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Volumn 122, Issue 2, 2013, Pages 93-102

Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR

Author keywords

3T3L1 adipocyte; AICAR; DUSP9 MKP 4; Insulin receptor substrate (IRS) 1; Insulin resistance

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 4; OKADAIC ACID; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84880775951     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12270FP     Document Type: Article
Times cited : (27)

References (32)
  • 1
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-846.
    • (2006) Nature. , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 2
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A. 2001;98:4640-4645.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6
  • 3
    • 2342428466 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
    • De Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem. 2004;279:17070-17078.
    • (2004) J Biol Chem. , vol.279 , pp. 17070-17078
    • De Alvaro, C.1    Teruel, T.2    Hernandez, R.3    Lorenzo, M.4
  • 4
    • 29444455533 scopus 로고    scopus 로고
    • Interleukin-1alpha inhibits insulin signaling with phosphorylat-ing insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes
    • He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, et al. Interleukin-1alpha inhibits insulin signaling with phosphorylat-ing insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes. Mol Endocrinol. 2006;20:114-124.
    • (2006) Mol Endocrinol. , vol.20 , pp. 114-124
    • He, J.1    Usui, I.2    Ishizuka, K.3    Kanatani, Y.4    Hiratani, K.5    Iwata, M.6
  • 5
    • 33646350774 scopus 로고    scopus 로고
    • Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
    • Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, et al. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem. 2006;281:7060-7067.
    • (2006) J Biol Chem. , vol.281 , pp. 7060-7067
    • Weigert, C.1    Hennige, A.M.2    Lehmann, R.3    Brodbeck, K.4    Baumgartner, F.5    Schaüble, M.6
  • 6
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest. 1994;94:1543-1549.
    • (1994) J Clin Invest. , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 7
    • 0042591261 scopus 로고    scopus 로고
    • Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
    • Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem. 2003;278:24944-24950.
    • (2003) J Biol Chem. , vol.278 , pp. 24944-24950
    • Gao, Z.1    Zuberi, A.2    Quon, M.J.3    Dong, Z.4    Ye, J.5
  • 9
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006;26:63-76.
    • (2006) Mol Cell Biol. , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 10
    • 0035844129 scopus 로고    scopus 로고
    • MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors
    • Tran SE, Holmstrom TH, Ahonen M, Kahari VM, Eriksson JE. MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors. J Biol Chem. 2001;276:16484-16490.
    • (2001) J Biol Chem. , vol.276 , pp. 16484-16490
    • Tran, S.E.1    Holmstrom, T.H.2    Ahonen, M.3    Kahari, V.M.4    Eriksson, J.E.5
  • 11
    • 12644272789 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/ SAPK) pathways at TNF receptor-associated factor 2
    • Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/ SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci U S A. 1997;94:9792-9796.
    • (1997) Proc Natl Acad Sci U S A. , vol.94 , pp. 9792-9796
    • Song, H.Y.1    Régnier, C.H.2    Kirschning, C.J.3    Goeddel, D.V.4    Rothe, M.5
  • 12
    • 0033556356 scopus 로고    scopus 로고
    • A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
    • Anderson CN, Tolkovsky AM. A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside. J Neurosci. 1999;19:664-673.
    • (1999) J Neurosci. , vol.19 , pp. 664-673
    • Anderson, C.N.1    Tolkovsky, A.M.2
  • 13
    • 0029753773 scopus 로고    scopus 로고
    • The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
    • Chen YR, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem. 1996;271: 31929-31936.
    • (1996) J Biol Chem. , vol.271 , pp. 31929-31936
    • Chen, Y.R.1    Wang, X.2    Templeton, D.3    Davis, R.J.4    Tan, T.H.5
  • 14
    • 33751566645 scopus 로고    scopus 로고
    • DUSP meet immunology: Dual specificity MAPK phosphatases in control of the inflammatory response
    • Lang R, Hammer M, Mages J. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol. 2006;177:7497-7504.
    • (2006) J Immunol. , vol.177 , pp. 7497-7504
    • Lang, R.1    Hammer, M.2    Mages, J.3
  • 15
    • 41549160315 scopus 로고    scopus 로고
    • Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    • Junttila MR, Li SP, Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 2008;22:954-965.
    • (2008) FASEB J. , vol.22 , pp. 954-965
    • Junttila, M.R.1    Li, S.P.2    Westermarck, J.3
  • 16
    • 0035863784 scopus 로고    scopus 로고
    • The serine/threo-nine phosphatase, PP2A: Endogenous regulator of inflammatory cell signaling
    • Shanley TP, Vasi N, Denenberg A, Wong HR. The serine/threo-nine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling. J Immunol. 2001;166:966-972.
    • (2001) J Immunol. , vol.166 , pp. 966-972
    • Shanley, T.P.1    Vasi, N.2    Denenberg, A.3    Wong, H.R.4
  • 17
    • 33644943620 scopus 로고    scopus 로고
    • AMPK: A key sensor of fuel and energy status in skeletal muscle
    • Hardie DG, Sakamoto K. AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda). 2006;21: 48-60.
    • (2006) Physiology (Bethesda). , vol.21 , pp. 48-60
    • Hardie, D.G.1    Sakamoto, K.2
  • 18
    • 85047689953 scopus 로고
    • 5-amino-imidazole-4-carboxamide ribonucleoside A specific method for activating AMP-activated protein kinase in intact cells?
    • Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-amino-imidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem. 1995;229:558-565.
    • (1995) Eur J Biochem. , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 19
    • 33847062845 scopus 로고    scopus 로고
    • The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic
    • Thong FS, Bilan PJ, Klip A. The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes. 2007;56:414-423.
    • (2007) Diabetes. , vol.56 , pp. 414-423
    • Thong, F.S.1    Bilan, P.J.2    Klip, A.3
  • 20
    • 44349104255 scopus 로고    scopus 로고
    • Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes
    • Takaguri A, Satoh K, Itagaki M, Tokumitsu Y, Ichihara K. Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes. J Pharmacol Sci. 2008; 107:80-89.
    • (2008) J Pharmacol Sci. , vol.107 , pp. 80-89
    • Takaguri, A.1    Satoh, K.2    Itagaki, M.3    Tokumitsu, Y.4    Ichihara, K.5
  • 21
    • 32544456122 scopus 로고    scopus 로고
    • A2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-/?-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle
    • Nakano M, Hamada T, Hayashi T, Yonemitsu S, Miyamoto L, Toyoda T, et al. a2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-/?-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle. Metabolism. 2006;55:300-308.
    • (2006) Metabolism. , vol.55 , pp. 300-308
    • Nakano, M.1    Hamada, T.2    Hayashi, T.3    Yonemitsu, S.4    Miyamoto, L.5    Toyoda, T.6
  • 24
    • 34447565964 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells
    • Fukuda T, Ishii K, Nanmoku T, Isobe K, Kawakami Y Takekoshi K. 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells. J Neuroendocrinol. 2007;19:621-631.
    • (2007) J Neuroendocrinol. , vol.19 , pp. 621-631
    • Fukuda, T.1    Ishii, K.2    Nanmoku, T.3    Isobe, K.4    Kawakami, Y.5    Takekoshi, K.6
  • 26
    • 55549133627 scopus 로고    scopus 로고
    • Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
    • Good DW, George T, Watts BA 3rd. Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb. J Biol Chem. 2008;283:26602-26611.
    • (2008) J Biol Chem. , vol.283 , pp. 26602-26611
    • Good, D.W.1    George, T.2
  • 27
    • 0242361561 scopus 로고    scopus 로고
    • Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
    • Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell. 2003;12:889-901.
    • (2003) Mol Cell. , vol.12 , pp. 889-901
    • Rajasekhar, V.K.1    Viale, A.2    Socci, N.D.3    Wiedmann, M.4    Hu, X.5    Holland, E.C.6
  • 28
    • 69149097363 scopus 로고    scopus 로고
    • The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
    • Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, et al. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009;106:12932-12937.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 12932-12937
    • Guo, D.1    Hildebrandt, I.J.2    Prins, R.M.3    Soto, H.4    Mazzotta, M.M.5    Dang, J.6
  • 29
    • 34248595035 scopus 로고    scopus 로고
    • Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
    • Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene. 2007;26:3203-3213.
    • (2007) Oncogene. , vol.26 , pp. 3203-3213
    • Owens, D.M.1    Keyse, S.M.2
  • 30
    • 42149155999 scopus 로고    scopus 로고
    • Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance
    • Emanuelli B, Eberlé D, Suzuki R, Kahn CR. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci U S A. 2008;105:3545-3550.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , pp. 3545-3550
    • Emanuelli, B.1    Eberlé, D.2    Suzuki, R.3    Kahn, C.R.4
  • 31
    • 34548541264 scopus 로고    scopus 로고
    • Role of MAPK phosphatase-1 in the induction of mono-cyte chemoattractant protein-1 during the course of adipocyte hypertrophy
    • Ito A, Suganami T, Miyamoto Y, Yoshimasa Y, Takeya M, Kamei Y, et al. Role of MAPK phosphatase-1 in the induction of mono-cyte chemoattractant protein-1 during the course of adipocyte hypertrophy. J Biol Chem. 2007;282:25445-25452.
    • (2007) J Biol Chem. , vol.282 , pp. 25445-25452
    • Ito, A.1    Suganami, T.2    Miyamoto, Y.3    Yoshimasa, Y.4    Takeya, M.5    Kamei, Y.6
  • 32
    • 20144386698 scopus 로고    scopus 로고
    • Long-term AICAR administration and exercise prevents diabetes in ZDF rats
    • Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes. 2005;54:928-934.
    • (2005) Diabetes. , vol.54 , pp. 928-934
    • Pold, R.1    Jensen, L.S.2    Jessen, N.3    Buhl, E.S.4    Schmitz, O.5    Flyvbjerg, A.6


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