Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes

Journal of Ethnopharmacology

Volumn 142, Issue 3, 2012, Pages 782-788

  Wang, Jianwei ^a   Rong, Xianglu ^b   Li, Wenlong ^c   Yang, Yifan ^d   Yamahara, Johji ^e   Li, Yuhao ^d  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Sydney Institute of Health Sciences   (Australia)

^e Pharmafood Institute   (Japan)

Author keywords

Insulin resistance; Rhodiola crenulata; The metabolic syndrome

Indexed keywords

ANTIDIABETIC AGENT; CHOLESTEROL; FATTY ACID; GLUCOSE; INSULIN; OLIVE OIL; PLANT EXTRACT; RHODIOLA CRENULATA EXTRACT; SUCROSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; MEDICINAL PLANT; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANT ROOT; RAT; RHODIOLA CRENULATA; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; HYPOGLYCEMIC AGENTS; LEPTIN; LIPID METABOLISM; LIVER; MALE; METABOLIC SYNDROME X; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, ZUCKER; RHODIOLA; TRIGLYCERIDES;

ANIMALIA; MUS; RATTUS; RHODIOLA; RHODIOLA CRENULATA;

EID: 84863986770     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.05.063     Document Type: Article

References (47)

1. A.G. Arbuzov, A.V. Krylatov, L.N. Maslov, V.N. Burkova, and N.V. Naryzhnaya Antihypoxic, cardioprotective, and antifibrillation effects of a combined adaptogenic plant preparation Bulletin of Experimental Biology and Medicine 142 2006 212 215 (Pubitemid 44781756)
2. S.C Chua Jr, W.K. Chung, X.S. Wu-Peng, Y. Zhang, S.M. Liu, L. Tartaglia, and R.L. Leibel Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271 1996 994 996 (Pubitemid 26066874)
3. M.A. Cornier, D. Dabelea, T.L. Hernandez, R.C. Lindstrom, A.J. Steig, N.R. Stob, R.E. Van Pelt, H. Wang, and R.H. Eckel The metabolic syndrome Endocrine Reviews 29 2008 777 822
4. R.H. Eckel, S.M. Grundy, and P.Z. Zimmet The metabolic syndrome Lancet 365 2005 1415 1428 (Pubitemid 40523737)
5. R.M. Evans, G.D. Barish, and Y.X. Wang PPARs and the complex journey to obesity Nature Medicine 10 2004 355 361 (Pubitemid 38508511)
6. Y. Fan, R. Tan, and L. Jiang Evaluation of treatment of 27 cases of type 2 diabetic patients with Rhodiola crenulata tea Chinese Journal of Modern Drug Application 1 2007 10 11
7. C. Fritschi, and L. Quinn Fatigue in patients with diabetes: a review Journal of Psychosomatic Research 69 2010 33 41
8. A. Gastaldelli, S.A. Harrison, R. Belfort-Aguilar, L.J. Hardies, B. Balas, S. Schenker, and K. Cusi Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with non-alcoholic steatohepatitis Hepatology 50 2009 1087 1093
9. S. Guan, H. Feng, B. Song, W. Guo, Y. Xiong, G. Huang, W. Zhong, M. Huo, N. Chen, J. Lu, and X. Deng Salidroside attenuates LPS-induced pro-inflammatory cytokine responses and improves survival in murine endotoxemia International Immunopharmacology 11 2011 2194 2199
10. A.A. Hedley, C.L. Ogden, C.L. Johnson, M.D. Carroll, L.R. Curtin, and K.M. Flegal Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002 The Journal of American Medical Association 291 2004 2847 2850 (Pubitemid 38747805)
11. T.H. Huang, G. Peng, B.P. Kota, G.Q. Li, J. Yamahara, B.D. Roufogalis, and Y. Li Anti-diabetic action of Punica granatum flower extract: activation of PPAR-γ and identification of an active component Toxicology and Applied Pharmacology 207 2005 160 169 (Pubitemid 41133502)
12. T.H. Huang, G. Peng, B.P. Kota, G.Q. Li, J. Yamahara, B.D. Roufogalis, and Y. Li Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids British Journal of Pharmacology 145 2005 767 774 (Pubitemid 41076283)
13. T.H. Huang, G. Peng, G.Q. Li, J. Yamahara, B.D. Roufogalis, and Y. Li Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-α Toxicology and Applied Pharmacology 210 2006 225 235 (Pubitemid 43107565)
14. T.H. Huang, Q. Yang, M. Harada, J. Uberai, J. Radford, G.Q. Li, J. Yamahara, B.D. Roufogalis, and Y. Li Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes Toxicology and Applied Pharmacology 210 2006 78 85 (Pubitemid 41790554)
15. T.H. Huang, L. He, Q. Qin, Q. Yang, P. Peng, M. Harad, Y. Qi, J. Yamahara, B.D. Roufogalis, and Y. Li Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: inhibition of cardiac expression of angiotensin II type 1 receptor Diabetes, Obesity and Metabolism 10 2008 574 585 (Pubitemid 351850901)
16. M.D. Jensen, M. Caruso, V. Heiling, and J.M. Miles Insulin regulation of lipolysis in nondiabetic and IDDM subjects Diabetes 38 1989 1595-601
17. W. Katon Depression and diabetes: unhealthy bedfellows Depress and Anxiety 27 2010 323 326
18. G.S. Kelly Rhodiola rosea: a possible plant adaptogen Alternative Medicine Review 6 2001 293 302 (Pubitemid 32591865)
19. D.E. Kemp, F. Ismail-Beigi, and JR. Calabrese Antidepressant response associated with pioglitazone: support for an overlapping pathophysiology between major depression and metabolic syndrome American Journal of Psychiatry 166 2009 619
20. D.E. Kemp, F. Ismail-Beigi, S.J. Ganocy, C. Conroy, K. Gao, S. Obral, E. Fein, R.L. Findling, and J.R. Calabrese Use of insulin sensitizers for the treatment of major depressive disorder: A pilot study of pioglitazone for major depression accompanied by abdominal obesity Journal of Affective Disorders 136 2012 1164 1173
21. K. Kobayashi, K. Yamada, T. Murata, T. Hasegawa, F. Takano, K. Koga, S. Fushiya, J. Batkhuu, and F. Yoshizaki Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal Planta Medica 74 2008 1716 1719
22. Y.I. Kwon, H.D. Jang, and K. Shetty Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension Asia Pacific Journal of Clinical Nutrition 15 2006 425 432 (Pubitemid 44423425)
23. J. Labad, J.F. Price, M.W. Strachan, F.G. Fowkes, J. Ding, I.J. Deary, A.J. Lee, B.M. Frier, J.R. Seckl, B.R. Walker, and R.M. Reynolds Edinburgh Type 2 Diabetes Study Investigators. Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study Diabetologia 53 2010 467 471
24. Y. Li, G. Peng, Q. Li, S. Wen, T.H. Huang, B.D. Roufogalis, and J. Yamahara Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats Life Sciences 75 2004 1735 1746 (Pubitemid 38961797)
25. Y. Li, S. Wen, B.P. Kota, G. Peng, G.Q. Li, J. Yamahara, and B.D. Roufogalis Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats Journal of Ethnopharmacology 99 2005 239 244 (Pubitemid 40724399)
26. M. Liang, Y. Zhang, and W. Xiang Clinical observation on therapeutic effects of combined use of Rhodioa rosea and losartan in treating diabetic nephropathy Chinese Journal of Integrated Traditional and Western Nephrology 9 2008 694 697
27. R. Lomonaco, C. Ortiz-Lopez, B. Orsak, A. Webb, J. Hardies, C. Darland, J. Finch, A. Gastaldelli, S. Harrison, F. Tio, and K. Cusi Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with NAFLD Hepatology 55 2012 1389 1397
28. J.M. McCaffery, R. Niaura, J.F. Todaro, G.E. Swan, and D. Carmelli Depressive symptoms and metabolic risk in adult male twins enrolled in the National Heart, Lung, and Blood Institute twin study Psychosomatic Medicine 65 2003 490 497 (Pubitemid 36628904)
29. S. Nakamura, X. Li, H. Matsuda, and M. Yoshikawa Bioactive constituents from Chinese natural medicines. XXVIII. Chemical structures of acyclic alcohol glycosides from the roots of Rhodiola crenulata Chemical Pharmaceutical Bulletin (Tokyo) 56 2008 536 540 (Pubitemid 351520140)
30. B.A. Neuschwander-Tetri Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites Hepatology 52 2010 774 788
31. A. Panossian, G. Wikman, and J. Sarris Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy Phytomedicine 17 2010 481 493
32. N. Rasgon, G. Jarvik, and L. Jarvik Affective disorders and Alzheimer disease: a missing-link hypothesis American Journal of Geriatric Psychiatry 9 2001 444 445 (Pubitemid 33015134)
33. N. Rasgon, and L. Jarvik Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59 2004 178 183 (Pubitemid 38269152)
34. N.L. Rasgon, H.A. Kenna, K.E. Williams, B. Powers, T. Wroolie, and A.F. Schatzberg Rosiglitazone add-on in treatment of depressed patients with insulin resistance: a pilot study ScientificWorld Journal 10 2010 321 328
35. X. Rong, Y. Li, K. Ebihara, M. Zhao, W. Aini, T. Kusakabe, M. Hirata, L. Miyamoto, M. Murray, and K. Nakao An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice Journal of Pharmacology and Experimental Therapeatics 331 2009 1096 1103
36. X. Rong, Y. Li, K. Ebihara, M. Zhao, T. Kusakabe, T. Tomita, M. Murray, and K. Nakao Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fak/fak) rats: a link to amelioration of hypertriglyceridaemia British Journal of Pharmacology160 2010 1796 1807
37. X. Rong, Y. Li, K. Ebihara, M. Zhao, J. Naowaboot, T. Kusakabe, K. Kuwahara, M. Murray, and K. Nakao Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice Diabetologia 53 2010 1727 1731
38. M.R. Skilton, P. Moulin, J.L. Terra, and F. Bonnet Associations between anxiety, depression, and the metabolic syndrome Biol Psychiatry 62 2007 1251 1257 (Pubitemid 350060887)
39. T. Takeuchi, M. Nakao, K. Nomura, M. Inoue, S. Tsurugano, Y. Shinozaki, and E. Yano Association of the metabolic syndrome with depression and anxiety in Japanese men: a 1-year cohort study Diabetes/Metabolism Research and Reviews 25 2009 762 767
40. A.N. Vgontzas, and A. Kales Sleep and its disorders Annual Review of Medicine 50 1999 387 400 (Pubitemid 29117074)
41. J. Wagner, N.A. Allen, L.M. Swalley, G.D. Melkus, and R. Whittemore Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetes Diabetes Research and Clinical Practice 86 2009 96 103
42. J.M. Wang, J.P. Shan, and S.Q. Wang Progress of research study on pharmacological action of Rhodiola Rosea Acta Chinese Medicine and Pharmacology 31 2003 57 59
43. K.E. Wellen, and G.S. Hotamisligil Inflammation, stress, and diabetes Journal of Clinical Investigation 115 2005 1111 1119 (Pubitemid 40629025)
44. J. Ye Adipose tissue vascularization: its role in chronic inflammation Current Diabes Reports 11 2011 203 210
45. J. Zhang, A. Liu, R. Hou, J. Zhang, X. Jia, W. Jiang, and J. Chen Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway European Journal of Pharmacology 607 2009 6 14
46. K.Y. Zheng, A.J. Guo, C.W. Bi, K.Y. Zhu, G.K. Chan, Q. Fu, S.L. Xu, J.Y. Zhan, D.T. Lau, T.T. Dong, R.C. Choi, and K.W. Tsim The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1α via blocking the degradation pathway in cultured kidney fibroblasts Planta Medica 77 2011 894 899
47. K.Y. Zheng, Z.X. Zhang, A.J. Guo, C.W. Bi, K.Y. Zhu, S.L. Xu, J.Y. Zhan, D.T. Lau, T.T. Dong, R.C. Choi, and K.W. Tsim Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells European Journal of Pharmacology 679 2012 34 39