메뉴 건너뛰기




Volumn 10, Issue 1, 2015, Pages

Next-generation sequencing: Hype and hope for development of personalized radiation therapy?

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA FRAGMENT; PROTEIN P53;

EID: 84940040608     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/s13014-015-0481-x     Document Type: Review
Times cited : (11)

References (80)
  • 2
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson M, Gabriel S, Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet. 2010;11(10):685-96.
    • (2010) Nat Rev Genet , vol.11 , Issue.10 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 4
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-associated genes
    • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499(7457):214-8.
    • (2013) Nature , vol.499 , Issue.7457 , pp. 214-218
    • Lawrence, M.S.1    Stojanov, P.2    Polak, P.3    Kryukov, G.V.4    Cibulskis, K.5    Sivachenko, A.6
  • 5
    • 81055157018 scopus 로고    scopus 로고
    • Studying the epigenome using next generation sequencing
    • Ku CS, Naidoo N, Wu M, Soong R. Studying the epigenome using next generation sequencing. J Med Genet. 2011;48(11):721-30.
    • (2011) J Med Genet , vol.48 , Issue.11 , pp. 721-730
    • Ku, C.S.1    Naidoo, N.2    Wu, M.3    Soong, R.4
  • 6
    • 84905489815 scopus 로고    scopus 로고
    • Next-generation sequencing and epigenomics research: a hammer in search of nails
    • Sarda S, Hannenhalli S. Next-generation sequencing and epigenomics research: a hammer in search of nails. Genomics Inform. 2014;12(1):2-11.
    • (2014) Genomics Inform , vol.12 , Issue.1 , pp. 2-11
    • Sarda, S.1    Hannenhalli, S.2
  • 7
    • 70350218818 scopus 로고    scopus 로고
    • Applications of new sequencing technologies for transcriptome analysis
    • Morozova O, Hirst M, Marra MA. Applications of new sequencing technologies for transcriptome analysis. Annu Rev Genomics Hum Genet. 2009;10:135-51.
    • (2009) Annu Rev Genomics Hum Genet. , vol.10 , pp. 135-151
    • Morozova, O.1    Hirst, M.2    Marra, M.A.3
  • 8
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet. 2009;10(1):57-63.
    • (2009) Nat Rev Genet , vol.10 , Issue.1 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 10
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies - the next generation
    • Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet. 2010;11(1):31-46.
    • (2010) Nat Rev Genet , vol.11 , Issue.1 , pp. 31-46
    • Metzker, M.L.1
  • 14
    • 0035865322 scopus 로고    scopus 로고
    • A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
    • Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001;409(6822):928-33.
    • (2001) Nature , vol.409 , Issue.6822 , pp. 928-933
    • Sachidanandam, R.1    Weissman, D.2    Schmidt, S.C.3    Kakol, J.M.4    Stein, L.D.5    Marth, G.6
  • 15
    • 84875909665 scopus 로고    scopus 로고
    • DNA Sequencing Costs: Data from the NHGRI Genome Sequencing Program (GSP)
    • Accessed [2015]
    • Wetterstrand KA. DNA Sequencing Costs: Data from the NHGRI Genome Sequencing Program (GSP) Available at: www.genome.gov/sequencingcosts . Accessed [2015].
    • Wetterstrand, K.A.1
  • 16
    • 70249111091 scopus 로고    scopus 로고
    • Targeted capture and massively parallel sequencing of 12 human exomes
    • Ng SB, Turner EH, Robertson PD, Flygare SD, Bigham AW, Lee C, et al. Targeted capture and massively parallel sequencing of 12 human exomes. Nature. 2009;461(7261):272-6.
    • (2009) Nature , vol.461 , Issue.7261 , pp. 272-276
    • Ng, S.B.1    Turner, E.H.2    Robertson, P.D.3    Flygare, S.D.4    Bigham, A.W.5    Lee, C.6
  • 17
    • 84877278637 scopus 로고    scopus 로고
    • Implementing personalized cancer genomics in clinical trials
    • Simon R, Roychowdhury S. Implementing personalized cancer genomics in clinical trials. Nat Rev Drug Discov. 2013;12(5):358-69.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.5 , pp. 358-369
    • Simon, R.1    Roychowdhury, S.2
  • 18
    • 84930455123 scopus 로고    scopus 로고
    • Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences
    • Kriegsmann M, Endris V, Wolf T, Pfarr N, Stenzinger A, Loibl S, et al. Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences. Oncotarget. 2014;5(20):9952-65.
    • (2014) Oncotarget , vol.5 , Issue.20 , pp. 9952-9965
    • Kriegsmann, M.1    Endris, V.2    Wolf, T.3    Pfarr, N.4    Stenzinger, A.5    Loibl, S.6
  • 19
    • 84902313616 scopus 로고    scopus 로고
    • Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue
    • Hedegaard J, Thorsen K, Lund MK, Hein AM, Hamilton-Dutoit SJ, Vang S, et al. Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue. PLoS One. 2014;9(5):e98187.
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e98187
    • Hedegaard, J.1    Thorsen, K.2    Lund, M.K.3    Hein, A.M.4    Hamilton-Dutoit, S.J.5    Vang, S.6
  • 20
    • 84926416450 scopus 로고    scopus 로고
    • Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types
    • Lebofsky R, Decraene C, Bernard V, Kamal M, Blin A, Leroy Q, et al. Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types. Mol Oncol. 2015;9(4):783-90.
    • (2015) Mol Oncol , vol.9 , Issue.4 , pp. 783-790
    • Lebofsky, R.1    Decraene, C.2    Bernard, V.3    Kamal, M.4    Blin, A.5    Leroy, Q.6
  • 21
    • 0016800090 scopus 로고
    • A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase
    • Sanger F, Coulson AR. A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol. 1975;94(3):441-8.
    • (1975) J Mol Biol , vol.94 , Issue.3 , pp. 441-448
    • Sanger, F.1    Coulson, A.R.2
  • 23
    • 84879634155 scopus 로고    scopus 로고
    • Comparison of commercially available target enrichment methods for next-generation sequencing
    • Bodi K, Perera AG, Adams PS, Bintzler D, Dewar K, Grove DS, et al. Comparison of commercially available target enrichment methods for next-generation sequencing. J Biomol Tech. 2013;24(2):73-86.
    • (2013) J Biomol Tech , vol.24 , Issue.2 , pp. 73-86
    • Bodi, K.1    Perera, A.G.2    Adams, P.S.3    Bintzler, D.4    Dewar, K.5    Grove, D.S.6
  • 24
    • 84928528797 scopus 로고    scopus 로고
    • Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants
    • Belkadi A, Bolze A, Itan Y, Cobat A, Vincent QB, Antipenko A, et al. Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants. Proc Natl Acad Sci U S A. 2015;112(17):5473-8.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.17 , pp. 5473-5478
    • Belkadi, A.1    Bolze, A.2    Itan, Y.3    Cobat, A.4    Vincent, Q.B.5    Antipenko, A.6
  • 26
    • 84946040120 scopus 로고    scopus 로고
    • COSMIC: exploring the world's knowledge of somatic mutations in human cancer
    • Forbes SA, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res. 2015;43(Database issue):D805-11.
    • (2015) Nucleic Acids Res , vol.43 , Issue.DATABASE ISSUE , pp. D805-D811
    • Forbes, S.A.1    Beare, D.2    Gunasekaran, P.3    Leung, K.4    Bindal, N.5    Boutselakis, H.6
  • 27
    • 0043122919 scopus 로고    scopus 로고
    • SIFT: Predicting amino acid changes that affect protein function
    • Ng PC, Henikoff S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 2003;31(13):3812-4.
    • (2003) Nucleic Acids Res , vol.31 , Issue.13 , pp. 3812-3814
    • Ng, P.C.1    Henikoff, S.2
  • 28
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
    • Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc. 2009;4(7):1073-81.
    • (2009) Nat Protoc , vol.4 , Issue.7 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 30
    • 80053189298 scopus 로고    scopus 로고
    • Predicting the functional impact of protein mutations: application to cancer genomics
    • Reva B, Antipin Y, Sander C. Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res. 2011;39(17):e118.
    • (2011) Nucleic Acids Res , vol.39 , Issue.17 , pp. e118
    • Reva, B.1    Antipin, Y.2    Sander, C.3
  • 31
    • 34548677928 scopus 로고    scopus 로고
    • Comment on "The consensus coding sequences of human breast and colorectal cancers"
    • Getz G, Hofling H, Mesirov JP, Golub TR, Meyerson M, Tibshirani R, et al. Comment on "The consensus coding sequences of human breast and colorectal cancers". Science. 2007;317(5844):1500.
    • (2007) Science , vol.317 , Issue.5844 , pp. 1500
    • Getz, G.1    Hofling, H.2    Mesirov, J.P.3    Golub, T.R.4    Meyerson, M.5    Tibshirani, R.6
  • 32
    • 84885100832 scopus 로고    scopus 로고
    • The mutational landscape of phosphorylation signaling in cancer
    • Reimand J, Wagih O, Bader GD. The mutational landscape of phosphorylation signaling in cancer. Sci Rep. 2013;3:2651.
    • (2013) Sci Rep. , vol.3 , pp. 2651
    • Reimand, J.1    Wagih, O.2    Bader, G.D.3
  • 33
    • 84937965263 scopus 로고    scopus 로고
    • Genome Medicine in Cancer: What's in a Name?
    • Schott AF, Perou CM, Hayes DF. Genome Medicine in Cancer: What's in a Name? Cancer Res. 2015;75(10):1930-5.
    • (2015) Cancer Res , vol.75 , Issue.10 , pp. 1930-1935
    • Schott, A.F.1    Perou, C.M.2    Hayes, D.F.3
  • 34
    • 84930575551 scopus 로고    scopus 로고
    • Survival Fraction at 2Gy and gammaH2AX Expression Kinetics in Peripheral Blood Lymphocytes From Cancer Patients: Relationship With Acute Radiation-Induced Toxicities
    • Pouliliou SE, Lialiaris TS, Dimitriou T, Giatromanolaki A, Papazoglou D, Pappa A, et al. Survival Fraction at 2Gy and gammaH2AX Expression Kinetics in Peripheral Blood Lymphocytes From Cancer Patients: Relationship With Acute Radiation-Induced Toxicities. Int J Radiat Oncol Biol Phys. 2015;92(3):667-74.
    • (2015) Int J Radiat Oncol Biol Phys , vol.92 , Issue.3 , pp. 667-674
    • Pouliliou, S.E.1    Lialiaris, T.S.2    Dimitriou, T.3    Giatromanolaki, A.4    Papazoglou, D.5    Pappa, A.6
  • 35
    • 80051783228 scopus 로고    scopus 로고
    • Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours
    • Menegakis A, Eicheler W, Yaromina A, Thames HD, Krause M, Baumann M. Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours. Radiother Oncol. 2011;100(1):137-44.
    • (2011) Radiother Oncol , vol.100 , Issue.1 , pp. 137-144
    • Menegakis, A.1    Eicheler, W.2    Yaromina, A.3    Thames, H.D.4    Krause, M.5    Baumann, M.6
  • 36
    • 0029839820 scopus 로고    scopus 로고
    • Feasibility of measuring radiation-induced DNA double strand breaks and their repair by pulsed field gel electrophoresis in freshly isolated cells from the mouse RIF-1 tumor
    • van Waarde MA, van Assen AJ, Konings AW, Kampinga HH. Feasibility of measuring radiation-induced DNA double strand breaks and their repair by pulsed field gel electrophoresis in freshly isolated cells from the mouse RIF-1 tumor. Int J Radiat Oncol Biol Phys. 1996;36(1):125-34.
    • (1996) Int J Radiat Oncol Biol Phys , vol.36 , Issue.1 , pp. 125-134
    • Waarde, M.A.1    Assen, A.J.2    Konings, A.W.3    Kampinga, H.H.4
  • 37
    • 58149180926 scopus 로고    scopus 로고
    • DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing
    • Rube CE, Grudzenski S, Kuhne M, Dong X, Rief N, Lobrich M, et al. DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing. Clin Cancer Res. 2008;14(20):6546-55.
    • (2008) Clin Cancer Res , vol.14 , Issue.20 , pp. 6546-6555
    • Rube, C.E.1    Grudzenski, S.2    Kuhne, M.3    Dong, X.4    Rief, N.5    Lobrich, M.6
  • 38
    • 0035201055 scopus 로고    scopus 로고
    • Impact of the tumour bed effect on microenvironment, radiobiological hypoxia and the outcome of fractionated radiotherapy of human FaDu squamous-cell carcinoma growing in the nude mouse
    • Zips D, Eicheler W, Bruchner K, Jackisch T, Geyer P, Petersen C, et al. Impact of the tumour bed effect on microenvironment, radiobiological hypoxia and the outcome of fractionated radiotherapy of human FaDu squamous-cell carcinoma growing in the nude mouse. Int J Radiat Biol. 2001;77(12):1185-93.
    • (2001) Int J Radiat Biol , vol.77 , Issue.12 , pp. 1185-1193
    • Zips, D.1    Eicheler, W.2    Bruchner, K.3    Jackisch, T.4    Geyer, P.5    Petersen, C.6
  • 39
    • 69549122386 scopus 로고    scopus 로고
    • Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform
    • Eschrich S, Zhang H, Zhao H, Boulware D, Lee JH, Bloom G, et al. Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform. Int J Radiat Oncol Biol Phys. 2009;75(2):497-505.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.2 , pp. 497-505
    • Eschrich, S.1    Zhang, H.2    Zhao, H.3    Boulware, D.4    Lee, J.H.5    Bloom, G.6
  • 41
    • 84455209531 scopus 로고    scopus 로고
    • Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck
    • Toustrup K, Sorensen BS, Lassen P, Wiuf C, Alsner J, Overgaard J, et al. Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck. Radiother Oncol. 2012;102(1):122-9.
    • (2012) Radiother Oncol , vol.102 , Issue.1 , pp. 122-129
    • Toustrup, K.1    Sorensen, B.S.2    Lassen, P.3    Wiuf, C.4    Alsner, J.5    Overgaard, J.6
  • 42
    • 84938970785 scopus 로고    scopus 로고
    • IAEA-HypoX. A randomized multicenter study of the hypoxic radiosensitizer nimorazole concomitant with accelerated radiotherapy in head and neck squamous cell carcinoma
    • Hassan Metwally MA, Ali R, Kuddu M, Shouman T, Strojan P, Iqbal K, et al. IAEA-HypoX. A randomized multicenter study of the hypoxic radiosensitizer nimorazole concomitant with accelerated radiotherapy in head and neck squamous cell carcinoma. Radiother Oncol. 2015.
    • (2015) Radiother Oncol
    • Hassan Metwally, M.A.1    Ali, R.2    Kuddu, M.3    Shouman, T.4    Strojan, P.5    Iqbal, K.6
  • 43
    • 84897070672 scopus 로고    scopus 로고
    • Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer
    • Teo MT, Dyrskjot L, Nsengimana J, Buchwald C, Snowden H, Morgan J, et al. Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer. Ann Oncol. 2014;25(4):877-83.
    • (2014) Ann Oncol , vol.25 , Issue.4 , pp. 877-883
    • Teo, M.T.1    Dyrskjot, L.2    Nsengimana, J.3    Buchwald, C.4    Snowden, H.5    Morgan, J.6
  • 45
    • 84940095520 scopus 로고    scopus 로고
    • Genomic profiling using targeted ultra-deep next-generation sequencing for prediction of treatment outcome after concurrent chemoradiation: Results from the German ARO-0401 trial
    • abstr 6002
    • Tinhofer I, Budach V, Endris V, Stenzinger A, Weichert W. Genomic profiling using targeted ultra-deep next-generation sequencing for prediction of treatment outcome after concurrent chemoradiation: Results from the German ARO-0401 trial. J Clin Oncol. 2014;32(5s):abstr 6002.
    • (2014) J Clin Oncol , vol.32 , Issue.5S
    • Tinhofer, I.1    Budach, V.2    Endris, V.3    Stenzinger, A.4    Weichert, W.5
  • 46
    • 84940095521 scopus 로고    scopus 로고
    • Mutational patterns of HPV+ and HPV- squamous cell carcinomas of the head and neck (SCCHN) and their interference with outcome after adjuvant chemoradiation: A multicenter biomarker study of the German Cancer Consortium Radiation Oncology Group
    • Tinhofer I, Budach V, Linge A, Lohaus F, Gkika E, Stuschke M, et al. Mutational patterns of HPV+ and HPV- squamous cell carcinomas of the head and neck (SCCHN) and their interference with outcome after adjuvant chemoradiation: A multicenter biomarker study of the German Cancer Consortium Radiation Oncology Group. J Clin Oncol. 2015;33(5s):abstr 6006.
    • (2015) J Clin Oncol. , vol.33 , Issue.5S
    • Tinhofer, I.1    Budach, V.2    Linge, A.3    Lohaus, F.4    Gkika, E.5    Stuschke, M.6
  • 48
    • 84855443905 scopus 로고    scopus 로고
    • TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence
    • Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, et al. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res. 2012;18(1):290-300.
    • (2012) Clin Cancer Res , vol.18 , Issue.1 , pp. 290-300
    • Skinner, H.D.1    Sandulache, V.C.2    Ow, T.J.3    Meyn, R.E.4    Yordy, J.S.5    Beadle, B.M.6
  • 49
    • 84923097689 scopus 로고    scopus 로고
    • Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions
    • Sakai K, Kazama S, Nagai Y, Murono K, Tanaka T, Ishihara S, et al. Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions. Oncotarget. 2014;5(20):9641-9.
    • (2014) Oncotarget , vol.5 , Issue.20 , pp. 9641-9649
    • Sakai, K.1    Kazama, S.2    Nagai, Y.3    Murono, K.4    Tanaka, T.5    Ishihara, S.6
  • 50
    • 84870948750 scopus 로고    scopus 로고
    • Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy
    • Rodriguez OC, Choudhury S, Kolukula V, Vietsch EE, Catania J, Preet A, et al. Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy. Cell Cycle. 2012;11(23):4436-46.
    • (2012) Cell Cycle , vol.11 , Issue.23 , pp. 4436-4446
    • Rodriguez, O.C.1    Choudhury, S.2    Kolukula, V.3    Vietsch, E.E.4    Catania, J.5    Preet, A.6
  • 51
    • 0036949663 scopus 로고    scopus 로고
    • Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database
    • Bykov VJ, Issaeva N, Selivanova G, Wiman KG. Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis. 2002;23(12):2011-8.
    • (2002) Carcinogenesis , vol.23 , Issue.12 , pp. 2011-2018
    • Bykov, V.J.1    Issaeva, N.2    Selivanova, G.3    Wiman, K.G.4
  • 52
    • 84929463303 scopus 로고    scopus 로고
    • Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution
    • Hu J, Adar S, Selby CP, Lieb JD, Sancar A. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution. Genes Dev. 2015;29(9):948-60.
    • (2015) Genes Dev , vol.29 , Issue.9 , pp. 948-960
    • Hu, J.1    Adar, S.2    Selby, C.P.3    Lieb, J.D.4    Sancar, A.5
  • 55
    • 84899836282 scopus 로고    scopus 로고
    • Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
    • Brown SD, Warren RL, Gibb EA, Martin SD, Spinelli JJ, Nelson BH, et al. Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res. 2014;24(5):743-50.
    • (2014) Genome Res , vol.24 , Issue.5 , pp. 743-750
    • Brown, S.D.1    Warren, R.L.2    Gibb, E.A.3    Martin, S.D.4    Spinelli, J.J.5    Nelson, B.H.6
  • 56
    • 84938546841 scopus 로고    scopus 로고
    • Radiotherapy and immune checkpoint blockade: potential interactions and future directions
    • Binder DC, Fu YX, Weichselbaum RR. Radiotherapy and immune checkpoint blockade: potential interactions and future directions. Trends Mol Med. 2015
    • (2015) Trends Mol Med
    • Binder, D.C.1    Fu, Y.X.2    Weichselbaum, R.R.3
  • 58
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333(6046):1154-7.
    • (2011) Science , vol.333 , Issue.6046 , pp. 1154-1157
    • Agrawal, N.1    Frederick, M.J.2    Pickering, C.R.3    Bettegowda, C.4    Chang, K.5    Li, R.J.6
  • 60
    • 84923197605 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of head and neck squamous cell carcinomas
    • The Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517(7536):576-82.
    • (2015) Nature. , vol.517 , Issue.7536 , pp. 576-582
  • 62
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science. 2007;318(5853):1108-13.
    • (2007) Science , vol.318 , Issue.5853 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjoblom, T.5    Leary, R.J.6
  • 63
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883-92.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6
  • 64
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: evolution through space and time
    • Swanton C. Intratumor heterogeneity: evolution through space and time. Cancer Res. 2012;72(19):4875-82.
    • (2012) Cancer Res , vol.72 , Issue.19 , pp. 4875-4882
    • Swanton, C.1
  • 65
    • 84907855592 scopus 로고    scopus 로고
    • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
    • de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, Yates L, et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science. 2014;346(6206):251-6.
    • (2014) Science , vol.346 , Issue.6206 , pp. 251-256
    • Bruin, E.C.1    McGranahan, N.2    Mitter, R.3    Salm, M.4    Wedge, D.C.5    Yates, L.6
  • 66
    • 76049098292 scopus 로고    scopus 로고
    • Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
    • Baldus SE, Schaefer KL, Engers R, Hartleb D, Stoecklein NH, Gabbert HE. Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res. 2010;16(3):790-9.
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 790-799
    • Baldus, S.E.1    Schaefer, K.L.2    Engers, R.3    Hartleb, D.4    Stoecklein, N.H.5    Gabbert, H.E.6
  • 67
    • 84873084388 scopus 로고    scopus 로고
    • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
    • Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science. 2013;339(6119):543-8.
    • (2013) Science , vol.339 , Issue.6119 , pp. 543-548
    • Kreso, A.1    O'Brien, C.A.2    Galen, P.3    Gan, O.I.4    Notta, F.5    Brown, A.M.6
  • 69
    • 84907481031 scopus 로고    scopus 로고
    • C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
    • Meier B, Cooke SL, Weiss J, Bailly AP, Alexandrov LB, Marshall J, et al. C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Genome Res. 2014;24(10):1624-36.
    • (2014) Genome Res , vol.24 , Issue.10 , pp. 1624-1636
    • Meier, B.1    Cooke, S.L.2    Weiss, J.3    Bailly, A.P.4    Alexandrov, L.B.5    Marshall, J.6
  • 70
    • 0030460578 scopus 로고    scopus 로고
    • Transplacental mutagenicity of cisplatin: H-ras codon 12 and 13 mutations in skin tumors of SENCAR mice
    • Munoz EF, Diwan BA, Calvert RJ, Weghorst CM, Anderson J, Rice JM, et al. Transplacental mutagenicity of cisplatin: H-ras codon 12 and 13 mutations in skin tumors of SENCAR mice. Carcinogenesis. 1996;17(12):2741-5.
    • (1996) Carcinogenesis , vol.17 , Issue.12 , pp. 2741-2745
    • Munoz, E.F.1    Diwan, B.A.2    Calvert, R.J.3    Weghorst, C.M.4    Anderson, J.5    Rice, J.M.6
  • 71
    • 0037205398 scopus 로고    scopus 로고
    • Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species
    • Cho HJ, Jeong HG, Lee JS, Woo ER, Hyun JW, Chung MH, et al. Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species. J Biol Chem. 2002;277(22):19358-66.
    • (2002) J Biol Chem , vol.277 , Issue.22 , pp. 19358-19366
    • Cho, H.J.1    Jeong, H.G.2    Lee, J.S.3    Woo, E.R.4    Hyun, J.W.5    Chung, M.H.6
  • 74
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • Forshew T, Murtaza M, Parkinson C, Gale D, Tsui DW, Kaper F, et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med. 2012;4(136):136ra68.
    • (2012) Sci Transl Med , vol.4 , Issue.136
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3    Gale, D.4    Tsui, D.W.5    Kaper, F.6
  • 75
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • Dawson SJ, Tsui DW, Murtaza M, Biggs H, Rueda OM, Chin SF, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013;368(13):1199-209.
    • (2013) N Engl J Med , vol.368 , Issue.13 , pp. 1199-1209
    • Dawson, S.J.1    Tsui, D.W.2    Murtaza, M.3    Biggs, H.4    Rueda, O.M.5    Chin, S.F.6
  • 76
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early- and late-stage human malignancies
    • Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014;6(224):224ra24.
    • (2014) Sci Transl Med , vol.6 , Issue.224
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3    Kinde, I.4    Wang, Y.5    Agrawal, N.6
  • 77
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • Newman AM, Bratman SV, To J, Wynne JF, Eclov NC, Modlin LA, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20(5):548-54.
    • (2014) Nat Med , vol.20 , Issue.5 , pp. 548-554
    • Newman, A.M.1    Bratman, S.V.2    To, J.3    Wynne, J.F.4    Eclov, N.C.5    Modlin, L.A.6
  • 78
    • 84940095522 scopus 로고    scopus 로고
    • Serial Next Generation Sequencing of Circulating Cell Free DNA Evaluating Tumour Clone Response To Molecularly Targeted Drug Administration
    • Frenel JS, Carreira S, Goodall J, Roda Perez D, Perez Lopez R, Tunariu N, et al. Serial Next Generation Sequencing of Circulating Cell Free DNA Evaluating Tumour Clone Response To Molecularly Targeted Drug Administration. Clin Cancer Res. 2015.
    • (2015) Clin Cancer Res
    • Frenel, J.S.1    Carreira, S.2    Goodall, J.3    Roda Perez, D.4    Perez Lopez, R.5    Tunariu, N.6
  • 79
    • 84879748358 scopus 로고    scopus 로고
    • Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
    • Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, et al. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science. 2013;341(6141):84-7.
    • (2013) Science , vol.341 , Issue.6141 , pp. 84-87
    • Martinez Molina, D.1    Jafari, R.2    Ignatushchenko, M.3    Seki, T.4    Larsson, E.A.5    Dan, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.