Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2-lipid bilayer interactions

Biochimica et Biophysica Acta - Biomembranes

Volumn 1848, Issue 10, 2015, Pages 2460-2470

  McDougle, Daniel R ^a   Baylon, Javier L ^a,b   Meling, Daryl D ^b   Kambalyal, Amogh ^b   Grinkova, Yelena V ^b   Hammernik, Jared ^b   Tajkhorshid, Emad ^a,b   Das, Aditi ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

CYP2J2; Cytochrome P450; Eicosanoids; Epoxygenase; F G loop; Nanodiscs

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; CYTOCHROME P450 2J2; NANODISC; PHOSPHOLIPID; PYRENE PHOSPHOLIPID; UNCLASSIFIED DRUG; AMINO ACID; ARACHIDONATE EPOXYGENASE; CYTOCHROME P450; LIPID BILAYER; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENZYME ACTIVITY; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; HYDROPHOBICITY; LIPID BILAYER; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; ENZYME ACTIVATION; PROTEIN CONFORMATION; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; LIPID BILAYERS; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84939496620     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2015.07.015     Document Type: Article

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