Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 53, Issue , 2014, Pages 80-89

  Li, Zong Yang ^a   Jiang, Yu Mao ^a   Liu, Ya Min ^a   Guo, Zhi ^a   Shen, Sheng Nan ^a   Liu, Xin Min ^a   Pan, Rui Le ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Corticosterone; Glucocorticoid receptor; Mitochondria; Neuroprotection; Saikosaponin D

Indexed keywords

ANNEXIN; CASPASE 3; CASPASE 9; CORTICOSTERONE; CYTOCHROME C; GLUCOCORTICOID INDUCED LEUCINE ZIPPER; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE 6; HOE 33342; I KAPPA B ALPHA; LEUCINE ZIPPER PROTEIN; PROPIDIUM IODIDE; PROTEIN BAD; PROTEIN KINASE B; SAIKOSAPONIN D; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CALCIUM; CARRIER PROTEIN; LIPOCORTIN 5; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL NUCLEUS; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NEUROPROTECTION; NICK END LABELING; PC12 CELL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANALYSIS OF VARIANCE; ANIMAL; CELL SURVIVAL; DIAGNOSTIC USE; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; METABOLISM; MITOCHONDRION; PC12 CELL LINE; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANNEXIN A5; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CALCIUM; CELL SURVIVAL; CORTICOSTERONE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OLEANOLIC ACID; PC12 CELLS; PROPIDIUM; RATS; RECEPTORS, GLUCOCORTICOID; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84897490414     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2014.02.010     Document Type: Article

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