Cisplatin-induced apoptosis in auditory cells: Role of death receptor and mitochondrial pathways

Hearing Research

Volumn 174, Issue 1-2, 2002, Pages 45-54

  Devarajan, Prasad ^a,c   Savoca, Michelle ^a   Castaneda, M Patricia ^a   Park, Moon Soo ^a   Esteban Cruciani, Nora ^a   Kalinec, Gilda ^b   Kalinec, Federico ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b HOUSE EAR INSTITUTE   (United States)

^c Hospital Medical Center   (United States)

Author keywords

Apoptosis; Auditory cell; Cisplatin; Ototoxicity

Indexed keywords

CASPASE; CASPASE 8; CASPASE 9; CISPLATIN; DEATH RECEPTOR; PROTEIN BAX; PROTEIN BID; PROTEIN P53; RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CYTOCHROME C; ION CHANNEL; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; ONCOPROTEIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUDITORY SYSTEM; COCHLEA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME ASSAY; IN VITRO STUDY; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; TOXICOKINETICS; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; PHYSIOLOGY; TIME; TISSUE DISTRIBUTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CELL LINE; CISPLATIN; COCHLEA; CYTOCHROME C GROUP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ION CHANNELS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TUMOR NECROSIS FACTOR; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0036888412     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(02)00634-2     Document Type: Article

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