Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis

Molecular Nutrition and Food Research

Volumn 55, Issue 12, 2011, Pages 1895-1899

  Rodríguez Ramiro, Ildefonso ^a   Ramos, Sonia ^a   López Oliva, Elvira ^b   Agis Torres, Angel ^b   Gómez Juaristi, Miren ^a   Mateos, Raquel ^a   Bravo, Laura ^a   Goya, Luis ^a   Martín, María Ángeles ^a,c  

^a INSTITUTE OF FOOD SCIENCE   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Bioactive compounds; Cocoa flavanols; Colorectal cancer; Glutathione enzymes; Oxidative stress

Indexed keywords

ANTINEOPLASTIC AGENT; AZOXYMETHANE; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; CASPASE 3; CCND1 PROTEIN, RAT; CYCLIN D1; PROTEIN BAX;

ANIMAL; APOPTOSIS; CACAO; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COLON; COLON TUMOR; DIET; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NOTE; OXIDATIVE STRESS; PATHOLOGY; PRECANCER; RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; AZOXYMETHANE; BCL-2-ASSOCIATED X PROTEIN; CACAO; CASPASE 3; CELL PROLIFERATION; COLON; COLONIC NEOPLASMS; CYCLIN D1; DIET; GENE EXPRESSION REGULATION; OXIDATIVE STRESS; PRECANCEROUS CONDITIONS; RATS;

EID: 82955187036     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100363     Document Type: Note

References (23)

1. Miller, P. E., Lesko, S. M., Muscat, J. E., Lazarus, P. et al., Dietary patterns and colorectal adenoma and cancer risk: a review of the epidemiological evidence. Nutr. Cancer 2010, 62, 413-424.
2. Reuter, S., Gupta, S. C., Chaturvedi, M. M., Aggarwal, B. B., Oxidative stress, inflammation, and cancer: how are they linked? Free Radic. Biol. Med. 2010, 49, 1603-1616.
3. Visioli, F., Bernaert, H., Cortie, R., Ferri, C. et al., Chocolate, lifestyle, and health. Crit. Rev. Food Sci. 2009, 49, 299-312.
4. Vinson, J. A., Proch, J., Bose, P., Muchler, S. et al., Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets. J. Agric. Food Chem. 2006, 54, 8071-8076.
5. D'Archivio, M., Santangelo, C., Scazzocchio, B., Varí, R. et al., Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention. Int. J. Mol. Sci. 2008, 9, 213-228.
6. Martín, M. A., Serrano, A. B., Ramos, S., Pulido, M. I. et al., Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells. J. Nutr. Biochem. 2010, 21, 196-205.
7. Rodríguez-Ramiro, I., Ramos, S., Bravo, L., Goya, L. et al., Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. J. Nutr. Biochem. 2011, in press, DOI: 10.1016/j.jnutbio.2010.10.005.
8. Granado-Serrano, A. B., Martín, M. A., Haegeman, G., Goya, L. et al., Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells. Br. J. Nutr. 2010, 103, 168-179.
9. González-Sarrías, A., Espín, J. C., Tomás-Barberán, F. A., García-Conesa, M. T., Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. Mol. Nutr. Food Res. 2009, 53, 686-698.
10. Martín, M. A., Ramos, S., Mateos, R., Granado-Serrano, A. B. et al., Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract. J. Agric. Food Chem. 2008, 56, 7765-7772.
11. Granado-Serrano, A. B., Martín, M. A., Bravo, L., Goya, L. et al., A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats. Food Chem. Toxicol. 2009, 47, 2499-2506.
12. Matsui, N., Ito, R., Nishimura, E., Yoshikawa, M. et al., Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism. Nutrition 2005, 21, 594-601.
13. Ramiro-Puig, E., Pérez-Cano, F. J., Ramos-Romero, S., Pérez-Berezo, T. et al., Intestinal immune system of young rats influenced by cocoa-enriched diet. J. Nutr. Biochem. 2008, 19, 555-565.
14. Pritchard, C. C., Grady, W. M., Colorectal cancer molecular biology moves into clinical practice. Gut 2011, 60, 116-129.
15. Chiou, Y.-S., Tsai, M.-L., Nagabhushanam, K., Wang, Y.-J. et al., Pterostilbene Is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-Related Factor 2 (Nrf2)-mediated antioxidant signaling pathway. J. Agric. Food Chem. 2011, 59, 2725-2733.
16. Ashokkumar, P., Sudhandiran, G., Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed. Pharmacother. 2008, 62, 590-597.
17. Sengottuvelan, M., Senthilkumar, R., Nalini, N., Modulatory influence of dietary resveratrol during different phases of 1, 2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim. Biophys. Acta 2006, 1760, 1175-1183.
18. Pan, M.-H., Lai, C. S., Wu, J.-Ch., Ho, C.-T., Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Mol. Nutr. Food Res. 2011, 55, 32-45.
19. Masella, R. T., Di Benedetto, R., Varỳ, R., Filesi, C. et al., Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J. Nutr. Biochem. 2005, 16, 577-586.
20. Cheung, K. L., Khor, T. O., Huang, M.-T., Kong, A.-N., Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM. Carcinogen 2010, 31, 880-885.
21. Storz, P., Reactive oxygen species in tumor progression. Front. Biosci. 2005, 10, 1881-1896.
22. Xavier, C. P. R., Lima, C. F., Preto, A., Seruca, R. et al., Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett. 2009, 281, 162-170.
23. Volate, S. R., Davenport, D. M., Muga, S. J., Wargovich, M. J., Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogen 2005, 26, 1450-1456.