The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP

Chemico-Biological Interactions

Volumn 186, Issue 1, 2010, Pages 36-42

  Um, Hee Jung ^a   Oh, Jung Hwa ^a   Kim, Yoon Nyun ^b   Choi, Yung Hyun ^c   Kim, Sang Hyun ^d   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Dongsan Medical Center   (South Korea)

^c Dong Eui University   (South Korea)

^d Kyungpook National University School of Medicine   (South Korea)

Author keywords

Apoptosis; Bcl 2; C FLIP; Caki; Kahweol; TRAIL

Indexed keywords

CASPASE 3; FLICE INHIBITORY PROTEIN; KAHWEOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DEATH; CELL TYPE; COFFEE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PROTEIN CLEAVAGE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CARCINOMA; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; CELLS, CULTURED; COFFEE; DITERPENES; DOWN-REGULATION; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

COFFEA ARABICA;

EID: 77952959577     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.04.013     Document Type: Article

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