메뉴 건너뛰기




Volumn 15, Issue 7, 2015, Pages 809-815

Is notch signaling a specific target in hepatocellular carcinoma?

Author keywords

Hepatocellular carcinoma; Notch signaling; Oncogene; Therapeutics; Tumor suppressor

Indexed keywords

CURCUMIN; DOXORUBICIN; NOTCH RECEPTOR; SMALL INTERFERING RNA; SORAFENIB; VALPROIC ACID; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE;

EID: 84938682383     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520615666150202102809     Document Type: Article
Times cited : (15)

References (54)
  • 1
    • 84896398914 scopus 로고    scopus 로고
    • Notch signaling and new therapeutic options in liver disease
    • Morell, C.M.; Strazzabosco, M. Notch signaling and new therapeutic options in liver disease. J. Hepatol., 2014, 60(4), 885- 890.
    • (2014) J. Hepatol , vol.60 , Issue.4 , pp. 885-890
    • Morell, C.M.1    Strazzabosco, M.2
  • 2
    • 84894422475 scopus 로고    scopus 로고
    • The roles of transforming growth factor- β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours
    • Bogaerts, E.; Heindryckx, F.; Vandewynckel, Y.P.; Van Grunsven, L.A.; Van Vlierberghe, H. The roles of transforming growth factor- β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours. Int. J. Oncol., 2014, 44(4), 1015-1022
    • (2014) Int. J. Oncol , vol.44 , Issue.4 , pp. 1015-1022
    • Bogaerts, E.1    Heindryckx, F.2    Vandewynckel, Y.P.3    Van Grunsven, L.A.4    Van Vlierberghe, H.5
  • 4
    • 84879925475 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma: Consider the population
    • Mittal, S.; El-Serag, H.B. Epidemiology of hepatocellular carcinoma: Consider the population. J. Clin. Gastroenterol., 2013, 47 Suppl, S2-6.
    • (2013) J. Clin. Gastroenterol , vol.47 , pp. S2-S6
    • Mittal, S.1    El-Serag, H.B.2
  • 5
    • 80053088189 scopus 로고    scopus 로고
    • Current concepts: Hepatocellular carcinoma
    • El-Serag, H.B. Current concepts: Hepatocellular carcinoma. N. Engl. J. Med., 2011, 365, 1118-1127.
    • (2011) N. Engl. J. Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 6
    • 85039836851 scopus 로고    scopus 로고
    • Progress in comprehensive treatment of primary liver cancer
    • Fan, J.; Wang, Z. Progress in comprehensive treatment of primary liver cancer. Int. J. Dig. Dis., 2013, 33, 73-76.
    • (2013) Int. J. Dig. Dis , vol.33 , pp. 73-76
    • Fan, J.1    Wang, Z.2
  • 7
    • 84885356350 scopus 로고    scopus 로고
    • Cancer epidemiology and control in China: State of the art
    • Zeng, H.; Chen, W. Cancer epidemiology and control in China: State of the art. Prog. Chemistry, 2013, 25, 1415-1420.
    • (2013) Prog. Chemistry , vol.25 , pp. 1415-1420
    • Zeng, H.1    Chen, W.2
  • 8
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • El-Serag, H.B. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology, 2012, 142, 1264-1273.
    • (2012) Gastroenterology , vol.142 , pp. 1264-1273
    • El-Serag, H.B.1
  • 9
    • 84901837328 scopus 로고    scopus 로고
    • Virus associated malignancies: The role of viral hepatitis in hepatocellular carcinoma
    • Shlomai, A.; De Jong, Y.P.; Rice, C.M. Virus associated malignancies: The role of viral hepatitis in hepatocellular carcinoma. Semin. Cancer Biol., 2014, 26, 78-88.
    • (2014) Semin. Cancer Biol , vol.26 , pp. 78-88
    • Shlomai, A.1    De Jong, Y.P.2    Rice, C.M.3
  • 10
    • 84862942769 scopus 로고    scopus 로고
    • Hepatitis B and C virus infection and hepatocellular carcinoma in China: A review of epidemiology and control measures
    • Tanaka, M.; Katayama, F.; Kato, H.; Tanaka, H.; Wang, J.; Qiao, Y.L.; Inoue, M. Hepatitis B and C virus infection and hepatocellular carcinoma in China: A review of epidemiology and control measures. J. Epidemiol., 2011, 21, 401-416.
    • (2011) J. Epidemiol , vol.21 , pp. 401-416
    • Tanaka, M.1    Katayama, F.2    Kato, H.3    Tanaka, H.4    Wang, J.5    Qiao, Y.L.6    Inoue, M.7
  • 11
    • 85039813338 scopus 로고    scopus 로고
    • Liver ancer in 2013: Mutational landscape of HCC-the end of the beginning
    • Villanueva, A.; Llovet, J.M. Liver ancer in 2013: Mutational landscape of HCC-the end of the beginning. Nat. Rev. Clin. Oncol., 2014, 25(2),196-209.
    • (2014) Nat. Rev. Clin. Oncol , vol.25 , Issue.2 , pp. 196-209
    • Villanueva, A.1    Llovet, J.M.2
  • 12
    • 84879579860 scopus 로고    scopus 로고
    • Emerging signaling pathways in hepatocellular carcinoma
    • Moeini, A.; Cornella, H.; Villanueva, A. Emerging signaling pathways in hepatocellular carcinoma. Liver Cancer, 2012, 1, 83-93.
    • (2012) Liver Cancer , vol.1 , pp. 83-93
    • Moeini, A.1    Cornella, H.2    Villanueva, A.3
  • 13
    • 84886950547 scopus 로고    scopus 로고
    • Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis
    • Morell, C.M.; Fiorotto, R.; Fabris, L.; Strazzabosco, M. Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis. Clin. Res. Hepatol. Gastroenterol., 2013, 37, 447-454.
    • (2013) Clin. Res. Hepatol. Gastroenterol , vol.37 , pp. 447-454
    • Morell, C.M.1    Fiorotto, R.2    Fabris, L.3    Strazzabosco, M.4
  • 16
    • 0033662392 scopus 로고    scopus 로고
    • MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
    • Wu, L.; Aster, J.C.; Blacklow, S.C.; Lake, R.; Artavanis-Tsakonas, S.; Griffin, J.D. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat. Genet., 2000, 26, 484-489.
    • (2000) Nat. Genet , vol.26 , pp. 484-489
    • Wu, L.1    Aster, J.C.2    Blacklow, S.C.3    Lake, R.4    Artavanis-Tsakonas, S.5    Griffin, J.D.6
  • 17
    • 34548452775 scopus 로고    scopus 로고
    • Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors
    • Kunnimalaiyaan, M.; Chen, H. Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist, 2007, 12, 535-542.
    • (2007) Oncologist , vol.12 , pp. 535-542
    • Kunnimalaiyaan, M.1    Chen, H.2
  • 18
    • 3342967780 scopus 로고    scopus 로고
    • Modulation of notch signaling by mastermindlike (MAML) transcriptional co-activators and their involvement in tumorigenesis
    • Wu, L.; Griffin, J.D. Modulation of notch signaling by mastermindlike (MAML) transcriptional co-activators and their involvement in tumorigenesis. Semin. Cancer Biol., 2004, 14, 348-356.
    • (2004) Semin. Cancer Biol , vol.14 , pp. 348-356
    • Wu, L.1    Griffin, J.D.2
  • 19
    • 80054742750 scopus 로고    scopus 로고
    • Notch signaling as a therapeutic target for breast cancer treatment?
    • Han, J.; Hendzel, M.J.; Allalunis-Turner, J. Notch signaling as a therapeutic target for breast cancer treatment? Breast Cancer Res., 2011, 13(3), 210.
    • (2011) Breast Cancer Res , vol.13 , Issue.3 , pp. 210
    • Han, J.1    Hendzel, M.J.2    Allalunis-Turner, J.3
  • 20
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray, S.J. Notch signalling: A simple pathway becomes complex. Nat. Rev. Mol. Cell Biol., 2006, 7, 678-689.
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 21
    • 77954215506 scopus 로고    scopus 로고
    • Notch signaling: Emerging molecular targets for cancer therapy
    • Yin, L.; Velazquez, O.C.; Liu, Z.J. Notch signaling: Emerging molecular targets for cancer therapy. Biochem. Pharmacol., 2010, 80, 690-701.
    • (2010) Biochem. Pharmacol , vol.80 , pp. 690-701
    • Yin, L.1    Velazquez, O.C.2    Liu, Z.J.3
  • 23
    • 84886739659 scopus 로고    scopus 로고
    • Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma
    • Giovannini, C.; Baglioni, M.; Toaldo, B.M.; Ventrucci, C.; D'Adamo, S.; Cipone, M.; Chieco, P.; Gramantieri, L.; Bolondi, L. Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma. Oncotarget, 2013, 4, 1618-1631.
    • (2013) Oncotarget , vol.4 , pp. 1618-1631
    • Giovannini, C.1    Baglioni, M.2    Toaldo, B.M.3    Ventrucci, C.4    D'Adamo, S.5    Cipone, M.6    Chieco, P.7    Gramantieri, L.8    Bolondi, L.9
  • 25
    • 0842324623 scopus 로고    scopus 로고
    • Multiple niches for Notch in cancer: Context is everything
    • Weng, A.P.; Aster, J.C. Multiple niches for Notch in cancer: Context is everything. Curr. Opin. Genet. Dev., 2004, 14, 48-54.
    • (2004) Curr. Opin. Genet. Dev , vol.14 , pp. 48-54
    • Weng, A.P.1    Aster, J.C.2
  • 26
    • 50849104230 scopus 로고    scopus 로고
    • Notch tumor suppressor function
    • Dotto, G.P. Notch tumor suppressor function. Oncogene, 2008, 27, 5115-5123.
    • (2008) Oncogene , vol.27 , pp. 5115-5123
    • Dotto, G.P.1
  • 28
    • 33644782668 scopus 로고    scopus 로고
    • Recent insights into the role of Notch signaling in tumorigenesis
    • Leong, K.G.; Karsan, A. Recent insights into the role of Notch signaling in tumorigenesis. Blood, 2006, 107, 2223-2233.
    • (2006) Blood , vol.107 , pp. 2223-2233
    • Leong, K.G.1    Karsan, A.2
  • 29
    • 38549148417 scopus 로고    scopus 로고
    • Notch and cancer: A double-edged sword
    • Koch, U.; Radtke, E. Notch and cancer: A double-edged sword. Cell. Mol. Life Sci., 2007, 64, 2746-2762.
    • (2007) Cell. Mol. Life Sci , vol.64 , pp. 2746-2762
    • Koch, U.1    Radtke, E.2
  • 30
    • 33646415906 scopus 로고    scopus 로고
    • Survival signaling by Notch1: Mammalian target of rapamycin (mTOR)-dependent inhibition of p53
    • Mungamuri, S.K.; Yang, X.; Thor, A.D.; Somasundaram, K. Survival signaling by Notch1: Mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res., 2006, 66, 4715- 4724.
    • (2006) Cancer Res , vol.66 , pp. 4715-4724
    • Mungamuri, S.K.1    Yang, X.2    Thor, A.D.3    Somasundaram, K.4
  • 31
    • 84920997369 scopus 로고    scopus 로고
    • Emerging roles of Notch signaling in liver disease
    • Geisler, F; Strazzabosco, M. Emerging roles of Notch signaling in liver disease. Hepatology. 2015, 61(1),382-392.
    • (2015) Hepatology , vol.61 , Issue.1 , pp. 382-392
    • Geisler, F.1    Strazzabosco, M.2
  • 33
    • 84879293697 scopus 로고    scopus 로고
    • Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma
    • Ahn, S.; Hyeon, J.; Park, C.K. Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma. Hepatobiliary Pancreat. Dis. Int., 2013, 12, 286-294.
    • (2013) Hepatobiliary Pancreat. Dis. Int , vol.12 , pp. 286-294
    • Ahn, S.1    Hyeon, J.2    Park, C.K.3
  • 34
    • 77953457718 scopus 로고    scopus 로고
    • Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma
    • Ning, L.; Wentworth, L.; Chen, H.; Weber, S.M. Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma. Am. J. Transl. Res., 2009, 1, 358-366.
    • (2009) Am. J. Transl. Res , vol.1 , pp. 358-366
    • Ning, L.1    Wentworth, L.2    Chen, H.3    Weber, S.M.4
  • 37
    • 84880585219 scopus 로고    scopus 로고
    • Aberrant expression of Notch3 predicts poor survival for hepatocellular carcinomas
    • Hu, L.; Xue, F.; Shao, M.; Deng, A.; Wei, G. Aberrant expression of Notch3 predicts poor survival for hepatocellular carcinomas. Biosci. Trends, 2013, 7(3), 152-156.
    • (2013) Biosci. Trends , vol.7 , Issue.3 , pp. 152-156
    • Hu, L.1    Xue, F.2    Shao, M.3    Deng, A.4    Wei, G.5
  • 38
    • 84863051750 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway
    • Wang, F.; Zhou, H.; Yang, Y.; Xia, X.; Sun, Q.; Luo, J.; Cheng, B. Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway. Oncol. Rep., 2012, 27, 1170-1176.
    • (2012) Oncol. Rep , vol.27 , pp. 1170-1176
    • Wang, F.1    Zhou, H.2    Yang, Y.3    Xia, X.4    Sun, Q.5    Luo, J.6    Cheng, B.7
  • 39
    • 84867803141 scopus 로고    scopus 로고
    • Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells
    • Gao, J.; Dong, Y.; Zhang, B.; Xiong, Y.; Xu, W.; Cheng, Y.; Dai, M.; Yu, Z.; Xu, H.; Zheng, G. Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells. Int. J. Oncol., 2012, 41, 1773-81.
    • (2012) Int. J. Oncol , vol.41 , pp. 1773-1781
    • Gao, J.1    Dong, Y.2    Zhang, B.3    Xiong, Y.4    Xu, W.5    Cheng, Y.6    Dai, M.7    Yu, Z.8    Xu, H.9    Zheng, G.10
  • 41
    • 0346365362 scopus 로고    scopus 로고
    • Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis
    • Qi, R.; An, H.; Yu, Y.; Zhang, M.; Liu, S.; Xu, H.; Guo, Z.; Cheng, T.; Cao, X. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res., 2003, 63, 8323-8329.
    • (2003) Cancer Res , vol.63 , pp. 8323-8329
    • Qi, R.1    An, H.2    Yu, Y.3    Zhang, M.4    Liu, S.5    Xu, H.6    Guo, Z.7    Cheng, T.8    Cao, X.9
  • 42
    • 67650236862 scopus 로고    scopus 로고
    • Notch1 signaling sensitizes tumor necrosis factorrelated apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression
    • Wang, C.; Qi, R.; Li, N.; Wang, Z.; An, H.; Zhang, Q.; Yu, Y.; Cao, X. Notch1 signaling sensitizes tumor necrosis factorrelated apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. J. Biol. Chem., 2009, 284, 16183-16190.
    • (2009) J. Biol. Chem , vol.284 , pp. 16183-16190
    • Wang, C.1    Qi, R.2    Li, N.3    Wang, Z.4    An, H.5    Zhang, Q.6    Yu, Y.7    Cao, X.8
  • 44
    • 84864150714 scopus 로고    scopus 로고
    • CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma
    • Giovannini, C.; Gramantieri, L.; Minguzzi, M.; Fornari, F.; Chieco, P.; Grazi, G.L.; Bolondi, L. CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma. Am. J. Pathol., 2012, 181, 413-422.
    • (2012) Am. J. Pathol , vol.181 , pp. 413-422
    • Giovannini, C.1    Gramantieri, L.2    Minguzzi, M.3    Fornari, F.4    Chieco, P.5    Grazi, G.L.6    Bolondi, L.7
  • 45
    • 84882949944 scopus 로고    scopus 로고
    • RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis
    • Wang, H.; Chen, G.; Wang, H.; Liu, C. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis. Oncol. Res., 2013, 20(10), 437-445.
    • (2013) Oncol. Res , vol.20 , Issue.10 , pp. 437-445
    • Wang, H.1    Chen, G.2    Wang, H.3    Liu, C.4
  • 46
    • 84927748882 scopus 로고    scopus 로고
    • A Cell surface β -Hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma
    • Aihara, A.; Huang, C.K.; Olsen, M.J.; Lin, Q.; Chung, W.; Tang, Q.; Dong, X.; Wands, J.R. A Cell surface β -Hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma. Hepatology, 2014, 60(4), 1302-1313.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 1302-1313
    • Aihara, A.1    Huang, C.K.2    Olsen, M.J.3    Lin, Q.4    Chung, W.5    Tang, Q.6    Dong, X.7    Wands, J.R.8
  • 47
    • 84893629663 scopus 로고    scopus 로고
    • Silybin-mediated inhibition of notch signaling exerts antitumor activity in human hepatocellular carcinoma cells
    • Zhang, S.; Yang, Y.; Liang, Z.; Duan, W.; Yang, J.; Yan, J.; Wang, N.; Feng, W.; Ding, M.; Nie, Y.; Jin, Z. Silybin-mediated inhibition of notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One, 2013, 8, e83699.
    • (2013) PLoS One , vol.8
    • Zhang, S.1    Yang, Y.2    Liang, Z.3    Duan, W.4    Yang, J.5    Yan, J.6    Wang, N.7    Feng, W.8    Ding, M.9    Nie, Y.10    Jin, Z.11
  • 48
    • 70349960028 scopus 로고    scopus 로고
    • Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells
    • Tatebe, H.; Shimizu, M.; Shirakami, Y.; Sakai, H.; Yasuda, Y.; Tsurumi, H.; Moriwaki, H. Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells. Cancer Lett., 2009, 285, 210-217.
    • (2009) Cancer Lett , vol.285 , pp. 210-217
    • Tatebe, H.1    Shimizu, M.2    Shirakami, Y.3    Sakai, H.4    Yasuda, Y.5    Tsurumi, H.6    Moriwaki, H.7
  • 49
    • 79959242392 scopus 로고    scopus 로고
    • Valproic acid inhibits human hepatocellular cancer cells growth in vitro and in vivo
    • Machado, M.C.; Bellodi-Privato, M.; Kubrusly, M.S. Valproic acid inhibits human hepatocellular cancer cells growth in vitro and in vivo. J. Exp. Ther. Oncol., 2011, 9, 85-92.
    • (2011) J. Exp. Ther. Oncol , vol.9 , pp. 85-92
    • Machado, M.C.1    Bellodi-Privato, M.2    Kubrusly, M.S.3
  • 50
    • 84879600898 scopus 로고    scopus 로고
    • Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells
    • Li, X.; Zhu, Y.; He, H.; Lou, L.; Ye, W.; Chen, Y.; Wang, J. Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells. Biochem. Biophys. Res. Commun., 2013, 436, 259-264.
    • (2013) Biochem. Biophys. Res. Commun , vol.436 , pp. 259-264
    • Li, X.1    Zhu, Y.2    He, H.3    Lou, L.4    Ye, W.5    Chen, Y.6    Wang, J.7
  • 51
    • 79955980009 scopus 로고    scopus 로고
    • Differential immunotoxicity of histone deacetylase inhibitors on malignant and naive hepatocytes
    • Weiller, M.; Weiland, T.; Dunstl, G.; Sack, U.; Kunstle, G.; Wendel, A. Differential immunotoxicity of histone deacetylase inhibitors on malignant and naive hepatocytes. Exp. Toxicol. Pathol., 2011, 63, 511-517.
    • (2011) Exp. Toxicol. Pathol , vol.63 , pp. 511-517
    • Weiller, M.1    Weiland, T.2    Dunstl, G.3    Sack, U.4    Kunstle, G.5    Wendel, A.6
  • 53
    • 84883351025 scopus 로고    scopus 로고
    • Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma
    • Ye, C.G.; Chen, G.G.; Ho, R.L.; Merchant, J.L.; He, M.L.; Lai, P.B. Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma. Biochim. Biophys. Acta, 2013, 1833, 2970-2979.
    • (2013) Biochim. Biophys. Acta , vol.1833 , pp. 2970-2979
    • Ye, C.G.1    Chen, G.G.2    Ho, R.L.3    Merchant, J.L.4    He, M.L.5    Lai, P.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.