-
1
-
-
0037308133
-
Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
-
DOI 10.1053/jhep.2003.50047
-
Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 37: 429-442, 2003. (Pubitemid 36152543)
-
(2003)
Hepatology
, vol.37
, Issue.2
, pp. 429-442
-
-
Llovet, J.M.1
Bruix, J.2
-
2
-
-
3042777392
-
Systemic treatment and liver transplantation for hepatocellular carcinoma: Two ends of the therapeutic spectrum
-
DOI 10.1016/S1470-2045(04)01508-6, PII S1470204504015086
-
Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol 5: 409-418, 2004. (Pubitemid 38878044)
-
(2004)
Lancet Oncology
, vol.5
, Issue.7
, pp. 409-418
-
-
Burroughs, A.1
Hochhauser, D.2
Meyer, T.3
-
3
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
SHARP Investigators Study Group
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359: 378-390, 2008.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
De Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Häussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
4
-
-
70350786544
-
Novel treatments for hepatocellular cancer
-
Kerr SH, Kerr DJ. Novel treatments for hepatocellular cancer. Cancer Lett 286: 114-120, 2009.
-
(2009)
Cancer Lett
, vol.286
, pp. 114-120
-
-
Kerr, S.H.1
Kerr, D.J.2
-
5
-
-
33644876853
-
Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy
-
Schuchmann M, Schulze-Bergkamen H, Fleischer B, Schattenberg JM, Siebler J, Weinmann A, Teufel A, Wörns M, Fischer T, Strand S, Lohse AW, Galle PR. Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. Oncol Rep 15: 227-230, 2006.
-
(2006)
Oncol Rep
, vol.15
, pp. 227-230
-
-
Schuchmann, M.1
Schulze-Bergkamen, H.2
Fleischer, B.3
Schattenberg, J.M.4
Siebler, J.5
Weinmann, A.6
Teufel, A.7
Wörns, M.8
Fischer, T.9
Strand, S.10
Lohse, A.W.11
Galle, P.R.12
-
6
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation N Engl J Med 348: 2042-2054, 2003.
-
(2003)
N Engl J Med
, vol.348
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
7
-
-
0035965343
-
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
-
Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276: 36734-36741, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 36734-36741
-
-
Phiel, C.J.1
Zhang, F.2
Huang, E.Y.3
Guenther, M.G.4
Lazar, M.A.5
Klein, P.S.6
-
8
-
-
70349960028
-
Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells
-
Tatebe H, Shimizu M, Shirakami Y, Sakai H, Yasuda Y, Tsurumi H Moriwaki H. Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells. Cancer Lett 285: 210-217, 2009.
-
(2009)
Cancer Lett
, vol.285
, pp. 210-217
-
-
Tatebe, H.1
Shimizu, M.2
Shirakami, Y.3
Sakai, H.4
Yasuda, Y.5
Tsurumi, H.6
Moriwaki, H.7
-
9
-
-
42649109021
-
Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors
-
Duenas-Gonzalez A, Candelaria M, Perez-Plascencia C, Perez-Cardenas E, de la Cruz-Hernandez E, Herrera LA. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treat Rev 34: 206-222, 2008.
-
(2008)
Cancer Treat Rev
, vol.34
, pp. 206-222
-
-
Duenas-Gonzalez, A.1
Candelaria, M.2
Perez-Plascencia, C.3
Perez-Cardenas, E.4
De La Cruz-Hernandez, E.5
Herrera, L.A.6
-
10
-
-
14944356392
-
Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells
-
DOI 10.1038/sj.bjc.6602309
-
Stockhausen MT, Sjölund J, Manetopoulos C, Axelson H. Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells. Br J Cancer 92: 751-759, 2005. (Pubitemid 40460614)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.4
, pp. 751-759
-
-
Stockhausen, M.-T.1
Sjolund, J.2
Manetopoulos, C.3
Axelson, H.4
-
11
-
-
34548463002
-
Valproic acid activates Notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells
-
DOI 10.1634/theoncologist.12-8-942
-
Greenblatt DY, Vaccaro AM, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M Chen H. Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. Oncologist 12: 942-951, 2007. (Pubitemid 47359136)
-
(2007)
Oncologist
, vol.12
, Issue.8
, pp. 942-951
-
-
Greenblatt, D.Y.1
Vaccaro, A.M.2
Jaskula-Sztul, R.3
Ning, L.4
Haymart, M.5
Kunnimalaiyaan, M.6
Chen, H.7
-
12
-
-
0036171675
-
The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells
-
DOI 10.1016/S0168-8278(01)00257-4, PII S0168827801002574
-
Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG Schuppan D. The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 36: 233-240, 2002. (Pubitemid 34146430)
-
(2002)
Journal of Hepatology
, vol.36
, Issue.2
, pp. 233-240
-
-
Herold, C.1
Ganslmayer, M.2
Ocker, M.3
Hermann, M.4
Geerts, A.5
Hahn, E.G.6
Schuppan, D.7
-
13
-
-
0037455825
-
Histone deacetylase inhibitor trichostatin a induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells
-
DOI 10.1002/ijc.10699
-
Yamashita Y, Shimada M, Harimoto N Rikimaru T, Shirabe K, Tanaka S, Sugimachi K. Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. Int J Cancer 103: 572-576, 2003. (Pubitemid 36091459)
-
(2003)
International Journal of Cancer
, vol.103
, Issue.5
, pp. 572-576
-
-
Yamashita, Y.-I.1
Shimada, M.2
Harimoto, N.3
Rikimaru, T.4
Shirabe, K.5
Tanaka, S.6
Sugimachi, K.7
-
14
-
-
12444296582
-
Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357
-
DOI 10.1016/j.jhep.2004.10.020, PII S0168827804004635
-
Armeanu S, Pathil A, Venturelli S, Mascagni P, Weiss TS, Göttlicher M, Gregor M, Lauer UM, Bitzer M. Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357. J Hepatol 42: 210-217, 2005. (Pubitemid 40143467)
-
(2005)
Journal of Hepatology
, vol.42
, Issue.2
, pp. 210-217
-
-
Armeanu, S.1
Pathil, A.2
Venturelli, S.3
Mascagni, P.4
Weiss, T.S.5
Gottlicher, M.6
Gregor, M.7
Lauer, U.M.8
Bitzer, M.9
-
15
-
-
85047688508
-
Notch signaling in cancer
-
Allenspach EJ, Maillard I, Aster JC, Pear WS. Notch signaling in cancer. Cancer Biol Ther 1: 466-476, 2002.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 466-476
-
-
Allenspach, E.J.1
Maillard, I.2
Aster, J.C.3
Pear, W.S.4
-
16
-
-
0042286558
-
Notch and cancer: Best to avoid the ups and downs
-
DOI 10.1016/S1535-6108(03)00052-7
-
Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell 3: 203-205, 2003. (Pubitemid 37443875)
-
(2003)
Cancer Cell
, vol.3
, Issue.3
, pp. 203-205
-
-
Maillard, I.1
Pear, W.S.2
-
17
-
-
0346365362
-
Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis
-
Qi R, An H, Yu Y, Zhang M, Liu S, Xu H Guo Z, Cheng T, Cao X. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res 63: 8323-8329, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 8323-8329
-
-
Qi, R.1
An, H.2
Yu, Y.3
Zhang, M.4
Liu, S.5
Xu, H.6
Guo, Z.7
Cheng, T.8
Cao, X.9
-
18
-
-
77953457718
-
Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma
-
Ning L, Wentworth L, Chen H, Weber SM. Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma. Am J Transl Res 1: 358-366, 2009.
-
(2009)
Am J Transl Res
, vol.1
, pp. 358-366
-
-
Ning, L.1
Wentworth, L.2
Chen, H.3
Weber, S.M.4
-
19
-
-
70449732855
-
Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma
-
Wang M, Xue L, Cao Q, Lin Y, Ding Y, Yang P, Che L. Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma. Neoplasma 56: 533-541, 2009.
-
(2009)
Neoplasma
, vol.56
, pp. 533-541
-
-
Wang, M.1
Xue, L.2
Cao, Q.3
Lin, Y.4
Ding, Y.5
Yang, P.6
Che, L.7
-
20
-
-
33748103527
-
Implication of frequent local ablation therapy for intrahepatic recurrence in prolonged survival of patients with hepatocellular carcinoma undergoing hepatic resection: An analysis of 610 patients over 16 years old
-
DOI 10.1097/01.sla.0000217921.28563.55, PII 0000065820060800000014
-
Taura K, Ikai I, Hatano E, Fujii H, Uyama N, Shimahara Y. Implication of frequent local ablation therapy for intrahepatic recurrence in prolonged survival of patients with hepatocellular carcinoma undergoing hepatic resection: an analysis of 610 patients over 16 years old. Ann Surg 244: 265-273, 2006. (Pubitemid 44305542)
-
(2006)
Annals of Surgery
, vol.244
, Issue.2
, pp. 265-273
-
-
Taura, K.1
Ikai, I.2
Hatano, E.3
Fujii, H.4
Uyama, N.5
Shimahara, Y.6
-
21
-
-
0036799144
-
Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: Review of the randomised clinical trials
-
DOI 10.1016/S1470-2045(02)00873-2
-
Schwartz JD, Schwartz M, Mandeli J, Sung M. Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials. Lancet Oncol 3: 593-603, 2002. (Pubitemid 35174678)
-
(2002)
Lancet Oncology
, vol.3
, Issue.10
, pp. 593-603
-
-
Schwartz, J.D.1
Schwartz, M.2
Mandeli, J.3
Sung, M.4
-
22
-
-
33847118123
-
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
-
DOI 10.1007/s00280-006-0393-4
-
Chang YS, Adnane J, Trail PA, Levy J, Henderson A, Xue D, Bortolon E, Ichetovkin M, Chen C, McNabola A, Wilkie D, Carter CA, Taylor IC, Lynch M, Wilhelm S. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol 59: 561-574, 2007. (Pubitemid 46295136)
-
(2007)
Cancer Chemotherapy and Pharmacology
, vol.59
, Issue.5
, pp. 561-574
-
-
Chang, Y.S.1
Adnane, J.2
Trail, P.A.3
Levy, J.4
Henderson, A.5
Xue, D.6
Bortolon, E.7
Ichetovkin, M.8
Chen, C.9
McNabola, A.10
Wilkie, D.11
Carter, C.A.12
Taylor, I.C.A.13
Lynch, M.14
Wilhelm, S.15
-
23
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7: 3129-3140, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
Villanueva, A.4
Llovet, J.M.5
Lynch, M.6
-
24
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1: 287-299, 2002. (Pubitemid 37361445)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.4
, pp. 287-299
-
-
Johnstone, R.W.1
-
25
-
-
0041347519
-
Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
-
Johnstone RW, Licht JD. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 4: 13-18, 2003.
-
(2003)
Cancer Cell
, vol.4
, pp. 13-18
-
-
Johnstone, R.W.1
Licht, J.D.2
-
26
-
-
0642379469
-
Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate
-
Svechnikova I, Gray SG, Kundrotiene J, Ponthan F, Kogner P, Ekström TJ. Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate. Int J Oncol. 22: 579-588, 2003.
-
(2003)
Int J Oncol
, vol.22
, pp. 579-588
-
-
Svechnikova, I.1
Gray, S.G.2
Kundrotiene, J.3
Ponthan, F.4
Kogner, P.5
Ekström, T.J.6
-
27
-
-
0042090495
-
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
-
Peart MJ, Tainton KM, Ruefli AA, Dear AE, Sedelies KA, O'Reilly LA, Waterhouse NJ, Trapani JA, Johnstone RW. Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res 63: 4460-4471, 2003. (Pubitemid 36951018)
-
(2003)
Cancer Research
, vol.63
, Issue.15
, pp. 4460-4471
-
-
Peart, M.J.1
Tainton, K.M.2
Ruefli, A.A.3
Dear, A.E.4
Sedelies, K.A.5
O'Reilly, L.A.6
Waterhouse, N.J.7
Trapani, J.A.8
Johnstone, R.W.9
-
28
-
-
0035185449
-
Notch receptor expression in adult human liver: A possible role in bile duct formation and hepatic neovascularization
-
DOI 10.1053/jhep.2001.29399
-
Nijjar SS, Crosby HA, Wallace L, Hubscher SG, Strain AJ. Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Hepatology 34: 1184-1192, 2001. (Pubitemid 33096591)
-
(2001)
Hepatology
, vol.34
, Issue.6
, pp. 1184-1192
-
-
Nijjar, S.S.1
Crosby, H.A.2
Wallace, L.3
Hubscher, S.G.4
Strain, A.J.5
-
29
-
-
0036094234
-
Altered Notch ligand expression in human liver disease: Further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects
-
Nijjar SS, Wallace L, Crosby HA, Hubscher SG, Strain AJ. Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am J Pathol 160: 1695-1703, 2002. (Pubitemid 34525649)
-
(2002)
American Journal of Pathology
, vol.160
, Issue.5
, pp. 1695-1703
-
-
Nijjar, S.S.1
Wallace, L.2
Crosby, H.A.3
Hubscher, S.G.4
Strain, A.J.5
|