Aging is not a disease: Implications for intervention

Aging and Disease

Volumn 5, Issue 3, 2014, Pages 196-202

  Rattan, Suresh I S ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Homeodynamics; Homeostasis; Hormesis; Hormetics; Hormetin; Longevity; Stress

Indexed keywords

EID: 84916601608     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2014.0500196     Document Type: Review

References (88)

1. Holliday R (2006). Aging is no longer an unsolved problem in biology. Ann NY Acad Sci, 1067:1-9.
2. Hayflick L (2007). Biological aging is no longer an unsolved problem. Ann NY Acad Sci, 1100:1-13.
3. Rattan SIS (2000). Biogerontology: the next step. Ann NY Acad Sci, 908:282-290.
4. Rattan SIS (2006). Theories of biological aging: genes, proteins and free radicals. Free Rad Res, 40:1230-1238.
5. Carnes BA (2007). Senescence viewed through the lens of comparative biology. Ann N Y Acad Sci, 1114:14-22.
6. Carnes BA (2011). What is lifespan regulation and why does it exist? Biogerontology, 12:367-374.
7. Carnes BA, Olshansky SJ, Grahn D (2003). Biological evidence for limits to the duration of life. Biogerontology, 4:31-45.
8. Mentis AF, Kararizou E (2010). Does ageing originate in utero? Biogerontology, 11:725-729.
9. Gavrilov LA, Gavrilova NS (2011). Mortality Measurement at Advanced Ages: A Study of the Social Security Administration Death Master File. N Am Actuar J, 15:432-447.
10. Gavrilov LA, Gavrilova NS (2012). Biodemography of exceptional longevity: early-life and mid-life predictors of human longevity. Biodemography Soc Biol, 58:14-39.
11. Carnes BA, Witten TM (2013). How long must humans live? J Gerontol Bio Sci, in press, doi:10.1093/gerona/glt164:
12. Hayflick L (2007). Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both. PLoS Genet, 3:e220.
13. Holliday R (2009). Genes and the evolution of longevities. Biogerontology, 10:1-2.
14. Holliday R, Rattan SIS (2010). Longevity mutants do not establish any "new science" of ageing. Biogerontology, 11:507-511.
15. Demetrius L (2013). Boltzmann, Darwin and directionality theory. Physics Reports, 530:1-85.
16. Gavrilov LA, Gavrilova NS (2001). The reliability theory of aging and longevity. J Theor Biol, 213:527-545.
17. Gladyshev VN (2013). The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet, 29:506-512.
18. Holliday R (2007). Ageing: the paradox of life. Dordrecht, The Netherlands, Springer.
19. Kirkwood TBL. Time of Our Lives. London, Weidenfeld & Nicolson, (1999).
20. Wensink M (2013). Age-specificity and the evolution of senescence: a discussion. Biogerontology, 14:99-105.
21. Wensink MJ, van Heemst D, Rozing MP, Westendorp RG (2012). The maintenance gap: a new theoretical perspective on the evolution of aging. Biogerontology, 13:197-201.
22. Martin GM (2007). Modalities of gene action predicted by the classical evolutionary theory of aging. Ann NY Acad Sci, 1100:14-20.
23. Rattan SIS (2008). Increased molecular damage and heterogeneity as the basis of aging. Biol Chem, 389:267-272.
24. Yates FE (1994). Order and complexity in dynamical systems: homeodynamics as a generalized mechanics for biology. Math Comput Model, 19:49-74.
25. Demirovic D, Rattan SIS (2013). Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol, 48:94-98.
26. Rattan SIS (2010). Taregeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis. Ann N Y Acad Sci, 1197:28-32.
27. Rattan SIS (2012). Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011. Biogerontology, 13:83-91.
28. Rattan SIS (2013). Healthy ageing, but what is health? Biogerontology, in press DOI 10.1007/s10522-013-9442-7
29. Rattan SIS, Demirovic D (2009). Hormesis and aging. In: Mattson MP, Calabrese E, editors. Hormesis: a revolution in biology, toxicology and medicine. New York, Springer: 153-175.
30. Rattan SIS (2007). Homeostasis, homeodynamics, and aging. In: Birren J, editor. Encyclopedia of Gerontology. UK, Elsevier Inc.: 696-699.
31. Rattan SIS (1995). Gerontogenes: real or virtual? FASEB J, 9:284-286.
32. Blagosklonny MV (2012). Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY), 4:159-165.
33. Demetrius L (2004). Calorie restricition, metabolic rate and entropy. J Gerontol Biol Sci, 59A:902-915.
34. Le Bourg E (2000). Gerontologists and the media: false hopes and fantasies can be hazardous for science. Biogerontology, 1:371-372.
35. Le Bourg E (2013). Obsolete ideas and logical confusions can be obstacles for biogerontology research. Biogerontology, 14:221-227.
36. Olshansky SJ, Carnes BA (2012). Science fact versus SENS foreseeable. Gerontology, 59:190-192.
37. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R et al. (2005). Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep, 6:1006-8.
38. O'Neill D (2013). 2012 - That was the year that was. Age Ageing
39. Tacutu R, Budovsky A, Yanai H, Fraifeld VE (2011). Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective. Aging (Albany NY), 3:1178-1191.
40. Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M et al. (2011). A genome-wide association study of aging. Neurobiol Aging, 32:2109 e15-28.
41. Watson J (2013). Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol, 3:120144.
42. Farrelly C (2008). A tale of two strategies. EMBO Rep, 9:92-95.
43. Olshansky SJ, Biggs S, Achenbaum WA, Davison GC, Fried L, Gutman G et al. (2011). The global agenda council on the ageing society: policy principles. Global Policy, 2:97-105.
44. Vaupel JW (2010). Biodemography of human ageing. Nature, 464:536-542.
45. Carnes BA, Olshansky SJ, Hayflick L (2012). Can Human Biology Allow Most of Us to Become Centenarians? J Gerontol A Biol Sci Med Sci
46. Goldman DP, Cutler D, Rowe JW, Michaud PC, Sullivan J, Peneva D et al. (2013). Substantial health and economic returns from delyaed aging may warrant a new focus for medical research. Health Aff (Millwood), 32:1698-1705.
47. Fulop T, Larbi A, Witkowski JM, McElhaney J, Loeb M, Mitnitski A et al. (2010). Aging, frailty and age-related diseases. Biogerontology, 11:547-563.
48. Hubbard RE, Woodhouse KW (2010). Frailty, inflammation and the elderly. Biogerontology, 11:635-641.
49. Mitnitski A, Song X, Rockwood K (2013). Assessing biological aging: the origin of deficit accumulation. Biogerontology, 14. in press.
50. Montesanto A, Lagani V, Martino C, Dato S, De Rango F, Berardelli M et al. (2010). A novel, population-specific approach to define frailty. Age 32:385-395.
51. Engberg H, Christensen K, Andersen-Ranberg K, Vaupel JW, Jeune B (2008). Improving activities of daily living in danish centenarians--but only in women: a comparative study of two birth cohorts born in 1895 and 1905. J Gerontol A Biol Sci Med Sci, 63:1186-1192.
52. Huber M, Knottnerus JA, Green L, van der Horst H, Jadad AR, Kromhout D et al. (2011). How should we define health? BMJ, 343:d4163.
53. Franco OH, Karnik K, Osborne G, Ordovas JM, Catt M, van der Ouderaa F (2009). Changing course in ageing research: The healthy ageing phenotype. Maturitas, 63:13-19.
54. Richter J, Schwarz M, Bauer B (2008). Personality characteristics determine health-related quality of life as an outcome indicator of geriatric inpatient rehabilitation. Curr Gerontol Geriatr Res, Article ID 474618; doi:10.1155/2008/474618:8.
55. Steptoe A, Leigh ES, Kumari M (2011). Positive affect and distressed affect over the day in older people. Psychol Aging, 26:956-965.
56. Byerley LO, Leamy L, Tam SW, Chou CW, Ravussin E (2010). Development of a serum profile for healthy aging. Age, 32:497-507.
57. Kitano H (2007). Towards a theory of biological robustness. Mol Syst Biol, 3:137.
58. Kriete A (2013). Robustness and aging- a systems-level perspective. Biosystems, 112:37-48.
59. Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Kulminski A, Akushevich I et al. (2013). How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data. Front Genet, 4:3.
60. Rattan SI (2012). Rationale and methods of discovering hormetins as drugs for healthy ageing. Expert Opin Drug Discov, 7:439-448.
61. Rattan SIS (2004). Aging, anti-aging, and hormesis. Mech Age Dev, 125:285-289.
62. Rattan SIS (2008). Hormesis in aging. Ageing Res Rev, 7:63-78.
63. Rattan SIS (2008). Principles and practice of hormetic treatment of aging and age-related diseases. Hum Exp Toxicol, 27:151-157.
64. Fuchs E, Chen T (2013). A matter of life and death: self-renewal in stem cells. EMBO Rep, 14:39-48.
65. Kuranda K, Vargaftig J, de la Rochere P, Dosquet C, Charron D, Bardin F et al. (2011). Age-related changes in human hematopoietic stem/progenitor cells. Aging Cell, 10:542-546.
66. Rodgerson DO, Harris AG (2011). A comparison of stem cells for therapeutic use. Stem Cell Rev, 7:782-796.
67. Seppet E, Paasuke M, Conte M, Capri M, Franceschi C (2011). Ethical aspects of aging research. Biogerontology, 12:491-502.
68. Franceschi C, Valensin S, Bonafè M, Paolisso G, Yashin AI, Monti D et al. (2000). The network and the remodeling theories of aging: historical background and new perspectives. Exp Gerontol, 35:879-896.
69. Bartke A, Westbrook R (2012). Metabolic characteristics of long-lived mice. Front Genet, 3:288.
70. Fontana L, Partridge L, Longo VD (2010). Extending healthy life span--from yeast to humans. Science, 328:321-326.
71. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013). The hallmarks of aging. Cell, 153:1194-1217.
72. Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L et al. (2011). Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature, 479:223-227.
73. Perez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J et al. (2009). Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A, 106:3059-3064.
74. Brunet-Rossinni AK, Austad SN (2004). Ageing studies on bats: a review. Biogerontology, 5:211-222.
75. Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S et al. (2013). Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Nat Commun, 4:2212.
76. Hamilton JB, Mestler GE (1969). Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population. J Gerontol, 24:395-411.
77. Min KJ, Lee CK, Park HN (2012). The lifespan of Korean eunuchs. Curr Biol, 22:R792-793.
78. Gutteridge JM, Halliwell B (2010). Antioxidants: Molecules, medicines, and myths. Biochem Biophys Res Commun, 393:561-564.
79. Hayes DP (2008). Adverse effects of nutritional inadequecy and excess: a hormetic model. Am J Clin Nutr, 88:578S-581S.
80. Le Bourg E (2005). Antioxidants and aging in human beings. In: Rattan SIS, editors. Aging Interventions and Therapies. Singapore, World Scientific Publishers: 85-107.
81. Wick G (2002). 'Anti-aging' medicine: does it exist? A critical discussion of 'anti-aging health products'. Exp Gerontol, 37:1137-1140.
82. Le Bourg E, Rattan SIS, Eds. Mild stress and healthy aging: applying hormesis in aging research and interventions. Dordrecht, The Netherlands, Springer; 2008.
83. Rattan SIS, Le Bourg E, Eds. Hormesis in health and disease. Boca Raton, CRC Press; 2013.
84. Rattan SIS, Demirovic D (2010). Hormesis can and does work in humans. Dose Response, 8:58-63.
85. Singh R, Lakhanpal D, Kumar S, Sharma S, Kataria H, Kaur M et al. (2011). Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats. Age (Dordr)
86. Rattan SIS, Fernandes RA, Demirovic D, Dymek B, Lima CF (2009). Heat stress and hormetin-induced hormesis in human cells: effects on aging, wound healing, angiogenesis and differentiation. Dose Response, 7:93-103.
87. Argyropoulou A, Aligiannis N, Trougakos IP, Skaltsounis AL (2013). Natural compounds with anti-ageing activity. Nat Prod Rep, 30:1412-1437.
88. Rattan SIS, Kryzch V, Schnebert S, Perrier E, Carine Nizard C (2013). Hormesis-based anti-aging products: a case study of a novel cosmetic. Dose Response, 11:99-108.