Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study

Osteoporosis International

Volumn 26, Issue 1, 2015, Pages 187-197

  Sun, Z B ^a   Wang, J W ^a   Xiao, H ^a   Zhang, Q S ^a   Kan, W S ^a   Mo, F B ^a   Hu, S ^a   Ye, S N ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ABCB1; Hypermethylation; Icariin; Steroid associated osteonecrosis

Indexed keywords

ABCB1 PROTEIN, HUMAN; FLAVONOID; GLUCOCORTICOID; HERBACEOUS AGENT; ICARIIN; MULTIDRUG RESISTANCE PROTEIN; REACTIVE OXYGEN METABOLITE;

ADIPOGENESIS; ADULT; AGED; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CHEMICALLY INDUCED; DNA METHYLATION; DRUG EFFECTS; DRUG SCREENING; FEMALE; FEMUR HEAD NECROSIS; GENETIC EPIGENESIS; GENETICS; HUMAN; MALE; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROCEDURES; PROMOTER REGION;

ADIPOGENESIS; ADULT; AGED; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DNA METHYLATION; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; EPIGENESIS, GENETIC; FEMALE; FEMUR HEAD NECROSIS; FLAVONOIDS; GLUCOCORTICOIDS; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; MOLECULAR TARGETED THERAPY; OSTEOGENESIS; P-GLYCOPROTEINS; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES;

EID: 84939893339     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-014-2809-z     Document Type: Article

References (42)

1. Murata M, Kumagai K, Miyata N et al (2007) Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid. J Orthop Sci 12:289–295
2. Yeh CH, Chang JK, Wang YH et al (2008) Ethanol may suppress Wnt/beta-catenin signaling on human bone marrow stroma cells: a preliminary study. Clin Orthop Relat Res 466:1047–1053
3. Drescher W, Lohse J, Varoga D et al (2010) Enhanced constriction of supplying arteries-a mechanism of femoral head necrosis in Wistar rats? Ann Anat 192:58–61
4. Drescher W, Varoga D, Liebs TR (2006) Femoral artery constriction by norepinephrine is enhanced by methylprednisolone in a rat model. J Bone Joint Surg Am 88:162–166
5. Urbaniak JR, Seaber AV, Chen LE (1997) Assessment of ischemia and reperfusion injury. Clin Orthop Relat Res 334:30–36
6. Cuadrado MJ, Lopez-Pedrera C (2003) Antiphospholipid syndrome. Clin Exp Med 3:129–139
7. Yun SI, Yoon HY, Jeong SY (2009) Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3beta. J Bone Miner Metab 27:140–148
8. Chen C, Yang S, Feng Y (2012) Impairment of two types of circulating endothelial progenitor cells in patients with glucocorticoid-induced avascular osteonecrosis of the femoral head. Joint Bone Spine 80:70–76
9. Tan G, Kang PD, Pei FX (2012) Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. Chin Med J (Engl) 125(1):134–139
10. Tanigawara Y (2000) Role of P-glycoprotein in drug disposition. Ther Drug Monit 22:137–140
11. Greiner B, Eichelbaum M, Fritz P et al (1999) The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest 104:147–153
12. Dickens D, Owen A, Alfirevic A et al (2013) ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. Pharmacogenet Genomics 23(6):314–323
13. Yang XY, Xu DH (2007) MDR1 (ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. Pharmazie 62:930–932
14. Han N, Yan ZQ, Guo CA et al (2010) Effect of rifampicin on the risk of steroid-induced osteonecrosis of the femoral head. Orthop Surg 2(2):124–133
15. Karssen AM, Meijer OC, van der Sandt IC et al (2002) The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone. J Endocrinol 175:251–260
16. Han N, Yan ZQ, Guo CA et al (2010) Effects of P-glycoprotein on steroid-induced osteonecrosis of the femoral head. Calcif Tissue Int 87:246–253
17. Kuribayashi M, Fujioka M, Takahashi KA et al (2008) Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head. J Orthop Sci 13:297–303
18. Petronis A (2010) Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 465:721–727
19. Zhang TY, Meaney MJ (2010) Epigenetics and the environmental regulation of the genome and its function. Annu Rev Psychol 61:439–466
20. Sun Z, Yang S, Ye S et al (2013) Aberrant CpG islands hypermethylation of ABCB1 in mesenchymal stem cells of patients with steroid-associated osteonecrosis. J Rheumatol 40(11):1913–1920
21. Nian H, Ma MH, Nian SS et al (2009) Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 16:320–326
22. Zheng D, Peng S, Yang SH et al (2012) The beneficial effect of icariin on bone is diminished in osteoprotegerin-deficient mice. Bone 51:85–92
23. Zhao JY, Ohba S, Shinkai M et al (2008) Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun 369:444–448
24. Koo KH, Kim R, Kim YS et al (2002) Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheumatol 21:299–303
25. Sun Z, Zhang Y, Yang S et al (2012) Growth differentiation factor 5 modulation of chondrogenesis of self-assembled constructs involves gap junction-mediated intercellular communication. Dev Growth Differ 54(9):809–817
26. Zhou YJ, Zhang SP, Liu CW et al (2009) The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK1 cells. Toxicol In Vitro 23:288–294
27. Yu WH, Li FG, Chen XY et al (2012) PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells. Int J Biochem Cell Biol 44:377–384
28. Irizarry RA, Ladd-Acosta C, Wen B et al (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 41:178–186
29. Zhao J, Ohba S, Komiyama Y et al (2010) Icariin: a potential osteoinductive compound for bone tissue engineering. Tissue Eng Part A 16(1):233–243
30. Chen KM, Ge BF, Ma HP et al (2005) Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells. Pharmazie 60(12):939–942
31. Zhang JF, Li G, Chan CY et al (2010) Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway. Mol Cell Endocrinol 314(1):70–74
32. Matsumoto T, Kano K, Kondo D et al (2008) Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential. J Cell Physiol 215:210–222
33. Chen J, Shi ZD, Ji X et al (2013) Enhanced osteogenesis of human mesenchymal stem cells by periodic heat shock in self-assembling peptide hydrogel. Tissue Eng Part A 19:716–728
34. Huang Y, Zheng L, Gong X et al (2012) Effect of cyclic strain on cardiomyogenic differentiation of rat bone marrow derived mesenchymal stem cells. PLoS ONE 7:e34960
35. Huang B, Tabata Y, Gao JQ (2012) Mesenchymal stem cells as therapeutic agents and potential targeted gene delivery vehicle for brain diseases. J Control Release 162:464–473
36. Zhang B, Yang S, Sun Z et al (2011) Human mesenchymal stem cells induced by growth differentiation factor 5: an improved self-assembly tissue engineering method for cartilage repair. Tissue Eng Part C 17:1189–1199
37. Lange C, Brunswig-Spickenheier B, Eissing L et al (2012) Platelet lysate suppresses the expression of lipocalin-type prostaglandin D2 synthase that positively controls adipogenic differentiation of human mesenchymal stromal cells. Exp Cell Res 318:2284–2296
38. Li X, Jin L, Cui Q et al (2005) Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int 16(1):101–108
39. Barbagallo I, Vanella A, Peterson SJ et al (2010) Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation. J Bone Miner Metab 28:276–288
40. Mody N, Parhami F, Sarafian TA et al (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31:509–519
41. Li G, Feng Y, Cheng T et al (2013) Edaravone, a novel free radical scavenger, prevents steroid-induced osteonecrosis in rabbits. Rheumatology (Oxford) 52:438–447
42. Liu H, Yang X, Zhang Y et al (2012) Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. J Orthop Res 30:1051–1057