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Volumn 26, Issue 7, 2015, Pages 704-712

Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats

Author keywords

Cocoa; Glucose homeostasis; Glucose tolerance; Insulin resistance; Insulin signaling pathway; Type 2 diabetic ZDF rats

Indexed keywords

GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); STRESS ACTIVATED PROTEIN KINASE; ANTIDIABETIC AGENT; GLYCOGEN SYNTHASE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, RAT;

EID: 84938827006     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.01.009     Document Type: Article
Times cited : (44)

References (48)
  • 2
    • 84885868900 scopus 로고    scopus 로고
    • Recent advances in understanding the anti-diabetic actions of dietary flavonoids
    • Babu PVA, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem 2013;24:1777-89.
    • (2013) J Nutr Biochem , vol.24 , pp. 1777-1789
    • Babu, P.V.A.1    Liu, D.2    Gilbert, E.R.3
  • 3
    • 78651276631 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011;34:S62-9.
    • (2011) Diabetes Care , vol.34 , pp. S62-S69
    • Association, A.D.1
  • 5
    • 84896994484 scopus 로고    scopus 로고
    • Therapeutic interventions to reduce the risk of progression from prediabetes to type 2 diabetes mellitus
    • Portero McLellan K-C, Wyne K, Trejo Villagomez E, Hsueh W-A. Therapeutic interventions to reduce the risk of progression from prediabetes to type 2 diabetes mellitus. Ther Clin Risk Manage 2014;10:173-88.
    • (2014) Ther Clin Risk Manage , vol.10 , pp. 173-188
    • Portero McLellan, K.-C.1    Wyne, K.2    Trejo Villagomez, E.3    Hsueh, W.-A.4
  • 6
    • 1542285160 scopus 로고    scopus 로고
    • Hepatocytes: critical for glucose homeostasis
    • Klover PJ, Mooney RA. Hepatocytes: critical for glucose homeostasis. Int J Biochem Cell Biol 2004;36:753-8.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 753-758
    • Klover, P.J.1    Mooney, R.A.2
  • 8
    • 33746163080 scopus 로고    scopus 로고
    • Transcriptional regulation of glucose sensors in pancreatic beta cells and liver
    • Im SS, Kim SY, Kim H, Ahn YH. Transcriptional regulation of glucose sensors in pancreatic beta cells and liver. Curr Diabetes Rev 2006;2:11-8.
    • (2006) Curr Diabetes Rev , vol.2 , pp. 11-18
    • Im, S.S.1    Kim, S.Y.2    Kim, H.3    Ahn, Y.H.4
  • 9
    • 54549088739 scopus 로고    scopus 로고
    • Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human HepG2 hepatoma cells
    • Lin CL, Lin JK. Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human HepG2 hepatoma cells. Mol Nutr Food Res 2008;52:930-9.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 930-939
    • Lin, C.L.1    Lin, J.K.2
  • 10
    • 78649916463 scopus 로고    scopus 로고
    • Grape powder extract attenuates tumor necrosis factor a-mediated inflammation and insulin resistance in primary cultures of human adipocytes
    • Chuang CC, Bumrungpert A, Kennedy A, Overman A, West T, Dawson B, et al. Grape powder extract attenuates tumor necrosis factor a-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr Biochem 2011;22:89-94.
    • (2011) J Nutr Biochem , vol.22 , pp. 89-94
    • Chuang, C.C.1    Bumrungpert, A.2    Kennedy, A.3    Overman, A.4    West, T.5    Dawson, B.6
  • 11
    • 84880775951 scopus 로고    scopus 로고
    • Inhibition of the TNF-alpha-induced serine phosphorylation of IRS-1 at 636/639 by AICAR
    • Shibata T, Takaguri A, Ichihara K, Satoh K. Inhibition of the TNF-alpha-induced serine phosphorylation of IRS-1 at 636/639 by AICAR. J Pharmacol Sci 2013;122: 93-102.
    • (2013) J Pharmacol Sci , vol.122 , pp. 93-102
    • Shibata, T.1    Takaguri, A.2    Ichihara, K.3    Satoh, K.4
  • 12
    • 33751234225 scopus 로고    scopus 로고
    • Chocolate is a powerful ex vivo and in vitro antioxidant, antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets
    • Vinson JA, Proch J, Bose P, Muchler S, Taffera P, Shutta D, et al. Chocolate is a powerful ex vivo and in vitro antioxidant, antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets. J Agric Food Chem 2006;54:8071-6.
    • (2006) J Agric Food Chem , vol.54 , pp. 8071-8076
    • Vinson, J.A.1    Proch, J.2    Bose, P.3    Muchler, S.4    Taffera, P.5    Shutta, D.6
  • 13
    • 84891441283 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols
    • Ali F, Ismail A, Kersten S. Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols. Mol Nutr Food Res 2014; 58:33-48.
    • (2014) Mol Nutr Food Res , vol.58 , pp. 33-48
    • Ali, F.1    Ismail, A.2    Kersten, S.3
  • 14
    • 84889681762 scopus 로고    scopus 로고
    • Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells
    • Cordero-Herrera I, Martín MA, Goya L, Ramos S. Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells. Food Chem Toxicol 2014;64:10-9.
    • (2014) Food Chem Toxicol , vol.64 , pp. 10-19
    • Cordero-Herrera, I.1    Martín, M.A.2    Goya, L.3    Ramos, S.4
  • 15
    • 84878921139 scopus 로고    scopus 로고
    • Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells
    • Cordero-Herrera I, Martín MA, Bravo L, Goya L, Ramos S. Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells. Mol Nutr Food Res 2013;57:974-85.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 974-985
    • Cordero-Herrera, I.1    Martín, M.A.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 16
    • 84896321557 scopus 로고    scopus 로고
    • Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding
    • Dorenkott MR, Griffin LE, Goodrich KM, Thompson-Witrick KA, Fundaro G, Ye L, et al. Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding. J Agric Food Chem 2014;62:2216-27.
    • (2014) J Agric Food Chem , vol.62 , pp. 2216-2227
    • Dorenkott, M.R.1    Griffin, L.E.2    Goodrich, K.M.3    Thompson-Witrick, K.A.4    Fundaro, G.5    Ye, L.6
  • 17
    • 84877278303 scopus 로고    scopus 로고
    • Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice
    • Fu Z, Yuskavage J, Liu D. Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice. J Agric Food Chem 2013;61:4303-9.
    • (2013) J Agric Food Chem , vol.61 , pp. 4303-4309
    • Fu, Z.1    Yuskavage, J.2    Liu, D.3
  • 18
    • 52649086293 scopus 로고    scopus 로고
    • Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obesediabetic (Ob-db) rats
    • Jalil A-M-M, Ismail A, Pei C-P, Hamid M, Kamaruddin S-H-S. Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obesediabetic (Ob-db) rats. J Agric Food Chem 2008;56:7877-84.
    • (2008) J Agric Food Chem , vol.56 , pp. 7877-7884
    • Jalil, A.-M.-M.1    Ismail, A.2    Pei, C.-P.3    Hamid, M.4    Kamaruddin, S.-H.-S.5
  • 19
    • 34047167381 scopus 로고    scopus 로고
    • Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice
    • Tomaru M, Takano H, Osakabe N, Yasuda A, Inoue K-I, Yanagisawa R, et al. Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice. Nutrition 2007;23:351-5.
    • (2007) Nutrition , vol.23 , pp. 351-355
    • Tomaru, M.1    Takano, H.2    Osakabe, N.3    Yasuda, A.4    Inoue, K.-I.5    Yanagisawa, R.6
  • 20
    • 14844314202 scopus 로고    scopus 로고
    • The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
    • Ruzaidi A, Amin I, Nawalyah AG, Hamid M, Faizul HA. The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats. J Ethnopharmacol 2005;98:55-60.
    • (2005) J Ethnopharmacol , vol.98 , pp. 55-60
    • Ruzaidi, A.1    Amin, I.2    Nawalyah, A.G.3    Hamid, M.4    Faizul, H.A.5
  • 21
    • 51049107708 scopus 로고    scopus 로고
    • Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate
    • Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr 2008;138:1671-6.
    • (2008) J Nutr , vol.138 , pp. 1671-1676
    • Grassi, D.1    Desideri, G.2    Necozione, S.3    Lippi, C.4    Casale, R.5    Properzi, G.6
  • 22
    • 0141528820 scopus 로고    scopus 로고
    • Cocoa powder increases postprandial insulinemia in lean young adults
    • Brand-Miller J, Holt SH, de Jong V, Petocz P. Cocoa powder increases postprandial insulinemia in lean young adults. J Nutr 2003;133:3149-52.
    • (2003) J Nutr , vol.133 , pp. 3149-3152
    • Brand-Miller, J.1    Holt, S.H.2    de Jong, V.3    Petocz, P.4
  • 23
    • 29744456063 scopus 로고    scopus 로고
    • Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes
    • Leonard BL, Watson RN, Loomes KM, Phillips ARJ, Cooper GJ. Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes. Acta Diabetol 2005;42:162-70.
    • (2005) Acta Diabetol , vol.42 , pp. 162-170
    • Leonard, B.L.1    Watson, R.N.2    Loomes, K.M.3    Phillips, A.R.J.4    Cooper, G.J.5
  • 25
    • 76749133701 scopus 로고    scopus 로고
    • Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells
    • Martín MA, Granado-Serrano AB, Ramos S, Izquierdo Pulido M, Bravo L, Goya L. Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells. J Nutr Biochem 2010;21:196-205.
    • (2010) J Nutr Biochem , vol.21 , pp. 196-205
    • Martín, M.A.1    Granado-Serrano, A.B.2    Ramos, S.3    Izquierdo Pulido, M.4    Bravo, L.5    Goya, L.6
  • 27
    • 82955187036 scopus 로고    scopus 로고
    • Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis
    • Rodríguez-Ramiro I, Ramos S, López-Oliva E, Agis-Torres A, Gómez-Juaristi M, Mateos R, et al. Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis. Mol Nutr Food Res 2011;55:1895-9.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1895-1899
    • Rodríguez-Ramiro, I.1    Ramos, S.2    López-Oliva, E.3    Agis-Torres, A.4    Gómez-Juaristi, M.5    Mateos, R.6
  • 28
    • 84863346623 scopus 로고    scopus 로고
    • Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats
    • Misawa E, Tanaka M, Nomaguchi K, Nabeshima K, Yamada M, Toida T, et al. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats. J Agric Food Chem 2012;60:2799-806.
    • (2012) J Agric Food Chem , vol.60 , pp. 2799-2806
    • Misawa, E.1    Tanaka, M.2    Nomaguchi, K.3    Nabeshima, K.4    Yamada, M.5    Toida, T.6
  • 29
    • 84863986770 scopus 로고    scopus 로고
    • Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes
    • Wang J, Rong X, Li W, Yang Y, Yamahara J, Li Y. Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes. J Ethnopharmacol 2012;142:782-8.
    • (2012) J Ethnopharmacol , vol.142 , pp. 782-788
    • Wang, J.1    Rong, X.2    Li, W.3    Yang, Y.4    Yamahara, J.5    Li, Y.6
  • 30
    • 20944441872 scopus 로고    scopus 로고
    • Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism
    • Matsui N, Itoa R, Nishimura E, Yoshikawa M, Kato M, Kamei M, et al. Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism. Nutrition 2005;21:594-601.
    • (2005) Nutrition , vol.21 , pp. 594-601
    • Matsui, N.1    Itoa, R.2    Nishimura, E.3    Yoshikawa, M.4    Kato, M.5    Kamei, M.6
  • 32
    • 84878015618 scopus 로고    scopus 로고
    • Purple sweet potato color attenuates hepatic insulin resistance via blocking oxidative stress and endoplasmic reticulum stress in high-fat-diet-treated mice
    • Zhang ZF, Lu J, Zheng YL, Wu DM, Hu B, Shan Q, et al. Purple sweet potato color attenuates hepatic insulin resistance via blocking oxidative stress and endoplasmic reticulum stress in high-fat-diet-treated mice. J Nutr Biochem 2013;24: 1008-18.
    • (2013) J Nutr Biochem , vol.24 , pp. 1008-1018
    • Zhang, Z.F.1    Lu, J.2    Zheng, Y.L.3    Wu, D.M.4    Hu, B.5    Shan, Q.6
  • 33
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats
    • Cline GW, Johnson K, Regittnig W, Perret P, Tozzo E, Xiao L, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes 2002;51:2903-10.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Cline, G.W.1    Johnson, K.2    Regittnig, W.3    Perret, P.4    Tozzo, E.5    Xiao, L.6
  • 34
    • 34547730995 scopus 로고    scopus 로고
    • Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet
    • Cao H, Hininger-Favier I, Kelly MA, Benaraba R, Dawson HD, Coves S, et al. Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet. J Agric Food Chem 2007;55:6372-8.
    • (2007) J Agric Food Chem , vol.55 , pp. 6372-6378
    • Cao, H.1    Hininger-Favier, I.2    Kelly, M.A.3    Benaraba, R.4    Dawson, H.D.5    Coves, S.6
  • 35
    • 80052831703 scopus 로고    scopus 로고
    • Solanum torvum Swartz fruit containing phenolic compounds shows antidiabetic and antioxidant effects in streptozotocin induced diabetic rats
    • Gandhi GR, Ignacimuthu S, Paulraj MG. Solanum torvum Swartz fruit containing phenolic compounds shows antidiabetic and antioxidant effects in streptozotocin induced diabetic rats. Food Chem Toxicol 2011;49:2725-33.
    • (2011) Food Chem Toxicol , vol.49 , pp. 2725-2733
    • Gandhi, G.R.1    Ignacimuthu, S.2    Paulraj, M.G.3
  • 36
    • 34547783227 scopus 로고    scopus 로고
    • The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice
    • Jung UJ, Baek N-I, Chung H-G, Bang M-H, Yoo J-S, Jeong TS, et al. The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice. Food Chem Toxicol 2007;45:2022-9.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2022-2029
    • Jung, U.J.1    Baek, N.-I.2    Chung, H.-G.3    Bang, M.-H.4    Yoo, J.-S.5    Jeong, T.S.6
  • 37
    • 84872765400 scopus 로고    scopus 로고
    • Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose-and lipid-regulating enzymes in db/db mice
    • Park HJ, Jung UJ, Cho SJ, Jung HK, Shim S, Choi MS. Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose-and lipid-regulating enzymes in db/db mice. J Nutr Biochem 2013;24:419-27.
    • (2013) J Nutr Biochem , vol.24 , pp. 419-427
    • Park, H.J.1    Jung, U.J.2    Cho, S.J.3    Jung, H.K.4    Shim, S.5    Choi, M.S.6
  • 38
    • 82955235212 scopus 로고    scopus 로고
    • Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes
    • Lou T, Zhang Z, Xi Z, Liu K, Li L, Liu B, et al. Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. Inflammation 2011;34:659-67.
    • (2011) Inflammation , vol.34 , pp. 659-667
    • Lou, T.1    Zhang, Z.2    Xi, Z.3    Liu, K.4    Li, L.5    Liu, B.6
  • 39
    • 63249123500 scopus 로고    scopus 로고
    • Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in Zucker diabetic fatty rats
    • Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, et al. Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in Zucker diabetic fatty rats. Diabetes 2009;58:78-86.
    • (2009) Diabetes , vol.58 , pp. 78-86
    • Torres, T.P.1    Catlin, R.L.2    Chan, R.3    Fujimoto, Y.4    Sasaki, N.5    Printz, R.L.6
  • 40
    • 33645892889 scopus 로고    scopus 로고
    • Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
    • Jung UJ, Lee MK, Park YB, Kang MA, Choi MS. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 2006;38:1134-45.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 1134-1145
    • Jung, U.J.1    Lee, M.K.2    Park, Y.B.3    Kang, M.A.4    Choi, M.S.5
  • 41
    • 84864771143 scopus 로고    scopus 로고
    • Antidiabetic effects of rice hull smoke extract on glucose-regulating mechanism in type 2 diabetic mice
    • Yang JY, Moon E, Nam SH, Friedman M. Antidiabetic effects of rice hull smoke extract on glucose-regulating mechanism in type 2 diabetic mice. J Agric Food Chem 2012;60:7442-9.
    • (2012) J Agric Food Chem , vol.60 , pp. 7442-7449
    • Yang, J.Y.1    Moon, E.2    Nam, S.H.3    Friedman, M.4
  • 42
    • 0842263985 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-γ in the glucose-sensing apparatus of liver and β-cells
    • Kim H-I, Ahn Y-H. Role of peroxisome proliferator-activated receptor-γ in the glucose-sensing apparatus of liver and β-cells. Diabetes 2004;53:S60-5.
    • (2004) Diabetes , vol.53 , pp. S60-S65
    • Kim, H.-I.1    Ahn, Y.-H.2
  • 43
    • 0034617286 scopus 로고    scopus 로고
    • Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells
    • Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, et al. Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells. J Biol Chem 2000;275: 20880-6.
    • (2000) J Biol Chem , vol.275 , pp. 20880-20886
    • Nakajima, K.1    Yamauchi, K.2    Shigematsu, S.3    Ikeo, S.4    Komatsu, M.5    Aizawa, T.6
  • 44
    • 84861802677 scopus 로고    scopus 로고
    • Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice
    • Ruan CT, Lam SH, Chi TC, Lee SS, Su MJ. Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice. Phytomedicine 2012;19:719-24.
    • (2012) Phytomedicine , vol.19 , pp. 719-724
    • Ruan, C.T.1    Lam, S.H.2    Chi, T.C.3    Lee, S.S.4    Su, M.J.5
  • 45
    • 77956051448 scopus 로고    scopus 로고
    • Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet
    • Souza-Mello V, Gregorio BM, Cardoso-de-Lemos FS, de Carvalho L, Aguila MB, Mandarim-de-Lacerda CA. Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet. Clin Sci 2010; 119:239-50.
    • (2010) Clin Sci , vol.119 , pp. 239-250
    • Souza-Mello, V.1    Gregorio, B.M.2    Cardoso-de-Lemos, F.S.3    de Carvalho, L.4    Aguila, M.B.5    Mandarim-de-Lacerda, C.A.6
  • 46
    • 0026543026 scopus 로고
    • Glucose transporter levels in tissues of spontaneously diabetic Zucker fa/fa rat (ZDF/drt) and viable yellow mouse (Avy/a)
    • Slieker LJ, Sundell KL, Heath WF, Osborne HE, Bue J, Manetta J, et al. Glucose transporter levels in tissues of spontaneously diabetic Zucker fa/fa rat (ZDF/drt) and viable yellow mouse (Avy/a). Diabetes 1992;41:187-93.
    • (1992) Diabetes , vol.41 , pp. 187-193
    • Slieker, L.J.1    Sundell, K.L.2    Heath, W.F.3    Osborne, H.E.4    Bue, J.5    Manetta, J.6
  • 48
    • 77349119823 scopus 로고    scopus 로고
    • Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats
    • Király MA, Campbell J, Park E, Bates HE, Yue JT, Rao V, et al. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab 2010;298:E671-82.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E671-E682
    • Király, M.A.1    Campbell, J.2    Park, E.3    Bates, H.E.4    Yue, J.T.5    Rao, V.6


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