C-MYC is a radiosensitive locus in human breast cells

Oncogene

Volumn 34, Issue 38, 2015, Pages 4985-4994

  Wade, M A ^a   Sunter, N J ^a   Fordham, S E ^a   Long, A ^a   Masic, D ^a   Russell, L J ^a   Harrison, C J ^a   Rand, V ^a   Elstob, C ^a   Bown, N ^a   Rowe, D ^a   Lowe, C ^a   Cuthbert, G ^a   Bennett, S ^a   Crosier, S ^a   Bacon, C M ^a   Onel, K ^b   Scott, K ^c   Scott, D ^d   Travis, L B ^e   May, F E B ^a   Allan, J M ^a   more..

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF YORK   (United Kingdom)

^d HARROGATE DISTRICT HOSPITAL   (United Kingdom)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN;

ARTICLE; BREAST CANCER; BREAST CELL; BREAST EPITHELIUM CELL; CONTROLLED STUDY; GENE AMPLIFICATION; GENE DOSAGE; GENE LOCUS; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; RADIOSENSITIVITY; BREAST; BREAST NEOPLASMS; CELL LINE; COPY NUMBER VARIATION; CYTOLOGY; FEMALE; GENETICS; HODGKIN DISEASE; ONCOGENE MYC; RADIATION INDUCED NEOPLASM; RADIATION RESPONSE; RADIATION TOLERANCE; SINGLE NUCLEOTIDE POLYMORPHISM;

BREAST; BREAST NEOPLASMS; CELL LINE; DNA COPY NUMBER VARIATIONS; FEMALE; GENES, MYC; HODGKIN DISEASE; HUMANS; NEOPLASMS, RADIATION-INDUCED; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIATION DOSAGE; RADIATION TOLERANCE;

EID: 84941879795     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.427     Document Type: Article

References (45)

1. Carmichael A, Sami AS, Dixon JM. Breast cancer risk among the survivors of atomic bomb and patients exposed to therapeutic ionising radiation. Eur J Surg Oncol 2003; 29: 475-479.
2. Travis LB, Hill DA, Dores GM, Gospodarowicz M, van Leeuwen FE, Holowaty E, et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 2003; 290: 465-475.
3. Tokunaga M, Land CE, Tokuoka S, Nishimori I, Soda M, Akiba S. Incidence of female breast cancer among atomic bomb survivors, 1950-1985. Radiat Res 1994; 138: 209-223.
4. Land CE, Tokunaga M, Koyama K, Soda M, Preston DL, Nishimori I, et al. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res 2003; 160: 707-717.
5. Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, et al. Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res 2007; 168: 1-64.
6. Davis FG, Boice JD Jr, Hrubec Z, Monson RR. Cancer mortality in a radiationexposed cohort of Massachusetts tuberculosis patients. Cancer Res 1989; 49: 6130-6136.
7. Hrubec Z, Boice JD Jr, Monson RR, Rosenstein M. Breast cancer after multiple chest fluoroscopies: second follow-up of Massachusetts women with tuberculosis. Cancer Res 1989; 49: 229-234.
8. Hoffman DA, Lonstein JE, Morin MM, Visscher W, Harris BS III, Boice JD Jr. Breast cancer in women with scoliosis exposed to multiple diagnostic x rays. J Natl Cancer Inst 1989; 81: 1307-1312.
9. Ma H, Hill CK, Bernstein L, Ursin G. Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: results from a case-control and a case-case comparison. Breast Cancer Res Treat 2008; 109: 77-90.
10. Broeks A, Braaf LM, Wessels LF, van de Vijver M, De Bruin ML, Stovall M, et al. Radiation-associated breast tumors display a distinct gene expression profile. Int J Radiat Oncol Biol Phys 2010; 76: 540-547.
11. Varma G, Varma R, Huang H, Pryshchepava A, Groth J, Fleming D, et al. Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York. Br J Cancer 2005; 93: 699-708.
12. Oikawa M, Yoshiura K, Kondo H, Miura S, Nagayasu T, Nakashima M. Significance of genomic instability in breast cancer in atomic bomb survivors: analysis of microarray-comparative genomic hybridization. Radiat Oncol 2011; 6: 168.
13. Behrens C, Travis LB, Wistuba II, Davis S, Maitra A, Clarke EA, et al. Molecular changes in second primary lung and breast cancers after therapy for Hodgkin's disease. Cancer Epidemiol Biomarkers Prev 2000; 9: 1027-1035.
14. Miura S, Nakashima M, Ito M, Kondo H, Meirmanov S, Hayashi T, et al. Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors: associations with radiation exposure and histologic grade. Cancer 2008; 112: 2143-2151.
15. Roy D, Calaf G, Hei TK. Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells. Carcinogenesis 2001; 22: 1685-1692.
16. Roy D, Calaf G, Hei TK. Allelic imbalance at 11p15.5-15.4 correlated with c-Ha-ras mutation during radiation-induced neoplastic transformation of human breast epithelial cells. Int J Cancer 2003; 103: 730-737.
17. Roy D, Calaf GM, Hande MP, Hei TK. Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression. Int J Oncol 2006; 28: 667-674.
18. Unger K, Wienberg J, Riches A, Hieber L, Walch A, Brown A, et al. Novel gene rearrangements in transformed breast cells identified by high-resolution breakpoint analysis of chromosomal aberrations. Endocr Relat Cancer 2010; 17: 87-98.
19. Cowell JK, LaDuca J, Rossi MR, Burkhardt T, Nowak NJ, Matsui S. Molecular characterization of the t(3;9) associated with immortalization in the MCF10A cell line. Cancer Genet Cytogenet 2005; 163: 23-29.
20. Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer 2011; 50: 25-33.
21. Felber M, Burns FJ, Garte SJ. Amplification of the c-myc oncogene in radiationinduced rat skin tumors as a function of linear energy transfer and dose. Radiat Res 1992; 131: 297-301.
22. Kadota M, Yang HH, Gomez B, Sato M, Clifford RJ, Meerzaman D, et al. Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines. PLoS ONE 2010; 5: e9201.
23. Arlt MF, Durkin SG, Ragland RL, Glover TW. Common fragile sites as targets for chromosome rearrangements. DNA Rep 2006; 5: 1126-1135.
24. Ferber MJ, Eilers P, Schuuring E, Fenton JA, Fleuren GJ, Kenter G, et al. Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13. Cancer Genet Cytogenet 2004; 154: 1-9.
25. Camats N, Ruiz-Herrera A, Parrilla JJ, Acien M, Paya P, Giulotto E, et al. Genomic instability in rat: breakpoints induced by ionising radiation and interstitial telomeric-like sequences. Mutat Res 2006; 595: 156-166.
26. Erisman MD, Rothberg PG, Diehl RE, Morse CC, Spandorfer JM, Astrin SM. Deregulation of C-Myc gene-expression in human-colon carcinoma is not accompanied by amplification or rearrangement of the gene. Mol Cell Biol 1985; 5: 1969-1976.
27. Sauter G, Carroll P, Moch H, Kallioniemi A, Kerschmann R, Narayan P, et al. C-Myc copy number gains in bladder-cancer detected by fluorescence in-situ hybridization. Am J Pathol 1995; 146: 1131-1139.
28. Chrzan P, Skokowski J, Karmolinski A, Pawelczyk T. Amplification of c-myc gene and overexpression of c-Myc protein in breast cancer and adjacent nonneoplastic tissue. Clin Biochem 2001; 34: 557-562.
29. Schleger C, Verbeke C, Hildenbrand R, Zentgraf H, Bleyl U. c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance. Mod Pathol 2002; 15: 462-469.
30. Xu J, Chen Y, Olopade OI. MYC and breast cancer. Genes Cancer 2010; 1: 629-640.
31. Pelengaris S, Khan M, Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002; 2: 764-776.
32. Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, et al. Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Nat Med 2011; 17: 941-943.
33. Obaya AJ, Mateyak MK, Sedivy JM. Mysterious liaisons: the relationship between c-Myc and the cell cycle. Oncogene 1999; 18: 2934-2941.
34. Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer. 2008; 8: 976-990.
35. Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, et al. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 2003; 22: 351-360.
36. Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, et al. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 2002; 16: 2530-2543.
37. Prochownik EV, Li Y. The ever expanding role for c-Myc in promoting genomic instability. Cell Cycle 2007; 6: 1024-1029.
38. Li Z, Owonikoko TK, Sun SY, Ramalingam SS, Doetsch PW, Xiao ZQ, et al. c-Myc suppression of DNA double-strand break repair. Neoplasia 2012; 14: 1190-1202.
39. Chiang CS, Sawyers CL, McBride WH. Oncogene expression and cellular radiation resistance: a modulatory role for c-myc. Mol Diagn 1998; 3: 21-27.
40. Davey RA, Locke VL, Henness S, Harvie RM, Davey MW. Cellular models of drug- and radiation-resistant small cell lung cancer. Anticancer Res 2004; 24: 465-471.
41. Kim BY, Kwak SY, Yang JS, Han YH. Phosphorylation and stabilization of c-Myc by NEMO renders cells resistant to ionizing radiation through up-regulation of gamma-GCS. Oncol Rep 2011; 26: 1587-1593.
42. Wang WJ, Wu SP, Liu JB, Shi YS, Huang X, Zhang QB, et al. MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res 2013; 73: 1219-1231.
43. Berg T. Small-molecule modulators of c-Myc/Max and Max/Max interactions. Curr Top Microbiol Immunol 2011; 348: 139-149.
44. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-268.
45. Soule HD, Maloney TM, Wolman SR, Peterson WD Jr, Brenz R, McGrath CM, et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 1990; 50: 6075-6086.