Does insulin bolster antioxidant defenses via the extracellular signal-regulated kinases-protein kinase B-nuclear factor erythroid 2 p45-related factor 2 pathway?

Antioxidants and Redox Signaling

Volumn 16, Issue 10, 2012, Pages 1061-1070

  Wang, Xin ^a   Wu, Hao ^a   Chen, Hongli ^a   Liu, Rui ^a   Liu, Jiangzheng ^a   Zhang, Tao ^a   Yu, Weihua ^a   Hai, Chunxu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ENZYME ACTIVATION; HORMONE ACTION; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVIEW;

ANIMALS; ANTIOXIDANTS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INSULIN; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TERT-BUTYLHYDROPEROXIDE;

EID: 84859239565     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2011.4460     Document Type: Review

References (9)

1. Frank GD, Eguchi S, and Motley ED. The role of reactive oxygen species in insulin signaling in the vasculature. Anti-oxid Redox Signal 7: 1053-1061, 2005. (Pubitemid 40967155)
2. Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, and King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinosi-tide 3-kinase/Akt-2 pathway. J Biol Chem 283: 34327-34336, 2008.
3. Kensler TW, Wakabayashi N, and Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Ann Rev Pharmacol Toxicol 47: 89-116, 2007.
4. Langston W, Circu ML, and Aw TY. Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Radic Biol Med 45: 1591-1599, 2008.
5. Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, and Andersen ME. ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol 244: 77-83, 2009.
6. Wang X and Hai CX. ROS acts as a double-edged sword in the pathogenesis of type 2 diabetes mellitus: is Nrf2 a potential target for the treatment? Mini Rev Med Chem 11: 1082-1092, 2011.
7. Wang X, Liu JZ, Hu JX, Wu H, Li YL, Chen HL, Bai H, and Hai CX. ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation. Free Radic Biol Med 51: 539-551, 2011.
8. Wang X, Tao L, and Hai CX. Redox-regulating role of insulin: the essence of insulin effect. Mol Cell Endocrinol 349: 111-127, 2012.
9. Wang X, Ye XL, Liu R, Chen HL, Bai H, Liang X, Zhang XD, Wang Z, Li WL, and Hai CX. Antioxidant activities of olea-nolic acid in vitro: possible role of Nrf2 and MAP kinases. Chem Biol Interact 184: 328-337, 2010.