Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells

Phytotherapy Research

Volumn 26, Issue 5, 2012, Pages 669-674

  Won, Suk Hyun ^a   Lee, Hyo Jeong ^a   Jeong, Soo Jin ^a   Lü, Junxuan ^b   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

androgen receptor; cyclin D1; G1 arrest; LNCaP; p53; tanshinone IIA

Indexed keywords

ANDROGEN RECEPTOR; BROXURIDINE; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; PROSTATE SPECIFIC ANTIGEN; PROTEIN P21; PROTEIN P27; PROTEIN P53; SMALL INTERFERING RNA; TANSHINONE IIA;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER PREVENTION; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; MALE; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEINASE INHIBITION; SIGNAL TRANSDUCTION;

ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; DITERPENES, ABIETANE; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; PLANT ROOTS; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84859903322     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3616     Document Type: Article

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