Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 1170-1176

  Wang, Fan ^a   Zhou, Haiyan ^a   Yang, Yuzhen ^a   Xia, Xiumei ^a   Sun, Qian ^a   Luo, Jin ^a   Cheng, Bin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

DAPT; HBx; HepG2; NICD; Notch

Indexed keywords

HEPATITIS B VIRUS X PROTEIN; JAGGED1; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR HES 1;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER GROWTH; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INTERACTION; GENETIC TRANSFECTION; HBX GENE; HEPATITIS B VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GENE; UPREGULATION; VIRUS CARCINOGENESIS;

APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM-BINDING PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DIPEPTIDES; HEP G2 CELLS; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MEMBRANE PROTEINS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATORS; TRANSFECTION;

EID: 84863051750     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1620     Document Type: Article

References (29)

1. El-Serag HB: Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 127: S27-S34, 2004.
2. Llovet JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet 362: 1907-1917, 2003. (Pubitemid 37518510)
3. Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD and Murray CJ: Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer 2: 37, 2002.
4. Koike K: Hepatitis B virus HBx gene and hepatocarcinogenesis. Intervirology 38: 134-142, 1995.
5. Lucito R and Schneider RJ: Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J Virol 66: 983-991, 1992.
6. Kekule AS, Lauer U, Weiss L, Luber B and Hofschneider PH: Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361: 742-745, 1993. (Pubitemid 23070485)
7. Maguire HF, Hoeffler JP and Siddiqui A: HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252: 842-844, 1991. (Pubitemid 121000525)
8. Doria M, Klein N, Lucito R and Schneider RJ: The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J 14: 4747-4757, 1995.
9. Klein NP and Schneider RJ: Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol 17: 6427-6436, 1997. (Pubitemid 27451188)
10. Gottlob K, Fulco M, Levrero M and Graessmann A: The hepatitis B virus HBx protein inhibits caspase 3 activity. J Biol Chem 273: 33347-33353, 1998. (Pubitemid 29005712)
11. Benn J and Schneider RJ: Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc Natl Acad Sci USA 92: 11215-11219, 1995.
12. Ding Q, Xia W, Liu JC, et al: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 19: 159-170, 2005. (Pubitemid 41019664)
13. Benn J and Schneider RJ: Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 91: 10350-10354, 1994.
14. Lee YI, Kang-Park S and Do SI: The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem 276: 16969-16977, 2001.
15. Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 284: 770-776, 1999. (Pubitemid 29291335)
16. Miele L: Notch signaling. Clin Cancer Res 12: 1074-1079, 2006.
17. Kopan R and Ilagan MX: Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5: 499-504, 2004.
18. Maillard I, Adler SH and Pear WS: Notch and the immune system. Immunity 19: 781-791, 2003. (Pubitemid 37542299)
19. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R and Israel A: Signalling downstream of activated mammalian Notch. Nature 377: 355-358, 1995.
20. Ohtsuka T, Sakamoto M, Guillemot F and Kageyama R: Roles of the basic helix-loop-helix genes Hes-1 and Hes5 in expansion of neural stem cells of the developing brain. J Biol Chem 276: 30467-30474, 2001.
21. Miele L, Golde T and Osborne B: Notch signaling in cancer. Curr Mol Med 6: 905-918, 2006. (Pubitemid 44883940)
22. Yanagawa S, Lee JS, Kakimi K, Matsuda Y, Honjo T and Ishimoto A: Identification of Notch-1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus. J Virol 74: 9786-9791, 2000.
23. Ellisen LW, Bird J, West DC, et al: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-661, 1991. (Pubitemid 121001701)
24. Sjolund J, Manetopoulos C, Stockhausen MT and Axelson H: The Notch pathway in cancer: differentiation gone awry. Eur J Cancer 41: 2620-2629, 2005. (Pubitemid 41607552)
25. Nijjar SS, Crosby HA, Wallace L, Hubscher SG and Strain AJ: Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Hepatology 34: 1184-1192, 2001. (Pubitemid 33096591)
26. Nijjar SS, Wallace L, Crosby HA, Hubscher SG and Strain AJ: Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am J Pathol 160: 1695-1703, 2002. (Pubitemid 34525649)
27. Cheng B, Guo X, Zheng Y, Wang Y, Liu C and Li P: The effects of HBx gene on the expression of DNA repair enzymes hOGG1 and hMYHalpha mRNA in HepG2 cells. J Huazhong Univ Sci Technolog Med Sci 29: 187-192, 2009.
28. Gao J, Chen C, Hong L, et al: Expression of Jagged-1 and its association with hepatitis B virus X protein in hepatocellular carcinoma. Biochem Biophys Res Commun 356: 341-347, 2007. (Pubitemid 46452552)
29. Balint K, Xiao M, Pinnix CC, et al: Activation of Notch-1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 115: 3166-3176, 2005. (Pubitemid 41567581)