Pilot-scale process development and scale up for antifungal production

Bioprocess and Biosystems Engineering

Volumn 32, Issue 4, 2009, Pages 443-458

  Junker, Beth ^a   Walker, Andre ^a   Hesse, Michelle ^a   Lester, Michael ^a   Vesey, Diane ^a   Christensen, Jens ^a   Burgess, Bruce ^a   Connors, Neal ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antifungal; Fungal; Pilot plant; Scale up; Secondary metabolite

Indexed keywords

AERATION RATE; ANTIFOAM; ANTIFUNGAL; ANTIFUNGAL COMPOUNDS; BACK PRESSURES; BROTH VISCOSITY; COBALT CHLORIDES; COST SAVING; FILAMENTOUS FUNGI; FUNGAL; HIGH PRODUCTIVITY; IMPELLER TIP SPEED; LACTOSE SOLUTION; MASS TRANSFER RATE; MULTIPLE DILUTIONS; PER UNIT VOLUME; PILOT SCALE; POWER REQUIREMENT; PROCESS DEVELOPMENT; PROCESS SCALE-UP; PRODUCTION PHASE; PRODUCTIVITY INCREASE; REDUCED VISCOSITY; SCALE-UP; SECONDARY METABOLITE; SUPERFICIAL VELOCITY; VOLATILE COMPOUNDS; WORKING VOLUME;

BIOCHEMICAL ENGINEERING; CARBON DIOXIDE; CHLORINE COMPOUNDS; COBALT; METABOLISM; METABOLITES; PILOT PLANTS; SUGARS; TRACE ELEMENTS; VISCOSITY;

PRODUCTIVITY;

ANTIFUNGAL AGENT; CARBON DIOXIDE; COBALT CHLORIDE; GALACTOSE; GLYCINE; LACTOSE; PHOSPHATE; TRACE ELEMENT; VOLATILE AGENT;

ARTICLE; BROTH DILUTION; FERMENTATION; FUNGUS; PILOT STUDY; PRIORITY JOURNAL; PRODUCTIVITY; VELOCITY; VISCOSITY;

ANTIFUNGAL AGENTS; ASCOMYCOTA; BIOMEDICAL ENGINEERING; BIOREACTORS; CULTURE MEDIA; FERMENTATION; GALACTOSE; GLYCEROL; LACTOSE; PHOSPHATES; PILOT PROJECTS; VISCOSITY;

FUNGI;

EID: 67349175266     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-008-0264-y     Document Type: Article

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