The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice

Bone

Volumn 51, Issue 1, 2012, Pages 85-92

  Zheng, Dong ^a   Peng, Songlin ^b   Yang, Shu Hua ^a   Shao, Zeng Wu ^a   Yang, Cao ^a   Feng, Yong ^a   Wu, Wei ^c   Zhen, Wan Xin ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JINAN UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bone formation; Bone resorption; Icariin; Osteoporosis; Osteoprotegerin

Indexed keywords

ICARIIN; OSTEOPROTEGERIN;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MASS; BONE STRUCTURE; BONE TURNOVER; COMPUTER ASSISTED TOMOGRAPHY; DRUG MECHANISM; FIBROBLAST CULTURE; GENE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENOTYPE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; OSTEOPROTEGERIN GENE; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TRABECULAR BONE; UPREGULATION;

ANIMALS; BONE AND BONES; BONE RESORPTION; FLAVONOIDS; MALE; MICE; MICE, KNOCKOUT; OSTEOGENESIS; OSTEOPROTEGERIN;

EID: 84860868401     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.04.006     Document Type: Article

References (25)

1. Khosla S. Increasing options for the treatment of osteoporosis. N Engl J Med 2009, 361:818-820.
2. Zhang G., Qin L., Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res 2007, 22:1072-1079.
3. Peng S., Zhang G., He Y., Wang X., Leung P., Leung K., Qin L. Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone 2009, 45:534-544.
4. Nian H., Ma M.H., Nian S.S., Xu L.L. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 2009, 16:320-326.
5. Mok S.K., Chen W.F., Lai W.P., Leung P.C., Wang X.L., Yao X.S., Wong M.S. Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. Br J Pharmacol 2010, 159:939-949.
6. Chen K.M., Ge B.F., Liu X.Y., Ma P.H., Lu M.B., Bai M.H., Wang Y. Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture. Pharmazie 2007, 62:388-391.
7. Hsieh T.P., Sheu S.Y., Sun J.S., Chen M.H. Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-kappaB regulated HIF-1alpha and PGE(2) synthesis. Phytomedicine 2011, 18:176-185.
8. Scheven B.A., Visser J.W., Nijweide P.J. In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell population. Nature 1986, 321:79-81.
9. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., Elliott R., Colombero A., Elliott G., Scully S., Hsu H., Sullivan J., Hawkins N., Davy E., Capparelli C., Eli A., Qian Y.X., Kaufman S., Sarosi I., Shalhoub V., Senaldi G., Guo J., Delaney J., Boyle W.J. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
10. O'Brien E.A., Williams J.H., Marshall M.J. Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria. Biochem Biophys Res Commun 2000, 274:281-290.
11. Burgess T.L., Qian Y., Kaufman S., Ring B.D., Van G., Capparelli C., Kelley M., Hsu H., Boyle W.J., Dunstan C.R., Hu S., Lacey D.L. The ligand for osteoprotegerin (L) directly activates mature osteoclasts. J Cell Biol 1999, 145:527-538.
12. Fuller K., Wong B., Fox S., Choi Y., Chambers T.J. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med 1998, 188:997-1001.
13. Udagawa N., Takahashi N., Yasuda H., Mizuno A., Itoh K., Ueno Y., Shinki T., Gillespie M.T., Martin T.J., Higashio K., Suda T. Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology 2000, 141:3478-3484.
14. Chen X.W., Garner S.C., Anderson J.J. Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun 2002, 295:417-422.
15. De Wilde A., Lieberherr M., Colin C., Pointillart A. A low dose of daidzein acts as an ERbeta-selective agonist in trabecular osteoblasts of young female piglets. J Cell Physiol 2004, 200:253-262.
16. Viereck V., Grundker C., Blaschke S., Siggelkow H., Emons G., Hofbauer L.C. Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts. J Cell Biochem 2002, 84:725-735.
17. Marini H., Minutoli L., Polito F., Bitto A., Altavilla D., Atteritano M., Gaudio A., Mazzaferro S., Frisina A., Frisina N., Lubrano C., Bonaiuto M., D'Anna R., Cannata M.L., Corrado F., Cancellieri F., Faraci M., Marini R., Adamo E.B., Wilson S., Squadrito F. OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration. J Bone Miner Res 2008, 23:715-720.
18. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., Ott S.M., Recker R.R. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
19. Peng S., Zhou G., Luk K.D., Cheung K.M., Li Z., Lam W.M., Zhou Z., Lu W.W. Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Cell Physiol Biochem 2009, 23:165-174.
20. Bucay N., Sarosi I., Dunstan C.R., Morony S., Tarpley J., Capparelli C., Scully S., Tan H.L., Xu W., Lacey D.L., Boyle W.J., Simonet W.S. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998, 12:1260-1268.
21. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., Nguyen H.Q., Wooden S., Bennett L., Boone T., Shimamoto G., DeRose M., Elliott R., Colombero A., Tan H.L., Trail G., Sullivan J., Davy E., Bucay N., Renshaw-Gegg L., Hughes T.M., Hill D., Pattison W., Campbell P., Sander S., Van G., Tarpley J., Derby P., Lee R., Boyle W.J. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997, 89:309-319.
22. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., Morony S., Oliveira-dos-Santos A.J., Van G., Itie A., Khoo W., Wakeham A., Dunstan C.R., Lacey D.L., Mak T.W., Boyle W.J., Penninger J.M. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999, 397:315-323.
23. Bossard M.J., Tomaszek T.A., Thompson S.K., Amegadzie B.Y., Hanning C.R., Jones C., Kurdyla J.T., McNulty D.E., Drake F.H., Gowen M., Levy M.A. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J Biol Chem 1996, 271:12517-12524.
24. Hsieh T.P., Sheu S.Y., Sun J.S., Chen M.H., Liu M.H. Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomedicine 2010, 17:414-423.
25. Kim M.H., Park J.S., Seo M.S., Jung J.W., Lee Y.S., Kang K.S. Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/beta-catenin signalling or lipolysis. Cell Prolif 2010, 43:594-605.