Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy

Diabetes

Volumn 60, Issue 1, 2011, Pages 248-257

  Bertin Maghit, Sebastien ^a   Pang, Dimeng ^a   O'Sullivan, Brendan ^a   Best, Shannon ^a   Duggan, Emily ^a   Paul, Sanjoy ^a   Thomas, Helen ^b   Kay, Thomas W H ^c   Harrison, Leonard C ^c   Steptoe, Raymond ^a   Thomas, Ranjeny ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; AUTOANTIGEN; CD4 ANTIGEN; CELL SURFACE MARKER; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL THERAPY; CELL TRANSFER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; FEMALE; GENE OVEREXPRESSION; GROUPS BY AGE; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; INTRAVENOUS ADMINISTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SPLEEN CELL; TH17 CELL; TRANSGENIC MOUSE;

ANIMALS; AUTOANTIGENS; BLOOD GLUCOSE; CYTOKINES; DENDRITIC CELLS; DIABETES MELLITUS; IMMUNE TOLERANCE; IMMUNOTHERAPY; INFLAMMATION; INSULIN; INTERLEUKIN-17; INTERLEUKIN-1BETA; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTOR RELB;

EID: 78751561859     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0104     Document Type: Article

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