메뉴 건너뛰기




Volumn 8, Issue 1, 2015, Pages

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; FRUCTOSE; INSULIN RECEPTOR; ISOPROTEIN;

EID: 84939812553     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/s13041-015-0138-6     Document Type: Article
Times cited : (66)

References (59)
  • 1
    • 84864395390 scopus 로고    scopus 로고
    • Insulin and IGF-1 signalling: Longevity, protein homoeostasis and Alzheimer's disease
    • 22817723 PubMed PMID: 22817723. Epub 2012/07/24. eng
    • O'Neill C, Kiely AP, Coakley MF, Manning S, Long-Smith CM. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. Biochem Soc Trans. 2012;40(4):721-7. PubMed PMID: 22817723. Epub 2012/07/24. eng.
    • (2012) Biochem Soc Trans , vol.40 , Issue.4 , pp. 721-727
    • O'Neill, C.1    Kiely, A.P.2    Coakley, M.F.3    Manning, S.4    Long-Smith, C.M.5
  • 2
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • 1:CAS:528:DC%2BD2MXjtFCgt7s%3D 15773910 PubMed PMID: 15773910. Epub 2005/03/19. eng
    • Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, et al. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem. 2005;93(1):105-17. PubMed PMID: 15773910. Epub 2005/03/19. eng.
    • (2005) J Neurochem , vol.93 , Issue.1 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6
  • 3
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • 1:CAS:528:DC%2BC3cXitlSntLY%3D 20079433 PubMed PMID: 20079433. Epub 2010/01/19. eng
    • Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 2010;1802(4):396-405. PubMed PMID: 20079433. Epub 2010/01/19. eng.
    • (2010) Biochim Biophys Acta , vol.1802 , Issue.4 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 4
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • 1:CAS:528:DC%2BC3MXpslaisLo%3D 21620960 PubMed PMID: 21620960. Epub 2011/05/31. eng
    • Hers I, Vincent EE, Tavare JM. Akt signalling in health and disease. Cell Signal. 2011;23(10):1515-27. PubMed PMID: 21620960. Epub 2011/05/31. eng.
    • (2011) Cell Signal , vol.23 , Issue.10 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 5
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • 1:CAS:528:DC%2BD1MXhsFGrsL3O 18479783 PubMed PMID: 18479783. Epub 2008/05/16. eng
    • Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R, O'Neill C. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging. 2010;31(2):224-43. PubMed PMID: 18479783. Epub 2008/05/16. eng.
    • (2010) Neurobiol Aging , vol.31 , Issue.2 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 6
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - Is this type 3 diabetes?
    • 1:CAS:528:DC%2BD2MXhvVSrtL8%3D 15750215 PubMed PMID: 15750215. Epub 2005/03/08. eng
    • Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J Alzheimers Dis. 2005;7(1):63-80. PubMed PMID: 15750215. Epub 2005/03/08. eng.
    • (2005) J Alzheimers Dis , vol.7 , Issue.1 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3    Cannon, J.L.4    Neely, T.R.5    Tavares, R.6
  • 7
    • 0036227542 scopus 로고    scopus 로고
    • Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    • 1:CAS:528:DC%2BD38Xis1Ois7Y%3D 11916953 PubMed PMID: 11916953. Epub 2002/03/28. eng
    • Peila R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes. 2002;51(4):1256-62. PubMed PMID: 11916953. Epub 2002/03/28. eng.
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 8
    • 29044449855 scopus 로고    scopus 로고
    • Risk of dementia in diabetes mellitus: A systematic review
    • 16361024 PubMed PMID: 16361024. Epub 2005/12/20. eng
    • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5(1):64-74. PubMed PMID: 16361024. Epub 2005/12/20. eng.
    • (2006) Lancet Neurol , vol.5 , Issue.1 , pp. 64-74
    • Biessels, G.J.1    Staekenborg, S.2    Brunner, E.3    Brayne, C.4    Scheltens, P.5
  • 9
    • 84874455392 scopus 로고    scopus 로고
    • Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated with This Relationship
    • 23314404 PubMed PMID: 23314404. Epub 2013/01/15. Eng
    • Vagelatos NT, Eslick GD. Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship. Epidemiol Rev. 2013;35:152-60. PubMed PMID: 23314404. Epub 2013/01/15. Eng.
    • (2013) Epidemiol Rev , vol.35 , pp. 152-160
    • Vagelatos, N.T.1    Eslick, G.D.2
  • 10
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: Redefining the functional architecture of the brain
    • 1:CAS:528:DC%2BD3sXns1Cgtbc%3D 14522144 PubMed PMID: 14522144. Epub 2003/10/03. eng
    • Nedergaard M, Ransom B, Goldman SA. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 2003;26(10):523-30. PubMed PMID: 14522144. Epub 2003/10/03. eng.
    • (2003) Trends Neurosci , vol.26 , Issue.10 , pp. 523-530
    • Nedergaard, M.1    Ransom, B.2    Goldman, S.A.3
  • 11
    • 84858704600 scopus 로고    scopus 로고
    • Glial cells in (patho)physiology
    • 3304021 1:CAS:528:DC%2BC38XmsVKlsb8%3D 22251135 PubMed PMID: 22251135. Pubmed Central PMCID: PMC3304021. Epub 2012/01/19. eng
    • Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, et al. Glial cells in (patho)physiology. J Neurochem. 2012;121(1):4-27. PubMed PMID: 22251135. Pubmed Central PMCID: PMC3304021. Epub 2012/01/19. eng.
    • (2012) J Neurochem , vol.121 , Issue.1 , pp. 4-27
    • Parpura, V.1    Heneka, M.T.2    Montana, V.3    Oliet, S.H.4    Schousboe, A.5    Haydon, P.G.6
  • 12
    • 34948898035 scopus 로고    scopus 로고
    • Cajal's contributions to the study of Alzheimer's disease
    • 17917161 PubMed PMID: 17917161. Epub 2007/10/06. eng
    • Garcia-Marin V, Garcia-Lopez P, Freire M. Cajal's contributions to the study of Alzheimer's disease. J Alzheimers Dis. 2007;12(2):161-74. PubMed PMID: 17917161. Epub 2007/10/06. eng.
    • (2007) J Alzheimers Dis , vol.12 , Issue.2 , pp. 161-174
    • Garcia-Marin, V.1    Garcia-Lopez, P.2    Freire, M.3
  • 13
    • 82755161978 scopus 로고    scopus 로고
    • Reactive astrocytes give neurons less support: Implications for Alzheimer's disease
    • PubMed PMID: 21051108. Epub 2010/11/06. Eng
    • Steele ML, Robinson SR. Reactive astrocytes give neurons less support: implications for Alzheimer's disease. Neurobiol Aging. 2010;33(2):423.e1-13. PubMed PMID: 21051108. Epub 2010/11/06. Eng.
    • (2010) Neurobiol Aging , vol.33 , Issue.2 , pp. 423.e1-423.e13
    • Steele, M.L.1    Robinson, S.R.2
  • 14
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: Biology and pathology
    • 2799634 20012068 PubMed PMID: 20012068. Pubmed Central PMCID: 2799634. Epub 2009/12/17. eng
    • Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010;119(1):7-35. PubMed PMID: 20012068. Pubmed Central PMCID: 2799634. Epub 2009/12/17. eng.
    • (2010) Acta Neuropathol , vol.119 , Issue.1 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 15
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • 15846805 PubMed PMID: 15846805. Epub 2005/04/23. eng
    • Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia. 2005;50(4):427-34. PubMed PMID: 15846805. Epub 2005/04/23. eng.
    • (2005) Glia , vol.50 , Issue.4 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 16
    • 60849109489 scopus 로고    scopus 로고
    • Astroglia in dementia and Alzheimer's disease
    • 1:CAS:528:DC%2BD1MXit1Wkur8%3D 19057621 PubMed PMID: 19057621. Epub 2008/12/06. eng
    • Rodriguez JJ, Olabarria M, Chvatal A, Verkhratsky A. Astroglia in dementia and Alzheimer's disease. Cell Death Differ. 2009;16(3):378-85. PubMed PMID: 19057621. Epub 2008/12/06. eng.
    • (2009) Cell Death Differ , vol.16 , Issue.3 , pp. 378-385
    • Rodriguez, J.J.1    Olabarria, M.2    Chvatal, A.3    Verkhratsky, A.4
  • 17
    • 77952573750 scopus 로고    scopus 로고
    • Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    • 20140958 PubMed PMID: 20140958. Epub 2010/02/09. eng
    • Olabarria M, Noristani HN, Verkhratsky A, Rodriguez JJ. Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia. 2010;58(7):831-8. PubMed PMID: 20140958. Epub 2010/02/09. eng.
    • (2010) Glia , vol.58 , Issue.7 , pp. 831-838
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 18
    • 77049085956 scopus 로고    scopus 로고
    • Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
    • 1:CAS:528:DC%2BC3cXhvFGgsbY%3D 18586353 PubMed PMID: 18586353. Epub 2008/07/01. eng
    • Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, et al. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiol Aging. 2010;31(4):578-90. PubMed PMID: 18586353. Epub 2008/07/01. eng.
    • (2010) Neurobiol Aging , vol.31 , Issue.4 , pp. 578-590
    • Simpson, J.E.1    Ince, P.G.2    Lace, G.3    Forster, G.4    Shaw, P.J.5    Matthews, F.6
  • 19
    • 79959764715 scopus 로고    scopus 로고
    • Epidemiological neuropathology: The MRC Cognitive Function and Aging Study experience
    • 21422529 PubMed PMID: 21422529. Epub 2011/03/23. eng
    • Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, et al. Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience. J Alzheimers Dis. 2011;25(2):359-72. PubMed PMID: 21422529. Epub 2011/03/23. eng.
    • (2011) J Alzheimers Dis , vol.25 , Issue.2 , pp. 359-372
    • Wharton, S.B.1    Brayne, C.2    Savva, G.M.3    Matthews, F.E.4    Forster, G.5    Simpson, J.6
  • 20
    • 84884274458 scopus 로고    scopus 로고
    • Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain
    • 1:CAS:528:DC%2BC3sXhslWms7rO 23421725 PubMed PMID: 23421725. Epub 2013/02/21. Eng
    • Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath P, Shaw PJ, et al. Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2013;39(7):788-99. PubMed PMID: 23421725. Epub 2013/02/21. Eng.
    • (2013) Neuropathol Appl Neurobiol , vol.39 , Issue.7 , pp. 788-799
    • Garwood, C.1    Faizullabhoy, A.2    Wharton, S.B.3    Ince, P.G.4    Heath, P.5    Shaw, P.J.6
  • 21
    • 80051576621 scopus 로고    scopus 로고
    • Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype
    • 1:CAS:528:DC%2BC3MXhtValtrfO 21705112 PubMed PMID: 21705112. Epub 2011/06/28. eng
    • Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, et al. Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiol Aging. 2011;32(10):1795-807. PubMed PMID: 21705112. Epub 2011/06/28. eng.
    • (2011) Neurobiol Aging , vol.32 , Issue.10 , pp. 1795-1807
    • Simpson, J.E.1    Ince, P.G.2    Shaw, P.J.3    Heath, P.R.4    Raman, R.5    Garwood, C.J.6
  • 22
    • 84876753599 scopus 로고    scopus 로고
    • Minireview: Nuclear insulin and insulin-like growth factor-1 receptors: A novel paradigm in signal transduction
    • 1:CAS:528:DC%2BC3sXntFWltL8%3D 23507573 PubMed PMID: 23507573. Epub 2013/03/20. eng
    • Sarfstein R, Werner H. Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction. Endocrinology. 2013;154(5):1672-9. PubMed PMID: 23507573. Epub 2013/03/20. eng.
    • (2013) Endocrinology , vol.154 , Issue.5 , pp. 1672-1679
    • Sarfstein, R.1    Werner, H.2
  • 23
    • 0031171216 scopus 로고    scopus 로고
    • The IRS-signalling system during insulin and cytokine action
    • 1:CAS:528:DyaK2sXks1Squr8%3D 9204766 PubMed PMID: 9204766. Epub 1997/06/01. eng
    • Yenush L, White MF. The IRS-signalling system during insulin and cytokine action. Bioessays. 1997;19(6):491-500. PubMed PMID: 9204766. Epub 1997/06/01. eng.
    • (1997) Bioessays , vol.19 , Issue.6 , pp. 491-500
    • Yenush, L.1    White, M.F.2
  • 24
    • 84882591485 scopus 로고    scopus 로고
    • Insulin concentration is critical in culturing human neural stem cells and neurons
    • 3763456 1:CAS:528:DC%2BC3sXht1Ggt77L 23928705 PubMed PMID: 23928705. Pubmed Central PMCID: PMC3763456. Epub 2013/08/10. eng
    • Rhee YH, Choi M, Lee HS, Park CH, Kim SM, Yi SH, et al. Insulin concentration is critical in culturing human neural stem cells and neurons. Cell Death Dis. 2013;4, e766. PubMed PMID: 23928705. Pubmed Central PMCID: PMC3763456. Epub 2013/08/10. eng.
    • (2013) Cell Death Dis , vol.4 , pp. e766
    • Rhee, Y.H.1    Choi, M.2    Lee, H.S.3    Park, C.H.4    Kim, S.M.5    Yi, S.H.6
  • 25
    • 63849175251 scopus 로고    scopus 로고
    • Uniquely hominid features of adult human astrocytes
    • 2819812 1:CAS:528:DC%2BD1MXjsVamtL0%3D 19279265 PubMed PMID: 19279265. Pubmed Central PMCID: PMC2819812. Epub 2009/03/13. eng
    • Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, et al. Uniquely hominid features of adult human astrocytes. J Neurosci. 2009;29(10):3276-87. PubMed PMID: 19279265. Pubmed Central PMCID: PMC2819812. Epub 2009/03/13. eng.
    • (2009) J Neurosci , vol.29 , Issue.10 , pp. 3276-3287
    • Oberheim, N.A.1    Takano, T.2    Han, X.3    He, W.4    Lin, J.H.5    Wang, F.6
  • 26
    • 0037334295 scopus 로고    scopus 로고
    • Regulation of chemokine receptor expression in human microglia and astrocytes
    • 1:CAS:528:DC%2BD3sXhs1ahtbs%3D 12620646 PubMed PMID: 12620646. Epub 2003/03/07. eng
    • Flynn G, Maru S, Loughlin J, Romero IA, Male D. Regulation of chemokine receptor expression in human microglia and astrocytes. J Neuroimmunol. 2003;136(1-2):84-93. PubMed PMID: 12620646. Epub 2003/03/07. eng.
    • (2003) J Neuroimmunol , vol.136 , Issue.1-2 , pp. 84-93
    • Flynn, G.1    Maru, S.2    Loughlin, J.3    Romero, I.A.4    Male, D.5
  • 27
    • 0029804116 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase B by insulin and IGF-1
    • 452479 1:CAS:528:DyaK2sXht1Oqs7o%3D 8978681 PubMed PMID: 8978681. Pubmed Central PMCID: PMC452479. Epub 1996/12/02. eng
    • Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 1996;15(23):6541-51. PubMed PMID: 8978681. Pubmed Central PMCID: PMC452479. Epub 1996/12/02. eng.
    • (1996) EMBO J , vol.15 , Issue.23 , pp. 6541-6551
    • Alessi, D.R.1    Andjelkovic, M.2    Caudwell, B.3    Cron, P.4    Morrice, N.5    Cohen, P.6
  • 28
    • 84863943793 scopus 로고    scopus 로고
    • PI3K-PKB/Akt pathway
    • 3428770 22952397 PubMed PMID: 22952397. Pubmed Central PMCID: PMC3428770. Epub 2012/09/07. eng
    • Hemmings BA, Restuccia DF. PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol. 2012;4(9):a011189. PubMed PMID: 22952397. Pubmed Central PMCID: PMC3428770. Epub 2012/09/07. eng.
    • (2012) Cold Spring Harb Perspect Biol , vol.4 , Issue.9
    • Hemmings, B.A.1    Restuccia, D.F.2
  • 29
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • 4011499 1:STN:280:DC%2BC38fmtVSrsg%3D%3D 22869320 PubMed PMID: 22869320. Pubmed Central PMCID: PMC4011499. Epub 2012/08/08. eng
    • Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia. 2012;55(10):2565-82. PubMed PMID: 22869320. Pubmed Central PMCID: PMC4011499. Epub 2012/08/08. eng.
    • (2012) Diabetologia , vol.55 , Issue.10 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 30
    • 84875211172 scopus 로고    scopus 로고
    • Sutherlandia frutescens prevents changes in diabetes-related gene expression in a fructose-induced insulin resistant cell model
    • 1:CAS:528:DC%2BC3sXislemu78%3D 23376105 PubMed PMID: 23376105. Epub 2013/02/05. eng
    • Williams S, Roux S, Koekemoer T, van de Venter M, Dealtry G. Sutherlandia frutescens prevents changes in diabetes-related gene expression in a fructose-induced insulin resistant cell model. J Ethnopharmacol. 2013;146(2):482-9. PubMed PMID: 23376105. Epub 2013/02/05. eng.
    • (2013) J Ethnopharmacol , vol.146 , Issue.2 , pp. 482-489
    • Williams, S.1    Roux, S.2    Koekemoer, T.3    Van De Venter, M.4    Dealtry, G.5
  • 31
    • 0026729382 scopus 로고
    • The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
    • 1:CAS:528:DyaK3sXkt1ajtbg%3D 1322798 PubMed PMID: 1322798. Epub 1992/08/07. eng
    • Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992;70(3):431-42. PubMed PMID: 1322798. Epub 1992/08/07. eng.
    • (1992) Cell , vol.70 , Issue.3 , pp. 431-442
    • Lowenstein, E.J.1    Daly, R.J.2    Batzer, A.G.3    Li, W.4    Margolis, B.5    Lammers, R.6
  • 32
    • 0027312272 scopus 로고
    • Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
    • 1:CAS:528:DyaK3sXksVWkurs%3D 8479541 PubMed PMID: 8479541. Epub 1993/05/06. eng
    • Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, et al. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 1993;363(6424):85-8. PubMed PMID: 8479541. Epub 1993/05/06. eng.
    • (1993) Nature , vol.363 , Issue.6424 , pp. 85-88
    • Li, N.1    Batzer, A.2    Daly, R.3    Yajnik, V.4    Skolnik, E.5    Chardin, P.6
  • 33
    • 84856496197 scopus 로고    scopus 로고
    • Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
    • 3349985 22329651 PubMed PMID: 22329651. Pubmed Central PMCID: PMC3349985. Epub 2012/02/15. eng
    • de la Monte SM. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res. 2012;9(1):35-66. PubMed PMID: 22329651. Pubmed Central PMCID: PMC3349985. Epub 2012/02/15. eng.
    • (2012) Curr Alzheimer Res , vol.9 , Issue.1 , pp. 35-66
    • De La Monte, S.M.1
  • 34
    • 84859718265 scopus 로고    scopus 로고
    • Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    • 3314463 1:CAS:528:DC%2BC38Xlt1egtbY%3D 22476197 PubMed PMID: 22476197. Pubmed Central PMCID: PMC3314463. Epub 2012/04/06. eng
    • Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122(4):1316-38. PubMed PMID: 22476197. Pubmed Central PMCID: PMC3314463. Epub 2012/04/06. eng.
    • (2012) J Clin Invest , vol.122 , Issue.4 , pp. 1316-1338
    • Talbot, K.1    Wang, H.Y.2    Kazi, H.3    Han, L.Y.4    Bakshi, K.P.5    Stucky, A.6
  • 35
    • 60549084867 scopus 로고    scopus 로고
    • Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers
    • 2634809 19188609 PubMed PMID: 19188609. Pubmed Central PMCID: PMC2634809. Epub 2009/02/04. eng
    • De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A. 2009;106(6):1971-6. PubMed PMID: 19188609. Pubmed Central PMCID: PMC2634809. Epub 2009/02/04. eng.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.6 , pp. 1971-1976
    • De Felice, F.G.1    Vieira, M.N.2    Bomfim, T.R.3    Decker, H.4    Velasco, P.T.5    Lambert, M.P.6
  • 36
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    • 4484598 1:CAS:528:DC%2BC3MXpt1Cns78%3D 21598254 PubMed PMID: 21598254. Epub 2011/05/21. eng
    • Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J Pathol. 2011;225(1):54-62. PubMed PMID: 21598254. Epub 2011/05/21. eng.
    • (2011) J Pathol , vol.225 , Issue.1 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 37
    • 84868282388 scopus 로고    scopus 로고
    • Insulin in central nervous system: More than just a peripheral hormone
    • 3303591 22500228 Pubmed Central PMCID: PMC3303591. Epub 2012/04/14. eng
    • Duarte AI, Moreira PI, Oliveira CR. Insulin in central nervous system: more than just a peripheral hormone. J Aging Res. 2012;2012:384017. Pubmed Central PMCID: PMC3303591. Epub 2012/04/14. eng.
    • (2012) J Aging Res , vol.2012
    • Duarte, A.I.1    Moreira, P.I.2    Oliveira, C.R.3
  • 38
    • 0030779032 scopus 로고    scopus 로고
    • Localization of the insulin-like growth factor I receptor in the cerebellum and hypothalamus of adult rats: An electron microscopic study
    • 1:CAS:528:DyaK2sXmtlCktLg%3D 9306246 English
    • Garcia-Segura LM, Rodriguez JR, Torres-Aleman I. Localization of the insulin-like growth factor I receptor in the cerebellum and hypothalamus of adult rats: an electron microscopic study. J Neurocytol. 1997;26(7):479-90. English.
    • (1997) J Neurocytol , vol.26 , Issue.7 , pp. 479-490
    • Garcia-Segura, L.M.1    Rodriguez, J.R.2    Torres-Aleman, I.3
  • 39
    • 0026670206 scopus 로고
    • Insulin in the brain: A hormonal regulator of energy balance
    • 1:CAS:528:DyaK38XmtVGhtbs%3D 1425482 PubMed PMID: 1425482. Epub 1992/08/11. eng
    • Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte Jr D. Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev. 1992;13(3):387-414. PubMed PMID: 1425482. Epub 1992/08/11. eng.
    • (1992) Endocr Rev , vol.13 , Issue.3 , pp. 387-414
    • Schwartz, M.W.1    Figlewicz, D.P.2    Baskin, D.G.3    Woods, S.C.4    Porte, D.5
  • 40
    • 0020962084 scopus 로고
    • Structural differences between insulin receptors in the brain and peripheral target tissues
    • 1:CAS:528:DyaL3sXkvVaruro%3D 6345543 PubMed PMID: 6345543. Epub 1983/07/25. eng
    • Heidenreich KA, Zahniser NR, Berhanu P, Brandenburg D, Olefsky JM. Structural differences between insulin receptors in the brain and peripheral target tissues. J Biol Chem. 1983;258(14):8527-30. PubMed PMID: 6345543. Epub 1983/07/25. eng.
    • (1983) J Biol Chem , vol.258 , Issue.14 , pp. 8527-8530
    • Heidenreich, K.A.1    Zahniser, N.R.2    Berhanu, P.3    Brandenburg, D.4    Olefsky, J.M.5
  • 41
    • 0027391758 scopus 로고
    • The cellular and physiological actions of insulin in the central nervous system
    • 1:CAS:528:DyaK3sXlt1Gnug%3D%3D 8443563 PubMed PMID: 8443563. Epub 1993/01/01. eng
    • Wozniak M, Rydzewski B, Baker SP, Raizada MK. The cellular and physiological actions of insulin in the central nervous system. Neurochem Int. 1993;22(1):1-10. PubMed PMID: 8443563. Epub 1993/01/01. eng.
    • (1993) Neurochem Int , vol.22 , Issue.1 , pp. 1-10
    • Wozniak, M.1    Rydzewski, B.2    Baker, S.P.3    Raizada, M.K.4
  • 42
    • 0021189287 scopus 로고
    • Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain
    • 1:CAS:528:DyaL2cXmtVCks74%3D 6384211 PubMed PMID: 6384211. Epub 1984/10/10. eng
    • Clarke DW, Boyd Jr FT, Kappy MS, Raizada MK. Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. J Biol Chem. 1984;259(19):11672-5. PubMed PMID: 6384211. Epub 1984/10/10. eng.
    • (1984) J Biol Chem , vol.259 , Issue.19 , pp. 11672-11675
    • Clarke, D.W.1    Boyd, F.T.2    Kappy, M.S.3    Raizada, M.K.4
  • 43
    • 79959576516 scopus 로고    scopus 로고
    • Insulin promotes glycogen storage and cell proliferation in primary human astrocytes
    • 3124526 1:CAS:528:DC%2BC3MXosVajurw%3D 21738722 PubMed PMID: 21738722. Pubmed Central PMCID: PMC3124526. Epub 2011/07/09. eng
    • Heni M, Hennige AM, Peter A, Siegel-Axel D, Ordelheide AM, Krebs N, et al. Insulin promotes glycogen storage and cell proliferation in primary human astrocytes. PLoS One. 2011;6(6):e21594. PubMed PMID: 21738722. Pubmed Central PMCID: PMC3124526. Epub 2011/07/09. eng.
    • (2011) PLoS One , vol.6 , Issue.6
    • Heni, M.1    Hennige, A.M.2    Peter, A.3    Siegel-Axel, D.4    Ordelheide, A.M.5    Krebs, N.6
  • 44
    • 0032932822 scopus 로고    scopus 로고
    • Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
    • 84122 1:CAS:528:DyaK1MXislSltLk%3D 10207053 PubMed PMID: 10207053. Pubmed Central PMCID: PMC84122. Epub 1999/04/17. eng
    • Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol. 1999;19(5):3278-88. PubMed PMID: 10207053. Pubmed Central PMCID: PMC84122. Epub 1999/04/17. eng.
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3278-3288
    • Frasca, F.1    Pandini, G.2    Scalia, P.3    Sciacca, L.4    Mineo, R.5    Costantino, A.6
  • 45
    • 84877601668 scopus 로고    scopus 로고
    • Neuron-astrocyte signaling and epilepsy
    • 21925173 PubMed PMID: 21925173. Epub 2011/09/20. eng
    • Seifert G, Steinhauser C. Neuron-astrocyte signaling and epilepsy. Exp Neurol. 2013;244:4-10. PubMed PMID: 21925173. Epub 2011/09/20. eng.
    • (2013) Exp Neurol , vol.244 , pp. 4-10
    • Seifert, G.1    Steinhauser, C.2
  • 46
    • 33644556491 scopus 로고    scopus 로고
    • Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes
    • 1383568 1:CAS:528:DC%2BD28Xhs1ertr4%3D 16467848 PubMed PMID: 16467848. Pubmed Central PMCID: PMC1383568. Epub 2006/02/10. eng
    • Wagner B, Natarajan A, Grunaug S, Kroismayr R, Wagner EF, Sibilia M. Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes. EMBO J. 2006;25(4):752-62. PubMed PMID: 16467848. Pubmed Central PMCID: PMC1383568. Epub 2006/02/10. eng.
    • (2006) EMBO J , vol.25 , Issue.4 , pp. 752-762
    • Wagner, B.1    Natarajan, A.2    Grunaug, S.3    Kroismayr, R.4    Wagner, E.F.5    Sibilia, M.6
  • 47
    • 84860487755 scopus 로고    scopus 로고
    • Nuclear IRS-1 and cancer
    • 3615708 1:CAS:528:DC%2BC38Xmt1yjurk%3D 22454254 PubMed PMID: 22454254. Pubmed Central PMCID: PMC3615708. Epub 2012/03/29. eng
    • Reiss K, Del Valle L, Lassak A, Trojanek J. Nuclear IRS-1 and cancer. J Cell Physiol. 2012;227(8):2992-3000. PubMed PMID: 22454254. Pubmed Central PMCID: PMC3615708. Epub 2012/03/29. eng.
    • (2012) J Cell Physiol , vol.227 , Issue.8 , pp. 2992-3000
    • Reiss, K.1    Del Valle, L.2    Lassak, A.3    Trojanek, J.4
  • 48
    • 82355170711 scopus 로고    scopus 로고
    • Molecular pathology and genetic advances in amyotrophic lateral sclerosis: An emerging molecular pathway and the significance of glial pathology
    • 1:CAS:528:DC%2BC3MXhsFCms7%2FP 22105541 PubMed PMID: 22105541. Epub 2011/11/23. eng
    • Ince PG, Highley JR, Kirby J, Wharton SB, Takahashi H, Strong MJ, et al. Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology. Acta Neuropathol. 2011;122(6):657-71. PubMed PMID: 22105541. Epub 2011/11/23. eng.
    • (2011) Acta Neuropathol , vol.122 , Issue.6 , pp. 657-671
    • Ince, P.G.1    Highley, J.R.2    Kirby, J.3    Wharton, S.B.4    Takahashi, H.5    Strong, M.J.6
  • 49
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype
    • 1:CAS:528:DC%2BD28XhtlCms70%3D 15964100 PubMed PMID: 15964100. Epub 2005/06/21. eng
    • Reger MA, Watson GS, Frey 2nd WH, Baker LD, Cholerton B, Keeling ML, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27(3):451-8. PubMed PMID: 15964100. Epub 2005/06/21. eng.
    • (2006) Neurobiol Aging , vol.27 , Issue.3 , pp. 451-458
    • Reger, M.A.1    Watson, G.S.2    Frey, W.H.3    Baker, L.D.4    Cholerton, B.5    Keeling, M.L.6
  • 50
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    • 1:CAS:528:DC%2BD1cXhtFels70%3D 17942819 PubMed PMID: 17942819. Epub 2007/10/19. eng
    • Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology. 2008;70(6):440-8. PubMed PMID: 17942819. Epub 2007/10/19. eng.
    • (2008) Neurology , vol.70 , Issue.6 , pp. 440-448
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3    Wilkinson, C.W.4    Baker, L.D.5    Cholerton, B.6
  • 51
    • 59649113824 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    • 19153380 author reply 3-4. PubMed PMID: 19153380. Epub 2009/01/21. eng
    • Dhamoon MS, Noble JM, Craft S. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology. 2009;72(3):292-3. author reply 3-4. PubMed PMID: 19153380. Epub 2009/01/21. eng.
    • (2009) Neurology , vol.72 , Issue.3 , pp. 292-293
    • Dhamoon, M.S.1    Noble, J.M.2    Craft, S.3
  • 52
    • 0038380346 scopus 로고    scopus 로고
    • Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells
    • 1:CAS:528:DC%2BD3sXmtFaksw%3D%3D 12516969 PubMed PMID: 12516969. Epub 2003/01/09. eng
    • Hailey J, Maxwell E, Koukouras K, Bishop WR, Pachter JA, Wang Y. Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells. Mol Cancer Ther. 2002;1(14):1349-53. PubMed PMID: 12516969. Epub 2003/01/09. eng.
    • (2002) Mol Cancer Ther , vol.1 , Issue.14 , pp. 1349-1353
    • Hailey, J.1    Maxwell, E.2    Koukouras, K.3    Bishop, W.R.4    Pachter, J.A.5    Wang, Y.6
  • 53
    • 0025131648 scopus 로고
    • Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells
    • 1131733 1:CAS:528:DyaK3cXlt1KrtLk%3D 1698059 PubMed PMID: 1698059. Pubmed Central PMCID: PMC1131733. Epub 1990/09/01. eng
    • Soos MA, Whittaker J, Lammers R, Ullrich A, Siddle K. Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells. Biochem J. 1990;270(2):383-90. PubMed PMID: 1698059. Pubmed Central PMCID: PMC1131733. Epub 1990/09/01. eng.
    • (1990) Biochem J , vol.270 , Issue.2 , pp. 383-390
    • Soos, M.A.1    Whittaker, J.2    Lammers, R.3    Ullrich, A.4    Siddle, K.5
  • 54
    • 84890009448 scopus 로고    scopus 로고
    • Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: Novel treatment strategies for cancer
    • PubMed PMID: 24338270. Epub 2013/12/18. eng
    • Singh P, Alex JM, Bast F. Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer. Med Oncol (Northwood, London, England). 2014;31(1):805. PubMed PMID: 24338270. Epub 2013/12/18. eng.
    • (2014) Med Oncol (Northwood, London, England) , vol.31 , Issue.1 , pp. 805
    • Singh, P.1    Alex, J.M.2    Bast, F.3
  • 55
    • 77958067823 scopus 로고    scopus 로고
    • Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): Rationale for cotargeting IGF-1R and IR in cancer
    • 1:CAS:528:DC%2BC3cXht1Khtr3E 20924128 PubMed PMID: 20924128. Epub 2010/10/07. eng
    • Buck E, Gokhale PC, Koujak S, Brown E, Eyzaguirre A, Tao N, et al. Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer. Mol Cancer Ther. 2010;9(10):2652-64. PubMed PMID: 20924128. Epub 2010/10/07. eng.
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2652-2664
    • Buck, E.1    Gokhale, P.C.2    Koujak, S.3    Brown, E.4    Eyzaguirre, A.5    Tao, N.6
  • 56
    • 84926469999 scopus 로고    scopus 로고
    • Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions
    • 4159174 25166345 PubMed PMID: 25166345. Pubmed Central PMCID: PMC4159174. Epub 2014/08/29. eng
    • Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TB, von Zglinicki T, et al. Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions. PLoS Comput Biol. 2014;10(8):e1003728. PubMed PMID: 25166345. Pubmed Central PMCID: PMC4159174. Epub 2014/08/29. eng.
    • (2014) PLoS Comput Biol , vol.10 , Issue.8
    • Dalle Pezze, P.1    Nelson, G.2    Otten, E.G.3    Korolchuk, V.I.4    Kirkwood, T.B.5    Von Zglinicki, T.6
  • 57
    • 84914815120 scopus 로고    scopus 로고
    • Astrocytes require insulin-like growth factor i to protect neurons against oxidative injury
    • 3954172 24715976 PubMed PMID: 24715976. Pubmed Central PMCID: PMC3954172. Epub 2014/04/10. eng
    • Genis L, Davila D, Fernandez S, Pozo-Rodrigalvarez A, Martinez-Murillo R, Torres-Aleman I. Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury. F1000Res. 2014;3:28. PubMed PMID: 24715976. Pubmed Central PMCID: PMC3954172. Epub 2014/04/10. eng.
    • (2014) F1000Res , vol.3 , pp. 28
    • Genis, L.1    Davila, D.2    Fernandez, S.3    Pozo-Rodrigalvarez, A.4    Martinez-Murillo, R.5    Torres-Aleman, I.6
  • 58
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • 4036520 1:CAS:528:DC%2BC3MXhsVSktbzP 22048062 PubMed PMID: 22048062. Epub 2011/11/04. eng
    • Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. 2011;12(12):723-38. PubMed PMID: 22048062. Epub 2011/11/04. eng.
    • (2011) Nat Rev Neurosci , vol.12 , Issue.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 59
    • 81055127451 scopus 로고    scopus 로고
    • Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line
    • 1:CAS:528:DC%2BC3MXhs1Gqtb7E 21434924 PubMed PMID: 21434924. Epub 2011/03/26. eng
    • Scholz D, Poltl D, Genewsky A, Weng M, Waldmann T, Schildknecht S, et al. Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem. 2011;119(5):957-71. PubMed PMID: 21434924. Epub 2011/03/26. eng.
    • (2011) J Neurochem , vol.119 , Issue.5 , pp. 957-971
    • Scholz, D.1    Poltl, D.2    Genewsky, A.3    Weng, M.4    Waldmann, T.5    Schildknecht, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.