Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: Benefits of α-1 antitrypsin treatment

Transplantation

Volumn 92, Issue 11, 2011, Pages 1222-1230

  Loganathan, Gopalakrishnan ^a   Dawra, Rajinder K ^a   Pugazhenthi, Subbiah ^b   Guo, Zhiguang ^c   Soltani, Sajjad M ^a   Wiseman, Alexander ^b   Sanders, Mark A ^d   Papas, Klearchos K ^a   Velayutham, Kumaravel ^e   Saluja, Ashok K ^a   Sutherland, David E R ^a   Hering, Bernhard J ^a   Balamurugan, A N ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTH DAKOTA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e Institute of Diabetes and Endocrinology   (India)

Author keywords

1 antitrypsin; Acinar cell protease; Impure islet culture; Insulin degradation; Islet cell transplantation; Protease inhibitor

Indexed keywords

ALPHA 1 ANTITRYPSIN; CHYMOTRYPSIN; ELASTASE; INSULIN; PROTEINASE; TRYPSIN;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GRANULE; CELL LOSS; CELL ULTRASTRUCTURE; COCULTURE; CONTROLLED STUDY; DELAYED GRAFT FUNCTION; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT SURVIVAL; HUMAN; HUMAN CELL; INSULIN DEGRADATION; INSULIN GRANULE; KIDNEY CAPSULE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ACINAR CELLS; ALPHA 1-ANTITRYPSIN; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GRAFT SURVIVAL; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, NUDE; PEPTIDE HYDROLASES; SERINE PROTEINASE INHIBITORS; STREPTOZOCIN; TRANSPLANTATION, HETEROLOGOUS; TREATMENT OUTCOME;

EID: 81855185898     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318237585c     Document Type: Article

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