Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines

Chemical Research in Toxicology

Volumn 28, Issue 8, 2015, Pages 1574-1583

  Chang, Chia Che ^b   Kuan, Cheng Ping ^c   Lin, Jyun Yi ^a   Lai, Jui Sheng ^c   Ho, Tsing Fen ^a  

^a CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c TAIWAN AGRICULTURAL RESEARCH INSTITUTE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CCAAT ENHANCER BINDING PROTEIN; DEATH RECEPTOR 5; JANUS KINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; TANSHINONE IIA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; DDIT3 PROTEIN, HUMAN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; TANSHINONE; TNFSF10 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CLONOGENESIS; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MTS ASSAY; OVARIAN CANCER CELL LINE; OVARY CARCINOMA; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING; BIOLOGICAL MODEL; CELL SURVIVAL; DRUG EFFECTS; GENETICS; METABOLISM; OVARIAN NEOPLASMS; TUMOR CELL LINE;

SALVIA MILTIORRHIZA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES, ABIETANE; FEMALE; HUMANS; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; OVARIAN NEOPLASMS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 84939249935     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00150     Document Type: Article

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