Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB

Journal of Ethnopharmacology

Volumn 174, Issue , 2015, Pages 37-44

  Park, Wook Ha ^a   Kang, Sora ^a   Piao, Ying ^a   Pak, Christine Jeehye ^a   Oh, Myung Sook ^b   Kim, Jinwoong ^c   Kang, Min Seo ^a   Pak, Youngmi Kim ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Anti inflammatory effects; Astrocytes; Bupleurum falcatum; Microglia; Neuroinflammation; Saikosaponin

Indexed keywords

ALCOHOL; ANTIINFLAMMATORY AGENT; BUPLEURUM FALCATUM EXTRACT; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SAIKOSAPONIN; SAIKOSAPONIN A; SAIKOSAPONIN B3; SAIKOSAPONIN B4; SAIKOSAPONIN D; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HERBACEOUS AGENT; OLEANOLIC ACID; SAPONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTE; BUPLEURUM FALCATUM; CELL NUCLEUS; CELL VIABILITY; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUCIFERASE ASSAY; MEDICINAL PLANT; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PLANT ROOT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLVENT EXTRACTION; SUBSTANTIA NIGRA; TRANSCRIPTION REGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BUPLEURUM; C57BL MOUSE; CELL SURVIVAL; DRUG EFFECTS; INFLAMMATION; ISOLATION AND PURIFICATION; MALE; METABOLISM; PHYSIOLOGY;

BUPLEURUM FALCATUM; MURINAE; MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BUPLEURUM; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ETHANOL; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; OLEANOLIC ACID; PLANT ROOTS; SAPONINS;

EID: 84939249152     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.07.039     Document Type: Article

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