Ginkgolide B protects against cisplatin-induced ototoxicity: Enhancement of Akt-Nrf2-HO-1 signaling and reduction of NADPH oxidase

Cancer Chemotherapy and Pharmacology

Volumn 75, Issue 5, 2015, Pages 949-959

  Ma, Weijun ^a   Hu, Juan ^a   Cheng, Ying ^a   Wang, Junli ^a   Zhang, Xiaotong ^a   Xu, Min ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Akt; Cisplatin; Ginkgolide B; NADPH oxidase; Nrf2 HO 1; Ototoxicity

Indexed keywords

CISPLATIN; CYBB PROTEIN, MOUSE; GINKGOLIDE; GINKGOLIDE B; HEME OXYGENASE 1; HMOX1 PROTEIN, MOUSE; LACTONE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CHEMICALLY INDUCED; COCHLEA; COCHLEAR DISEASES; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; HEARING LOSS; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; RANDOMIZATION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL LINE; CISPLATIN; COCHLEA; COCHLEAR DISEASES; ENZYME ACTIVATION; GINKGOLIDES; HEARING LOSS; HEME OXYGENASE-1; LACTONES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MICE; NADPH OXIDASE; NF-E2-RELATED FACTOR 2; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84938690515     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-015-2716-9     Document Type: Article

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