Saikosaponin-d inhibits T cell activation through the modulation of PKCθ, JNK, and NF-κB transcription factor

Biochemical and Biophysical Research Communications

Volumn 338, Issue 4, 2005, Pages 1920-1927

  Leung, Chung Yee ^a   Liu, Liang ^a   Wong, Ricky N S ^a   Zeng, Yao Ying ^b   Li, Ming ^a   Zhou, Hua ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b UNIVERSITY OF JINAN   (China)

Author keywords

CD69; CD71; ERK; I B ; JNK; PKC ; Saikosaponin d; Signal transduction; T cell activation

Indexed keywords

CD69 ANTIGEN; CD71 ANTIGEN; CONCANAVALIN A; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; SAIKOSAPONIN D; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CYTOSOL; ENZYME PHOSPHORYLATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; I-KAPPA B PROTEINS; INTERLEUKIN-2; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; OLEANOLIC ACID; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTORS, TRANSFERRIN; SAPONINS; T-LYMPHOCYTES;

ANIMALIA; APIACEAE; BUPLEURUM FALCATUM;

EID: 27844538290     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.10.175     Document Type: Article

References (53)

1. P.B. Benito, M.J. Martinez, A.M. Sen, A.S. Gomez, M. Fernandez, S.S. Contreras, and A.M. Lanza In vivo and in vitro anti-inflammatory activity of saikosaponins Life Sci. 63 1998 1147 1156
2. M.C. Recio, M.J. Just, R.M. Giner, S. Manez, J.L. Rios, and K. Hostettmann Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliate J. Nat. Prod. 58 1995 140 144
3. S. Hiai, H. Yokovama, T. Nagasawa, and H. Oura Stimulation of the pituitary-adrenocortical axis by saikosaponin of Bupleuri radix Chem. Pharmacol. Bull. 29 1981 495 499
4. Y. Ushio, and H. Abe The effects of saikosaponin-d on yeast phagocytosis and degradation in peritoneal macrophages: related increase in Fc receptor expression and altered cytoplasmic organization Jpn. J. Pharmacol. 56 1991 167 175
5. N. Yamaguchi, H. Kohno, M. Tawara, S. Odashima, and H. Abe Effect of saikosaponin derivatives upon the immune response against T-dependent and T-independent antigens in mice Int. J. Immunopharmacol. 7 1985 827 832
6. W.C. Chang, and F.L. Hsu Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds Prostaglandins Leukot. Essent. Fatty Acids 44 1991 51 56
7. G. Iezzi, K. Karjalainen, and A. Lanzavecchia The duration of antigenic stimulation determines the fate of naive and effector T cells Immunity 8 1998 89 95
8. S. Valitutti, M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton J. Exp. Med. 181 1995 577 584
9. M.A. Goldsmith, and A. Weiss Early signal transduction by the antigen receptor without commitment to T cell activation Science 240 1988 1029 1031
10. R. Marzio, J. Mauel, and S. Betz-Corradin CD69 and regulation of the immune function Immunopharmacol. Immunotoxicol. 21 1999 565 582
11. K.O. Schowengerdt, F.J. Fricker, K.S. Bahjat, and S.T. Kuntz Increased expression of the lymphocyte early activation marker CD69 in peripheral blood correlates with histologic evidence of cardiac allograft rejection Transplantation 69 2000 2102 2107
12. A.M. Posselt, F. Vincenti, M. Bedolli, M. Lantz, J.P. Roberts, and R. Hirose CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients Transplantation 76 2003 190 195
13. A.J. Barrett, K. Rezvani, S. Solomon, A.M. Dickinson, X.N. Wang, G. Stark, H. Cullup, M. Jarvis, P.G. Middleton, and N. Chao New developments in allotransplant immunology Hematology 2003 350 371
14. S. Osada, K. Mizuno, T.C. Saido, K. Suzuki, T. Kuroki, and S. Ohno A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle Mol. Cell. Biol. 12 1992 3930 3938
15. G. Baier, D. Telford, L. Giampa, K.M. Coggeshall, G. Baier-Bitterlich, N. Isakov, and A. Altman Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells J. Biol. Chem. 268 1993 4997 5004
16. J.D. Chang, Y. Xu, M.K. Raychowdhury, and J.A. Ware Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets J. Biol. Chem. 268 1993 14208 14214
17. N. Meller, A. Altman, and N. Isakov New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C Stem Cells (Dayton) 16 1998 178 192
18. A. Altman, K.M. Coggeshall, and T. Mustelin Molecular events mediating T cell activation Adv. Immunol. 48 1990 227 360
19. C.R. Monks, H. Kupfer, I. Tamir, A. Barlow, and A. Kupfer Selective modulation of protein kinase C-theta during T cell activation Nature 385 1997 83 86
20. C.R. Monks, B.A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer Three-dimensional segregation of supramolecular clusters in T cells Nature 395 1998 82 86
21. G. Baier-Bitterlich, F. Überall, B. Bauer, F. Fresser, H. Wachter, H. Grünicke, G. Utermann, A. Altman, and G. Baier PKCθ isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes Mol. Cell. Biol. 16 1996 1842 1850
22. N. Coudronniere, M. Villalba, N. Englund, and A. Altman NF-κB activation induced by CD28 costimulation is mediated by PKCθ Proc. Natl. Acad. Sci. USA 97 2000 3394 3399
23. X. Lin, A. O'Mahony, R. Geleziunas, and W.C. Greene Protein kinase Cθ participates in NF-κB/Rel activation induced by CD3/CD28 costimulation through selective activation of IκBβ (IKKβ) Mol. Cell. Biol. 20 2000 2933 2940
24. G. Werlen, E. Jacinto, Y. Xia, and M. Karin Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes EMBO J. 17 1998 3103 3111
25. N. Ghaffari-Tabrizi, B. Bauer, A. Altman, G. Utermann, F. Uberall, and G. Baier Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells Eur. J. Immunol. 29 1999 132 142
26. Y. Ushio, and H. Abe The effects of saikosaponin on macrophage functions and lymphocyte proliferation Planta Med. 57 1991 511 514
27. J. Bajorath, and A. Aruffo Molecular model of the extracellular lectin-like domain in CD69 J. Biol. Chem. 269 1994 32457 32463
28. F. Sanchez-Madrid White cell differentiation antigens: overview of CD69 S.F. Schlossman L. Boumsell W. Gilks J.M. Harlan T. Kishimoto C. Morimoto J. Ritz S. Shaw R. Silverstein T. Springer T.F. Tedder R.F. Todd Leukocyte Typing V 1995 Oxford University Press New York 1123
29. D. Sancho, A.G. Santis, J.L. Alonso-Lebrero, F. Viedma, R. Tejedor, and F. Sanchez-Madrid Functional analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors J. Immunol. 165 2000 3868 3875
30. K.S. Ullman, J.P. Northrop, C.L. Verweij, and G.R. Crabtree Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link Annu. Rev. Immunol. 8 1990 421 452
31. A. Weiss T lymphocyte activation W.E. Paul Fundamental Immunology second ed. 1989 Raven Press New York 359 384
32. P.C. Beverley Activation antigens: new and previously defined clusters A.J. McMichael Leucocyte Typing III 1987 Oxford University Press Oxford 516 528
33. N. Meller, Y.C. Liu, T.L. Collins, N. Bonnefoy Berard, G. Baier, N. Isakov, and A. Altman Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function Mol. Cell. Biol. 16 1996 5782 5791
34. D. Mochly-Rosen Localization of protein kinases by anchoring proteins: a theme in signal transduction Science 268 1995 247 251
35. A.C. Newton Protein kinase C. Seeing two domains Curr. Biol. 5 1995 973 976
36. Z. Sun, C.W. Arendt, W. Ellmeier, E.M. Schaeffer, M.J. Sunshine, L. Gandhi, J. Annes, D. Petrzilka, A. Kupfer, P.L. Schwartzberg, and D.R. Littman PKCθ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes Nature 404 2000 402 407
37. M. Villalba, N. Coudronniere, M. Deckert, E. Teixeiro, P. Mas, and A. Altman A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation Immunity 12 2000 151 160
38. M. Grilli, J. Chiu, and M. Lenardo NF-κB and Rel: participants in a multiform transcriptional regulatory system Int. Rev. Cytol. 143 1993 1 62
39. M.J. Lenardo, and D. Baltimore NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control Cell 58 1989 227 229
40. A.S. Baldwin The NF-κB and IκB proteins: new discoveries and insights Annu. Rev. Immunol. 14 1996 649 681
41. P.A. Baeuerle, and D. Baltimore Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor Cell 53 1988 211 217
42. P.A. Baeuerle, and D. Baltimore IκB: a specific inhibitor of the NF-κB transcription factor Science 242 1988 540 546
43. A.A. Beg, S.M. Ruben, R.I. Scheinman, S. Haskill, C.A. Rosen, and A.S. Baldwin IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasm retention Genes Dev. 6 1992 1899 1913
44. A.A. Beg, and A.S. Baldwin The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors Genes Dev. 7 1993 2064 2070
45. K. Brown, S. Park, T. Kanno, G. Franzoso, and U. Siebenlist Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα Proc. Natl. Acad. Sci. USA 90 1993 2532 2536
46. T. Henkel, T. Machleidt, I. Alkalay, M. Kronke, Y. Ben-Neriah, and P. Baeuerle Rapid proteolysis of IκBα is necessary in the activation of transcription factor NF-κB Nature (London) 365 1993 182 185
47. K. Hardy, and G. Chaudhri Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes Immunol. Cell Biol. 75 1997 528 545
48. R.J. Davis MAPKs: new JNK expand the group Trends Biochem. Sci. 19 1994 470 473
49. B. Derijard, M. Hibi, I.H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R.J. Davis JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 76 1994 1025 1037
50. K. Deacon, and J.L. Blank Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3 J. Biol. Chem. 272 1997 14489 14496
51. H. Ellinger-Ziegelbauer, K. Brown, and U. Siebenlist Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative J. Biol. Chem. 272 1997 2668 2674
52. J. Raingeaud, A.J. Whitmarsh, T. Barrett, B. Berijard, and R.J. Davis MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway Mol. Cell. Biol. 16 1996 1247 1255
53. A. Avraham, S. Jung, Y. Samuels, R. Seger, and Y. Ben-Neriah Co-stimulation dependent activation of a JNK-kinase in T lymphocytes Eur. J. Immunol. 28 1998 2320 2330