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Volumn 67, Issue 5, 2015, Pages 1010-1015

Involvement of endogenous opioid peptides in the peripheral antinociceptive effect induced by the coffee specific diterpene kahweol

Author keywords

Coffee diterpene; Kahweol; Opioid system; Peripheral antinociception; Endorphin

Indexed keywords

BESTATIN; BETA ENDORPHIN; KAHWEOL; NALOXONE; OPIATE PEPTIDE; ANALGESIC AGENT; COFFEE; DITERPENE; LEUCINE; NARCOTIC ANTAGONIST; PEPTIDE; PROSTAGLANDIN E2;

EID: 84940046157     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2015.02.009     Document Type: Article
Times cited : (14)

References (55)
  • 1
    • 33644631621 scopus 로고    scopus 로고
    • Coffee and health: a review of recent human research
    • J.V. Higdon, and B. Frei Coffee and health: a review of recent human research Crit Rev Food Sci Nutr 46 2 2006 101 126
    • (2006) Crit Rev Food Sci Nutr , vol.46 , Issue.2 , pp. 101-126
    • Higdon, J.V.1    Frei, B.2
  • 2
    • 0030943042 scopus 로고    scopus 로고
    • Analysis of the content of the diterpenes cafestol and kahweol in coffee brews
    • G. Gross, E. Jaccaud, and A.C. Huggett Analysis of the content of the diterpenes cafestol and kahweol in coffee brews Food Chem Toxicol 35 6 1997 547 554
    • (1997) Food Chem Toxicol , vol.35 , Issue.6 , pp. 547-554
    • Gross, G.1    Jaccaud, E.2    Huggett, A.C.3
  • 3
    • 0029907542 scopus 로고    scopus 로고
    • The cholesterol-raising factor from coffee beans
    • R. Urgert, and M.B. Katan The cholesterol-raising factor from coffee beans J R Soc Med 89 11 1996 618 623
    • (1996) J R Soc Med , vol.89 , Issue.11 , pp. 618-623
    • Urgert, R.1    Katan, M.B.2
  • 4
    • 0030752316 scopus 로고    scopus 로고
    • The cholesterol-raising factor from coffee beans
    • R. Urgert, and M.B. Katan The cholesterol-raising factor from coffee beans Annu Rev Nutr 17 1997 305 324
    • (1997) Annu Rev Nutr , vol.17 , pp. 305-324
    • Urgert, R.1    Katan, M.B.2
  • 5
    • 0031657286 scopus 로고    scopus 로고
    • The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism
    • C. Cavin, D. Holzhauser, A. Constable, A.C. Huggett, and B. Schilter The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism Carcinogenesis 19 8 1998 1369 1375
    • (1998) Carcinogenesis , vol.19 , Issue.8 , pp. 1369-1375
    • Cavin, C.1    Holzhauser, D.2    Constable, A.3    Huggett, A.C.4    Schilter, B.5
  • 7
    • 62149091477 scopus 로고    scopus 로고
    • Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells
    • H.G. Kim, Y.P. Hwang, and H.G. Jeong Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells Toxicol Lett 187 1 2009 28 34
    • (2009) Toxicol Lett , vol.187 , Issue.1 , pp. 28-34
    • Kim, H.G.1    Hwang, Y.P.2    Jeong, H.G.3
  • 8
    • 70349783669 scopus 로고    scopus 로고
    • The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK
    • J.H. Oh, J.T. Lee, E.S. Yang, J.S. Chang, D.S. Lee, S.H. Kim, and et al. The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK Apoptosis 14 11 2009 1378 1386
    • (2009) Apoptosis , vol.14 , Issue.11 , pp. 1378-1386
    • Oh, J.H.1    Lee, J.T.2    Yang, E.S.3    Chang, J.S.4    Lee, D.S.5    Kim, S.H.6
  • 9
    • 77952959577 scopus 로고    scopus 로고
    • The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP
    • H.J. Um, J.H. Oh, Y.-N. Kim, Y.H. Choi, S.H. Kim, J.-W. Park, and et al. The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP Chem Biol Interact 186 1 2010 36 42
    • (2010) Chem Biol Interact , vol.186 , Issue.1 , pp. 36-42
    • Um, H.J.1    Oh, J.H.2    Kim, Y.-N.3    Choi, Y.H.4    Kim, S.H.5    Park, J.-W.6
  • 10
    • 0035003959 scopus 로고    scopus 로고
    • Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells
    • C. Cavin, K. Mace, E.A. Offord, and B. Schilter Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells Food Chem Toxicol 39 6 2001 549 556
    • (2001) Food Chem Toxicol , vol.39 , Issue.6 , pp. 549-556
    • Cavin, C.1    Mace, K.2    Offord, E.A.3    Schilter, B.4
  • 11
    • 39149134628 scopus 로고    scopus 로고
    • Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver
    • W.W. Huber, W. Rossmanith, M. Grusch, E. Haslinger, S. Prustomersky, B. Peter-Vörösmarty, and et al. Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver Food Chem Toxicol 46 4 2008 1230 1238
    • (2008) Food Chem Toxicol , vol.46 , Issue.4 , pp. 1230-1238
    • Huber, W.W.1    Rossmanith, W.2    Grusch, M.3    Haslinger, E.4    Prustomersky, S.5    Peter-Vörösmarty, B.6
  • 12
    • 0035987086 scopus 로고    scopus 로고
    • Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol
    • W.W. Huber, S. Prustomersky, E. Delbanco, M. Uhl, G. Scharf, R.J. Turesky, and et al. Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol Arch Toxicol 76 4 2002 209 217
    • (2002) Arch Toxicol , vol.76 , Issue.4 , pp. 209-217
    • Huber, W.W.1    Prustomersky, S.2    Delbanco, E.3    Uhl, M.4    Scharf, G.5    Turesky, R.J.6
  • 13
    • 0037469372 scopus 로고    scopus 로고
    • Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver-comparison with phase II xenobiotic metabolism
    • W.W. Huber, G. Scharf, G. Nagel, S. Prustomersky, R. Schulte-Hermann, and B. Kaina Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver-comparison with phase II xenobiotic metabolism Mutat Res Fund Mol Mech Mutagen 522 1-2 2003 57 68
    • (2003) Mutat Res Fund Mol Mech Mutagen , vol.522 , Issue.1-2 , pp. 57-68
    • Huber, W.W.1    Scharf, G.2    Nagel, G.3    Prustomersky, S.4    Schulte-Hermann, R.5    Kaina, B.6
  • 14
    • 7444245030 scopus 로고    scopus 로고
    • Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities
    • W.W. Huber, C.H. Teitel, B.F. Coles, R.S. King, F.W. Wiese, K.R. Kaderlik, and et al. Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities Environ Mol Mutagen 44 4 2004 265 276
    • (2004) Environ Mol Mutagen , vol.44 , Issue.4 , pp. 265-276
    • Huber, W.W.1    Teitel, C.H.2    Coles, B.F.3    King, R.S.4    Wiese, F.W.5    Kaderlik, K.R.6
  • 15
    • 34748870909 scopus 로고    scopus 로고
    • Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice
    • K.J. Lee, J.H. Choi, and H.G. Jeong Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice Food Chem Toxicol 45 11 2007 2118 2125
    • (2007) Food Chem Toxicol , vol.45 , Issue.11 , pp. 2118-2125
    • Lee, K.J.1    Choi, J.H.2    Jeong, H.G.3
  • 16
    • 34548471732 scopus 로고    scopus 로고
    • Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage
    • K.J. Lee, and H.G. Jeong Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage Toxicol Lett 173 2 2007 80 87
    • (2007) Toxicol Lett , vol.173 , Issue.2 , pp. 80-87
    • Lee, K.J.1    Jeong, H.G.2
  • 17
    • 46749135955 scopus 로고    scopus 로고
    • The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress
    • H.P. Hwang, and H.G. Jeong The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress FEBS Lett 582 17 2008 2655 2662
    • (2008) FEBS Lett , vol.582 , Issue.17 , pp. 2655-2662
    • Hwang, H.P.1    Jeong, H.G.2
  • 18
    • 33645715637 scopus 로고    scopus 로고
    • Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats
    • J.Y. Kim, D.H. Kim, and H.G. Jeong Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats Biofactors 26 1 2006 17 28
    • (2006) Biofactors , vol.26 , Issue.1 , pp. 17-28
    • Kim, J.Y.1    Kim, D.H.2    Jeong, H.G.3
  • 19
    • 33845193845 scopus 로고    scopus 로고
    • The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells
    • H.G. Kim, J.Y. Kim, Y.P. Hwang, K.J. Lee, K.Y. Lee, D.H. Kim, and et al. The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells Toxicol Appl Pharmacol 217 3 2006 332 341
    • (2006) Toxicol Appl Pharmacol , vol.217 , Issue.3 , pp. 332-341
    • Kim, H.G.1    Kim, J.Y.2    Hwang, Y.P.3    Lee, K.J.4    Lee, K.Y.5    Kim, D.H.6
  • 20
    • 3042646706 scopus 로고    scopus 로고
    • Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages
    • J.Y. Kim, K.S. Jung, and H.G. Jeong Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages FEBS Lett 569 1-3 2004 321 326
    • (2004) FEBS Lett , vol.569 , Issue.1-3 , pp. 321-326
    • Kim, J.Y.1    Jung, K.S.2    Jeong, H.G.3
  • 21
    • 4344611534 scopus 로고    scopus 로고
    • The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages
    • J.Y. Kim, K.S. Jung, K.J. Lee, H.K. Na, H.K. Chun, Y.H. Kho, and et al. The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages Cancer Lett 213 2 2004 147 154
    • (2004) Cancer Lett , vol.213 , Issue.2 , pp. 147-154
    • Kim, J.Y.1    Jung, K.S.2    Lee, K.J.3    Na, H.K.4    Chun, H.K.5    Kho, Y.H.6
  • 22
    • 0018653423 scopus 로고
    • II - Prostaglandin hyperalgesia, the peripheral analgesic activity of morphine, enkephalin and opioid antagonists
    • S.H. Ferreira, and M. Nakamura II - Prostaglandin hyperalgesia, the peripheral analgesic activity of morphine, enkephalin and opioid antagonists Prostaglandins 18 2 1979 191 200
    • (1979) Prostaglandins , vol.18 , Issue.2 , pp. 191-200
    • Ferreira, S.H.1    Nakamura, M.2
  • 23
    • 84860249984 scopus 로고    scopus 로고
    • Cafestol, a coffee-specific diterpene, induces peripheral antinociception mediated by endogenous opioid peptides
    • L.S. Guzzo, A.C. Perez, T.R.L. Romero, A.O. Azevedo, and I.D.G. Duarte Cafestol, a coffee-specific diterpene, induces peripheral antinociception mediated by endogenous opioid peptides Clin Exp Pharmacol Physiol 39 5 2012 412 416
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , Issue.5 , pp. 412-416
    • Guzzo, L.S.1    Perez, A.C.2    Romero, T.R.L.3    Azevedo, A.O.4    Duarte, I.D.G.5
  • 24
    • 33746926359 scopus 로고    scopus 로고
    • Endogenous opioids mediate the hypoalgesia induced by inhibitors of cyclooxygenase-2 in rat paws treated with carrageenan
    • D.S. França, D.L. Ferreira-Alves, I.D. Duarte, M.C. Ribeiro, R.M. Rezende, Y.S. Bakhle, and et al. Endogenous opioids mediate the hypoalgesia induced by inhibitors of cyclooxygenase-2 in rat paws treated with carrageenan Neuropharmacology 51 1 2006 37 43
    • (2006) Neuropharmacology , vol.51 , Issue.1 , pp. 37-43
    • França, D.S.1    Ferreira-Alves, D.L.2    Duarte, I.D.3    Ribeiro, M.C.4    Rezende, R.M.5    Bakhle, Y.S.6
  • 25
    • 0023864304 scopus 로고
    • Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances
    • M. Nakamura, and H.S. Ferreira Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances Eur J Pharmacol 146 2-3 1988 223 228
    • (1988) Eur J Pharmacol , vol.146 , Issue.2-3 , pp. 223-228
    • Nakamura, M.1    Ferreira, H.S.2
  • 26
    • 0023891483 scopus 로고
    • Peripheral modulation of pain in conscious guinea pigs: effect of morphine, nalorphine and clonidine
    • M. Nakamura, and M.C. Lico Peripheral modulation of pain in conscious guinea pigs: effect of morphine, nalorphine and clonidine Braz J Med Biol Res 21 3 1988 577 583
    • (1988) Braz J Med Biol Res , vol.21 , Issue.3 , pp. 577-583
    • Nakamura, M.1    Lico, M.C.2
  • 27
    • 63149143193 scopus 로고    scopus 로고
    • Probable involvement of α2C-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine
    • T.R.L. Romero, A.C. Perez, J.N. Francischi, and I.D.G. Duarte Probable involvement of α2C-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine Eur J Pharmacol 608 1-3 2009 23 27
    • (2009) Eur J Pharmacol , vol.608 , Issue.1-3 , pp. 23-27
    • Romero, T.R.L.1    Perez, A.C.2    Francischi, J.N.3    Duarte, I.D.G.4
  • 28
    • 0036758643 scopus 로고    scopus 로고
    • Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner
    • A. Khodorova, M.U. Fareed, A. Gokin, G.R. Strichartz, and G. Davar Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner J Neurosci 22 17 2002 7788 7796
    • (2002) J Neurosci , vol.22 , Issue.17 , pp. 7788-7796
    • Khodorova, A.1    Fareed, M.U.2    Gokin, A.3    Strichartz, G.R.4    Davar, G.5
  • 29
    • 77951767804 scopus 로고    scopus 로고
    • Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice
    • P.N. Quang, and B.L. Schmidt Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice Pain 149 2 2010 254 262
    • (2010) Pain , vol.149 , Issue.2 , pp. 254-262
    • Quang, P.N.1    Schmidt, B.L.2
  • 30
    • 84958295215 scopus 로고
    • A comparison of heat and pressure analgesiometric methods in rats
    • A.F. Green, and P.A. Young A comparison of heat and pressure analgesiometric methods in rats Br J Pharmacol 6 4 1951 572 585
    • (1951) Br J Pharmacol , vol.6 , Issue.4 , pp. 572-585
    • Green, A.F.1    Young, P.A.2
  • 31
    • 84960959252 scopus 로고
    • A method for measurement of analgesic activity on inflamed tissues
    • L.O. Randall, and J.J. Sellito A method for measurement of analgesic activity on inflamed tissues Arch Int Pharmacodyn Ther 111 4 1957 409 419
    • (1957) Arch Int Pharmacodyn Ther , vol.111 , Issue.4 , pp. 409-419
    • Randall, L.O.1    Sellito, J.J.2
  • 32
    • 80051497162 scopus 로고    scopus 로고
    • 2 and pain - an update
    • 2 and pain - an update Biol Pharm Bull 34 8 2011 1170 1173
    • (2011) Biol Pharm Bull , vol.34 , Issue.8 , pp. 1170-1173
    • Kawabata, A.1
  • 35
    • 84855608446 scopus 로고    scopus 로고
    • Inflammation mobilizes local resources to control hyperalgesia: the role of endogenous opioid peptides
    • D.P. Alves, P.G. da Motta, P.P. Lima, C.M. Queiroz-Junior, M.V. Caliari, D.F. Pacheco, and et al. Inflammation mobilizes local resources to control hyperalgesia: the role of endogenous opioid peptides Pharmacology 89 1-2 2012 22 28
    • (2012) Pharmacology , vol.89 , Issue.1-2 , pp. 22-28
    • Alves, D.P.1    Da Motta, P.G.2    Lima, P.P.3    Queiroz, C.M.4    Caliari, M.V.5    Pacheco, D.F.6
  • 36
    • 0033555286 scopus 로고    scopus 로고
    • Transmitters involved in antinociception in the spinal cord
    • S. Fürst Transmitters involved in antinociception in the spinal cord Brain Res Bull 48 2 1999 129 141
    • (1999) Brain Res Bull , vol.48 , Issue.2 , pp. 129-141
    • Fürst, S.1
  • 37
    • 0036277865 scopus 로고    scopus 로고
    • Descending control of pain
    • M.J. Millan Descending control of pain Prog Neurobiol 66 6 2002 335 474
    • (2002) Prog Neurobiol , vol.66 , Issue.6 , pp. 335-474
    • Millan, M.J.1
  • 38
    • 43649101960 scopus 로고    scopus 로고
    • Peripherally-acting opioids
    • H.S. Smith Peripherally-acting opioids Pain Physician 11 2 2008 S121 S132
    • (2008) Pain Physician , vol.11 , Issue.2 , pp. S121-S132
    • Smith, H.S.1
  • 39
    • 0041965945 scopus 로고    scopus 로고
    • Attacking pain at its source: new perspectives on opioids
    • C. Stein, M. Schäfer, and H. Machelska Attacking pain at its source: new perspectives on opioids Nat Med 9 8 2003 1003 1008
    • (2003) Nat Med , vol.9 , Issue.8 , pp. 1003-1008
    • Stein, C.1    Schäfer, M.2    Machelska, H.3
  • 40
    • 81155135694 scopus 로고    scopus 로고
    • The analgesic activity of Bestatin as a potent APN inhibitor
    • M.-R. Jia, T. Wei, and W.-F. Xu The analgesic activity of Bestatin as a potent APN inhibitor Front Neurosci 4 2010 1 10
    • (2010) Front Neurosci , vol.4 , pp. 1-10
    • Jia, M.-R.1    Wei, T.2    Xu, W.-F.3
  • 41
    • 20044368975 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
    • M.M. Ibrahim, F. Porreca, J. Lai, P.J. Albrecht, F.L. Rice, A. Khodorova, and et al. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids PNAS 102 8 2005 3093 3098
    • (2005) PNAS , vol.102 , Issue.8 , pp. 3093-3098
    • Ibrahim, M.M.1    Porreca, F.2    Lai, J.3    Albrecht, P.J.4    Rice, F.L.5    Khodorova, A.6
  • 42
    • 0038129424 scopus 로고    scopus 로고
    • Regulation of human epidermal melanocyte biology by beta-endorphin
    • S. Kauser, K. Schallreuter, A. Thody, C. Gummer, and D. Tobin Regulation of human epidermal melanocyte biology by beta-endorphin J Invest Dermatol 120 6 2003 1073 1080
    • (2003) J Invest Dermatol , vol.120 , Issue.6 , pp. 1073-1080
    • Kauser, S.1    Schallreuter, K.2    Thody, A.3    Gummer, C.4    Tobin, D.5
  • 43
    • 0041888477 scopus 로고    scopus 로고
    • Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
    • A. Khodorova, B. Navarro, L.S. Jouaville, J.E. Murphy, F.L. Rice, J.E. Mazurkiewicz, and et al. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury Nat Med 9 8 2003 1055 1061
    • (2003) Nat Med , vol.9 , Issue.8 , pp. 1055-1061
    • Khodorova, A.1    Navarro, B.2    Jouaville, L.S.3    Murphy, J.E.4    Rice, F.L.5    Mazurkiewicz, J.E.6
  • 44
    • 5644248023 scopus 로고    scopus 로고
    • Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin
    • M. Bigliardi-Qi, L.T. Sumanovski, S. Büchner, T. Rufli, and P.L. Bigliardi Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin Dermatology 209 3 2004 183 189
    • (2004) Dermatology , vol.209 , Issue.3 , pp. 183-189
    • Bigliardi-Qi, M.1    Sumanovski, L.T.2    Büchner, S.3    Rufli, T.4    Bigliardi, P.L.5
  • 45
    • 0028219514 scopus 로고
    • Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes
    • E. Schauer, F. Trautinger, A. Köck, A. Schwarz, R. Bhardwaj, M. Simon, and et al. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes J Clin Invest 93 5 1994 2258 2262
    • (1994) J Clin Invest , vol.93 , Issue.5 , pp. 2258-2262
    • Schauer, E.1    Trautinger, F.2    Köck, A.3    Schwarz, A.4    Bhardwaj, R.5    Simon, M.6
  • 46
    • 0030005810 scopus 로고    scopus 로고
    • Proopiomelanocortin gene product regulation in keratinocytes
    • M. Wintzen, M. Yaar, P. Burbach, and B. Gilchrest Proopiomelanocortin gene product regulation in keratinocytes J Invest Dermatol 106 4 1996 673 678
    • (1996) J Invest Dermatol , vol.106 , Issue.4 , pp. 673-678
    • Wintzen, M.1    Yaar, M.2    Burbach, P.3    Gilchrest, B.4
  • 47
    • 0025362849 scopus 로고
    • Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation
    • C. Stein, A.H. Hassan, R. Przewłocki, C. Gramsch, K. Peter, and A. Herz Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation Proc Natl Acad Sci USA 87 15 1990 5935 5939
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.15 , pp. 5935-5939
    • Stein, C.1    Hassan, A.H.2    Przewłocki, R.3    Gramsch, C.4    Peter, K.5    Herz, A.6
  • 48
    • 0034900301 scopus 로고    scopus 로고
    • Opioid peptide expressing leukocytes: identification, recruitment and simultaneously increasing inhibition of inflammatory pain
    • H.L. Rittner, A. Brack, H. Machelska, S.A. Mousa, M. Bauer, M. Schäfer, and et al. Opioid peptide expressing leukocytes: identification, recruitment and simultaneously increasing inhibition of inflammatory pain Anesthesiology 95 2 2001 500 508
    • (2001) Anesthesiology , vol.95 , Issue.2 , pp. 500-508
    • Rittner, H.L.1    Brack, A.2    Machelska, H.3    Mousa, S.A.4    Bauer, M.5    Schäfer, M.6
  • 49
    • 0030814120 scopus 로고    scopus 로고
    • Immune cell-derived β-endorphin: production, release and control of inflammatory pain in a rats
    • P.J. Cabot, L. Carter, C. Gaiddon, Q. Zhang, M. Schäfer, J.P. Loefflerm, and et al. Immune cell-derived β-endorphin: production, release and control of inflammatory pain in a rats J Clin Invest 100 1 1997 142 148
    • (1997) J Clin Invest , vol.100 , Issue.1 , pp. 142-148
    • Cabot, P.J.1    Carter, L.2    Gaiddon, C.3    Zhang, Q.4    Schäfer, M.5    Loefflerm, J.P.6
  • 50
    • 1442323646 scopus 로고    scopus 로고
    • Subcellular pathways of β-endorphin synthesis, processing, and release from immunocytes in inflammatory pain
    • S.A. Mousa, M. Shakibaei, N. Sitte, M. Schäfer, and C. Stein Subcellular pathways of β-endorphin synthesis, processing, and release from immunocytes in inflammatory pain Endocrinology 145 3 2004 1331 1341
    • (2004) Endocrinology , vol.145 , Issue.3 , pp. 1331-1341
    • Mousa, S.A.1    Shakibaei, M.2    Sitte, N.3    Schäfer, M.4    Stein, C.5
  • 51
    • 0026520443 scopus 로고
    • Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception
    • R. Przewłocki, A.H. Hassan, W. Lason, C. Epplen, A. Herz, and C. Stein Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception Neuroscience 48 2 1992 491 500
    • (1992) Neuroscience , vol.48 , Issue.2 , pp. 491-500
    • Przewłocki, R.1    Hassan, A.H.2    Lason, W.3    Epplen, C.4    Herz, A.5    Stein, C.6
  • 52
    • 0035081365 scopus 로고    scopus 로고
    • Prostaglandins and cicloxygenase in the spinal cord
    • H. Vanegas, and H. Schaible Prostaglandins and cicloxygenase in the spinal cord Prog Neurobiol 64 4 2001 327 363
    • (2001) Prog Neurobiol , vol.64 , Issue.4 , pp. 327-363
    • Vanegas, H.1    Schaible, H.2
  • 54
    • 0019222421 scopus 로고
    • Multiple opiate receptors sites on primary afferent fibers
    • H.L. Fields, P.C. Emson, B.K. Leigh, R.F. Gilbert, and L.L. Iversen Multiple opiate receptors sites on primary afferent fibers Nature 284 5754 1980 351 353
    • (1980) Nature , vol.284 , Issue.5754 , pp. 351-353
    • Fields, H.L.1    Emson, P.C.2    Leigh, B.K.3    Gilbert, R.F.4    Iversen, L.L.5
  • 55
    • 59349088060 scopus 로고    scopus 로고
    • Peripheral mechanisms of opioid analgesia
    • C. Stein, and L.J. Lang Peripheral mechanisms of opioid analgesia Curr Opin Pharmacol 9 1 2009 3 8
    • (2009) Curr Opin Pharmacol , vol.9 , Issue.1 , pp. 3-8
    • Stein, C.1    Lang, L.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.