71, 1397-1421 (2006
-
(2006)
Biochemical Pharmacology
, vol.71
, pp. 1397-1421
-
-
Aggarwal, B.B.1
Shishodia, S.2
-
41
-
-
84876549277
-
Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the il-6/stat3 and pdgf-bb/pdgfr pathways
-
Yu, Y. C., et al. Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways. Scientific reports 3, 1675, doi: 10.1038/srep01675 (2013
-
(2013)
Scientific Reports
, vol.3
, Issue.1675
-
-
Yu, Y.C.1
-
42
-
-
84882409064
-
Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of mdr1 and reactive oxygen species in cisplatin-resistant car human oral cancer cells
-
1110)
-
Chang, P. Y. Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. International Journal of Oncology 43, 1141-1150(1110) (2013
-
(2013)
International Journal of Oncology
, vol.43
, pp. 1141-1150
-
-
Chang, P.Y.1
-
43
-
-
84907865261
-
Chemoprevention of head and neck squamous cell carcinoma through inhibition of nf-? B signaling
-
Vander, B. R., Snow, G. E., Chen, Z. & Van, W. C. Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-? B signaling. Oral Oncology 50, 930-941 (2014
-
(2014)
Oral Oncology
, vol.50
, pp. 930-941
-
-
Vander, B.R.1
Snow, G.E.2
Chen, Z.3
Van, W.C.4
-
44
-
-
18544367201
-
Nf-kappa b as a therapeutic target in multiple myeloma
-
Hideshima, T., et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 277, 16639-16647, doi: 10.1074/jbc. M200360200 (2002
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
-
45
-
-
84922658820
-
Antinociceptive effects of curcumin in a rat model of postoperative pain
-
Zhu, Q., et al. Antinociceptive effects of curcumin in a rat model of postoperative pain. Scientific reports 4, 4932, doi: 10.1038/srep04932 (2014
-
(2014)
Scientific Reports
, vol.4
, Issue.4932
-
-
Zhu, Q.1
|