Intradermal αl-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease

Diabetologia

Volumn 53, Issue 10, 2010, Pages 2198-2204

  Ma, H ^a,b   Lu, Y ^b   Li, H ^b   Campbell Thompson, M ^c   Parker, M ^c   Wasserfall, C ^c   Haller, M ^c   Brantly, M ^c   Schatz, D ^c   Atkinson, M ^c   Song, S ^b  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

1 Antitrypsin; Disease prevention; Non obese diabetic mice; Type 1 diabetes

Indexed keywords

ALPHA 1 ANTITRYPSIN; GLUCOSE; INSULIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENTIATION; FATALITY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TOLERANCE TEST; MONOTHERAPY; MOUSE; NONHUMAN; PRIMARY PREVENTION; PRIORITY JOURNAL; SINGLE DRUG DOSE; ANIMAL; BLOOD; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; NONOBESE DIABETIC MOUSE;

ALPHA 1-ANTITRYPSIN; ANAPHYLAXIS; ANIMALS; AREA UNDER CURVE; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN; MICE; MICE, INBRED NOD;

EID: 77958066901     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1829-2     Document Type: Article

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