메뉴 건너뛰기




Volumn 127, Issue 6, 2013, Pages 536-541

Mechanisms of cisplatin ototoxicity: Theoretical review

Author keywords

Cisplatin; Cochlea; Free Radicals; Hearing Loss; Toxicity

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMIFOSTINE; CASPASE; CELL DNA; CISPLATIN; FOSFOMYCIN; GINKGO BILOBA EXTRACT; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; SODIUM THIOSULFATE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

EID: 84878790018     PISSN: 00222151     EISSN: 17485460     Source Type: Journal    
DOI: 10.1017/S0022215113000947     Document Type: Review
Times cited : (70)

References (69)
  • 1
    • 18244379333 scopus 로고    scopus 로고
    • Cellular processing of platinum anticancer drugs
    • Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 2005;4:307-20
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 307-320
    • Wang, D.1    Lippard, S.J.2
  • 2
    • 0032769076 scopus 로고    scopus 로고
    • Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum
    • Jordan JA, Schwade ND, Truelson JM. Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum. Laryngoscope 1999;109:1259-62
    • (1999) Laryngoscope , vol.109 , pp. 1259-1262
    • Jordan, J.A.1    Schwade, N.D.2    Truelson, J.M.3
  • 3
    • 33750339195 scopus 로고    scopus 로고
    • Ototoxicity, otoprotection and self defense of the cochlear outer hair cells [in Brazilian Portuguese]
    • Hyppolito MA, Oliveira JA. Ototoxicity, otoprotection and self defense of the cochlear outer hair cells [in Brazilian Portuguese]. Medicina (Ribeirão Preto) 2005;38:279-89
    • (2005) Medicina (Ribeirão Preto) , vol.38 , pp. 279-289
    • Hyppolito, M.A.1    Oliveira, J.A.2
  • 4
    • 22544470879 scopus 로고    scopus 로고
    • Protective effects of L-Arginine against cisplatin-induced renal oxidative stress and toxicity: Role of nitric oxide
    • Saleh S, El-Demerdash E. Protective effects of L-Arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic Clin Pharmacol Toxicol 2005;97:91-7
    • (2005) Basic Clin Pharmacol Toxicol , vol.97 , pp. 91-97
    • Saleh, S.1    El-Demerdash, E.2
  • 6
    • 84892442119 scopus 로고    scopus 로고
    • Cisplatin-induced ototoxicity in guinea pigs: Dose-related effects - A functional evaluation [in Brazilian Portuguese]
    • Ilha L, Kasse C, Mesquita Neto O, Almeida CR, Cruz OLM. Cisplatin-induced ototoxicity in guinea pigs: dose-related effects - a functional evaluation [in Brazilian Portuguese]. ACTA ORL/Técnicas em Otorrinolaringologia 2007;25: 112-18
    • (2007) ACTA ORL/Técnicas em Otorrinolaringologia , vol.25 , pp. 112-118
    • Ilha, L.1    Kasse, C.2    Mesquita Neto, O.3    Almeida, C.R.4    Olm, C.5
  • 7
    • 70449645189 scopus 로고    scopus 로고
    • Cisplatin ototoxicity and protection: Clinical and experimental studies
    • Rybak LP, Mukherjea D, Jajoo S, Ramkumar V. Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med 2009;219:177-86
    • (2009) Tohoku J Exp Med , vol.219 , pp. 177-186
    • Rybak, L.P.1    Mukherjea, D.2    Jajoo, S.3    Ramkumar, V.4
  • 9
    • 0027241325 scopus 로고
    • Cisplatin-induced ototoxicity: The effect of pigmentation and inhibitory agents
    • Schweitzer VG. Cisplatin-induced ototoxicity: the effect of pigmentation and inhibitory agents. Laryngoscope 1993;103:1-52
    • (1993) Laryngoscope , vol.103 , pp. 1-52
    • Schweitzer, V.G.1
  • 10
    • 0028793686 scopus 로고
    • Temporal bone histopathology of cisplatin ototoxicity
    • Hinojosa R, Riggs LC, Strauss M, Matz GJ. Temporal bone histopathology of cisplatin ototoxicity. Am J Otol 1995;16:731-41
    • (1995) Am J Otol , vol.16 , pp. 731-741
    • Hinojosa, R.1    Riggs, L.C.2    Strauss, M.3    Matz, G.J.4
  • 12
    • 0022971318 scopus 로고
    • Early morphological and chemical changes induced by cisplatin in the guinea pig organ of Corti
    • Comis SD, Rhys-Evans PH, Osborne MP, Pickles JO, Jeffries DJR, Pearse HAC. Early morphological and chemical changes induced by cisplatin in the guinea pig organ of Corti. J Laryngol Otol 1986;100:1375-83
    • (1986) J Laryngol Otol , vol.100 , pp. 1375-1383
    • Comis, S.D.1    Rhys-Evans, P.H.2    Osborne, M.P.3    Pickles, J.O.4    Djr, J.5    Hac, P.6
  • 15
    • 0036629056 scopus 로고    scopus 로고
    • The incidence of hearing impairment after successful treatment of neuroblastoma
    • Simon T, Hero B, DupuisW, Selle B, Berthold F. The incidence of hearing impairment after successful treatment of neuroblastoma. Klin Pediatr 2002;214:149-52
    • (2002) Klin Pediatr , vol.214 , pp. 149-152
    • Simon, T.1    Hero, B.2    Dupuisw Selle, B.3    Berthold, F.4
  • 18
    • 12444290858 scopus 로고    scopus 로고
    • Audiological monitoring of cisplatin exposed patients [in Brazilian Portuguese]
    • Garcia AP, Iório MCM, Petrilli AS. Audiological monitoring of cisplatin exposed patients [in Brazilian Portuguese]. Rev Bras Otorrinolaringol 2003;69:215-21
    • (2003) Rev Bras Otorrinolaringol , vol.69 , pp. 215-221
    • Garcia, A.P.1    McM, I.2    Petrilli, A.S.3
  • 19
    • 7044260303 scopus 로고    scopus 로고
    • Predicting cisplatin ototoxicity in children: Influence of age and the cumulative dose
    • Li Y, Womer RB, Silber JH. Predicting cisplatin ototoxicity in children: influence of age and the cumulative dose. Eur J Cancer 2004;40:2445-51
    • (2004) Eur J Cancer , vol.40 , pp. 2445-2451
    • Li, Y.1    Womer, R.B.2    Silber, J.H.3
  • 20
    • 7244224701 scopus 로고    scopus 로고
    • Oxygen free radicals and exercise: Mechanisms of synthesis and adaptation to physical training [in Brazilian Portuguese]
    • Schneider CD, Oliveira AR. Oxygen free radicals and exercise: mechanisms of synthesis and adaptation to physical training [in Brazilian Portuguese]. Rev Bras Med Esporte 2004;10:308-13
    • (2004) Rev Bras Med Esporte , vol.10 , pp. 308-313
    • Schneider, C.D.1    Oliveira, A.R.2
  • 21
    • 0030624049 scopus 로고    scopus 로고
    • Free radicals: Concepts, diseases, defense system and oxidative stress [in Brazilian Portuguese]
    • Ferreira ALA, Matsubara LS. Free radicals: concepts, diseases, defense system and oxidative stress [in Brazilian Portuguese]. Rev Assoc Med Bras 1997;43:61-8
    • (1997) Rev Assoc Med Bras , vol.43 , pp. 61-68
    • Ala, F.1    Matsubara, L.S.2
  • 22
    • 33644909056 scopus 로고    scopus 로고
    • Oxidative stress: Relations between the formation of reactive species and the organism's defense [in Brazilian Portuguese]
    • Barreiros ALBS, David JM, David JP. Oxidative stress: relations between the formation of reactive species and the organism's defense [in Brazilian Portuguese]. Quim Nova 2006;29:113-23
    • (2006) Quim Nova , vol.29 , pp. 113-123
    • Albs, B.1    David, J.M.2    David, J.P.3
  • 23
    • 0020427486 scopus 로고
    • Biology of disease: Free radical and tissue injury
    • Freeman BA, Crapo JD. Biology of disease: free radical and tissue injury. Lab Invest 1982;47:412-26
    • (1982) Lab Invest , vol.47 , pp. 412-426
    • Freeman, B.A.1    Crapo, J.D.2
  • 26
    • 77949485324 scopus 로고    scopus 로고
    • Antioxidants: Molecules, medicines and myths
    • Gutteridge JMC, Halliwell B. Antioxidants: molecules, medicines and myths. Biochem Biophys Res Commun 2010;393: 561-4
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 561-564
    • Jmc, G.1    Halliwell, B.2
  • 28
    • 0034453767 scopus 로고    scopus 로고
    • Ototoxicity: Mechanisms, protective agents and monitoring
    • Campbell KCM, Kalkanis J, Glatz FR. Ototoxicity: mechanisms, protective agents and monitoring. Curr Opin Otol Head Neck Sur 2000;8:436-40
    • (2000) Curr Opin Otol Head Neck sur , vol.8 , pp. 436-440
    • Kcm, C.1    Kalkanis, J.2    Glatz, F.R.3
  • 29
    • 18044362704 scopus 로고    scopus 로고
    • Immunohistochemical detection of platinatedDNA in the cochlea of cisplatin-treated guinea pigs
    • Van Rujven MWM, De Groot JCMJ, Hendriksen F, Smoorenburg GF. Immunohistochemical detection of platinatedDNA in the cochlea of cisplatin-treated guinea pigs. Hear Res 2005;203:112-21
    • (2005) Hear Res , vol.203 , pp. 112-121
    • Van Rujven Mwm1    De Groot Jcmj2    Hendriksen, F.3    Smoorenburg, G.F.4
  • 30
    • 58149395091 scopus 로고    scopus 로고
    • Short interfering RNA against transient receptor potential vanilloid-1 attenuates cisplatin-induced hearing loss in the rat
    • Mukherjea D, Jajoo S, Whitworth CA, Bunch JR, Turner JG, Rybak LP et al. Short interfering RNA against transient receptor potential vanilloid-1 attenuates cisplatin-induced hearing loss in the rat. J Neurosci 2008;28:13056-65
    • (2008) J Neurosci , vol.28 , pp. 13056-13065
    • Mukherjea, D.1    Jajoo, S.2    Whitworth, C.A.3    Bunch, J.R.4    Turner, J.G.5    Rybak, L.P.6
  • 32
    • 34548485284 scopus 로고    scopus 로고
    • Mechanisms of cisplatin ototoxicity and progress in otoprotection
    • Rybak LP. Mechanisms of cisplatin ototoxicity and progress in otoprotection. Curr Opin Otolaryngol Head Neck Surg 2007;15: 364-9
    • (2007) Curr Opin Otolaryngol Head Neck Surg , vol.15 , pp. 364-369
    • Rybak, L.P.1
  • 33
    • 0027409215 scopus 로고
    • Effects of free radicals on the intracellular calcium concentration in the isolated hair cell of the guinea pig cochlea
    • Ikeda K, Sunose H, Takasaka T. Effects of free radicals on the intracellular calcium concentration in the isolated hair cell of the guinea pig cochlea. Acta Otolaryngol 1993;113:137-41
    • (1993) Acta Otolaryngol , vol.113 , pp. 137-141
    • Ikeda, K.1    Sunose, H.2    Takasaka, T.3
  • 34
    • 0025057048 scopus 로고
    • Glutathione peroxidase, superoxide dismutase and catalase inactivation by peroxides and oxygen derived free radicals
    • Pigeolet E, Corbisier P, Houbion A, Lambert D, Michiels C, Raes M et al. Glutathione peroxidase, superoxide dismutase and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 1990;50:283-97
    • (1990) Mech Ageing Dev , vol.50 , pp. 283-297
    • Pigeolet, E.1    Corbisier, P.2    Houbion, A.3    Lambert, D.4    Michiels, C.5    Raes, M.6
  • 36
    • 0037216692 scopus 로고    scopus 로고
    • Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes
    • Southall MD, Li T, Gharibova LS, Pei Y, Nicol GD, Travers JB. Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther 2003;304:217-22
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 217-222
    • Southall, M.D.1    Li, T.2    Gharibova, L.S.3    Pei, Y.4    Nicol, G.D.5    Travers, J.B.6
  • 37
    • 0037486951 scopus 로고    scopus 로고
    • Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti
    • Zheng J, Dai C, Steyger PS, Kim Y, Vass Z, Ren T et al. Vanilloid receptors in hearing: altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti. J Neurophysiol 2003;90:444-55
    • (2003) J Neurophysiol , vol.90 , pp. 444-455
    • Zheng, J.1    Dai, C.2    Steyger, P.S.3    Kim, Y.4    Vass, Z.5    Ren, T.6
  • 39
    • 0029012886 scopus 로고
    • Mechanism of cisplatin ototoxicity: Antioxidant system
    • Ravi R, Somani SM, Rybak LP. Mechanism of cisplatin ototoxicity: antioxidant system. Pharmacol Toxicol 1995;76:386-94
    • (1995) Pharmacol Toxicol , vol.76 , pp. 386-394
    • Ravi, R.1    Somani, S.M.2    Rybak, L.P.3
  • 40
    • 84878773640 scopus 로고    scopus 로고
    • Cell Injury Rubin E, Gorstein F, Rubin R, Schwarting R, Strayer D. Rubin's Pathology: Clinicopathologic Foundations of Medicine, 4th edn [in Brazilian Portuguese]
    • Strayer DS, Rubin E. Cell injury. In: Rubin E, Gorstein F, Rubin R, Schwarting R, Strayer D. Rubin's Pathology: Clinicopathologic Foundations of Medicine, 4th edn [in Brazilian Portuguese]. São Paulo: Guanabara-Koogan, 2006; 2-39
    • (2006) São Paulo: Guanabara-Koogan , pp. 2-39
    • Strayer, D.S.1    Rubin, E.2
  • 41
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407:770-6
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 42
    • 17344385626 scopus 로고    scopus 로고
    • Oxidative stress-induced apoptosis of cochlear sensory cells: Otoprotective strategies
    • Huang T, Cheng AG, Stupak H, LiuW, Kim A, Staecker H et al. Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci 2000;18:259-70
    • (2000) Int J Dev Neurosci , vol.18 , pp. 259-270
    • Huang, T.1    Cheng, A.G.2    Stupak, H.3    Liu, W.4    Kim, A.5    Staecker, H.6
  • 43
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell death
    • Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell death. Science 1998;281:1322-6
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 46
    • 65749118790 scopus 로고    scopus 로고
    • Involvement of caspase-8, 9, and 3 in high glucose-induced apoptosis in PC12 cells
    • Sharifia AM, Eslami H, Larijani B, Davoodi J. Involvement of caspase-8, 9, and 3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett 2009;459:47-51
    • (2009) Neurosci Lett , vol.459 , pp. 47-51
    • Sharifia, A.M.1    Eslami, H.2    Larijani, B.3    Davoodi, J.4
  • 47
    • 76149128932 scopus 로고    scopus 로고
    • Apoptosis: Programmed cell death [in Brazilian Portuguese]
    • Grivicich I, Regner A, Rocha AB. Apoptosis: programmed cell death [in Brazilian Portuguese]. Rev Bras Cancerol 2007;53: 335-43
    • (2007) Rev Bras Cancerol , vol.53 , pp. 335-343
    • Grivicich, I.1    Regner, A.2    Rocha, A.B.3
  • 48
    • 0034525374 scopus 로고    scopus 로고
    • The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability
    • Harris MH, Thompson CB. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ 2000;7:1182-91
    • (2000) Cell Death Differ , vol.7 , pp. 1182-1191
    • Harris, M.H.1    Thompson, C.B.2
  • 49
    • 0037213368 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions
    • Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003;39:615-47
    • (2003) Mol Immunol , vol.39 , pp. 615-647
    • Borner, C.1
  • 50
    • 0033781027 scopus 로고    scopus 로고
    • The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
    • Golstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nature Cell Biol 2000;2: 156-62
    • (2000) Nature Cell Biol , vol.2 , pp. 156-162
    • Golstein, J.C.1    Waterhouse, N.J.2    Juin, P.3    Evan, G.I.4    Green, D.R.5
  • 51
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998;281:1312-16
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 53
    • 84892437231 scopus 로고    scopus 로고
    • Apoptosis as a mechanism of tissue injury in hepatobiliary diseases [in Brazilian Portuguese]
    • Paronlin MB, Reason IJ. Apoptosis as a mechanism of tissue injury in hepatobiliary diseases [in Brazilian Portuguese]. Arq Gastroenterol São Paulo 2001;38:38-44
    • (2001) Arq Gastroenterol São Paulo , vol.38 , pp. 38-44
    • Paronlin, M.B.1    Reason, I.J.2
  • 54
  • 56
    • 20444481639 scopus 로고    scopus 로고
    • Correlation of increased activities of Na +, K+ -ATP-Ase and Ca2+ -ATPase with the reversal of cisplatin ototoxicity induced by D-methionine in guinea pigs
    • Cheng PW, Liu SH, Hsu CJ, Lin-Shiau SY. Correlation of increased activities of Na +, K+ -ATP-Ase and Ca2+ -ATPase with the reversal of cisplatin ototoxicity induced by D-methionine in guinea pigs. Hear Res 2005;205:102-9
    • (2005) Hear Res , vol.205 , pp. 102-109
    • Cheng, P.W.1    Liu, S.H.2    Hsu, C.J.3    Lin-Shiau, S.Y.4
  • 57
    • 0034104744 scopus 로고    scopus 로고
    • Histological effects of co-Administration of an ACTH(4-9) analog ORG 2766 on cisplatin ototoxicity in the albino guinea pig
    • Cardinaal RM, de Groot JC, Huizing EH, Veldman JE, Smoorenburg GF. Histological effects of co-Administration of an ACTH(4-9) analog ORG 2766 on cisplatin ototoxicity in the albino guinea pig. Hear Res 2000;144:157-67
    • (2000) Hear Res , vol.144 , pp. 157-167
    • Cardinaal, R.M.1    De Groot, J.C.2    Huizing, E.H.3    Veldman, J.E.4    Smoorenburg, G.F.5
  • 59
    • 0032694345 scopus 로고    scopus 로고
    • Application of antioxidants and other agents to prevent cisplatin ototoxicity
    • Rybak L, Whitworth C, Somani S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope 1999;109:1740-4
    • (1999) Laryngoscope , vol.109 , pp. 1740-1744
    • Rybak, L.1    Whitworth, C.2    Somani, S.3
  • 61
    • 0035033342 scopus 로고    scopus 로고
    • Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals
    • Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001;155:1-8
    • (2001) Hear Res , vol.155 , pp. 1-8
    • Sha, S.H.1    Taylor, R.2    Forge, A.3    Schacht, J.4
  • 62
    • 0030463938 scopus 로고    scopus 로고
    • Differential cellular distribution of glutathione - An endogenous antioxidant - In the guinea pig inner ear
    • Usami S, Hjelle OP, Ottersen OP. Differential cellular distribution of glutathione - an endogenous antioxidant - in the guinea pig inner ear. Brain Res 1996;743:337-40
    • (1996) Brain Res , vol.743 , pp. 337-340
    • Usami, S.1    Hjelle, O.P.2    Ottersen, O.P.3
  • 63
    • 0033959645 scopus 로고    scopus 로고
    • Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity
    • Muldoon LL, Pagel MA, Kroll RA, Brummett RE, Doolittle ND, Zuhowski EG et al. Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity. Clin Cancer Res 2000;6:309-15
    • (2000) Clin Cancer Res , vol.6 , pp. 309-315
    • Muldoon, L.L.1    Pagel, M.A.2    Kroll, R.A.3    Brummett, R.E.4    Doolittle, N.D.5    Zuhowski, E.G.6
  • 64
    • 23844527954 scopus 로고    scopus 로고
    • Amifostine otoprotection to cisplatin ototoxicity: A guinea pig study using otoacoustic emission distortion products (DPOEA) and scanning electron microscopy [in Brazilian Portuguese]
    • Hyppolito MA, Oliveira JAA, Lessa RM, Rossato M. Amifostine otoprotection to cisplatin ototoxicity: a guinea pig study using otoacoustic emission distortion products (DPOEA) and scanning electron microscopy [in Brazilian Portuguese]. Rev Bras Otorrinolaringol 2005;71:168-273
    • (2005) Rev Bras Otorrinolaringol , vol.71 , pp. 168-273
    • Hyppolito, M.A.1    Jaa, O.2    Lessa, R.M.3    Rossato, M.4
  • 65
    • 12444306336 scopus 로고    scopus 로고
    • Cisplatin ototoxicity and otoprotector to ciliated cells by ginkgo biloba extract: Anatomic and electrophysiologic study [in Brazilian Portuguese]
    • Hyppolito MA, Oliveira JAA, Rossato M, Holanda F. Cisplatin ototoxicity and otoprotector to ciliated cells by ginkgo biloba extract: anatomic and electrophysiologic study [in Brazilian Portuguese]. Rev Bras Otorrinolaringol 2003;69:504-11
    • (2003) Rev Bras Otorrinolaringol , vol.69 , pp. 504-511
    • Hyppolito, M.A.1    Jaa, O.2    Rossato, M.3    Holanda, F.4
  • 67
    • 0034944185 scopus 로고    scopus 로고
    • L-N-Acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity
    • Feghali JG, Liu W, Van De Water TR. L-N-Acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity. Laryngoscope 2001;111:1147-55
    • (2001) Laryngoscope , vol.111 , pp. 1147-1155
    • Feghali, J.G.1    Liu, W.2    Van De Water, T.R.3
  • 69
    • 84872919014 scopus 로고    scopus 로고
    • Transtympanic injections of N-Acetylcysteine for the prevention of cisplatin-induced ototoxicity: A feasible method with promising efficacy
    • Riga MG, Chelis L, Kakolyris S, Papadopoulos S, Stathakidou S, Chamalidou E et al. Transtympanic injections of N-Acetylcysteine for the prevention of cisplatin-induced ototoxicity: a feasible method with promising efficacy. Am J Clin Oncol 2013;36: 1-6
    • (2013) Am J Clin Oncol , vol.36 , pp. 1-6
    • Riga, M.G.1    Chelis, L.2    Kakolyris, S.3    Papadopoulos, S.4    Stathakidou, S.5    Chamalidou, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.