메뉴 건너뛰기




Volumn 62, Issue 1, 2015, Pages 71-80

Immune protective effect of human alpha-1-antitrypsin gene during β cell transplantation in diabetic mice

Author keywords

Alpha 1 antitrypsin; Immune protective effect; Type 1 diabetes; cell transplantation

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYTOKINE; MESSENGER RNA;

EID: 84939965262     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-015-8636-2     Document Type: Article
Times cited : (6)

References (40)
  • 1
    • 84936928828 scopus 로고    scopus 로고
    • Advances in management of type 1 diabetes mellitus
    • PID: 25317246
    • Aathira R, Jain V. Advances in management of type 1 diabetes mellitus. World J Diabetes. 2014;5(5):689–96. doi:10.4239/wjd.v5.i5.689.
    • (2014) World J Diabetes , vol.5 , Issue.5 , pp. 689-696
    • Aathira, R.1    Jain, V.2
  • 2
    • 84903279290 scopus 로고    scopus 로고
    • Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
    • COI: 1:CAS:528:DC%2BC2cXhvF2nsLfF, PID: 25018643
    • Bruni A, Gala-Lopez B, Pepper AR, Abualhassan NS, Shapiro AJ. Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes. 2014;7:211–23. doi:10.2147/DMSO.S50789.
    • (2014) Diabetes Metab Syndr Obes. , vol.7 , pp. 211-223
    • Bruni, A.1    Gala-Lopez, B.2    Pepper, A.R.3    Abualhassan, N.S.4    Shapiro, A.J.5
  • 3
    • 84884589725 scopus 로고    scopus 로고
    • Immune monitoring of islet and pancreas transplant recipients
    • COI: 1:CAS:528:DC%2BC3sXhsVOgtrrK
    • Abreu JR, Roep BO. Immune monitoring of islet and pancreas transplant recipients. Curr Diabetes Rep. 2013;13(5):704–12. doi:10.1007/s11892-013-0399-3.
    • (2013) Curr Diabetes Rep. , vol.13 , Issue.5 , pp. 704-712
    • Abreu, J.R.1    Roep, B.O.2
  • 5
    • 77649159849 scopus 로고    scopus 로고
    • Immunological aspects of pancreatic islet cell transplantation
    • PID: 20383895
    • Azzi J, Geara AS, El-Sayegh S, Abdi R. Immunological aspects of pancreatic islet cell transplantation. Expert Rev Clin Immunol. 2010;6(1):111–24.
    • (2010) Expert Rev Clin Immunol. , vol.6 , Issue.1 , pp. 111-124
    • Azzi, J.1    Geara, A.S.2    El-Sayegh, S.3    Abdi, R.4
  • 6
    • 77955536367 scopus 로고    scopus 로고
    • Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery
    • COI: 1:CAS:528:DC%2BC3cXpvVyktr0%3D, PID: 20692406
    • Loganathan G, Dawra RK, Pugazhenthi S, Wiseman AC, Sanders MA, Saluja AK, et al. Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery. Transplant Proc. 2010;42(6):2055–7. doi:10.1016/j.transproceed.2010.05.119.
    • (2010) Transplant Proc. , vol.42 , Issue.6 , pp. 2055-2057
    • Loganathan, G.1    Dawra, R.K.2    Pugazhenthi, S.3    Wiseman, A.C.4    Sanders, M.A.5    Saluja, A.K.6
  • 7
    • 81855185898 scopus 로고    scopus 로고
    • Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of alpha-1 antitrypsin treatment
    • COI: 1:CAS:528:DC%2BC3MXhsFant7fI, PID: 22089666
    • Loganathan G, Dawra RK, Pugazhenthi S, Guo Z, Soltani SM, Wiseman A, et al. Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of alpha-1 antitrypsin treatment. Transplantation. 2011;92(11):1222–30. doi:10.1097/TP.0b013e318237585c.
    • (2011) Transplantation , vol.92 , Issue.11 , pp. 1222-1230
    • Loganathan, G.1    Dawra, R.K.2    Pugazhenthi, S.3    Guo, Z.4    Soltani, S.M.5    Wiseman, A.6
  • 8
    • 84866525419 scopus 로고    scopus 로고
    • Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival
    • COI: 1:CAS:528:DC%2BC38XhsVyjtLvF, PID: 22949661
    • Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, et al. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci USA. 2012;109(38):15443–8. doi:10.1073/pnas.1018366109.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.38 , pp. 15443-15448
    • Koulmanda, M.1    Bhasin, M.2    Fan, Z.3    Hanidziar, D.4    Goel, N.5    Putheti, P.6
  • 9
    • 24644461309 scopus 로고    scopus 로고
    • Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice
    • COI: 1:CAS:528:DC%2BD2MXps1yqs74%3D, PID: 16093309
    • Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci USA. 2005;102(34):12153–8. doi:10.1073/pnas.0505579102.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.34 , pp. 12153-12158
    • Lewis, E.C.1    Shapiro, L.2    Bowers, O.J.3    Dinarello, C.A.4
  • 10
    • 34248178516 scopus 로고    scopus 로고
    • Alpha1-antitrypsin protects beta-cells from apoptosis
    • COI: 1:CAS:528:DC%2BD2sXltlanur8%3D, PID: 17360983
    • Zhang B, Lu Y, Campbell-Thompson M, Spencer T, Wasserfall C, Atkinson M, et al. Alpha1-antitrypsin protects beta-cells from apoptosis. Diabetes. 2007;56(5):1316–23. doi:10.2337/db06-1273.
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1316-1323
    • Zhang, B.1    Lu, Y.2    Campbell-Thompson, M.3    Spencer, T.4    Wasserfall, C.5    Atkinson, M.6
  • 11
    • 79953250407 scopus 로고    scopus 로고
    • Alpha 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic beta-cells
    • PID: 21099312
    • Kalis M, Kumar R, Janciauskiene S, Salehi A, Cilio CM. Alpha 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic beta-cells. Islets. 2010;2(3):185–9. doi:10.4161/isl.2.3.11654.
    • (2010) Islets , vol.2 , Issue.3 , pp. 185-189
    • Kalis, M.1    Kumar, R.2    Janciauskiene, S.3    Salehi, A.4    Cilio, C.M.5
  • 12
    • 55849101706 scopus 로고    scopus 로고
    • Alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
    • COI: 1:CAS:528:DC%2BD1cXhtlSju7jM, PID: 18852465
    • Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, et al. Alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci USA. 2008;105(42):16236–41. doi:10.1073/pnas.0807627105.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.42 , pp. 16236-16241
    • Lewis, E.C.1    Mizrahi, M.2    Toledano, M.3    Defelice, N.4    Wright, J.L.5    Churg, A.6
  • 13
    • 84871510833 scopus 로고    scopus 로고
    • Novel therapeutic uses of alpha-1 antitrypsin: a window to the future
    • PID: 23205701
    • Wanner A, Arce AD, Pardee E. Novel therapeutic uses of alpha-1 antitrypsin: a window to the future. COPD. 2012;9(6):583–8. doi:10.3109/15412555.2012.717125.
    • (2012) COPD , vol.9 , Issue.6 , pp. 583-588
    • Wanner, A.1    Arce, A.D.2    Pardee, E.3
  • 14
    • 84858776868 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection
    • COI: 1:CAS:528:DC%2BC3MXhtlCgsbjL, PID: 21670848
    • Shahaf G, Moser H, Ozeri E, Mizrahi M, Abecassis A, Lewis EC. Alpha-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection. Mol Med. 2011;17(9–10):1000–11. doi:10.2119/molmed.2011.00145.
    • (2011) Mol Med. , vol.17 , Issue.9-10 , pp. 1000-1011
    • Shahaf, G.1    Moser, H.2    Ozeri, E.3    Mizrahi, M.4    Abecassis, A.5    Lewis, E.C.6
  • 15
    • 51349135580 scopus 로고    scopus 로고
    • Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice
    • COI: 1:CAS:528:DC%2BD1cXht1Cmu73P, PID: 18759852
    • Lu Y, Parker M, Pileggi A, Zhang B, Choi YK, Molano RD, et al. Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice. Clin Exp Immunol. 2008;154(1):15–21. doi:10.1111/j.1365-2249.2008.03721.x.
    • (2008) Clin Exp Immunol. , vol.154 , Issue.1 , pp. 15-21
    • Lu, Y.1    Parker, M.2    Pileggi, A.3    Zhang, B.4    Choi, Y.K.5    Molano, R.D.6
  • 16
    • 77958066901 scopus 로고    scopus 로고
    • Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease
    • COI: 1:CAS:528:DC%2BC3cXhtV2gtrbP, PID: 20593162
    • Ma H, Lu Y, Li H, Campbell-Thompson M, Parker M, Wasserfall C, et al. Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease. Diabetologia. 2010;53(10):2198–204. doi:10.1007/s00125-010-1829-2.
    • (2010) Diabetologia , vol.53 , Issue.10 , pp. 2198-2204
    • Ma, H.1    Lu, Y.2    Li, H.3    Campbell-Thompson, M.4    Parker, M.5    Wasserfall, C.6
  • 17
    • 84874522014 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin for the improvement of autoimmunity and allograft rejection in beta cell transplantation
    • COI: 1:CAS:528:DC%2BC3sXjvFCls7c%3D, PID: 23333354
    • Ye J, Liao YT, Jian YQ, Zhang XD, Wei P, Qi H, et al. Alpha-1-antitrypsin for the improvement of autoimmunity and allograft rejection in beta cell transplantation. Immunol Lett. 2013;150(1–2):61–8. doi:10.1016/j.imlet.2013.01.009.
    • (2013) Immunol Lett. , vol.150 , Issue.1-2 , pp. 61-68
    • Ye, J.1    Liao, Y.T.2    Jian, Y.Q.3    Zhang, X.D.4    Wei, P.5    Qi, H.6
  • 18
    • 84899526359 scopus 로고    scopus 로고
    • The immunoregulation effect of alpha 1-antitrypsin prolong beta-cell survival after transplantation
    • PID: 24722487
    • Wang Y, Yan HJ, Zhou SY, Wang YS, Qi H, Deng CY, et al. The immunoregulation effect of alpha 1-antitrypsin prolong beta-cell survival after transplantation. PLoS One. 2014;9(4):e94548. doi:10.1371/journal.pone.0094548.
    • (2014) PLoS One , vol.9 , Issue.4 , pp. 94548
    • Wang, Y.1    Yan, H.J.2    Zhou, S.Y.3    Wang, Y.S.4    Qi, H.5    Deng, C.Y.6
  • 19
    • 77954641328 scopus 로고    scopus 로고
    • Immune modulation of co-transplantation mesenchymal stem cells with islet on T and dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXhtV2itLnF, PID: 20456412
    • Li FR, Wang XG, Deng CY, Qi H, Ren LL, Zhou HX. Immune modulation of co-transplantation mesenchymal stem cells with islet on T and dendritic cells. Clin Exp Immunol. 2010;161(2):357–63. doi:10.1111/j.1365-2249.2010.04178.x.
    • (2010) Clin Exp Immunol. , vol.161 , Issue.2 , pp. 357-363
    • Li, F.R.1    Wang, X.G.2    Deng, C.Y.3    Qi, H.4    Ren, L.L.5    Zhou, H.X.6
  • 20
    • 84864285400 scopus 로고    scopus 로고
    • A role for anti-CD45RB monoclonal antibody treatment upon dendritic cells
    • COI: 1:CAS:528:DC%2BC38XntVeiurs%3D, PID: 22539131
    • Qi H, Liu JP, Deng CY, Zhou HX, Deng SP, Li FR. A role for anti-CD45RB monoclonal antibody treatment upon dendritic cells. Immunol Res. 2012;52(3):250–7. doi:10.1007/s12026-012-8336-0.
    • (2012) Immunol Res. , vol.52 , Issue.3 , pp. 250-257
    • Qi, H.1    Liu, J.P.2    Deng, C.Y.3    Zhou, H.X.4    Deng, S.P.5    Li, F.R.6
  • 21
    • 80052773697 scopus 로고    scopus 로고
    • Role of T and dendritic cells in mouse islet allografts treated with anti-CD45RB monoclonal antibodies
    • COI: 1:CAS:528:DC%2BC3MXhtFGgur7N, PID: 21911152
    • Deng CY, Qi H, Wang XG, Zhou HX, Deng SP, Li FR. Role of T and dendritic cells in mouse islet allografts treated with anti-CD45RB monoclonal antibodies. Transplant Proc. 2011;43(7):2721–7. doi:10.1016/j.transproceed.2011.05.049.
    • (2011) Transplant Proc. , vol.43 , Issue.7 , pp. 2721-2727
    • Deng, C.Y.1    Qi, H.2    Wang, X.G.3    Zhou, H.X.4    Deng, S.P.5    Li, F.R.6
  • 22
    • 84920285151 scopus 로고    scopus 로고
    • Mechanistic evidence in support of alpha1-antitrypsin as a therapeutic approach for type 1 diabetes
    • PID: 25155845
    • Fleixo-Lima G, Ventura H, Medini M, Bar L, Strauss P, Lewis EC. Mechanistic evidence in support of alpha1-antitrypsin as a therapeutic approach for type 1 diabetes. J Diabetes Sci Technol. 2014;8(6):1193–203. doi:10.1177/1932296814547096.
    • (2014) J Diabetes Sci Technol. , vol.8 , Issue.6 , pp. 1193-1203
    • Fleixo-Lima, G.1    Ventura, H.2    Medini, M.3    Bar, L.4    Strauss, P.5    Lewis, E.C.6
  • 23
    • 84865214922 scopus 로고    scopus 로고
    • Expanding the clinical indications for alpha(1)-antitrypsin therapy
    • COI: 1:CAS:528:DC%2BC38XhsVWgsrfO, PID: 22634722
    • Lewis EC. Expanding the clinical indications for alpha(1)-antitrypsin therapy. Mol Med. 2012;18:957–70. doi:10.2119/molmed.2011.00196.
    • (2012) Mol Med. , vol.18 , pp. 957-970
    • Lewis, E.C.1
  • 24
    • 84902968614 scopus 로고    scopus 로고
    • Transcription of the gene encoding TNF-alpha is increased by IL-1beta in rat and human islets and beta-cell lines
    • COI: 1:CAS:528:DC%2BC2cXhsVehsrrK, PID: 24972324
    • Burke SJ, Lu D, Sparer TE, Karlstad MD, Collier JJ. Transcription of the gene encoding TNF-alpha is increased by IL-1beta in rat and human islets and beta-cell lines. Mol Immunol. 2014;62(1):54–62. doi:10.1016/j.molimm.2014.05.019.
    • (2014) Mol Immunol. , vol.62 , Issue.1 , pp. 54-62
    • Burke, S.J.1    Lu, D.2    Sparer, T.E.3    Karlstad, M.D.4    Collier, J.J.5
  • 25
    • 0037603320 scopus 로고    scopus 로고
    • IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction
    • COI: 1:CAS:528:DC%2BD3sXkt1Glurk%3D, PID: 12791316
    • Wachlin G, Augstein P, Schroder D, Kuttler B, Kloting I, Heinke P, et al. IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction. J Autoimmun. 2003;20(4):303–12.
    • (2003) J Autoimmun. , vol.20 , Issue.4 , pp. 303-312
    • Wachlin, G.1    Augstein, P.2    Schroder, D.3    Kuttler, B.4    Kloting, I.5    Heinke, P.6
  • 26
    • 84860992385 scopus 로고    scopus 로고
    • The role of TNF-alpha in mice with type 1- and 2- diabetes
    • COI: 1:CAS:528:DC%2BC38XnslOqtr0%3D, PID: 22606220
    • Koulmanda M, Bhasin M, Awdeh Z, Qipo A, Fan Z, Hanidziar D, et al. The role of TNF-alpha in mice with type 1- and 2- diabetes. PLoS One. 2012;7(5):e33254. doi:10.1371/journal.pone.0033254.
    • (2012) PLoS One , vol.7 , Issue.5 , pp. 33254
    • Koulmanda, M.1    Bhasin, M.2    Awdeh, Z.3    Qipo, A.4    Fan, Z.5    Hanidziar, D.6
  • 27
    • 84905821474 scopus 로고    scopus 로고
    • Alpha1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1beta responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes
    • COI: 1:CAS:528:DC%2BC2cXhsVSgu7fK, PID: 24527714
    • Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, et al. Alpha1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1beta responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014;99(8):E1418–26. doi:10.1210/jc.2013-3864.
    • (2014) J Clin Endocrinol Metab. , vol.99 , Issue.8 , pp. 1418-1426
    • Gottlieb, P.A.1    Alkanani, A.K.2    Michels, A.W.3    Lewis, E.C.4    Shapiro, L.5    Dinarello, C.A.6
  • 28
    • 84905047377 scopus 로고    scopus 로고
    • Alpha1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation
    • COI: 1:CAS:528:DC%2BC2cXhtFeiu7%2FL, PID: 25000533
    • Abecassis A, Schuster R, Shahaf G, Ozeri E, Green R, Ochayon DE, et al. Alpha1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation. Cell Mol Immunol. 2014;11(4):377–86. doi:10.1038/cmi.2014.17.
    • (2014) Cell Mol Immunol. , vol.11 , Issue.4 , pp. 377-386
    • Abecassis, A.1    Schuster, R.2    Shahaf, G.3    Ozeri, E.4    Green, R.5    Ochayon, D.E.6
  • 29
    • 65549125443 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood
    • COI: 1:CAS:528:DC%2BD1MXlvVCks7Y%3D, PID: 19197072
    • Pott GB, Chan ED, Dinarello CA, Shapiro L. Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J Leukoc Biol. 2009;85(5):886–95. doi:10.1189/jlb.0208145.
    • (2009) J Leukoc Biol. , vol.85 , Issue.5 , pp. 886-895
    • Pott, G.B.1    Chan, E.D.2    Dinarello, C.A.3    Shapiro, L.4
  • 31
    • 0035692747 scopus 로고    scopus 로고
    • Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits
    • COI: 1:STN:280:DC%2BD38nhtlSluw%3D%3D, PID: 12369724
    • Suarez-Pinzon WL, Rabinovitch A. Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits. Int J Exp Diabetes Res. 2001;2(1):3–17.
    • (2001) Int J Exp Diabetes Res. , vol.2 , Issue.1 , pp. 3-17
    • Suarez-Pinzon, W.L.1    Rabinovitch, A.2
  • 33
    • 84899438742 scopus 로고    scopus 로고
    • Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors
    • COI: 1:CAS:528:DC%2BC2cXktlCisLs%3D, PID: 24410777
    • Sugimoto K, Itoh T, Takita M, Shimoda M, Chujo D, SoRelle JA, et al. Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. Transpl Int. 2014;27(4):408–15. doi:10.1111/tri.12265.
    • (2014) Transpl Int. , vol.27 , Issue.4 , pp. 408-415
    • Sugimoto, K.1    Itoh, T.2    Takita, M.3    Shimoda, M.4    Chujo, D.5    SoRelle, J.A.6
  • 34
    • 78751561859 scopus 로고    scopus 로고
    • Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: implications for the timing of tolerizing immunotherapy
    • COI: 1:CAS:528:DC%2BC3MXosVWnsg%3D%3D, PID: 20980463
    • Bertin-Maghit S, Pang D, O’Sullivan B, Best S, Duggan E, Paul S, et al. Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: implications for the timing of tolerizing immunotherapy. Diabetes. 2011;60(1):248–57. doi:10.2337/db10-0104.
    • (2011) Diabetes , vol.60 , Issue.1 , pp. 248-257
    • Bertin-Maghit, S.1    Pang, D.2    O’Sullivan, B.3    Best, S.4    Duggan, E.5    Paul, S.6
  • 35
    • 79959379140 scopus 로고    scopus 로고
    • Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+ FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice
    • COI: 1:CAS:528:DC%2BC3MXntFGjtLs%3D, PID: 21437674
    • Subramanian S, Shahaf G, Ozeri E, Miller LM, Vandenbark AA, Lewis EC, et al. Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+ FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice. Metab Brain Dis. 2011;26(2):107–13. doi:10.1007/s11011-011-9239-9.
    • (2011) Metab Brain Dis. , vol.26 , Issue.2 , pp. 107-113
    • Subramanian, S.1    Shahaf, G.2    Ozeri, E.3    Miller, L.M.4    Vandenbark, A.A.5    Lewis, E.C.6
  • 36
    • 84878713500 scopus 로고    scopus 로고
    • The potential role of dendritic cells in the therapy of Type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3sXosFKrsbo%3D, PID: 23725283
    • Lee CN, Lew AM, Wu L. The potential role of dendritic cells in the therapy of Type 1 diabetes. Immunotherapy. 2013;5(6):591–606. doi:10.2217/imt.13.48.
    • (2013) Immunotherapy , vol.5 , Issue.6 , pp. 591-606
    • Lee, C.N.1    Lew, A.M.2    Wu, L.3
  • 37
    • 84887356904 scopus 로고    scopus 로고
    • Protection of islet grafts through transforming growth factor-beta-induced tolerogenic dendritic cells
    • COI: 1:CAS:528:DC%2BC3sXhtl2jtLzP, PID: 23715623
    • Thomas DC, Wong FS, Zaccone P, Green EA, Wallberg M. Protection of islet grafts through transforming growth factor-beta-induced tolerogenic dendritic cells. Diabetes. 2013;62(9):3132–42. doi:10.2337/db12-1740.
    • (2013) Diabetes , vol.62 , Issue.9 , pp. 3132-3142
    • Thomas, D.C.1    Wong, F.S.2    Zaccone, P.3    Green, E.A.4    Wallberg, M.5
  • 38
    • 84864290495 scopus 로고    scopus 로고
    • Functional study of immature dendritic cells co-transfected with IL-10 and TGF-beta 1 genes in vitro
    • COI: 1:CAS:528:DC%2BC38XlvFarsrs%3D, PID: 22294105
    • Chen L, Qiu M, He W, Huang A, Liu J. Functional study of immature dendritic cells co-transfected with IL-10 and TGF-beta 1 genes in vitro. Mol Biol Rep. 2012;39(6):6633–9. doi:10.1007/s11033-012-1468-4.
    • (2012) Mol Biol Rep. , vol.39 , Issue.6 , pp. 6633-6639
    • Chen, L.1    Qiu, M.2    He, W.3    Huang, A.4    Liu, J.5
  • 39
    • 84862860546 scopus 로고    scopus 로고
    • Alpha-1 antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells
    • COI: 1:CAS:528:DC%2BC38XovVyrsr0%3D, PID: 22634621
    • Ozeri E, Mizrahi M, Shahaf G, Lewis EC. Alpha-1 antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells. J Immunol. 2012;189(1):146–53. doi:10.4049/jimmunol.1101340.
    • (2012) J Immunol. , vol.189 , Issue.1 , pp. 146-153
    • Ozeri, E.1    Mizrahi, M.2    Shahaf, G.3    Lewis, E.C.4
  • 40
    • 85138030930 scopus 로고    scopus 로고
    • Alpha1-Antitrypsin modifies general NK cell interactions with dendritic cells and specific interactions with islet beta-cells in favor of protection from autoimmune diabetes
    • PID: 25308894
    • Guttman O, Yossef R, Freixo-Lima G, Rider P, Porgador A, Lewis EC. Alpha1-Antitrypsin modifies general NK cell interactions with dendritic cells and specific interactions with islet beta-cells in favor of protection from autoimmune diabetes. Immunology. 2014;. doi:10.1111/imm.12403.
    • (2014) Immunology
    • Guttman, O.1    Yossef, R.2    Freixo-Lima, G.3    Rider, P.4    Porgador, A.5    Lewis, E.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.