Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice

Metabolic Brain Disease

Volumn 26, Issue 2, 2011, Pages 107-113

  Subramanian, Sandhya ^a   Shahaf, Galit ^b   Ozeri, Eyal ^b   Miller, Lisa M ^a,c   Vandenbark, Arthur A ^a,c   Lewis, Eli C ^b   Offner, Halina ^a,c  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

CCR6; EAE; hAAT; Pro inflammatory cytokines; Tregs

Indexed keywords

ALPHA 1 ANTITRYPSIN; CHEMOKINE RECEPTOR CCR6; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DEMYELINATION; DISEASE COURSE; GENE OVEREXPRESSION; HISTOPATHOLOGY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPINAL CORD; SPLEEN;

ALPHA 1-ANTITRYPSIN; ANIMALS; APOPTOSIS; CASPASES; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FORKHEAD TRANSCRIPTION FACTORS; GLYCOPROTEINS; HUMANS; INFLAMMATION; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; RECEPTORS, CCR6; SPINAL CORD; SPLEEN; T-LYMPHOCYTES, REGULATORY;

MUS; MUS MUSCULUS;

EID: 79959379140     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-011-9239-9     Document Type: Article

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