Tanshinone IIa induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 11, 2010, Pages 1828-1834

  Won, Suk Hyun ^a   Lee, Hyo Jeong ^a   Jeong, Soo Jin ^a   Lee, Hyo Jung ^a   Lee, Eun Ok ^a   Jung, Deok Beom ^a   Shin, Ji Min ^a   Kwon, Tae Rin ^a   Yun, Sun Mi ^a   Lee, Min Ho ^a   Choi, Seung Hoon ^a   Lü, Junxuan ^b   Kim, Sung Hoon ^a,b  

^a Kyung Hee University   (South Korea)

^b University of Minnesota Hormel Institute   (United States)

Author keywords

Apoptosis; LNCaP; Mitochondria; Phosphoinositide 3 kinase AKT; Tanshinone iia

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CYTOCHROME C; DNA; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN P53; TANSHINONE IIA;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL COUNT; CELL CYCLE G1 PHASE; CELL STRAIN LNCAP; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DNA CONTENT; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; ENZYME SUBSTRATE; ENZYME SUBUNIT; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NICK END LABELING; PLANT ROOT; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FAMILY; SALVIA MILTIORRHIZA; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DITERPENES, ABIETANE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYMES; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION;

EID: 78249235878     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1828     Document Type: Article

References (43)

1. Steller H., Science, 267, 1445-1449 (1995).
2. Kerr J. F., J Pathol., 105, 13-20 (1971).
3. Yang R., Liu A., Ma X., Li L., Su D., Liu J., J. Cardiovasc. Pharmacol., 51, 396-401 (2008).
4. Neto C. C., Amoroso J. W., Liberty A. M., Mol. Nutr. Food Res., 52 (Suppl. 1), S18-S27 (2008).
5. Kaur M., Agarwal R., Curr. Cancer Drug Targets, 7, 355-367 (2007).
6. Hu W., Kavanagh J. J., Lancet Oncol., 4, 721-729 (2003).
7. Budihardjo I., Oliver H., Lutter M., Luo X., Wang X., Annu. Rev. Cell Dev. Biol., 15, 269-290 (1999).
8. Igney F. H., Krammer P. H., Nat. Rev. Cancer, 2, 277-288 (2002).
9. Kim D., Chung J., J. Biochem. Mol. Biol., 35, 106-115 (2002).
10. Zhou L., Zuo Z., Chow M. S., J. Clin. Pharmacol., 45, 1345-1359 (2005).
11. Cao E. H., Liu X. Q., Wang J. J., Xu N. F., Free Radic. Biol. Med., 20, 801-806 (1996).
12. Jin U. H., Suh S. J., Chang H. W., Son J. K., Lee S. H., Son K. H., Chang Y. C., Kim C. H., J. Cell Biochem., 104, 15-26 (2008).
13. Jang S. I., Jeong S. I., Kim K. J., Kim H. J., Yu H. H., Park R., Kim H. M., You Y. O., Planta Med., 69, 1057-1059 (2003).
14. Tang Z., Tang Y., Fu L., J. Huazhong Univ. Sci. Technolog. Med. Sci., 23, 166-168, 172 (2003).
15. Tang Z. Z., Tang Y., Fu L. B., Di Yi Jun Yi Da Xue Xue Bao, 23, 595-597, 601 (2003).
16. Wang X., Yuan S., Huang R., Song Y., Hua Xi Yi Ke Da Xue Xue Bao, 27, 388-391 (1996).
17. Zhong Z. H., Chen W. G., Liu Y. H., Li Q. X., Qiu Y., Zhong Nan Da Xue Xue Bao Yi Xue Ban, 32, 99-103 (2007).
18. Su C. C., Lin Y. H., Int. J. Mol. Med., 22, 357-361 (2008).
19. Sung H. J., Choi S. M., Yoon Y., An K. S., Exp. Mol. Med., 31, 174-178 (1999).
20. Choi H. S., Cho D. I., Choi H. K., Im S. Y., Ryu S. Y., Kim K. M., Arch. Pharm. Res., 27, 1233-1237 (2004).
21. Dejean L. M., Martinez-Caballero S., Manon S., Kinnally K. W., Biochim. Biophys. Acta, 1762, 191-201 (2006).
22. Wang Z. B., Liu Y. Q., Cui Y. F., Cell Biol. Int., 29, 489-496 (2005).
23. Kothakota S., Azuma T., Reinhard C., Klippel A., Tang J., Chu K., McGarry T. J., Kirschner M. W., Koths K., Kwiatkowski D. J., Williams L. T., Science, 278, 294-298 (1997).
24. Shimizu S., Narita M., Tsujimoto Y., Nature (London), 399, 483-487 (1999).
25. Petit P. X., Zamzami N., Vayssiere J. L., Mignotte B., Kroemer G., Castedo M., Mol. Cell Biochem., 174, 185-188 (1997).
26. Fu Y., Wey S., Wang M., Ye R., Liao C. P., Roy-Burman P., Lee A. S., Proc. Natl. Acad. Sci. U.S.A., 105, 19444-19449 (2008).
27. Kanda S., Kanetake H., Miyata Y., J. Cancer Res. Clin. Oncol., 135, 303-311 (2009).
28. Lee A. R., Wu W. L., Chang W. L., Lin H. C., King M. L., J. Nat. Prod., 50, 157-160 (1987).
29. Breyer-Pfaff U., Nill K., Xenobiotica, 25, 1311-1325 (1995).
30. Chiu T. L., Su C. C., Int. J. Mol. Med., 25, 231-236 (2010).
31. Su C. C., Chen G. W., Kang J. C., Chan M. H., Planta Med., 74, 1357-1362 (2008).
32. Yuxian X., Feng T., Ren L., Zhengcai L., Tumori, 95, 789-795 (2009).
33. Carroll A. G., Voeller H. J., Sugars L., Gelmann E. P., Prostate, 23, 123-134 (1993).
34. Isaacs W. B., Carter B. S., Ewing C. M., Cancer Res., 51, 4716-4720 (1991).
35. Reed J. C., Miyashita T., Takayama S., Wang H. G., Sato T., Krajewski S., Aime-Sempe C., Bodrug S., Kitada S., Hanada M., J. Cell Biochem., 60, 23-32 (1996).
36. Chao D. T., Korsmeyer S. J., Annu. Rev. Immunol., 16, 395-419 (1998).
37. Sullivan P. G., Dragicevic N. B., Deng J. H., Bai Y., Dimayuga E., Ding Q., Chen Q., Bruce-Keller A. J., Keller J. N., J. Biol. Chem., 279, 20699-20707 (2004).
38. Chung T. D., Yu J. J., Kong T. A., Spiotto M. T., Lin J. M., Prostate, 42, 1-7 (2000).
39. Li L., Ittmann M. M., Ayala G., Tsai M. J., Amato R. J., Wheeler T. M., Miles B. J., Kadmon D., Thompson T. C., Prostate Cancer Prostatic Dis., 8, 108-118 (2005).
40. Hu H., Jiang C., Li G., Lu J., Carcinogenesis, 26, 1374-1381 (2005).
41. Cantley L. C., Neel B. G., Proc. Natl. Acad. Sci. U.S.A., 96, 4240-4245 (1999).
42. Kaarbo M., Mikkelsen O. L., Malerod L., Qu S., Lobert V. H., Akgul G., Halvorsen T., Maelandsmo G. M., Saatcioglu F., Cell Oncol., 32, 11-27.
43. Morgan T. M., Koreckij T. D., Corey E., Curr. Cancer Drug Targets, 9, 237-249 (2009).