What is an anti-aging treatment?

Experimental Gerontology

Volumn 58, Issue , 2014, Pages 14-18

  Gems, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; Biogerontology; Disease; Prevention; Translation

Indexed keywords

AGE; AGING; ANIMAL; CALORIC RESTRICTION; CELL AGING; DRUG EFFECTS; GERIATRICS; HEALTH STATUS; HUMAN; LONGEVITY; NOMENCLATURE; PATHOLOGY; PRIMARY PREVENTION; PROCEDURES; ALTERNATIVE MEDICINE; ANTI AGING TREATMENT; ELDERLY CARE; GERIATRIC DISORDER; GERONTOLOGY; LIFE CYCLE; LIFE EXPECTANCY; LIFE EXTENSION; NONHUMAN; NOTE; SENESCENCE;

AGE FACTORS; AGING; ANIMALS; CALORIC RESTRICTION; CELL AGING; GERIATRICS; HEALTH STATUS; HUMANS; LONGEVITY; PRIMARY PREVENTION; TERMINOLOGY AS TOPIC;

EID: 84897871341     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.07.003     Document Type: Note

References (35)

1. Berrington de Gonzalez A., Hartge P., Cerhan J.R., Flint A.J., Hannan L., MacInnis R.J., Moore S.C., Tobias G.S., Anton-Culver H., Freeman L.B., Beeson W.L., Clipp S.L., English D.R., Folsom A.R., Freedman D.M., Giles G., Hakansson N., Henderson K.D., Hoffman-Bolton J., Hoppin J.A., Koenig K.L., Lee I.M., Linet M.S., Park Y., Pocobelli G., Schatzkin A., Sesso H.D., Weiderpass E., Willcox B.J., Wolk A., Zeleniuch-Jacquotte A., Willett W.C., Thun M.J. Body-mass index and mortality among 1.46million white adults. N. Engl. J. Med. 2010, 363:2211-2219.
2. Blagosklonny M.V. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006, 5:2087-2102.
3. Blagosklonny M.V. Aging: ROS or TOR. Cell Cycle 2008, 7:3344-3354.
4. Blagosklonny M.V. Validation of anti-aging drugs by treating age-related diseases. Aging 2009, 1:281-288.
5. Blumenthal H.T. The aging-disease dichotomy: true or false?. J. Gerontol. A Biol. Sci. Med. Sci. 2003, 58:138-145.
6. Bodkin N.L., Alexander T.M., Ortmeyer H.K., Johnson E., Hansen B.C. Mortality and morbidity in laboratory-maintained rhesus monkeys and effects of long-term dietary restriction. J. Gerontol. A Biol. Sci. Med. Sci. 2003, 58:212-219.
7. Boorse C. Health as a theoretical concept. Philos. Sci. 1977, 44:542-573.
8. Boseley S. Tests start on pill that could lengthen millions of lives. The Guardian 2008.
9. Butler R.N., Miller R.A., Perry D., Carnes B.A., Williams T.F., Cassel C., Brody J., Bernard M.A., Partridge L., Kirkwood T., Martin G.M., Olshansky S.J. New model of health promotion and disease prevention for the 21st century. BMJ 2008, 337:a399.
10. Campbell A.J., Buchner D.M. Unstable disability and the fluctuations of frailty. Age Ageing 1997, 26:315-318.
11. Caplan A.L. Death as an unnatural process. Why is it wrong to seek a cure for aging?. EMBO Rep. 2005, 6:S72-S75. (Spec No).
12. Colman R.J., Anderson R.M., Johnson S.C., Kastman E.K., Kosmatka K.J., Beasley T.M., Allison D.B., Cruzen C., Simmons H.A., Kemnitz J.W., Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009, 325:201-204.
13. Demirovic D., Rattan S.I. Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp. Gerontol. 2013, 48:94-98.
14. Fisher B., Costantino J.P., Wickerham D.L., Redmond C.K., Kavanah M., Cronin W.M., Vogel V., Robidoux A., Dimitrov N., Atkins J., Daly M., Wieand S., Tan-Chiu E., Ford L., Wolmark N. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Natl. Cancer Inst. 1998, 90:1371-1388.
15. Fontana L., Meyer T., Klein S., Holloszy J. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:6659-6663.
16. Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., Seeman T., Tracy R., Kop W.J., Burke G., McBurnie M.A. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 2001, 56:M146-M156.
17. Gems D. Tragedy and delight: the ethics of decelerated ageing. Philos. Trans. R. Soc. 2011, 366:108-112.
18. Gems D., Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu. Rev. Physiol. 2013, 75:621-644.
19. Gruman G.J. A history of ideas about the prolongation of life. Trans. Am. Philos. Soc. 1966, 56:1-97.
20. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine 2007, Oxford University Press, Oxford. Fourth edition.
21. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
22. Hill R.C. Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition and health". Nutritional therapies to improve health: lessons from companion animals. Proc. Nutr. Soc. 2009, 68:98-102.
23. Kass L. The case for mortality. Am. Sch. 1983, 52:173-191.
24. Kenyon C. The genetics of ageing. Nature 2010, 464:504-512.
25. Kirkwood T.B.L. Evolution of ageing. Nature 1977, 270:301-304.
26. Lucke J.C., Diedrichs P.C., Partridge B., Hall W.D. Anticipating the anti-ageing pill. Lessons from the history of the oral contraceptive pill and hormone replacement therapy. EMBO Rep. 2009, 10:108-113.
27. Mattison J.A., Roth G.S., Beasley T.M., Tilmont E.M., Handy A.M., Herbert R.L., Longo D.L., Allison D.B., Young J.E., Bryant M., Barnard D., Ward W.F., Qi W., Ingram D.K., de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012, 489:318-321.
28. Medawar P.B. An Unsolved Problem Of Biology 1952, H.K. Lewis, London.
29. Partridge L., Barton N.H. Optimality, mutation and the evolution of ageing. Nature 1993, 362:305-311.
30. Perez V.I., Bokov A., Van Remmen H., Mele J., Ran Q., Ikeno Y., Richardson A. Is the oxidative stress theory of aging dead?. Biochim. Biophys. Acta 2009, 1790:1005-1014.
31. Tejada-Vera B. Mortality from Alzheimer's disease in the United States: data for 2000 and 2010. NCHS Data Brief 2013, 1-8.
32. Tsang C.K., Qi H., Liu L.F., Zheng X.F. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 2007, 12:112-124.
33. Van Raamsdonk J.M., Hekimi S. Reactive oxygen species and aging in Caenorhabditis elegans: causal or casual relationship?. Antioxid. Redox Signal. 2010, 13:1911-1953.
34. Wald N.J., Law M.R. A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003, 326:1419.
35. Williams G.C. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957, 11:398-411.