메뉴 건너뛰기




Volumn 35, Issue 5, 2015, Pages 937-967

Toward a Cancer Drug of Fungal Origin

Author keywords

Anguidine; Aphidicolin; Clinical trials; Drug resistance; Fumagillin; Fungal metabolites; Illudin S; Phenylahistin; Rhizoxin; Wortmannin

Indexed keywords

ANTINEOPLASTIC AGENT; APHIDICOLIN; APICIDIN; CHAETOCIN; COTYLENIN A; CYTOCHALASIN E; DESTRUXIN; DESTRUXIN B; DIACETOXYSCIRPENOL; EPOXYQUINOL B; FUMAGILLIN; GALIELLALACTONE; GLIOCLADICILLINS A; GLIOCLADICILLINS B; ILLUDIN S; NATURAL PRODUCT; PALMARUMYCIN CP1; PHENYLAHISTIN; RHIZOXIN; THERMOZYMOCIDIN; TRIORNICIN; UNCLASSIFIED DRUG; WORTMANNIN; ANDROSTANE DERIVATIVE; BIOLOGICAL PRODUCT; CYCLOHEXANE DERIVATIVE; MACROLIDE; PIPERAZINEDIONE; SESQUITERPENE; TRICHOTHECENE DERIVATIVE; UNSATURATED FATTY ACID;

EID: 84938743842     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.21348     Document Type: Article
Times cited : (74)

References (201)
  • 1
    • 64249135764 scopus 로고    scopus 로고
    • Novel agents on the horizon for cancer therapy
    • Ma WW, Adjei AA. Novel agents on the horizon for cancer therapy. CA Cancer J Clin 2009;59:111-137.
    • (2009) CA Cancer J Clin , vol.59 , pp. 111-137
    • Ma, W.W.1    Adjei, A.A.2
  • 4
    • 84879799563 scopus 로고    scopus 로고
    • Understanding, recognizing, and managing toxicities of targeted anticancer therapies
    • Dy GK, Adjei AA. Understanding, recognizing, and managing toxicities of targeted anticancer therapies. CA Cancer J Clin 2013;63:249-279.
    • (2013) CA Cancer J Clin , vol.63 , pp. 249-279
    • Dy, G.K.1    Adjei, A.A.2
  • 8
    • 77954668887 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Current strategies and future prospects
    • Cook KM, Figg WD. Angiogenesis inhibitors: Current strategies and future prospects. CA Cancer J Clin 2010;60:222-243.
    • (2010) CA Cancer J Clin , vol.60 , pp. 222-243
    • Cook, K.M.1    Figg, W.D.2
  • 9
    • 67650675111 scopus 로고    scopus 로고
    • Impact of natural products on developing new anti-cancer agents
    • Cragg GM, Grothaus PG, Newman DJ. Impact of natural products on developing new anti-cancer agents. Chem Rev 2009;109:3012-3043.
    • (2009) Chem Rev , vol.109 , pp. 3012-3043
    • Cragg, G.M.1    Grothaus, P.G.2    Newman, D.J.3
  • 10
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012;75:311-335.
    • (2012) J Nat Prod , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 11
    • 84876002671 scopus 로고    scopus 로고
    • Natural products: A continuing source of novel drug leads
    • Cragg GM, Newman DJ. Natural products: A continuing source of novel drug leads. Biochim Biophys Acta 2013;1830:3670-3695.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 3670-3695
    • Cragg, G.M.1    Newman, D.J.2
  • 12
    • 80051742943 scopus 로고    scopus 로고
    • Interaction of natural products with cell survival and signaling pathways in the biochemical elucidation of drug targets in cancer
    • Qurishi Y, Hamid A, Majeed R, Hussain A, Qazi AK, Ahmed M, Zargar MA, Singh SK, Saxena AK. Interaction of natural products with cell survival and signaling pathways in the biochemical elucidation of drug targets in cancer. Future Oncol 2011;7:1007-1021.
    • (2011) Future Oncol , vol.7 , pp. 1007-1021
    • Qurishi, Y.1    Hamid, A.2    Majeed, R.3    Hussain, A.4    Qazi, A.K.5    Ahmed, M.6    Zargar, M.A.7    Singh, S.K.8    Saxena, A.K.9
  • 13
    • 84926257214 scopus 로고    scopus 로고
    • From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment
    • Cerella C, Teiten MH, Radogna F, Dicato M, Diederich M. From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment. Biotechnol Adv 2014;32:1111-1122.
    • (2014) Biotechnol Adv , vol.32 , pp. 1111-1122
    • Cerella, C.1    Teiten, M.H.2    Radogna, F.3    Dicato, M.4    Diederich, M.5
  • 14
    • 84926262041 scopus 로고    scopus 로고
    • Plant-derived epigenetic modulators for cancer treatment and prevention
    • Schnekenburger M, Dicato M, Diederich M. Plant-derived epigenetic modulators for cancer treatment and prevention. Biotechnol Adv 2014;32:1123-1132.
    • (2014) Biotechnol Adv , vol.32 , pp. 1123-1132
    • Schnekenburger, M.1    Dicato, M.2    Diederich, M.3
  • 15
    • 33745024719 scopus 로고    scopus 로고
    • From natural products discovery to commercialization: A success story
    • Demain AL. From natural products discovery to commercialization: A success story. J Ind Microbiol Biotechnol 2006;33:486-495.
    • (2006) J Ind Microbiol Biotechnol , vol.33 , pp. 486-495
    • Demain, A.L.1
  • 21
    • 0016040077 scopus 로고
    • The production of aphidicolin by Nigrospora sphaerica
    • Starratt AN, Loschiavo SR. The production of aphidicolin by Nigrospora sphaerica. Canad J Microbiol 1974;20:416-417.
    • (1974) Canad J Microbiol , vol.20 , pp. 416-417
    • Starratt, A.N.1    Loschiavo, S.R.2
  • 23
    • 33748941131 scopus 로고    scopus 로고
    • Ophiobolin E and 8-epi-ophiobolin J produced by Drechslera gigantea, potential mycoherbicide of weedy grasses
    • Evidente A, Andolfi A, Cimmino A, Vurro M, Fracchiolla M, Charudattan R, Motta A. Ophiobolin E and 8-epi-ophiobolin J produced by Drechslera gigantea, potential mycoherbicide of weedy grasses. Phytochemistry 2006;67:2281-2287.
    • (2006) Phytochemistry , vol.67 , pp. 2281-2287
    • Evidente, A.1    Andolfi, A.2    Cimmino, A.3    Vurro, M.4    Fracchiolla, M.5    Charudattan, R.6    Motta, A.7
  • 28
    • 33847258680 scopus 로고    scopus 로고
    • Production of mycophenolic acid by Penicillium brevicompactum immobilized in a rotating fibrous-bed bioreactor
    • Xu ZN, Yang ST. Production of mycophenolic acid by Penicillium brevicompactum immobilized in a rotating fibrous-bed bioreactor. Enzyme Microb Technol 2007;40:623-628.
    • (2007) Enzyme Microb Technol , vol.40 , pp. 623-628
    • Xu, Z.N.1    Yang, S.T.2
  • 29
    • 0030309982 scopus 로고    scopus 로고
    • Production of secondary metabolites by solid-state fermentation
    • Barrios-González J, Mejía A. Production of secondary metabolites by solid-state fermentation. Biotechnol Annu Rev 1996;2:85-121.
    • (1996) Biotechnol Annu Rev , vol.2 , pp. 85-121
    • Barrios-González, J.1    Mejía, A.2
  • 30
    • 0034255892 scopus 로고    scopus 로고
    • Defined media and inert supports: Their potential as solid-state fermentation production systems
    • Ooijkaas LP, Weber FJ, Buitelaar RM, Tramper J, Rinzema A. Defined media and inert supports: Their potential as solid-state fermentation production systems. Trends Biotechnol 2000;18:356-360.
    • (2000) Trends Biotechnol , vol.18 , pp. 356-360
    • Ooijkaas, L.P.1    Weber, F.J.2    Buitelaar, R.M.3    Tramper, J.4    Rinzema, A.5
  • 34
    • 0036902202 scopus 로고    scopus 로고
    • Big effects from small changes: Possible ways to explore nature's chemical diversity
    • Bode HB, Bethe B, Höfs R, Zeeck A. Big effects from small changes: Possible ways to explore nature's chemical diversity. Chem Bio Chem 2002;3:619-627
    • (2002) Chem Bio Chem , vol.3 , pp. 619-627
    • Bode, H.B.1    Bethe, B.2    Höfs, R.3    Zeeck, A.4
  • 35
    • 29044440615 scopus 로고    scopus 로고
    • Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomopsis asparagi
    • Christian OE. Compton J, Christian KR, Mooberry SL, Valeriote FA, Crews P. Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomopsis asparagi. J Nat Prod 2005;68:1592-1597.
    • (2005) J Nat Prod , vol.68 , pp. 1592-1597
    • Christian, O.E.1    Compton, J.2    Christian, K.R.3    Mooberry, S.L.4    Valeriote, F.A.5    Crews, P.6
  • 36
    • 33748254906 scopus 로고    scopus 로고
    • Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining
    • Scherlach K, Hertweck C. Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org Biomol Chem 2006;4:3517-3520.
    • (2006) Org Biomol Chem , vol.4 , pp. 3517-3520
    • Scherlach, K.1    Hertweck, C.2
  • 37
    • 0006131850 scopus 로고    scopus 로고
    • Cytochalasins from Phytopathogenic Ascochyta and Phoma species
    • Upadhyay RK and Mukerji KG, Eds Oxford: IBH Publishing Co. Pvt. Ltd
    • Vurro M, Bottalico A, Capasso R, Evidente A. Cytochalasins from Phytopathogenic Ascochyta and Phoma species. In (Upadhyay RK and Mukerji KG, Eds) Toxins in Plant Disease Development and Evolving Biotechnology. Oxford: IBH Publishing Co. Pvt. Ltd.; 1997. p 127-147.
    • (1997) Toxins in Plant Disease Development and Evolving Biotechnology , pp. 127-147
    • Vurro, M.1    Bottalico, A.2    Capasso, R.3    Evidente, A.4
  • 38
    • 67349089225 scopus 로고    scopus 로고
    • Mixed fermentation for natural product drug discovery
    • Pettit RK. Mixed fermentation for natural product drug discovery. Appl Microbiol Biotechnol 2009;83:19-25.
    • (2009) Appl Microbiol Biotechnol , vol.83 , pp. 19-25
    • Pettit, R.K.1
  • 40
    • 0031002160 scopus 로고    scopus 로고
    • Accumulation of trichothecenes in liquid cultures of a Fusarium sporotrichioides mutant lacking a functional trichothecene C-15 hydroxylase
    • McCormick SP, Hohn TM. Accumulation of trichothecenes in liquid cultures of a Fusarium sporotrichioides mutant lacking a functional trichothecene C-15 hydroxylase. Appl Environ Microbiol 1997;63:1685-1688.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 1685-1688
    • McCormick, S.P.1    Hohn, T.M.2
  • 42
    • 77149133405 scopus 로고    scopus 로고
    • Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
    • Chen Y, Smanski MJ, Shen B. Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol 2010;86:19-25.
    • (2010) Appl Microbiol Biotechnol , vol.86 , pp. 19-25
    • Chen, Y.1    Smanski, M.J.2    Shen, B.3
  • 43
    • 64549150542 scopus 로고    scopus 로고
    • Triggering cryptic natural product biosynthesis in microorganisms
    • Scherlach K, Hertweck C. Triggering cryptic natural product biosynthesis in microorganisms. Org Biomol Chem 2009;7:1753-1760.
    • (2009) Org Biomol Chem , vol.7 , pp. 1753-1760
    • Scherlach, K.1    Hertweck, C.2
  • 45
    • 84899070293 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in cancer chemotherapy: Coordinated role and regulation of efflux transporters and metabolizing enzymes
    • Vadlapatla RK, Vadlapudi AD, Pal D, Mitra AK. Mechanisms of drug resistance in cancer chemotherapy: Coordinated role and regulation of efflux transporters and metabolizing enzymes. Curr Pharm Des 2013;19:7126-7140.
    • (2013) Curr Pharm Des , vol.19 , pp. 7126-7140
    • Vadlapatla, R.K.1    Vadlapudi, A.D.2    Pal, D.3    Mitra, A.K.4
  • 46
    • 84906085263 scopus 로고    scopus 로고
    • Editorial: Signaling pathways in anti-cancer drug resistance
    • Chen C, Chen J, Zhao KN. Editorial: Signaling pathways in anti-cancer drug resistance. Curr Med Chem 2014;21:3007-3008.
    • (2014) Curr Med Chem , vol.21 , pp. 3007-3008
    • Chen, C.1    Chen, J.2    Zhao, K.N.3
  • 47
    • 77954341696 scopus 로고    scopus 로고
    • Survival signalling and apoptosis resistance in glioblastomas: Opportunities for targeted therapeutics
    • Krakstad C, Chekenya M. Survival signalling and apoptosis resistance in glioblastomas: Opportunities for targeted therapeutics. Mol Cancer 2010;9:135.
    • (2010) Mol Cancer , vol.9 , pp. 135
    • Krakstad, C.1    Chekenya, M.2
  • 48
    • 84880404541 scopus 로고    scopus 로고
    • Mitochondrial alterations during carcinogenesis: A review of metabolic transformation and targets for anticancer treatments
    • Wang X, Peralta S, Moraes CT. Mitochondrial alterations during carcinogenesis: A review of metabolic transformation and targets for anticancer treatments. Adv Cancer Res 2013;119:127-160.
    • (2013) Adv Cancer Res , vol.119 , pp. 127-160
    • Wang, X.1    Peralta, S.2    Moraes, C.T.3
  • 49
    • 84887621878 scopus 로고    scopus 로고
    • Anoikis molecular pathways and its role in cancer progression
    • Paoli P, Giannoni E, Chiarugi P. Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta 2013;1833:3481-3498.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 3481-3498
    • Paoli, P.1    Giannoni, E.2    Chiarugi, P.3
  • 50
    • 84878831559 scopus 로고    scopus 로고
    • Overcoming acquired resistance to anticancer therapy: Focus on the PI3K/AKT/mTOR pathway
    • Burris HA 3rd. Overcoming acquired resistance to anticancer therapy: Focus on the PI3K/AKT/mTOR pathway. Cancer Chemother Pharmacol 2013;71:829-842.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 829-842
    • Burris, H.A.1
  • 51
    • 84904718537 scopus 로고    scopus 로고
    • Nanocarriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers
    • Tsouris V, Joo MK, Kim SH, Kwon IC, Won YY. Nanocarriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers. Biotechnol Adv 2014;32:1037-1050.
    • (2014) Biotechnol Adv , vol.32 , pp. 1037-1050
    • Tsouris, V.1    Joo, M.K.2    Kim, S.H.3    Kwon, I.C.4    Won, Y.Y.5
  • 54
    • 84926262041 scopus 로고    scopus 로고
    • Plant-derived epigenetic modulators for cancer treatment and prevention
    • Schnekenburger M, Dicato M, Diederich M. Plant-derived epigenetic modulators for cancer treatment and prevention. Biotechnol Adv 2014;32:1123-1132.
    • (2014) Biotechnol Adv , vol.32 , pp. 1123-1132
    • Schnekenburger, M.1    Dicato, M.2    Diederich, M.3
  • 57
    • 85200168784 scopus 로고    scopus 로고
    • Recent developments in mushrooms as anti-cancer therapeutics: A review
    • Patel S, Goyal A. Recent developments in mushrooms as anti-cancer therapeutics: A review. 3 Biotech 2012;2:1-15.
    • (2012) 3 Biotech , vol.2 , pp. 1-15
    • Patel, S.1    Goyal, A.2
  • 60
    • 0020611745 scopus 로고
    • Phase-II evaluation of anguidine in central nervous-system tumors-A southwest oncology group-study
    • Goodwin J, Bottomley R, Vaughn C, Frank J, Pugh R. Phase-II evaluation of anguidine in central nervous-system tumors-A southwest oncology group-study. Cancer Treat Rep 1983;67:285-286.
    • (1983) Cancer Treat Rep , vol.67 , pp. 285-286
    • Goodwin, J.1    Bottomley, R.2    Vaughn, C.3    Frank, J.4    Pugh, R.5
  • 61
    • 0020046066 scopus 로고
    • Phase-II study of anguidine in gastrointestinal malignancies-A southwest oncology group-study
    • Bukowski R, Vaughn C, Bottomley R, Chen, T. Phase-II study of anguidine in gastrointestinal malignancies-A southwest oncology group-study. Cancer Treat Rep 1982;66:381-383.
    • (1982) Cancer Treat Rep , vol.66 , pp. 381-383
    • Bukowski, R.1    Vaughn, C.2    Bottomley, R.3    Chen, T.4
  • 62
    • 0019520936 scopus 로고
    • Therapy for advanced colorectal-cancer with a combination of 5-FU and anguidine-A southwest oncology group-study
    • Goodwin W, Stephens R, Mccracken J, Groppe C. Therapy for advanced colorectal-cancer with a combination of 5-FU and anguidine-A southwest oncology group-study. Cancer Treat Rep 1981;65:359-359.
    • (1981) Cancer Treat Rep , vol.65 , pp. 359-359
    • Goodwin, W.1    Stephens, R.2    Mccracken, J.3    Groppe, C.4
  • 63
    • 0019426435 scopus 로고
    • Phase-II trial of anguidine in patients with sarcomas unresponsive to prior chemotherapy-A southwest-oncology-group study
    • Thigpen J, Vaughn C, Stuckey W. Phase-II trial of anguidine in patients with sarcomas unresponsive to prior chemotherapy-A southwest-oncology-group study. Cancer Treat Rep 1981;65:881-882.
    • (1981) Cancer Treat Rep , vol.65 , pp. 881-882
    • Thigpen, J.1    Vaughn, C.2    Stuckey, W.3
  • 65
    • 37049116614 scopus 로고
    • X-ray crystallographic determination of the structure of the antibiotic aphidicolin: A tetracyclic diterpenoid containing a new ring system
    • Brundret KM, Dalzeil W, Hesp B, Jarvis JAJ, Neidle S. X-ray crystallographic determination of the structure of the antibiotic aphidicolin: A tetracyclic diterpenoid containing a new ring system. J Chem Soc Chem Commun 1972;1027-1028.
    • (1972) J Chem Soc Chem Commun , pp. 1027-1028
    • Brundret, K.M.1    Dalzeil, W.2    Hesp, B.3    Jarvis, J.A.J.4    Neidle, S.5
  • 66
    • 37049131268 scopus 로고
    • The structure and absolute configuration of the antibiotic aphidicolin: A tetracyclic diterpenoid containing a new ring system
    • Dalzeil W, Hesp B, Stevenson KM, Jarvis JAJ. The structure and absolute configuration of the antibiotic aphidicolin: A tetracyclic diterpenoid containing a new ring system. J Chem Soc Perkin Trans I 1974;2841-2851.
    • (1974) J Chem Soc Perkin Trans I , pp. 2841-2851
    • Dalzeil, W.1    Hesp, B.2    Stevenson, K.M.3    Jarvis, J.A.J.4
  • 67
    • 37049086173 scopus 로고
    • Aphidicolin synthetis studies: A sterocontrolled end game
    • Rizzo CJ, Smith AB. Aphidicolin synthetis studies: A sterocontrolled end game. J Chem Soc Perkin Trans I 1991;969-979.
    • (1991) J Chem Soc Perkin Trans I , pp. 969-979
    • Rizzo, C.J.1    Smith, A.B.2
  • 70
    • 0021180180 scopus 로고
    • Studies on macrocyclic lactone antibiotic. VII. Structure of a phytotoxin "rhizoxin" produced Rhizopus chinensis
    • Iwasaki S, Kobayashi H, Funkawa J, Namikoshi M, Okura S, Sato Z, Matsuda I, Noda T. Studies on macrocyclic lactone antibiotic. VII. Structure of a phytotoxin "rhizoxin" produced Rhizopus chinensis. J Antibiot 1984;37:354-362.
    • (1984) J Antibiot , vol.37 , pp. 354-362
    • Iwasaki, S.1    Kobayashi, H.2    Funkawa, J.3    Namikoshi, M.4    Okura, S.5    Sato, Z.6    Matsuda, I.7    Noda, T.8
  • 76
    • 0030032650 scopus 로고    scopus 로고
    • Single agent activity of rhizoxin in non-small-cell lung cancer: A Phase II trial of the EORTC early clinical trials group
    • Kaplan S, Hanauske AR, Pavlidis N, Bruntsch U, teVelde A, Wanders J, Heinrich B, Verweij J. Single agent activity of rhizoxin in non-small-cell lung cancer: A Phase II trial of the EORTC early clinical trials group. Br J Cancer 1996;73:403-405.
    • (1996) Br J Cancer , vol.73 , pp. 403-405
    • Kaplan, S.1    Hanauske, A.R.2    Pavlidis, N.3    Bruntsch, U.4    teVelde, A.5    Wanders, J.6    Heinrich, B.7    Verweij, J.8
  • 77
    • 44049102210 scopus 로고
    • Fumagillin, an antibiotic from Aspergillus fumigatus H-3
    • Eble TE, Hanson FR. Fumagillin, an antibiotic from Aspergillus fumigatus H-3. Antibiot Chemother 1951;1:54-58.
    • (1951) Antibiot Chemother , vol.1 , pp. 54-58
    • Eble, T.E.1    Hanson, F.R.2
  • 79
    • 0014530267 scopus 로고
    • Studies in realtion to byosynthesis. Part XXXVIII. A preliminary study of fumagillin
    • Birch AG, Hussain SF. Studies in realtion to byosynthesis. Part XXXVIII. A preliminary study of fumagillin. J Chem Soc (C) 1969:1473-1474.
    • (1969) J Chem Soc (C) , pp. 1473-1474
    • Birch, A.G.1    Hussain, S.F.2
  • 80
    • 43649096745 scopus 로고    scopus 로고
    • Rapid analyses of fungal culture and dried figs for secondary metabolites by LC/TOF/MS
    • Senyuva HZ, Gilbert J, Oeztuerkoglu S. Rapid analyses of fungal culture and dried figs for secondary metabolites by LC/TOF/MS. Anal Chim Acta 2008;617:97-106.
    • (2008) Anal Chim Acta , vol.617 , pp. 97-106
    • Senyuva, H.Z.1    Gilbert, J.2    Oeztuerkoglu, S.3
  • 83
    • 76549234433 scopus 로고
    • Antibiotic substances from basydiomycete. VII. Clitocybe illudens
    • Anchel M, Hervey A, Robbins WJ. Antibiotic substances from basydiomycete. VII. Clitocybe illudens. Proc Natl Acad Sci USA 1950;36:300-305.
    • (1950) Proc Natl Acad Sci USA , vol.36 , pp. 300-305
    • Anchel, M.1    Hervey, A.2    Robbins, W.J.3
  • 86
    • 0032079236 scopus 로고    scopus 로고
    • Production of antibiotics by Colybia nivalis, Omphalateus olearius, Flavoloschia, and a Pterula species on natural substrates
    • Engler M, Anke T, Sterner O. Production of antibiotics by Colybia nivalis, Omphalateus olearius, Flavoloschia, and a Pterula species on natural substrates. Biosciences 1998;53:318-324.
    • (1998) Biosciences , vol.53 , pp. 318-324
    • Engler, M.1    Anke, T.2    Sterner, O.3
  • 90
    • 37049129640 scopus 로고
    • The structure of wortmannin, a steroidal fungal metabolite
    • MacMillan J, Vanstone AE, Yeboah SK. The structure of wortmannin, a steroidal fungal metabolite. Chem Comm 1968;613-614.
    • (1968) Chem Comm , pp. 613-614
    • MacMillan, J.1    Vanstone, A.E.2    Yeboah, S.K.3
  • 92
    • 37049126596 scopus 로고
    • Crystal structure and absolute configuration of wortmannin and of wortmannin p-bromobenzoate
    • Petcher TJ, Weber H-P, Kis Z. Crystal structure and absolute configuration of wortmannin and of wortmannin p-bromobenzoate. J Chem Soc Chem Commun 1972;1061-1062.
    • (1972) J Chem Soc Chem Commun , pp. 1061-1062
    • Petcher, T.J.1    Weber, H.-P.2    Kis, Z.3
  • 93
    • 0029186936 scopus 로고
    • Chemical and physiological characterization of taxa in the Fusarium sambucinum complex
    • Thrane U, Hansen U. Chemical and physiological characterization of taxa in the Fusarium sambucinum complex. Mycopathologia 1995;129:183-190.
    • (1995) Mycopathologia , vol.129 , pp. 183-190
    • Thrane, U.1    Hansen, U.2
  • 95
    • 77950243447 scopus 로고    scopus 로고
    • Drugging the PI3 kinome: From chemical tools to drugs in the clinic
    • Workman P, Clarke PA, Raynaud FI, van Montfort RL. Drugging the PI3 kinome: From chemical tools to drugs in the clinic. Cancer Res 2010;70:2146-2157.
    • (2010) Cancer Res , vol.70 , pp. 2146-2157
    • Workman, P.1    Clarke, P.A.2    Raynaud, F.I.3    van Montfort, R.L.4
  • 96
    • 51849098272 scopus 로고    scopus 로고
    • Drug discovery approaches targeting the PI3K/Akt pathway in cancer
    • Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008;27:5511-5526.
    • (2008) Oncogene , vol.27 , pp. 5511-5526
    • Garcia-Echeverria, C.1    Sellers, W.R.2
  • 100
    • 84863248391 scopus 로고    scopus 로고
    • The development of MetAP-2 inhibitors in cancer treatment
    • Yin S-Q, Wang, J-J, Zhang C-M, Liu Z-P. The development of MetAP-2 inhibitors in cancer treatment. Curr Med Chem 2012;19:1021-1035.
    • (2012) Curr Med Chem , vol.19 , pp. 1021-1035
    • Yin, S.-Q.1    Wang, J.-J.2    Zhang, C.-M.3    Liu, Z.-P.4
  • 105
    • 77956058589 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer
    • Shin SJ, Jeung H-C, Ahn JB, Rha SY, Roh JK, Park KS, Kim D-H, Kim C, Chung HC. A Phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer. Invest New Drugs 2010;28:650-658.
    • (2010) Invest New Drugs , vol.28 , pp. 650-658
    • Shin, S.J.1    Jeung, H.-C.2    Ahn, J.B.3    Rha, S.Y.4    Roh, J.K.5    Park, K.S.6    Kim, D.-H.7    Kim, C.8    Chung, H.C.9
  • 106
    • 84862256989 scopus 로고    scopus 로고
    • A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy
    • Shin SJ, Ahn JB, Park KS, Lee YJ, Hong YS, Kim TW, Kim HR, Rha SY, Roh JK, Kim D-H, Kim C, Chung HC. A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy. Invest New Drugs 2012;30:672-680.
    • (2012) Invest New Drugs , vol.30 , pp. 672-680
    • Shin, S.J.1    Ahn, J.B.2    Park, K.S.3    Lee, Y.J.4    Hong, Y.S.5    Kim, T.W.6    Kim, H.R.7    Rha, S.Y.8    Roh, J.K.9    Kim, D.-H.10    Kim, C.11    Chung, H.C.12
  • 109
    • 79960671502 scopus 로고    scopus 로고
    • A Phase 2 evaluation of Irofulven as second-line treatment of recurrent or persistent intermediately platinum-sensitive ovarian or primary peritoneal cancer A Gynecologic Oncology Group Trial
    • Schilder RJ, Blessing JA, Shahin MS, Miller DS, Tewari KS, Muller CY, Warshal DP, McMeekin S, Rotmensch J. A Phase 2 evaluation of Irofulven as second-line treatment of recurrent or persistent intermediately platinum-sensitive ovarian or primary peritoneal cancer A Gynecologic Oncology Group Trial. Int J Gynecol Cancer 2010;20:1137-1141.
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 1137-1141
    • Schilder, R.J.1    Blessing, J.A.2    Shahin, M.S.3    Miller, D.S.4    Tewari, K.S.5    Muller, C.Y.6    Warshal, D.P.7    McMeekin, S.8    Rotmensch, J.9
  • 111
    • 0019519611 scopus 로고
    • Structure of triornicin, a new siderophore
    • Clay BF, Bentley MD, Shive W. Structure of triornicin, a new siderophore. Biochemistry 1981;20:2436-2438.
    • (1981) Biochemistry , vol.20 , pp. 2436-2438
    • Clay, B.F.1    Bentley, M.D.2    Shive, W.3
  • 112
    • 0019890099 scopus 로고
    • Production and isolation of siderophores from the soil fungus Epicoccum purpurascens
    • Frederick C, Szaniszlo P, Vickrey P, Bentley M, Shive W. Production and isolation of siderophores from the soil fungus Epicoccum purpurascens. Biochemistry 1981;20:2432-2436.
    • (1981) Biochemistry , vol.20 , pp. 2432-2436
    • Frederick, C.1    Szaniszlo, P.2    Vickrey, P.3    Bentley, M.4    Shive, W.5
  • 114
    • 85016859819 scopus 로고
    • Cytochalasin E: Production by strain Aspergillus clavatus and toxic effects upon embryonic chick
    • Doubravka V, Vesely D, Jelink R. Cytochalasin E: Production by strain Aspergillus clavatus and toxic effects upon embryonic chick. Microbiol Aliment Nutr 1983;4:393-398.
    • (1983) Microbiol Aliment Nutr , vol.4 , pp. 393-398
    • Doubravka, V.1    Vesely, D.2    Jelink, R.3
  • 115
    • 51249166210 scopus 로고
    • Production of cytochalasin C, D, and E from Dematiaceous hyphomycetes
    • El-Kady IA, Mustafa ME. Production of cytochalasin C, D, and E from Dematiaceous hyphomycetes. Folia Microbiol (Prague) 1995;40:301-303.
    • (1995) Folia Microbiol (Prague) , vol.40 , pp. 301-303
    • El-Kady, I.A.1    Mustafa, M.E.2
  • 116
    • 0034518542 scopus 로고    scopus 로고
    • Thre new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella
    • Wagenaaar MM, Corwin J, Strobel G, Clardy J. Thre new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J Nat Prod 2000;63:1692-1695.
    • (2000) J Nat Prod , vol.63 , pp. 1692-1695
    • Wagenaaar, M.M.1    Corwin, J.2    Strobel, G.3    Clardy, J.4
  • 117
    • 33746562821 scopus 로고    scopus 로고
    • 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine derived fungus Spicaria elegans
    • Liu R, Gu Q, Zhu W, Cui C, Fan G, Fang Y, Zhu T, Liu H. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine derived fungus Spicaria elegans. J Nat Prod 2006;69:871-875.
    • (2006) J Nat Prod , vol.69 , pp. 871-875
    • Liu, R.1    Gu, Q.2    Zhu, W.3    Cui, C.4    Fan, G.5    Fang, Y.6    Zhu, T.7    Liu, H.8
  • 118
    • 84870754466 scopus 로고    scopus 로고
    • Characterization of the high cytochalsin e and rosellichalasin producibng-Aspergillus sp. nov, F1 from marine solar saltern China
    • Xiao L, Liu H, Wu N, Liu M, Wei J, Zhang Y, Lin X. Characterization of the high cytochalsin e and rosellichalasin producibng-Aspergillus sp. nov, F1 from marine solar saltern China. World J Microbiol Biotechnol 2013;29:11-17.
    • (2013) World J Microbiol Biotechnol , vol.29 , pp. 11-17
    • Xiao, L.1    Liu, H.2    Wu, N.3    Liu, M.4    Wei, J.5    Zhang, Y.6    Lin, X.7
  • 121
    • 0033925380 scopus 로고    scopus 로고
    • Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth
    • Udagawa T, Yuan J, Panigrahy D, Chang YH, Shah J, D'Amato RJ. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther 2000;294:421-427.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 421-427
    • Udagawa, T.1    Yuan, J.2    Panigrahy, D.3    Chang, Y.H.4    Shah, J.5    D'Amato, R.J.6
  • 122
    • 0016661771 scopus 로고
    • The structures of cotylenines A, B, C, D and E
    • and references therein cited.
    • Sassa T, Tokashi M, Kitaguchi T. The structures of cotylenines A, B, C, D and E. Agric Biol Chem 1975;39:1735-1744 (and references therein cited).
    • (1975) Agric Biol Chem , vol.39 , pp. 1735-1744
    • Sassa, T.1    Tokashi, M.2    Kitaguchi, T.3
  • 123
    • 85007900731 scopus 로고
    • Promotion of the enlargement of cotyledons by cotylenins A and B
    • Sassa T. Promotion of the enlargement of cotyledons by cotylenins A and B. Agric Biol Chem 1970;34:1588-1589.
    • (1970) Agric Biol Chem , vol.34 , pp. 1588-1589
    • Sassa, T.1
  • 124
    • 0000893068 scopus 로고
    • Cotylenins, leaf growth substances produced by a fungus. Isolation and characterization of cotylenins A and B
    • Sassa T. Cotylenins, leaf growth substances produced by a fungus. Isolation and characterization of cotylenins A and B. Agric Biol Chem 1971;35:1515-1518.
    • (1971) Agric Biol Chem , vol.35 , pp. 1515-1518
    • Sassa, T.1
  • 125
    • 0011472309 scopus 로고
    • Cotylenin, leaf growth produced by a fungus. II Production of a new fungal metabolites, cotylenol
    • Sassa T, Negoro T, Ueki H. Cotylenin, leaf growth produced by a fungus. II Production of a new fungal metabolites, cotylenol. Agric Biol Chem 1972;36:2281-2285.
    • (1972) Agric Biol Chem , vol.36 , pp. 2281-2285
    • Sassa, T.1    Negoro, T.2    Ueki, H.3
  • 126
    • 0038353474 scopus 로고    scopus 로고
    • Treatment of human promyelocytic leukemia in the SLID mouse model with cotylenin A, an inducer of myelomonocytic differentiation of leukemia cells
    • Honma Y, Ishii Y, Sassa T, Asahi K. Treatment of human promyelocytic leukemia in the SLID mouse model with cotylenin A, an inducer of myelomonocytic differentiation of leukemia cells. Leuk Res 2003;27:1019-1025.
    • (2003) Leuk Res , vol.27 , pp. 1019-1025
    • Honma, Y.1    Ishii, Y.2    Sassa, T.3    Asahi, K.4
  • 127
    • 0024326102 scopus 로고
    • Flavovirin-A new antifungal antibiotic produced by the pyrenomycete Melanconis flavovirens
    • Sailer M, Sasek V, Sejbal J, Budesinky M, MUsilek V. Flavovirin-A new antifungal antibiotic produced by the pyrenomycete Melanconis flavovirens. J Basic Microbiol 1989;29:375-381.
    • (1989) J Basic Microbiol , vol.29 , pp. 375-381
    • Sailer, M.1    Sasek, V.2    Sejbal, J.3    Budesinky, M.4    MUsilek, V.5
  • 130
    • 3242684513 scopus 로고    scopus 로고
    • Inhibition of serine palmitoyl trnsferase by myoricin, a natural mycotoxin, causes induction of c-myc in mouse liver
    • He Q, Johnson VJ, Osuchowski MF, Sharma RP. Inhibition of serine palmitoyl trnsferase by myoricin, a natural mycotoxin, causes induction of c-myc in mouse liver. Mycopathologia 2004;157:339-347.
    • (2004) Mycopathologia , vol.157 , pp. 339-347
    • He, Q.1    Johnson, V.J.2    Osuchowski, M.F.3    Sharma, R.P.4
  • 131
    • 12944287883 scopus 로고    scopus 로고
    • Cicadapeoptins I and II: New Aib-contining peptides from entomopathogenic fungus Cordyceps heteropoda
    • Krasnoff SB, Reategui RR, Wagenaar MM, Gloer JB, Gibson DM. Cicadapeoptins I and II: New Aib-contining peptides from entomopathogenic fungus Cordyceps heteropoda. J Nat Prod 2005;68:50-55.
    • (2005) J Nat Prod , vol.68 , pp. 50-55
    • Krasnoff, S.B.1    Reategui, R.R.2    Wagenaar, M.M.3    Gloer, J.B.4    Gibson, D.M.5
  • 132
    • 85027945635 scopus 로고    scopus 로고
    • Fingolimod: A review of its use in relapsing-remitting multiple sclerosis
    • Sanford M. Fingolimod: A review of its use in relapsing-remitting multiple sclerosis. Drugs 2014;74:1411-1433.
    • (2014) Drugs , vol.74 , pp. 1411-1433
    • Sanford, M.1
  • 134
    • 84928589926 scopus 로고    scopus 로고
    • FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway
    • Zhang L, Wang H, Zhu J, Ding K, Xu J. FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. Tumor Biol 2014;35:10707-10714.
    • (2014) Tumor Biol , vol.35 , pp. 10707-10714
    • Zhang, L.1    Wang, H.2    Zhu, J.3    Ding, K.4    Xu, J.5
  • 135
    • 17144398831 scopus 로고    scopus 로고
    • Possible future issues in the treatment of glioblastomas: Special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
    • Lefranc F, Brotchi J, Kiss R. Possible future issues in the treatment of glioblastomas: Special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J Clin Oncol 2005;23:2411-2422.
    • (2005) J Clin Oncol , vol.23 , pp. 2411-2422
    • Lefranc, F.1    Brotchi, J.2    Kiss, R.3
  • 136
    • 84872177015 scopus 로고    scopus 로고
    • Enhancement of palmarumycins C12 and C13 production in liquid culture of endophytic fungus Berkleasmium sp. Dzf12 after treatment with metal ions
    • Mou Y, Luo H, Mao Z, Shan T, Sun W, Zhou K, Zhou L. Enhancement of palmarumycins C12 and C13 production in liquid culture of endophytic fungus Berkleasmium sp. Dzf12 after treatment with metal ions. Int J Mol Sci 2013;14:979-998.
    • (2013) Int J Mol Sci , vol.14 , pp. 979-998
    • Mou, Y.1    Luo, H.2    Mao, Z.3    Shan, T.4    Sun, W.5    Zhou, K.6    Zhou, L.7
  • 137
    • 84883782458 scopus 로고
    • Palmarumycins Cp1-Cp4 from Conyothyrium palmarum. Isolation, structure elucidation, and biological activity
    • Krohn K, Michel A, Lorke U, Aust H-J, Draeger S, Schulz B. Palmarumycins Cp1-Cp4 from Conyothyrium palmarum. Isolation, structure elucidation, and biological activity. Liebigs Ann Chem 1994;1093-1097.
    • (1994) Liebigs Ann Chem , pp. 1093-1097
    • Krohn, K.1    Michel, A.2    Lorke, U.3    Aust, H.-J.4    Draeger, S.5    Schulz, B.6
  • 138
    • 33645466124 scopus 로고    scopus 로고
    • Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors thioredoxin reductase
    • Powis G, Wipf P, Lynch SM, Birmingham A, Kirkpatrick DL. Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors thioredoxin reductase. Mol Cancer Ther 2006;5:630-636.
    • (2006) Mol Cancer Ther , vol.5 , pp. 630-636
    • Powis, G.1    Wipf, P.2    Lynch, S.M.3    Birmingham, A.4    Kirkpatrick, D.L.5
  • 139
    • 84938752409 scopus 로고    scopus 로고
    • Synthesis of Epi-Galiellalactone Analogs
    • 240th ACS National Meeeting, Boston, MA; August 22-26.
    • Ritha G, Johansson M, Sterner O. Synthesis of Epi-Galiellalactone Analogs. Abstracts of Papers, in 240th ACS National Meeeting, Boston, MA; 2010 August 22-26.
    • (2010) Abstracts of Papers
    • Ritha, G.1    Johansson, M.2    Sterner, O.3
  • 140
    • 0037077413 scopus 로고    scopus 로고
    • Galiellalactone and its biogenetic precursor as chemotaxonomic markers of the Sarcosomataceae (Ascomycota)
    • Kopcke B, Weber RWS, Heidrun A. Galiellalactone and its biogenetic precursor as chemotaxonomic markers of the Sarcosomataceae (Ascomycota). Phytochemistry 2002;60:709-714.
    • (2002) Phytochemistry , vol.60 , pp. 709-714
    • Kopcke, B.1    Weber, R.W.S.2    Heidrun, A.3
  • 141
    • 0036168824 scopus 로고    scopus 로고
    • Biologically active secondary metabolites from the ascomycete Aiii-95:2. Structure elucidation
    • Johansson M, Kopcke B, Heidrun A, Sterner O. Biologically active secondary metabolites from the ascomycete Aiii-95:2. Structure elucidation. J Antibiot 2002;55:104-106.
    • (2002) J Antibiot , vol.55 , pp. 104-106
    • Johansson, M.1    Kopcke, B.2    Heidrun, A.3    Sterner, O.4
  • 142
    • 0035818012 scopus 로고    scopus 로고
    • Synthesis of (+)-galiellalactone. Absolute configuration of galiellalactone
    • Johansoon M, Sterner O. Synthesis of (+)-galiellalactone. Absolute configuration of galiellalactone. Org Lett 2001;3:2843-2845.
    • (2001) Org Lett , vol.3 , pp. 2843-2845
    • Johansoon, M.1    Sterner, O.2
  • 143
    • 34548540632 scopus 로고    scopus 로고
    • Galiellalactone inhibits growth of prostate cancer cell xenografts and induces apoptosis of human prostate cancer cells expressing active Stat3
    • Hellsten R, Johansson M, Sterner O, Bjartell A. Galiellalactone inhibits growth of prostate cancer cell xenografts and induces apoptosis of human prostate cancer cells expressing active Stat3. Eur Urol Suppl 2006;5:797-797.
    • (2006) Eur Urol Suppl , vol.5 , pp. 797-797
    • Hellsten, R.1    Johansson, M.2    Sterner, O.3    Bjartell, A.4
  • 144
    • 39449098191 scopus 로고    scopus 로고
    • Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3
    • Hellsten R, Johansson M, Dahlman A, Dizeyi N, Sterner O, Bjartell A. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. Prostate 2008;68:269-280.
    • (2008) Prostate , vol.68 , pp. 269-280
    • Hellsten, R.1    Johansson, M.2    Dahlman, A.3    Dizeyi, N.4    Sterner, O.5    Bjartell, A.6
  • 146
    • 0036749138 scopus 로고    scopus 로고
    • Epoxiquinol B, a fungal metabolite with a potent atiangiogenic activity
    • Kakeya H, Onose R, Yoshida A, Hiroyuki K, Hiroyuki O. Epoxiquinol B, a fungal metabolite with a potent atiangiogenic activity. J Antibiot 2002;55:829-831.
    • (2002) J Antibiot , vol.55 , pp. 829-831
    • Kakeya, H.1    Onose, R.2    Yoshida, A.3    Hiroyuki, K.4    Hiroyuki, O.5
  • 147
    • 34547776294 scopus 로고    scopus 로고
    • Chemistry of epoxyquinols A, B, and C and epoxytwinol A
    • Mitsuru S, Hayashi Y. Chemistry of epoxyquinols A, B, and C and epoxytwinol A. Eur J Org Chem 2007;3783-3800.
    • (2007) Eur J Org Chem , pp. 3783-3800
    • Mitsuru, S.1    Hayashi, Y.2
  • 148
    • 79952300552 scopus 로고    scopus 로고
    • Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp
    • Ding G, Zhang F, Chen H, Guo L, Zhongmei Z, Yongsheng C. Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp. J Nat Prod 2011;74:286-291.
    • (2011) J Nat Prod , vol.74 , pp. 286-291
    • Ding, G.1    Zhang, F.2    Chen, H.3    Guo, L.4    Zhongmei, Z.5    Yongsheng, C.6
  • 149
    • 43149089385 scopus 로고    scopus 로고
    • Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR
    • Kamiyama H, Kakeya H, Usui T, Nishikawa K, Shoji M, Hayashi Y, Osada H. Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR. Oncol Res 2008;17:11-21.
    • (2008) Oncol Res , vol.17 , pp. 11-21
    • Kamiyama, H.1    Kakeya, H.2    Usui, T.3    Nishikawa, K.4    Shoji, M.5    Hayashi, Y.6    Osada, H.7
  • 150
    • 79551520348 scopus 로고    scopus 로고
    • Treatment-related mortality with bevacizumab in cancer patients: A meta-analysis
    • Ranpura V, Hapani S, Wu S. Treatment-related mortality with bevacizumab in cancer patients: A meta-analysis. JAMA 2011;305:487-494.
    • (2011) JAMA , vol.305 , pp. 487-494
    • Ranpura, V.1    Hapani, S.2    Wu, S.3
  • 151
    • 79955567607 scopus 로고    scopus 로고
    • Noncardiac vascular toxicities of vascular endothelial growth factor inhibitors in advanced cancer: A review
    • Keefe D, Bowen J, Gibson R, Tan T, Okera M, Stringer A. Noncardiac vascular toxicities of vascular endothelial growth factor inhibitors in advanced cancer: A review. Oncologist 2011;16:432-444.
    • (2011) Oncologist , vol.16 , pp. 432-444
    • Keefe, D.1    Bowen, J.2    Gibson, R.3    Tan, T.4    Okera, M.5    Stringer, A.6
  • 152
    • 84880278381 scopus 로고    scopus 로고
    • Risk of liver toxicity with the angiogenesis inhibitor pazopanib in cancer patients
    • Kapadia S, Hapani S, Choueri TK, Wu S. Risk of liver toxicity with the angiogenesis inhibitor pazopanib in cancer patients. Acta Oncol 2013;52:1202-1212.
    • (2013) Acta Oncol , vol.52 , pp. 1202-1212
    • Kapadia, S.1    Hapani, S.2    Choueri, T.K.3    Wu, S.4
  • 153
    • 84876879157 scopus 로고    scopus 로고
    • Adverse events associated with antiangiogenic agents in combination with cytotoxic chemotherapy in metastatic colorectal cancer and their management
    • Cartwright TH. Adverse events associated with antiangiogenic agents in combination with cytotoxic chemotherapy in metastatic colorectal cancer and their management. Clin Colorectal Cancer 2013;12:86-94.
    • (2013) Clin Colorectal Cancer , vol.12 , pp. 86-94
    • Cartwright, T.H.1
  • 154
    • 84881544724 scopus 로고    scopus 로고
    • Risk of hematologic toxicities in cancer patients treated with sunitinib: A systematic review and meta-analysis
    • Funakoshi T, Latif A, Galsky MD. Risk of hematologic toxicities in cancer patients treated with sunitinib: A systematic review and meta-analysis. Cancer Treat Rev 2013;39:818-830.
    • (2013) Cancer Treat Rev , vol.39 , pp. 818-830
    • Funakoshi, T.1    Latif, A.2    Galsky, M.D.3
  • 155
    • 84875886935 scopus 로고    scopus 로고
    • Cardiovascular complications associated with novel angiogenesis inhibitors: Emerging evidence and evolving perspectives
    • Bair SM, Choueiri TK, Moslehi J. Cardiovascular complications associated with novel angiogenesis inhibitors: Emerging evidence and evolving perspectives. Trends Cardiovasc Med 2013;23:104-113.
    • (2013) Trends Cardiovasc Med , vol.23 , pp. 104-113
    • Bair, S.M.1    Choueiri, T.K.2    Moslehi, J.3
  • 156
    • 70350450561 scopus 로고    scopus 로고
    • Ecology screen identifies new metabolites from Cordyceps-clonizing fungus as cancer cell proliferationinhibitors and apoptosis inducers
    • Chen Y, Guo H, Du Z, Liu X-Z, Che Y, Ye YX. Ecology screen identifies new metabolites from Cordyceps-clonizing fungus as cancer cell proliferationinhibitors and apoptosis inducers. Cell Proliferation 2009;42:838-847.
    • (2009) Cell Proliferation , vol.42 , pp. 838-847
    • Chen, Y.1    Guo, H.2    Du, Z.3    Liu, X.-Z.4    Che, Y.5    Ye, Y.X.6
  • 160
    • 74549147514 scopus 로고    scopus 로고
    • Anti-tumor effect of apicidin on Ishikawa human endometrial cancer cells both in vitro and in vivo by blocking histone deacetylase 3 and 4
    • Ahn MY, Chung HY, Choi WS, Lee BM, Yoon S, Kim HS. Anti-tumor effect of apicidin on Ishikawa human endometrial cancer cells both in vitro and in vivo by blocking histone deacetylase 3 and 4. Int J Oncol 2010;36:125-131.
    • (2010) Int J Oncol , vol.36 , pp. 125-131
    • Ahn, M.Y.1    Chung, H.Y.2    Choi, W.S.3    Lee, B.M.4    Yoon, S.5    Kim, H.S.6
  • 161
    • 84865660690 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing
    • Ahn MY, Kang DO, Na YJ, Yoon S, Choi WS, Kang KW, Chung HY, Jung JH, Min DS, Kim HS. Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing. Cancer Lett 2012;325:189-199.
    • (2012) Cancer Lett , vol.325 , pp. 189-199
    • Ahn, M.Y.1    Kang, D.O.2    Na, Y.J.3    Yoon, S.4    Choi, W.S.5    Kang, K.W.6    Chung, H.Y.7    Jung, J.H.8    Min, D.S.9    Kim, H.S.10
  • 162
    • 0014725912 scopus 로고
    • Isolation and structure elucidation of cheatocin
    • Hauser D, Weber HP, Sigg HP. Isolation and structure elucidation of cheatocin. Helv Chim Acta 1970;53:1061-1073.
    • (1970) Helv Chim Acta , vol.53 , pp. 1061-1073
    • Hauser, D.1    Weber, H.P.2    Sigg, H.P.3
  • 163
    • 0018344342 scopus 로고
    • The production of chaetoglobosins, sterigmatocystin, O-methylsterigmatocystin, and chaetocin by Chaetomium subspecies and related fungi
    • Udagawa S, Muroi T, Kurata H, Semita S, Yoshihira K, Natori S, Umeda N. The production of chaetoglobosins, sterigmatocystin, O-methylsterigmatocystin, and chaetocin by Chaetomium subspecies and related fungi. Can J Microbiol 1979;25:170-177.
    • (1979) Can J Microbiol , vol.25 , pp. 170-177
    • Udagawa, S.1    Muroi, T.2    Kurata, H.3    Semita, S.4    Yoshihira, K.5    Natori, S.6    Umeda, N.7
  • 164
  • 165
    • 84856416162 scopus 로고    scopus 로고
    • The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
    • Isham CR, Tibodeau JD, Bossou AR, Merchan JR, Bible KC. The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation. Br J Cancer 2012;106:314-323.
    • (2012) Br J Cancer , vol.106 , pp. 314-323
    • Isham, C.R.1    Tibodeau, J.D.2    Bossou, A.R.3    Merchan, J.R.4    Bible, K.C.5
  • 167
    • 84900029890 scopus 로고    scopus 로고
    • Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vitro antitumor activity by disrupting the HIF-1alpha/p300 complex in a preclinical model of prostate cancer
    • Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, Venzon DJ, Liewehr DJ, Chau CH, Price DK, Figg WD. Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vitro antitumor activity by disrupting the HIF-1alpha/p300 complex in a preclinical model of prostate cancer. Mol Cancer 2014;13:article number 91.
    • (2014) Mol Cancer , vol.13
    • Reece, K.M.1    Richardson, E.D.2    Cook, K.M.3    Campbell, T.J.4    Pisle, S.T.5    Holly, A.J.6    Venzon, D.J.7    Liewehr, D.J.8    Chau, C.H.9    Price, D.K.10    Figg, W.D.11
  • 168
    • 84938742750 scopus 로고    scopus 로고
    • Analysis of pathogenic toxin from Alternaria brassicae. (1) Purification and chemical structure identification of destruxin B
    • Ma Z, Dong J, Muzhen F, Yunhi L, Li Z. Analysis of pathogenic toxin from Alternaria brassicae. (1) Purification and chemical structure identification of destruxin B. Yunwu Xitong 2000;19:360-365.
    • (2000) Yunwu Xitong , vol.19 , pp. 360-365
    • Ma, Z.1    Dong, J.2    Muzhen, F.3    Yunhi, L.4    Li, Z.5
  • 169
    • 40749119762 scopus 로고    scopus 로고
    • Destruxin B produced by Alternaria brassicae does not induce accessibility of host plants to fungal invasion
    • Parada RY, Oka K, Yamagishi D, Kodama M, Otani H. Destruxin B produced by Alternaria brassicae does not induce accessibility of host plants to fungal invasion. Physiol Mol Plant Pathol 2007;71:48-54.
    • (2007) Physiol Mol Plant Pathol , vol.71 , pp. 48-54
    • Parada, R.Y.1    Oka, K.2    Yamagishi, D.3    Kodama, M.4    Otani, H.5
  • 170
    • 0032928838 scopus 로고    scopus 로고
    • Purification and quantification of destruxins A and B from Metarhizium anisopliae
    • Chen J-W, Liu B-L, Tzeng Y-M. Purification and quantification of destruxins A and B from Metarhizium anisopliae. J Chromatogr 1999;833:115-125.
    • (1999) J Chromatogr , vol.833 , pp. 115-125
    • Chen, J.-W.1    Liu, B.-L.2    Tzeng, Y.-M.3
  • 173
    • 84860507443 scopus 로고    scopus 로고
    • Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging
    • Yeh C-T, Rao Y K, Ye M, Wu W-S, Chang T-C, Wang L-S, Wu C-H, Wu ATH, Tzeng Y-M. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. Toxicol Appl Pharmacol 2012;261:31-41.
    • (2012) Toxicol Appl Pharmacol , vol.261 , pp. 31-41
    • Yeh, C.-T.1    Rao, Y.K.2    Ye, M.3    Wu, W.-S.4    Chang, T.-C.5    Wang, L.-S.6    Wu, C.-H.7    Wu, A.T.H.8    Tzeng, Y.-M.9
  • 177
    • 34047255599 scopus 로고    scopus 로고
    • Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway
    • Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT, Fan ST. Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway. Int J Oncol 2007;30:375-380.
    • (2007) Int J Oncol , vol.30 , pp. 375-380
    • Ng, K.T.1    Man, K.2    Ho, J.W.3    Sun, C.K.4    Lee, T.K.5    Zhao, Y.6    Lo, C.M.7    Poon, R.T.8    Fan, S.T.9
  • 178
  • 181
    • 84938752410 scopus 로고
    • Cytochalasin compositions and therapeutic methods
    • Fondy TP, Bogyo D. Cytochalasin compositions and therapeutic methods. Patent number WO90013293; 1990.
    • (1990)
    • Fondy, T.P.1    Bogyo, D.2
  • 182
    • 84938752410 scopus 로고
    • Cytochalasin compositions and therapeutic methods
    • Fondy TP, Bogyo D. Cytochalasin compositions and therapeutic methods. Patent number EP429585; 1991.
    • (1991)
    • Fondy, T.P.1    Bogyo, D.2
  • 183
  • 184
    • 84938752412 scopus 로고    scopus 로고
    • Chimeric fusicoccane synthase and gene of the same family
    • Patent number
    • Toyomasu T, Sassa T, Dairi T, Kato N. Chimeric fusicoccane synthase and gene of the same family. Patent number WO08129699; 2008.
    • (2008)
    • Toyomasu, T.1    Sassa, T.2    Dairi, T.3    Kato, N.4
  • 185
    • 84938742764 scopus 로고    scopus 로고
    • Combination therapy for treatment of inflammatory demyelinating disease
    • Steinman L, Ho PPK. Combination therapy for treatment of inflammatory demyelinating disease. Patent number WO13022882; 2013.
    • (2013)
    • Steinman, L.1    Ho, P.P.K.2
  • 186
    • 84938748462 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes with FTY720
    • Ma Z. Treatment of type 2 diabetes with FTY720. Patent number US08653026; 2014.
    • (2014)
    • Ma, Z.1
  • 187
    • 84938752413 scopus 로고    scopus 로고
    • Synthesis and methods of use of new antimitotic agents
    • Lazo JS, Wipf P, Day BW. Synthesis and methods of use of new antimitotic agents. Patent number US20020049221; 2002.
    • (2002)
    • Lazo, J.S.1    Wipf, P.2    Day, B.W.3
  • 188
    • 84938752413 scopus 로고    scopus 로고
    • Syntheses and methods of use of new antimitotic agents
    • Lazo JS, Wipf P, Day BW. Syntheses and methods of use of new antimitotic agents. Patent number US20046673937; 2004.
    • (2004)
    • Lazo, J.S.1    Wipf, P.2    Day, B.W.3
  • 189
    • 84938746489 scopus 로고    scopus 로고
    • Palmarumycin based inhibitors of thioredoxin and methods of using same
    • Powis G, Wipf P. Palmarumycin based inhibitors of thioredoxin and methods of using same. Patent number WO070035641; 2007.
    • (2007)
    • Powis, G.1    Wipf, P.2
  • 190
    • 84938746489 scopus 로고    scopus 로고
    • Palmarumycin based inhibitors of thioredoxin and methods of using same
    • Powis G, Wipf P. Palmarumycin based inhibitors of thioredoxin and methods of using same. Patent number EP1933820; 2010.
    • (2010)
    • Powis, G.1    Wipf, P.2
  • 191
    • 84938746489 scopus 로고    scopus 로고
    • Palmarumycin based inhibitors of thioredoxin and methods of using same
    • Powis G, Wipf P. Palmarumycin based inhibitors of thioredoxin and methods of using same. Patent number US20090131511; 2009.
    • (2009)
    • Powis, G.1    Wipf, P.2
  • 192
    • 84938752414 scopus 로고    scopus 로고
    • Drug for prevention and treatment of disease by using apicidin
    • Patent number
    • Takehana K, Umemura T, Nakajo H, Itou S, Kobayashi M. Drug for prevention and treatment of disease by using apicidin. Patent number JP41998226652; 1998.
    • (1998)
    • Takehana, K.1    Umemura, T.2    Nakajo, H.3    Itou, S.4    Kobayashi, M.5
  • 193
    • 84938743494 scopus 로고    scopus 로고
    • Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them
    • Lee HW, Jung YH, Han JW, Lee SY, Lee YW, Lee HY. Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them. Patent number US20040014647; 2004.
    • (2004)
    • Lee, H.W.1    Jung, Y.H.2    Han, J.W.3    Lee, S.Y.4    Lee, Y.W.5    Lee, H.Y.6
  • 194
    • 84938743494 scopus 로고    scopus 로고
    • Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them
    • Jung YH, Han JW, Lee SY, Lee YW, Lee HY, Lee HW. Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them. Patent number US6831061; 2004.
    • (2004)
    • Jung, Y.H.1    Han, J.W.2    Lee, S.Y.3    Lee, Y.W.4    Lee, H.Y.5    Lee, H.W.6
  • 195
    • 84938752415 scopus 로고    scopus 로고
    • Use of diketodithiopiperazine antibiotics for the preparation of antiangiogenic pharmaceutical compositions
    • De Munari S, Grugni M, Menta E, Cassin M, Colella G. Use of diketodithiopiperazine antibiotics for the preparation of antiangiogenic pharmaceutical compositions. Patent number WO06066775; 2006.
    • (2006)
    • De Munari, S.1    Grugni, M.2    Menta, E.3    Cassin, M.4    Colella, G.5
  • 196
    • 84938752415 scopus 로고    scopus 로고
    • Use of diketodithiopiperazine antibiotics for the preparation of antiangiogenic pharmaceutical compositions
    • De Munari S, Grugni M, Menta E, Cassin M, Collela G. Use of diketodithiopiperazine antibiotics for the preparation of antiangiogenic pharmaceutical compositions. Patent number US20080255099; 2008.
    • (2008)
    • De Munari, S.1    Grugni, M.2    Menta, E.3    Cassin, M.4    Collela, G.5
  • 197
    • 78650951326 scopus 로고    scopus 로고
    • Methods and compositions for treating cancer
    • Bible KC, Isham CR, Xu R, Tibodeau JD. Methods and compositions for treating cancer. Patent number WO08112014; 2008.
    • (2008)
    • Bible, K.C.1    Isham, C.R.2    Xu, R.3    Tibodeau, J.D.4
  • 198
    • 84938752416 scopus 로고
    • Control of insects by roseotoxin B
    • Dowd PF, Cole RJ. Control of insects by roseotoxin B. Patent number US4956343; 1990.
    • (1990)
    • Dowd, P.F.1    Cole, R.J.2
  • 199
    • 84938752417 scopus 로고    scopus 로고
    • Cardiotonic agent and its production
    • Sumio A, Kamijo M, Miyajima H. Cardiotonic agent and its production. Patent number JP1997315996; 1997.
    • (1997)
    • Sumio, A.1    Kamijo, M.2    Miyajima, H.3
  • 200
    • 84938752418 scopus 로고    scopus 로고
    • Pharmaceutical composition for prevention and remedy of osteoporosis
    • Nagai K. Pharmaceutical composition for prevention and remedy of osteoporosis. Patent number WO02064155; 2002.
    • (2002)
    • Nagai, K.1
  • 201
    • 84938752418 scopus 로고    scopus 로고
    • Pharmaceutical composition for prevention and remedy of osteoporosis
    • Nagai K. Pharmaceutical composition for prevention and remedy of osteoporosis. Patent number US20040102365; 2004.
    • (2004)
    • Nagai, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.