Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy

Cell Cycle

Volumn 11, Issue 23, 2012, Pages 4436-4446

  Rodriguez, Olga Catalina ^a   Choudhury, Sujatra ^a   Kolukula, Vamsi ^a   Vietsch, Eveline E ^a   Catania, Jason ^a   Preet, Anju ^a   Reynoso, Katherine ^b   Bargonetti, Jill ^b   Wellstein, Anton ^a   Albanese, Chris ^a   Avantaggiati, Maria Laura ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Acetylation; Autophagy; Cancer; Diet; Glucose; Mutant; Mutations; p53; Proteasome; Tumor

Indexed keywords

ADENOVIRUS VECTOR; BECLIN 1; DOXORUBICIN; GLUCOSE; MUTANT PROTEIN; PROTEIN MDM2; PROTEIN P53; PROTEIN P62; RAPAMYCIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER THERAPY; CELL DEATH; CONTROLLED STUDY; DIET; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; METABOLIC STRESS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STARVATION; TUMOR CELL; TUMOR XENOGRAFT;

EID: 84870948750     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.22778     Document Type: Article

References (39)

1. Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev 2012; 26:1268-86; PMID:22713868; http://dx.doi.org/10.1101/gad.190678.112.
2. Prives C, White E. Does control of mutant p53 by Mdm2 complicate cancer therapy? Genes Dev 2008; 22:1259-64; PMID:18483214; http://dx.doi.org/10.1101/ gad.1680508.
3. Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 2004; 119:861-72; PMID:15607981; http://dx.doi.org/10.1016/j.cell.2004.11. 006.
4. Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004; 119:847-60; PMID:15607980; http://dx.doi.org/10.1016/j.cell.2004.11.004.
5. Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA, et al. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev 2008; 22:1337-44; PMID:18483220; http://dx.doi.org/10.1101/gad.1662908.
6. Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 2009; 9:701-13; PMID:19693097.
7. Kruse JP, Gu W. Modes of p53 regulation. Cell 2009; 137:609-22; PMID:19450511; http://dx.doi.org/10.1016/j.cell.2009.04.050.
8. Knights CD, Catania J, Di Giovanni S, Muratoglu S, Perez R, Swartzbeck A, et al. Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol 2006; 173:533-44; PMID:16717128; http://dx.doi.org/10.1083/jcb.200512059.
9. Singh R, Cuervo AM. Autophagy in the cellular energetic balance. Cell Metab 2011; 13:495-504; PMID:21531332; http://dx.doi.org/10.1016/j.cmet.2011.04. 004.
10. Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev 2011; 25:1999-2010; PMID:21979913; http://dx.doi.org/10.1101/gad.17558811.
11. Liu EY, Ryan KM. Autophagy and cancer - issues we need to digest. J Cell Sci 2012; 125:2349-58; PMID:22641689; http://dx.doi.org/10.1242/jcs.093708.
12. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672-6; PMID:10604474; http://dx.doi.org/10.1038/45257.
13. Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 2008; 14:90-102; PMID:18598947; http://dx.doi.org/10.1016/j.ccr.2008.06. 004.
14. Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M. p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci USA 2010; 107:18511-6; PMID:20937856; http://dx.doi.org/10.1073/pnas.1006124107.
15. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126:121-34; PMID:16839881; http://dx.doi.org/10.1016/j.cell.2006.05.034.
16. Tasdemir E, Chiara Maiuri M, Morselli E, Criollo A, D'Amelio M, Djavaheri-Mergny M, et al. A dual role of p53 in the control of autophagy. Autophagy 2008; 4:810-4; PMID:18604159.
17. Morselli E, Tasdemir E, Maiuri MC, Galluzzi L, Kepp O, Criollo A, et al. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 2008; 7:3056-61; PMID:18818522; http://dx.doi.org/10.4161/cc.7.19.6751.
18. Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18:283-93; PMID:15866171; http://dx.doi.org/10.1016/j.mol-cel.2005.03.027.
19. Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009; 324:1076-80; PMID:19461003; http://dx.doi.org/10.1126/science.1164097.
20. Moll UM, Petrenko O. The MDM2-p53 interaction. Mol Cancer Res 2003; 1:1001-8; PMID:14707283.
21. White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12:401-10; PMID:22534666; http://dx.doi.org/10. 1038/nrc3262.
22. Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, et al. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci USA 2006; 103:4952-7; PMID:16547133; http://dx.doi.org/10.1073/pnas.0511288103.
23. Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 2012; 148:244-58; PMID:22265415; http://dx.doi.org/10.1016/j.cell.2011.12.017.
24. Peng T, Golub TR, Sabatini DM. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 2002; 22:5575-84; PMID:12101249; http://dx.doi.org/10.1128/MCB.22.15. 5575-5584.2002.
25. Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene 2011; 30:3305-16; PMID:21516129; http://dx.doi.org/10.1038/onc.2011.91.
26. Donehower LA, Lozano G. 20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer 2009; 9:831-41; PMID:19776746; http://dx.doi.org/10.1038/nrc2731.
27. Harvey M, Vogel H, Morris D, Bradley A, Bernstein A, Donehower LA. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet 1995; 9:305-11; PMID:7773294; http://dx.doi.org/10.1038/ng0395-305.
28. Tzeng YJ, Zimmermann C, Guhl E, Berg B, Avantaggiati ML, Graessmann A. SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors. Oncogene 1998; 16:2103-14; PMID:9572491; http://dx.doi.org/10.1038/sj.onc.1201733.
29. Maddocks OD, Vousden KH. Metabolic regulation by p53. J Mol Med (Berl) 2011; 89:237-45; PMID:21340684; http://dx.doi.org/10.1007/s00109-011-0735-5.
30. Vousden KH, Ryan KM. p53 and metabolism. Nat Rev Cancer 2009; 9:691-700; PMID:19759539; http://dx.doi.org/10.1038/nrc2715.
31. Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov 2007; 6:304-12; PMID:17396135; http://dx.doi.org/10.1038/nrd2272.
32. Gusdon AM, Chu CT. To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease. Antioxid Redox Signal 2011; 14:1979-87; PMID:21126205; http://dx.doi.org/10.1089/ars.2010.3763.
33. Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, et al. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget 2012; In press; PMID:23100451.
34. Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 2012; 149:1269-83; PMID:22682249; http://dx.doi.org/10.1016/j.cell.2012.04. 026.
35. Perez RE, Knights CD, Sahu G, Catania J, Kolukula VK, Stoler D, et al. Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol 2010; 225:394-405; PMID:20589832; http://dx.doi.org/10.1002/jcp.22285.
36. Ding WX, Yin XM. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 2008; 4:141-50; PMID:17986870.
37. Dey A, Lane DP, Verma CS. Modulating the p53 pathway. Semin Cancer Biol 2010; 20:3-9; PMID:20193765; http://dx.doi.org/10.1016/j.sem-cancer.2010.02.004. h
38. Stanga S, Lanni C, Govoni S, Uberti D, D'Orazi G, Racchi M. Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link? Aging (Albany NY) 2010; 2:545-54; PMID:20876941.
39. Thomas M, Dadgar N, Aphale A, Harrell JM, Kunkel R, Pratt WB, et al. Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts. J Biol Chem 2004; 279:8389-95; PMID:14670946; http://dx.doi.org/10.1074/jbc.M311761200.