Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of notch-1 and NF-κB signaling pathways

Journal of Cellular Biochemistry

Volumn 112, Issue 4, 2011, Pages 1055-1065

  Liao, Shengkai ^a   Xia, Jun ^a   Chen, Zhiwen ^a   Zhang, Shunhua ^a   Ahmad, Aamir ^b   Miele, Lucio ^c   Sarkar, Fazlul H ^b   Wang, Zhiwei ^b,d  

^a BENGBU MEDICAL COLLEGE   (China)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d NONE   (United States)

Author keywords

Curcumin; NF k B; Notch 1 signaling pathway; Oral cancer

Indexed keywords

CURCUMIN; CYCLIN D1; GELATINASE B; HER 5 PROTEIN; HEY 1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH1 RECEPTOR; PROTEIN; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INVASION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUTH CARCINOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 9; MOUTH NEOPLASMS; NF-KAPPA B; RECEPTOR, NOTCH1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79952554406     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23019     Document Type: Article

References (36)

1. Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB. 2004. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int J Cancer 111:679-692. (Pubitemid 39062889)
2. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. 2008. Curcumin and cancer: An "old-age" disease with an "age-old" solution. Cancer Lett 267:133-164.
3. Bollrath J, Greten FR. 2009. IKK/NF-kappaB and STAT3 pathways: Central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep 10:1314-1319.
4. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. 2003. Regulation of matrix metalloproteinases: An overview. Mol Cell Biochem 253:269-285.
5. Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. 2010. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prev Res (Phila Pa) 3:331-338.
6. Chang KW, Hung PS, Lin IY, Hou CP, Chen LK, Tsai YM, Lin SC. 2010. Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression. Int J Cancer 127:9-20.
7. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. 2008. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci 65:1631-1652.
8. Hijioka H, Setoguchi T, Miyawaki A, Gao H, Ishida T, Komiya S, Nakamura N. 2010. Upregulation of Notch pathway molecules in oral squamous cell carcinoma. Int J Oncol 36:817-822.
9. Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD. 1996. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol 16:952-959. (Pubitemid 26061666)
10. Jemal A, Siegel R, Xu J, Ward E. 2010. Cancer statistics, 2010. CA Cancer J Clin 60:277-300.
11. Jiang L, Ji N, Zhou Y, Li J, Liu X, Wang Z, Chen Q, Zeng X. 2009. CAL 27 is an oral adenosquamous carcinoma cell line. Oral Oncol 45:e204-e207.
12. Joo YH, Jung CK, Kim MS, Sun DI. 2009. Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer. Otolaryngol Head Neck Surg 140:512-518.
13. Kong D, Banerjee S, Ahmad A, Li Y, Wang Z, Sethi S, Sarkar FH. 2010. Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS ONE 5:e12445.
14. Kopan R, Ilagan MX. 2009. The canonical Notch signaling pathway: Unfolding the activation mechanism. Cell 137:216-233.
15. Kunnumakkara AB, Anand P, Aggarwal BB. 2008. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269:199-225.
16. Li N, Chen X, Liao J, Yang G, Wang S, Josephson Y, Han C, Chen J, Huang MT, Yang CS. 2002. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis 23:1307-1313.
17. LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES, Wang MB. 2005. Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res 11:6994-7002. (Pubitemid 41428759)
18. Miele L. 2006. Notch signaling. Clin Cancer Res 12:1074-1079. (Pubitemid 43342494)
19. Miele L, Osborne B. 1999. Arbiter of differentiation and death: Notch signaling meets apoptosis. J Cell Physiol 181:393-409. (Pubitemid 29513408)
20. Prasad S, Ravindran J, Aggarwal BB. 2010. NF-kappaB and cancer: How intimate is this relationship. Mol Cell Biochem 336:25-37.
21. Ravindran J, Prasad S, Aggarwal BB. 2009. Curcumin and cancer cells: How many ways can curry kill tumor cells selectively? AAPS J 11:495-510.
22. Sarkar FH, Li Y, Wang Z, Padhye S. 2010. Lesson learned from nature for the development of novel anti-cancer agents: Implication of isoflavone, curcumin, and their synthetic analogs. Curr Pharm Des 16:1801-1812.
23. Shin HK, Kim J, Lee EJ, Kim SH. 2010. Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD-10B cells via suppression of ERK and NF-kappaB activations. Phytother Res 24:577-582.
24. Stan SD, Singh SV, Brand RE. 2010. Chemoprevention strategies for pancreatic cancer. Nat Rev Gastroenterol Hepatol 7:347-356.
25. Strimpakos AS, Sharma RA. 2008. Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 10:511-545.
26. Takahashi H, Shibuya M. 2005. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) 109:227-241.
27. Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH. 2006a. Down-regulation of Notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 66:2778-2784.
28. Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. 2006b. Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 106:2503-2513. (Pubitemid 43787677)
29. Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. 2006c. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 5:483-493.
30. Wang Z, Li Y, Banerjee S, Sarkar FH. 2008. Exploitation of the Notch signaling pathway as a novel target for cancer therapy. Anticancer Res 28:3621-3630.
31. Wang Z, Azmi AS, Ahmad A, Banerjee S, Wang S, Sarkar FH, Mohammad RM. 2009. TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: Involvement of Notch-1 signaling pathway. Cancer Res 69:2757-2765.
32. Wang Z, Li Y, Banerjee S, Kong D, Ahmad A, Nogueira V, Hay N, Sarkar FH. 2010a. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J Cell Biochem 109:726-736.
33. Wang Z, Li Y, Kong D, Sarkar FH. 2010b. The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness. Curr Drug Targets 11:745-751.
34. Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L. 2002. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 8:979-986. (Pubitemid 35033702)
35. Yao J, Duan L, Fan M, Wu X. 2007. Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells. Oral Dis 13:555-563. (Pubitemid 47609890)
36. Yoon JH, Kim SA, Kwon SM, Park JH, Park HS, Kim YC, Yoon JH, Ahn SG. 2010. 50-Nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling. Biochim Biophys Acta 1800:352-358.