-
1
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-846.
-
(2006)
Nature.
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
2
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A. 2001;98:4640-4645.
-
(2001)
Proc Natl Acad Sci U S A.
, vol.98
, pp. 4640-4645
-
-
Ozes, O.N.1
Akca, H.2
Mayo, L.D.3
Gustin, J.A.4
Maehama, T.5
Dixon, J.E.6
-
3
-
-
2342428466
-
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
-
De Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem. 2004;279:17070-17078.
-
(2004)
J Biol Chem.
, vol.279
, pp. 17070-17078
-
-
De Alvaro, C.1
Teruel, T.2
Hernandez, R.3
Lorenzo, M.4
-
4
-
-
29444455533
-
Interleukin-1alpha inhibits insulin signaling with phosphorylat-ing insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes
-
He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, et al. Interleukin-1alpha inhibits insulin signaling with phosphorylat-ing insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes. Mol Endocrinol. 2006;20:114-124.
-
(2006)
Mol Endocrinol.
, vol.20
, pp. 114-124
-
-
He, J.1
Usui, I.2
Ishizuka, K.3
Kanatani, Y.4
Hiratani, K.5
Iwata, M.6
-
5
-
-
33646350774
-
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
-
Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, et al. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem. 2006;281:7060-7067.
-
(2006)
J Biol Chem.
, vol.281
, pp. 7060-7067
-
-
Weigert, C.1
Hennige, A.M.2
Lehmann, R.3
Brodbeck, K.4
Baumgartner, F.5
Schaüble, M.6
-
6
-
-
0028031569
-
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
-
Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest. 1994;94:1543-1549.
-
(1994)
J Clin Invest.
, vol.94
, pp. 1543-1549
-
-
Hotamisligil, G.S.1
Budavari, A.2
Murray, D.3
Spiegelman, B.M.4
-
7
-
-
0042591261
-
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
-
Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem. 2003;278:24944-24950.
-
(2003)
J Biol Chem.
, vol.278
, pp. 24944-24950
-
-
Gao, Z.1
Zuberi, A.2
Quon, M.J.3
Dong, Z.4
Ye, J.5
-
9
-
-
33644886769
-
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
-
Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006;26:63-76.
-
(2006)
Mol Cell Biol.
, vol.26
, pp. 63-76
-
-
Tzatsos, A.1
Kandror, K.V.2
-
10
-
-
0035844129
-
MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors
-
Tran SE, Holmstrom TH, Ahonen M, Kahari VM, Eriksson JE. MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors. J Biol Chem. 2001;276:16484-16490.
-
(2001)
J Biol Chem.
, vol.276
, pp. 16484-16490
-
-
Tran, S.E.1
Holmstrom, T.H.2
Ahonen, M.3
Kahari, V.M.4
Eriksson, J.E.5
-
11
-
-
12644272789
-
Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/ SAPK) pathways at TNF receptor-associated factor 2
-
Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/ SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci U S A. 1997;94:9792-9796.
-
(1997)
Proc Natl Acad Sci U S A.
, vol.94
, pp. 9792-9796
-
-
Song, H.Y.1
Régnier, C.H.2
Kirschning, C.J.3
Goeddel, D.V.4
Rothe, M.5
-
12
-
-
0033556356
-
A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
-
Anderson CN, Tolkovsky AM. A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside. J Neurosci. 1999;19:664-673.
-
(1999)
J Neurosci.
, vol.19
, pp. 664-673
-
-
Anderson, C.N.1
Tolkovsky, A.M.2
-
13
-
-
0029753773
-
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
-
Chen YR, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem. 1996;271: 31929-31936.
-
(1996)
J Biol Chem.
, vol.271
, pp. 31929-31936
-
-
Chen, Y.R.1
Wang, X.2
Templeton, D.3
Davis, R.J.4
Tan, T.H.5
-
14
-
-
33751566645
-
DUSP meet immunology: Dual specificity MAPK phosphatases in control of the inflammatory response
-
Lang R, Hammer M, Mages J. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol. 2006;177:7497-7504.
-
(2006)
J Immunol.
, vol.177
, pp. 7497-7504
-
-
Lang, R.1
Hammer, M.2
Mages, J.3
-
15
-
-
41549160315
-
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
-
Junttila MR, Li SP, Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 2008;22:954-965.
-
(2008)
FASEB J.
, vol.22
, pp. 954-965
-
-
Junttila, M.R.1
Li, S.P.2
Westermarck, J.3
-
16
-
-
0035863784
-
The serine/threo-nine phosphatase, PP2A: Endogenous regulator of inflammatory cell signaling
-
Shanley TP, Vasi N, Denenberg A, Wong HR. The serine/threo-nine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling. J Immunol. 2001;166:966-972.
-
(2001)
J Immunol.
, vol.166
, pp. 966-972
-
-
Shanley, T.P.1
Vasi, N.2
Denenberg, A.3
Wong, H.R.4
-
17
-
-
33644943620
-
AMPK: A key sensor of fuel and energy status in skeletal muscle
-
Hardie DG, Sakamoto K. AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda). 2006;21: 48-60.
-
(2006)
Physiology (Bethesda).
, vol.21
, pp. 48-60
-
-
Hardie, D.G.1
Sakamoto, K.2
-
18
-
-
85047689953
-
5-amino-imidazole-4-carboxamide ribonucleoside A specific method for activating AMP-activated protein kinase in intact cells?
-
Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-amino-imidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem. 1995;229:558-565.
-
(1995)
Eur J Biochem.
, vol.229
, pp. 558-565
-
-
Corton, J.M.1
Gillespie, J.G.2
Hawley, S.A.3
Hardie, D.G.4
-
19
-
-
33847062845
-
The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic
-
Thong FS, Bilan PJ, Klip A. The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes. 2007;56:414-423.
-
(2007)
Diabetes.
, vol.56
, pp. 414-423
-
-
Thong, F.S.1
Bilan, P.J.2
Klip, A.3
-
20
-
-
44349104255
-
Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes
-
Takaguri A, Satoh K, Itagaki M, Tokumitsu Y, Ichihara K. Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes. J Pharmacol Sci. 2008; 107:80-89.
-
(2008)
J Pharmacol Sci.
, vol.107
, pp. 80-89
-
-
Takaguri, A.1
Satoh, K.2
Itagaki, M.3
Tokumitsu, Y.4
Ichihara, K.5
-
21
-
-
32544456122
-
A2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-/?-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle
-
Nakano M, Hamada T, Hayashi T, Yonemitsu S, Miyamoto L, Toyoda T, et al. a2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-/?-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle. Metabolism. 2006;55:300-308.
-
(2006)
Metabolism.
, vol.55
, pp. 300-308
-
-
Nakano, M.1
Hamada, T.2
Hayashi, T.3
Yonemitsu, S.4
Miyamoto, L.5
Toyoda, T.6
-
22
-
-
0038321436
-
-
Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, et al. Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. 2003;52:1319-1325.
-
(2003)
Reduced Activation of phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor substrate-1 in Primary Culture of Skeletal Muscle Cells from Patients with Type 2 Diabetes
, vol.52
, pp. 1319-1325
-
-
Bouzakri, K.1
Roques, M.2
Gual, P.3
Espinosa, S.4
Guebre-Egziabher, F.5
Riou, J.P.6
-
24
-
-
34447565964
-
5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells
-
Fukuda T, Ishii K, Nanmoku T, Isobe K, Kawakami Y Takekoshi K. 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells. J Neuroendocrinol. 2007;19:621-631.
-
(2007)
J Neuroendocrinol.
, vol.19
, pp. 621-631
-
-
Fukuda, T.1
Ishii, K.2
Nanmoku, T.3
Isobe, K.4
Kawakami, Y.5
Takekoshi, K.6
-
25
-
-
23944475571
-
Roles of mTOR and JNK in serine phosphorylation, transloca-tion, and degradation of IRS-1
-
Hiratani K, Haruta T, Tani A, Kawahara J, Usui I, Kobayashi M. Roles of mTOR and JNK in serine phosphorylation, transloca-tion, and degradation of IRS-1. Biochem Biophys Res Commun. 2005;335:836-842.
-
(2005)
Biochem Biophys Res Commun.
, vol.335
, pp. 836-842
-
-
Hiratani, K.1
Haruta, T.2
Tani, A.3
Kawahara, J.4
Usui, I.5
Kobayashi, M.6
-
26
-
-
55549133627
-
Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
-
Good DW, George T, Watts BA 3rd. Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb. J Biol Chem. 2008;283:26602-26611.
-
(2008)
J Biol Chem.
, vol.283
, pp. 26602-26611
-
-
Good, D.W.1
George, T.2
-
27
-
-
0242361561
-
Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
-
Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell. 2003;12:889-901.
-
(2003)
Mol Cell.
, vol.12
, pp. 889-901
-
-
Rajasekhar, V.K.1
Viale, A.2
Socci, N.D.3
Wiedmann, M.4
Hu, X.5
Holland, E.C.6
-
28
-
-
69149097363
-
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
-
Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, et al. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009;106:12932-12937.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, pp. 12932-12937
-
-
Guo, D.1
Hildebrandt, I.J.2
Prins, R.M.3
Soto, H.4
Mazzotta, M.M.5
Dang, J.6
-
29
-
-
34248595035
-
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
-
Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene. 2007;26:3203-3213.
-
(2007)
Oncogene.
, vol.26
, pp. 3203-3213
-
-
Owens, D.M.1
Keyse, S.M.2
-
30
-
-
42149155999
-
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance
-
Emanuelli B, Eberlé D, Suzuki R, Kahn CR. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci U S A. 2008;105:3545-3550.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 3545-3550
-
-
Emanuelli, B.1
Eberlé, D.2
Suzuki, R.3
Kahn, C.R.4
-
31
-
-
34548541264
-
Role of MAPK phosphatase-1 in the induction of mono-cyte chemoattractant protein-1 during the course of adipocyte hypertrophy
-
Ito A, Suganami T, Miyamoto Y, Yoshimasa Y, Takeya M, Kamei Y, et al. Role of MAPK phosphatase-1 in the induction of mono-cyte chemoattractant protein-1 during the course of adipocyte hypertrophy. J Biol Chem. 2007;282:25445-25452.
-
(2007)
J Biol Chem.
, vol.282
, pp. 25445-25452
-
-
Ito, A.1
Suganami, T.2
Miyamoto, Y.3
Yoshimasa, Y.4
Takeya, M.5
Kamei, Y.6
-
32
-
-
20144386698
-
Long-term AICAR administration and exercise prevents diabetes in ZDF rats
-
Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes. 2005;54:928-934.
-
(2005)
Diabetes.
, vol.54
, pp. 928-934
-
-
Pold, R.1
Jensen, L.S.2
Jessen, N.3
Buhl, E.S.4
Schmitz, O.5
Flyvbjerg, A.6
|